• Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
  • The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)
  • In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)
  • In addition, we differentiate for the first time the contributions of ERBB1 and ERBB2 to the key metastatic properties of in vivo tumor cell invasion and intravasation. (aacrjournals.org)
  • SOX4 has been revealed to induce EMT, a key process during organ development and the progression of epithelial tumors to metastatic cancers ( 9 ), via its activation of the Wnt and transforming growth factor β signaling pathways in cancer cells ( 10 , 11 ). (spandidos-publications.com)
  • In addition, metastatic sites may re-seed primary tumors in a multi-directional fashion [ 8 ]. (oncotarget.com)
  • We selected cN0 NSCLC patients with tumor diameter ≤ 30 mm and without imaging metastatic lymph nodes before surgery to study the incidence and risk factors for lymph node metastasis, thereby to provide the surgical indications for lymph node dissection in cN0 NSCLC. (biomedcentral.com)
  • Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. (ac.ir)
  • Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
  • Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
  • The morphologic features characteristic of the disease's pathology include small tumor cells with minimal cytoplasm, nuclear molding, fine chromatin pattern, extensive tumor necrosis/apoptosis, and a brisk mitotic rate. (medscape.com)
  • Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
  • When oxidative stress levels are reduced in cancer cells, their growth is more easily controlled through a process called apoptosis. (pinestreetfoundation.org)
  • During apoptosis, cells are removed by the immune system before they lose their cell wall, thus avoiding an inflammatory response to the dying cells. (pinestreetfoundation.org)
  • The authors of the above-mentioned study on Burkitt lymphoma cells and chemotherapy suggest that including antioxidants in the treatment protocol may enhance chemotherapy-induced apoptosis and phagocytosis. (pinestreetfoundation.org)
  • 2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
  • In this study, it was found that oxidative stress inhibited apoptosis by depleting cells of their energy source, which is called adenosine triphosphate (ATP). (pinestreetfoundation.org)
  • Then, the chemical count kit-8 cell viability assay, Annexin V-FITC apoptosis detection, EdU labeling proliferation detection, transwell and wound healing experiments were performed. (researchsquare.com)
  • The NFAT2 overexpression suppressed the cell viability, invasion and migration capabilities, and promoted apoptosis of HepG2 cells. (researchsquare.com)
  • In this study, we constructed NFAT2 overexpressed cells (HepG2/NFAT2) based on HepG2 and investigated the effect of NFAT2 overexpression on HepG2 cells' viability, apoptosis, proliferation, invasion and migration. (researchsquare.com)
  • When GTP is bound, for instance, Ras proteins can interact with effectors and other molecules to affect cell proliferation, differentiation and apoptosis. (justia.com)
  • Lung cancer cells induce senescence and apoptosis of pleural mesothelial cells via transforming growth factor-beta1. (cellosaurus.org)
  • In this work, for the first time we have demonstrated that ATRA affected on cell proliferation of GIST-T1 and GIST-882 cell line through inhibition of cell growth in a dose dependent manner and induced apoptosis. (biomedcentral.com)
  • In further examination, we found that the ATRA-induced apoptosis in GIST-T1 cells was accompanied by the down-regulated expression of survivin and up-regulated expression of Bax protein. (biomedcentral.com)
  • Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species. (cri.or.th)
  • Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
  • Accordingly, cell viability and apoptosis were measured using MTT and flow cytometry assays, respectively. (ac.ir)
  • Especially at the concentration of 20 ug/ml, the apoptosis rate was remarkably high in AGS (P-value= 0.003) and SW480 cells (P-value= 0.0007). (ac.ir)
  • Inhibiting PAK1 signals induce tumor cell apoptosis (cell death). (thehealthyplanet.com)
  • Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor. (nih.gov)
  • William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)
  • The hsa-miR-371-373 cluster (counteracting cellular senescence and linked with differentiation potency), as well as hsa-miR-520c/-520h (inhibiting the tumor suppressor p21) were 3.9-16.3 fold up-regulated in two of the three cisplatin resistant cell lines. (biomedcentral.com)
  • Collectively, these results indicated that miR‑320 acts as a tumor suppressor in breast cancer tumorigenesis and progression. (spandidos-publications.com)
  • this evidence suggests that miR-320 functions as a tumor suppressor ( 24 - 29 ). (spandidos-publications.com)
  • A previous study demonstrated that various proteins are dysregulated in primary tumors, and are associated with breast cancer development and progression ( 2 ). (spandidos-publications.com)
  • Incidence and occurrence of second primary tumors. (cancercentrum.se)
  • We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
  • A novel recombinant human Frizzled-7 protein exhibits anti-tumor activity against triple negative breast cancer via abating Wnt/β-catenin pathway. (ac.ir)
  • Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)
  • Recent studies demonstrated that piperine potentiates curcumin's inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. (frontiersin.org)
  • GBM stem-like cells (GSCs) represent a subpopulation of the tumor which is responsible for tumor initiation, progression, and re-growth after chemoradiation [ 5 , 6 ], as well as supporting tumor vessel growth and function [ 7 ]. (oncotarget.com)
  • sFzd7 decoy receptor inhibits tumor cell progression by attenuating the Wnt pathway through inhibiting Fzd7 receptors and Wnt ligand interaction. (ac.ir)
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
  • The proliferation of spleen cells were assessed by Bromodeoxyuridine (BrdU) assay. (biomedcentral.com)
  • We showed higher DTH, increased lymphocyte proliferation, decreased tumor growth and reduced JAK2/STAT3 phosphorylation in mice treated with naringenin and CPT. (biomedcentral.com)
  • During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
  • The ligand-binding area of S2RPgrmc1 is of interest as a healing focus on, and an S2RPgrmc1 inhibitor, AG-205 (26, 37), inhibits cancers cell proliferation (26), destabilizes EGFR (28) and reverses S2RPgrmc1 agonist binding (29). (nos-nop.org)
  • Therefore, besides the regulation of immune cells, NFAT2 also exerts modulatory effect of proliferation, invasion, metastasis and malignancy in breast cancer, lung cancer, melanoma and leukemia [13-15]. (researchsquare.com)
  • Other phenolic constituents such as phytic acid was shown to exhibit anticancer properties through the regulation of vital cellular functions such as signal transduction, cell proliferation and differentiation ( Vucenik and Shamsuddin, 2006 ). (scialert.net)
  • The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S. (justia.com)
  • Thus, existing techniques and current knowledge have not used nor addressed the interactions of GEF-H1 with other proteins as a means by which cell proliferation can be controlled or the detection and treatment of cancerous, tumorigenic cells and tissues be developed. (justia.com)
  • SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. (cancerindex.org)
  • Overexpression of SOX9 promoted NPC cell proliferation, migration and invasion. (cancerindex.org)
  • Cell proliferation was determined by trypan blue dye exclusion test. (biomedcentral.com)
  • Thereafter, the downstream signaling pathways are activated promoting cell proliferation and/or survival. (biomedcentral.com)
  • In addition, knockdown of miR‑320 in breast cancer cell lines promoted cell proliferation and invasion in vitro, whereas miR‑320 overexpression had the opposite effect. (spandidos-publications.com)
  • Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
  • In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
  • Establishment and characterization of two primary breast cancer cell lines from young Indian breast cancer patients mutation analysis. (gitam.edu)
  • In 1991, he joined the Institute of Parasitology-McGill as an Assistant Professor to work on drug resistance in Malaria, while continuing with his work on ABC-mediated drug resistance in cancer cells. (mcgill.ca)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Multifunctional magnetic iron-oxide nanoparticles (IONPs) can be directly imaged by magnetic resonance imaging (MRI) and designed to therapeutically target cancer cells. (oncotarget.com)
  • suggesting that this substance could influence the response of cancer cells to immunotherapy. (biomedcentral.com)
  • Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
  • To this topic, lycopene had been demonstrated to have synergism from the combination of oxaliplatin in a human ovarian cancer cell line ( 20 ), suggesting that the adjuvant property on the anticancer of lycopene. (frontiersin.org)
  • Cancer Biol. (scielo.br)
  • Taking a deeper look into the research literature yields many examples where oxidative stress on cancer cells has been shown to be counterproductive. (pinestreetfoundation.org)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • However, when oxidative stress levels go up, cancer cell death happens through a slower, messier, and less effective pathway called pyknosis or necrosis. (pinestreetfoundation.org)
  • Additionally, the ability of the body to "clean up" the resulting cellular debris from cancer cell death is also inhibited by oxidative stress. (pinestreetfoundation.org)
  • Dr. Multani has extensive expertise in the field of Human and Mammalian Cytogenetics, and specializes in the evaluation of genetic instability and complex chromosomal rearrangements in cancer cells, telomere dysfunction, characterization of embryonic stem cells, and authentication of cell lines. (mdanderson.org)
  • Methods: We established SW1116 colorectal cancer cell line stably transfected with UBE2Q1. (eurekaselect.com)
  • Nakamura, H. Ubiquitination and downregulation of ErbB2 and estrogen receptor-alpha by kinase inhibitor MP-412 in human breast cancer cells. (eurekaselect.com)
  • PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation. (nih.gov)
  • The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration. (nih.gov)
  • Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (aacrjournals.org)
  • Only the has-miR-10b involved in breast cancer invasion and metastasis and has-miR-512-3p appeared to be up-regulated (2-3-fold) in all three cell lines. (biomedcentral.com)
  • Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent widely used in the treatment of several solid tumors, among them testicular cancer, lung cancer, breast cancer, and bladder cancer. (biomedcentral.com)
  • Synergistic effect of carboplatin and piroxicam on two bladder cancer cell lines. (livedna.net)
  • Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). (cellosaurus.org)
  • Establishment of a human lung alveolar cancer cell strain and its characteristics. (cellosaurus.org)
  • Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A. An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines. (cellosaurus.org)
  • Next-generation characterization of the Cancer Cell Line Encyclopedia. (cellosaurus.org)
  • Differential expression of miRNAs has been widely described in breast cancers, and suggests that certain miRNAs, including miR-206 ( 19 ), miR-129 ( 20 ), miR-200 ( 21 ) and miR-34 ( 22 ), may function as oncogenes or tumor suppressors in breast cancer. (spandidos-publications.com)
  • It is the result of the dissemination of cancer cells to the bone marrow. (oncotarget.com)
  • Due to the difficulty in sampling and detection, few techniques exist to efficiently and consistently detect and quantify disseminated tumor cells (DTCs) in the bone marrow of cancer patients. (oncotarget.com)
  • DTCs occupy the hematopoietic stem cell niche within the bone marrow [ 5 ], often remaining dormant for years before becoming reactivated, leading to cancer recurrence [ 6 ]. (oncotarget.com)
  • It is difficult to determine the lymph node metastasis of patients with clinically negative lymph nodes (cN0) non-small cell lung cancer (NSCLC) before surgery. (biomedcentral.com)
  • Lung cancer has become the most common malignant tumor in China with the highest morbidity and mortality, of which non-small cell lung cancer (NSCLC) accounts for 80% [ 1 , 2 ]. (biomedcentral.com)
  • 1998). p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. (nature.com)
  • The effect of sFzd7 was evaluated on AGS gastric and SW480 colon cancer cell lines expressing high levels of Fzd7 receptor. (ac.ir)
  • 6. Sherwood V. WNT signaling: an emerging mediator of cancer cell metabolism? (ac.ir)
  • 12. Cheng Y, Li L, Pan S, Jiang H, Jin H. Targeting frizzled-7 decreases stemness and chemotherapeutic resistance in gastric cancer cells by suppressing Myc expression. (ac.ir)
  • 15. Schmuck R, Warneke V, Behrens H-M, Simon E, Weichert W, Röcken C. Genotypic and phenotypic characterization of side population of gastric cancer cell lines. (ac.ir)
  • A physician who heard my lecture at one of the conferences told me that Ivermectin has anti-cancer properties and anti-cancer stem cell properties. (thehealthyplanet.com)
  • Cancer stem cells are the reason why cancer cells often develop resistance to chemotherapies. (thehealthyplanet.com)
  • These researches are telling us that a combination of chemo agents with Ivermectin is targeting cancer stem cells. (thehealthyplanet.com)
  • Killing cancer stem cells is the holy grail of cancer therapy. (thehealthyplanet.com)
  • Bauer Research Foundation published on December 12, 2012 that Praziquantel , my other favorite parasite medication for liver flukes, synergistically enhances Paclitaxel (Taxol) efficacy to inhibit cancer cell growth (PloS ONE 7(12): e51721). (thehealthyplanet.com)
  • Taxol is a common chemo agent for ovarian cancer, breast cancer, small cell lung cancer, head and neck cancer, esophageal cancer, prostate and bladder cancer. (thehealthyplanet.com)
  • Pancreatic cancer primary tumor size measurements are often discordant between CT and pathologic specimen after resection. (medscape.com)
  • Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)
  • Multi-omics biomarkers of response to the discovered drugs were identified using human breast cancer cell lines. (cdc.gov)
  • Cancer antigen 19-9 (CA 19-9) is a tumor-associated mucin glycoprotein antigen that is related to the Lewis blood group protein. (medscape.com)
  • Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • Epigenetic Alteration of the Cancer-Related Gene TGFBI in B Cells Infected with Epstein-Barr Virus and Exposed to Aflatoxin B1: Potential Role in Burkitt Lymphoma Development. (who.int)
  • Small cell carcinoma of the prostate is a high-grade malignant neoplasm with neuroendocrine differentiation. (medscape.com)
  • Malignant gliomas remain aggressive and lethal primary brain tumors in adults. (oncotarget.com)
  • Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
  • These results indicate that ERBB inhibition should be considered for blocking other tumor cell malignant properties besides growth. (aacrjournals.org)
  • 2004). Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. (nature.com)
  • Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)
  • The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
  • Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)
  • Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
  • Moreover, we describe for the first time an association of the up-regulation of micro-RNA species such as hsa-miR-512-3p/-515/-517/-518/-525 and down-regulation of hsa-miR-99a/-100/-145 with a cisplatin resistant phenotype in human germ cell tumors. (biomedcentral.com)
  • Our approach was designed to characterize the role of micro-RNAs on the presumably multifactorial phenomenon of acquired cisplatin resistance in germ cell tumors. (biomedcentral.com)
  • Clinical studies using ERBB inhibitors have focused on tumor growth effects, but ERBBs can contribute to malignancy independent of their effects on tumor growth. (aacrjournals.org)
  • Our studies were designed to evaluate the effect of ERBB inhibition on tumor cell motility and intravasation in vivo using clinically relevant small-molecule inhibitors. (aacrjournals.org)
  • Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. (nature.com)
  • PKCa and PKCe activities were inhibited using isoform-specific pharmacologic inhibitors and genetically modified dominant-negative (DN) expressing cell lines. (cdc.gov)
  • Using gefitinib, ERBB1 inhibition rapidly inhibits tumor cell motility and invasion but not intravasation, whereas ERBB2 inhibition by AG825 rapidly blocks intravasation. (aacrjournals.org)
  • Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
  • Our outcomes indicate nevertheless that Cav-1 isn't essential for membrane localization from the GR since CCRF-CEM and Jurkat cells possess an operating mGR, but didn't communicate this caveolar proteins. (fabretp.org)
  • The lifestyle of such a receptor was also reported inside a mouse pituitary cell range (22), suggesting a second gene can be mixed up in manifestation of the GC-binding proteins at least in the central anxious system. (fabretp.org)
  • Nevertheless, in rats a GR immunoreactive proteins was detected for the plasma membrane of liver organ cells (10), of hippocampal and hypothalamic neurons (11), and of glial and neuronal cells Pyrantel pamoate in the lateral amygdala. (fabretp.org)
  • Moreover, we recently reported that lycopene inhibits the metastasis of human liver adenocarcinoma SK-Hep-1 cells by downregulation of the NADPH oxidase 4 (NOX4) proteins ( 18 ). (frontiersin.org)
  • Conclusion: Our data suggest that UBE2Q1 as an E2 enzyme of ubiquitination system can interact with B4GALT1 and P53, and may contribute to the accumulation of misfolded important proteins and colorectal tumor development. (eurekaselect.com)
  • 1978. Altered erythrocyte membrane proteins in sickle cell patients associated with the severity of the disease. (mote.org)
  • We hypothesised that these anionic proteins are perceived by the innate immune system as arising from infection or damaged cell components, producing an inflammatory response within the lung involving the receptor RAGE. (bvsalud.org)
  • CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)
  • The determination of testosterone in the female is helpful in the evaluation of cengenital adrenal hyperplasia, PCOS, and when an ovarian tumor, adrenal tumor, adrenal hyperplasia, or ovarian insufficiency is suspected. (cdc.gov)
  • A molecular signature response classifier (MSRC) that predicts which patients with RA are unlikely to respond to tumor necrosis factor-α inhibitor (TNFi) therapy would have wide clinical utility. (springer.com)
  • 5. Force WR, Glass AA, Benedict CA, Cheung TC, Lama J, Ware CF. Discrete signaling regions in the lymphotoxin-β receptor for tumor necrosis factor receptor-associated factor binding, subcellular localization, and activation of cell death and NF-κB pathways. (southernbiotech.com)
  • Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor. (cdc.gov)
  • however, mechanisms through which these bioactive compounds act on epithelial cells have not been identified. (biorxiv.org)
  • Dust samples collected from Nebraska swine confinement facilities (hog dust extract [HDE]) are known to elicit proinflammatory cytokine release from human bronchial epithelial (HBE) cells in vitro. (cdc.gov)
  • 2018. Curcumin and rutin down-regulate cyclooxygenase-2 and reduce tumor-associated inflammation in HPV16-transgenic mice. (livedna.net)
  • 2018. Laurus nobilis (laurel) aqueous leaf extract's toxicological and anti-tumor activities in HPV16-transgenic mice. (livedna.net)
  • To be published on line in early May 2018 in Cell. (lu.se)
  • Furthermore, the scracht assay result suggested that ATRA was a potential reagent to prevent the invasion or metastasis of GIST cells. (biomedcentral.com)
  • Bone metastasis occurs through a complex cascade of events that ultimately results in circulating tumor cells (CTCs) from the blood extravasating and invading the bone marrow - these cells within the bone marrow are referred to as disseminated tumor cells (DTCs) [ 4 ]. (oncotarget.com)
  • For patients with tumor parenchyma ≤ 16.5 mm, the probability of lymph node metastasis is lower and lymph node sampling is feasible. (biomedcentral.com)
  • Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
  • Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)
  • Additionally, the population of intra-tumor CD4 + CD25 + Foxp3 + T cells was significantly lower in naringenin + CPT treated animals than that in controls. (biomedcentral.com)
  • More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
  • ERBB1 and ERBB2 inhibition rapidly (within 3 h) inhibits both tumor cell motility and intravasation. (aacrjournals.org)
  • ERBB1 and ERBB2 inhibition can rapidly block tumor cell invasive properties. (aacrjournals.org)
  • Postinternalization inhibition of adenovirus gene expression and infectious virus production in human T-cell lines. (southernbiotech.com)
  • In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
  • The combined treatment induced significant mitotic arrest and activated the apoptotic cascades, tumor cell death. (thehealthyplanet.com)
  • In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
  • Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)
  • PCR arrays looking into target genes from the main signaling pathways indicated how the mGR will not exert its results through the transcriptional activity of the most common kinases in these leukemic cells, but RhoA signaling surfaced from our pathway evaluation. (fabretp.org)
  • Study of single nucleotide polymorphisms of tumor necrosis factors and HSP genes in Nasopharyngeal carcinoma in North East India. (gitam.edu)
  • Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. (mdpi.com)
  • The epidermal growth factor receptor family (ERBB) is overexpressed in a wide variety of tumor types and is correlated with poor prognosis. (aacrjournals.org)
  • Glioma, originating from neuroglial progenitor cells, is a type of intrinsic brain tumor with poor prognosis. (bvsalud.org)
  • It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
  • Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST) patients. (biomedcentral.com)
  • PKC-specific inhibitor or PKCaDN cells abolish this HDE-mediated effect. (cdc.gov)
  • The paternal cell lines are (1) the p53-wt (wild type) pluripotent gonadal germ cell tumor cell line NTERA-2, (2) the p53-mutated pluripotent extragonadal nonseminomatous germ cell tumor cell line NCCIT and (3) the p53-wt nullipotent embryonal cell carcinoma 2102EP, derived from a primary human testicular teratocarcinoma. (biomedcentral.com)
  • for example, in 1858 Louis Pasteur was the first to show that there is a complex balance of oxygen use in animal cells, and that cells use multiple pathways to accomplish energy con-version (Pasteur, 1858). (nobelprize.org)
  • The median interval between initial diagnosis of prostatic adenocarcinoma and recurrence of small cell carcinoma is 25 months. (medscape.com)
  • GBM stem-like cells (GSCs) present in tumors are felt to be highly tumorigenic and responsible for tumor recurrence. (oncotarget.com)
  • Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)
  • Small cell carcinoma of the prostate is rare, accounting for less than 1% of all prostate cancers . (medscape.com)
  • Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden. (biorxiv.org)
  • Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)
  • The aim of this study was to investigate the potential of cryptotanshinone (CPT), naringenin, and their combination in modulating the immune response towards Th1 cells and the involvement of JAK2/STAT3 signaling pathway in these effects. (biomedcentral.com)
  • NFAT2, as an important transcriptional promoter, regulates expression of TNF-α, myc proto-oncogene protein (c-myc), cyclooxygenase-2 (COX-2), Fas ligand (FasL) and also generates crosstalks with ERK/MAPK pathway and AKT/GSK3b signaling, which achieves its control of the cell fate [7-12]. (researchsquare.com)
  • Tumor consolidation diameter and preoperative serum CEA are independent factors to predict cN0 NSCLC with tumor size ≤ 30 mm. (biomedcentral.com)
  • High CA 19-9 levels (ie, greater than 1000 U/mL) correlate with unresectable or more advanced tumors, although this preoperative evaluation of CA 19-9 has not been widely used to establish inoperability. (medscape.com)
  • The lifestyle of a glucocorticoid receptor (GR) in plasma membrane was initially reported inside a mouse lymphoma cell range (S-49) and it had been proposed to become functionally connected with glucocorticoid-induced cell loss of life (5). (fabretp.org)
  • To day liposome-based fluorescence amplification methods have been utilized (26), permitting the recognition of only 50 receptor substances per cell. (fabretp.org)
  • Functional experiments proved that oxidized LDL receptor 1 (OLR1) promotes TMZ resistance of glioma cells. (bvsalud.org)
  • Tumor incidence (%) in C and RB 5% and RB 10% were 100, 55 and 64, respectively. (scialert.net)
  • 0.05) reduced the incidence of AOM induced colon tumors in Fisher 344 male rats. (scialert.net)
  • We compared microRNA expression patterns in three cisplatin resistant sublines derived from paternal cisplatin sensitive germ cell tumor cell lines in order to improve our understanding of the mechanisms of cisplatin resistance. (biomedcentral.com)
  • Three cisplatin resistant sublines (NTERA-2-R, NCCIT-R, 2102EP-R) showing 2.7-11.3-fold increase in drug resistance after intermittent exposure to increasing doses of cisplatin were compared to their parental counterparts, three well established relatively cisplatin sensitive germ cell tumor cell lines (NTERA-2, NCCIT, 2102EP). (biomedcentral.com)
  • Beside intrinsic resistance, acquired or gradually developing resistance has been observed in tumors under therapy. (biomedcentral.com)
  • We created an in vitro model of acquired cisplatin resistance by long term exposure of three well established germ cell tumor cell lines to cisplatin, resulting in sublines with significantly increased resistance to cisplatin. (biomedcentral.com)
  • CircTTLL13 enhances TMZ resistance of glioma cells via modulating OLR1. (bvsalud.org)
  • Nuclear factor of activated T cells 2 (NFAT2, also known as NFATc and NFATc1) is an important member of NFAT family which plays a vital role in T cell activation and differentiation [4]. (researchsquare.com)
  • The SRY-box 4 (SOX4) gene, which is located on chromosome 6p22.3, encodes a 47-kDa protein that is a member of the sex-determining region Y-related high-mobility group-box transcription factor family and has functions in embryonic development and cell differentiation ( 3 , 4 ). (spandidos-publications.com)
  • Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
  • For xenografts, athymic nude feminine mice (5C6 weeks outdated, Harlan Laboratories, Indianapolis, IN) had been injected subcutaneously with either A549/con or A549/shNGAL cells (3 106 cells in 100 l of PBS) in to the higher flank. (nos-nop.org)
  • Besides, administration of concentrated extracts of Morinda citrifolia in tumor containing animals increased the immune response of the animals with a concomitant reduction in tumor burden 7 . (nature.com)
  • The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)
  • The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed T cell markers, namely T cell depletion and clinically significant immune compromise. (mdpi.com)
  • Invasion was dependant on adding 1 105 A549 cells towards the internal chamber of the Matrigel-coated invasion chamber (BD Biosciences, 8 m pore size). (nos-nop.org)
  • Furthermore, NFAT2 participates in the early growth response factor 2 (Egr2)-regulated anergic phenotype which impairs the migration and invasion of leukaemia cells [16]. (researchsquare.com)
  • These experiments temporally and molecularly separate two key stages in tumor cell entry into blood vessels: invasion and intravasation. (aacrjournals.org)
  • 1996). Expression of Egr-1 correlates with the transformed phenotype and the type of viral latency in EBV genome positive lymphoid cell lines. (nature.com)
  • The factors and cellular processes required for the induction of dormancy and subsequent tumor cell reactivation remain largely undefined [ 6 ]. (oncotarget.com)
  • These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)
  • Cell Metabolism, currently under review. (lu.se)
  • [ 2 ] Another 25-40% of cases are initially diagnosed as prostatic adenocarcinoma and recur as small cell carcinoma after hormonal therapy. (medscape.com)
  • Unlike prostatic adenocarcinoma, small cell carcinoma of the prostate may present with metastases in up to 25% of patients. (medscape.com)
  • The distribution of prostatic small cell carcinoma is similar to that of prostatic adenocarcinoma. (medscape.com)
  • The risk factors for prostatic small cell carcinoma are related to those for prostatic adenocarcinoma and include age, race, and family history. (medscape.com)
  • this finding is not surprising, since many patients actually have prostatic adenocarcinoma with a component of small cell carcinoma. (medscape.com)
  • [ 7 ] The genetic features may be similar to prostatic adenocarcinoma but may contain additional genetic alterations that make these tumors androgen independent and more aggressive. (medscape.com)
  • In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. (frontiersin.org)
  • Hier de conclusie van deze review en daaronder een studie abstract met ranpirnasse uit 2002 met bijzonder goede resultaten op de mediane overlevingstijd. (kanker-actueel.nl)
  • 10. Mongini PK, Inman JK, Han H, Kalled SL, Fattah RJ, McCormick S. Innate immunity and human B cell clonal expansion: effects on the recirculating B2 subpopulation. (southernbiotech.com)
  • We conducted a retrospective study of patients with tumor size ≤ 30 mm who underwent radical resection of NSCLC. (biomedcentral.com)
  • Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)
  • The sensitivity and Ca 2+ mobilization of HepG2 cells was also inhibited by NFAT2 overexpression. (researchsquare.com)
  • Lycopene is a powerful antioxidant that might help protect cells from damage. (medlineplus.gov)
  • SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
  • Human Papillomavirus and Risk of Head and Neck Squamous Cell Carcinoma in Iran. (who.int)
  • This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. (cancerindex.org)