• vascular
  • Many studies have postulated that increased production of cell adhesion molecules (CAMs) on the vascular endothelium (blood vessel lining) plays a role in the development of arterial plaque, with the suggestion from both in vitro and in vivo studies that the CAM production is increased by dyslipidemia (abnormal lipid levels in the blood). (wikipedia.org)
  • 2002
  • Betson M, Lozano E, Zhang J, Braga VM (2002) Rac activation upon cell-cell contact formation is dependent on signaling from the epidermal growth factor receptor. (springer.com)
  • PECAM1
  • Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. (uniprot.org)
  • During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. (uniprot.org)
  • membrane
  • 1 In addition, they straddle the cell membrane and play an important role in initiating intracellular events in response to extracellular stimuli. (bmj.com)
  • Molecular and cellular biology portal Cell membrane Cell migration Immunological synapse Trogocytosis Cell Adhesion Molecules at the US National Library of Medicine Medical Subject Headings (MeSH) Brackenbury R, Rutishauser U, Edelman GM (January 1981). (wikipedia.org)
  • ILRs play a role in protein-protein interaction and are found in the plasma membrane of plant cells in the leaf, root and vasculature of plants. (wikipedia.org)
  • For example, Rubus fruticosus cells have a uniformed distribution of ILRs on their cellular membrane while Arabidopsis thaliana contains ILRs that cluster resulting in cell growth clusters. (wikipedia.org)
  • These virtonectin-like and fibronectin-like protein provide further support that compounds in the cell membrane of plant cells have important regulatory functions in the immune response such as the activation of immune cells. (wikipedia.org)
  • NDR1 is also believed to be involved in cell wall adhesion to the plasma membrane and fluid retention of the cell. (wikipedia.org)
  • AGPs contains a protein backbone of varied length (5-30 kDa) with N-terminal secretory peptide followed by AGP, fasciclin (FAS) domains, and a C-terminal glycosylphosphatidylinositol (GPI) lipid anchor site There are 85 predicted AGPs in Arabidopsis, with most of them containing a GPI plasma membrane anchor sequence that ties the extracellular AGPs to the plasma membrane and positions them to function as potential signaling molecules. (wikipedia.org)
  • While studying the critical tension required to detach a membrane bound to a surface through adhesion molecules, it was found that some adhesion molecules bound more tightly in response to tensions higher than the critical tension. (wikipedia.org)
  • Coated outside the membrane of leukocytes are microvilli, which have various types of adhesive molecules, including P-selectin glycoprotein ligand-1 (PSGL-1), a glycoprotein that is normally decorated with sulfated sialyl-Lewis x. the sulfated-sialyl-Lewis-x-contained PSGL-1 molecule has the ability to bind to any type of selectin. (wikipedia.org)
  • integrins
  • The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. (kobo.com)
  • They determine a variety of lymphocyte functions but, perhaps more importantly in the context of cardiovascular disease, they also play a pivotal role in the "trafficking" of leucocytes through tissues, interacting with β 2 integrins on white cells. (bmj.com)
  • In addition, integrins participate in cell-matrix interactions, while other CAM families participate in cell-cell interactions. (wikipedia.org)
  • Integrins provide essential links between the extracellular environment and the intracellular signalling pathways, which can play roles in cell behaviours such as apoptosis, differentiation, survival, and transcription. (wikipedia.org)
  • True homologs of integrins exist in mammals, invertebrates, and some fungi but not in plant cells. (wikipedia.org)
  • This protein shares functional homology with mammalian integrins in that it connects the ECM to the intracellular matrix to both stabilize the cell structure and allow for signal exchange. (wikipedia.org)
  • proliferation
  • Adhesive interactions, however, are also involved in the pathogenesis of cardiovascular disease, regulating thrombus formation, facilitating leucocyte infiltration, mediating the migration and proliferation of smooth muscle cells, and enabling the deposition of fibrotic tissue. (bmj.com)
  • 2005. The RNA-binding protein IMP-3 is a translational activator of insulin-growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells. (wikipedia.org)
  • differentiation
  • Moreover, immunohistochemical examination of 44 lung carcinomas showed that both molecules were coexpressed in all of them, and suggested that expression of P-cadherin was closely related to the differentiation of carcinoma cells. (aacrjournals.org)
  • homophilic
  • Homophilic binding occurs between NCAM molecules on opposing surfaces (trans-) and NCAM molecules on the same surface (cis-)1. (wikipedia.org)
  • Current models suggest trans- homophilic binding occurs between two NCAM molecules binding antiparallel between all five Ig domains or just IgI and IgII. (wikipedia.org)
  • NCAM exhibits glycoforms as it can be posttranslationally modified by the addition of polysialic acid (PSA) to the fifth Ig domain, which is thought to abrogate its homophilic binding properties and can lead to reduced cell adhesion important in cell migration and invasion. (wikipedia.org)
  • cadherin
  • In these epithelial tumors, cadherin engagement can promote cell survival by a process termed "synoikis" that involves the receptor tyrosine kinase, EGFR. (springer.com)
  • Purified tryptic fragments of the antigen recognized by NCC-CAD-299 showed cross-reactivity with a rabbit antiserum against mouse P-cadherin, indicating that this molecule was the human homologue of P-cadherin. (aacrjournals.org)
  • On the other hand, the antigen recognized by HECD-1 showed essentially the same tissue distribution pattern as E-cadherin in the mouse, suggesting that this molecule is the human homologue of E-cadherin. (aacrjournals.org)
  • Many cell types express combinations of cadherin types. (wikipedia.org)
  • According to the researchers, "Robust cadherin adhesion is essential for maintaining the integrity of tissue such as the skin, blood vessels, cartilage and muscle that are exposed to continuous mechanical assault. (wikipedia.org)
  • tissues
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • Later in development, NCAM1 (CD56) expression is found on various differentiated tissues and is a major CAM mediating adhesion among neurons and between neurons and muscle. (wikipedia.org)
  • Normal cells that stain positively for CD56 include NK cells, activated T cells, the brain and cerebellum, and neuroendocrine tissues. (wikipedia.org)
  • NCAM
  • The experimental data clearly show that only the embryonic NCAM molecule carrying the poly-α-(2,8)-linked N -acetylneuraminic acid moiety can be regarded as a specific serum marker for small cell lung cancer. (aacrjournals.org)
  • NCAM2 is found in lower levels in synapses in the hippocampuses of Alzheimers sufferers and is found to be broken down by beta-amyloid NCAM has been used as a target molecule for experimental antibody-based immunotherapy. (wikipedia.org)
  • Selectin
  • Leukocytes, as well as other types of white blood cells, normally form weak and short-lived bonds with other cells via selectin. (wikipedia.org)
  • During this process, leukocytes move through the circulatory system to sites of infection, and in doing so they 'roll' and bind to selectin molecules on the vessel wall. (wikipedia.org)