Cell SurvivalSurvival RateApoptosisDisease-Free SurvivalSurvivalCell Line, TumorSurvival AnalysisSignal TransductionGraft SurvivalS PhaseG1 PhaseCell CycleCell ProliferationTime FactorsCell LineCells, CulturedLeechesPhosphorylationTumor Cells, CulturedCell DivisionTreatment OutcomeAntineoplastic AgentsProtein-Serine-Threonine KinasesProto-Oncogene ProteinsRNA, Small InterferingBlotting, WesternCell DeathGene Expression Regulation, NeoplasticKaplan-Meier EstimateTransfectionProto-Oncogene Proteins c-aktRetrospective StudiesEnzyme ActivationMutationImmunohistochemistryTumor Suppressor Protein p53Phosphatidylinositol 3-KinasesBreast NeoplasmsCell DifferentiationCyclin-Dependent Kinase Inhibitor p21Neoplasm StagingCell Cycle ProteinsRNA, MessengerMultiple MyelomaDose-Response Relationship, DrugProportional Hazards ModelsEnzyme InhibitorsDNA-Binding ProteinsMice, Inbred C57BLDrug Resistance, NeoplasmGene Expression RegulationFollow-Up Studiesbcl-X ProteinMice, KnockoutProto-Oncogene Proteins c-bcl-2bcl-Associated Death ProteinAntineoplastic Combined Chemotherapy ProtocolsDNA DamageCyclin-Dependent Kinase Inhibitor p27NeuronsLung NeoplasmsMimosineCombined Modality TherapyMolecular Sequence DataCaspase 3Transcription FactorsDown-RegulationCyclinsG1 Phase Cell Cycle CheckpointsMice, NudeTumor Suppressor ProteinsNeoplasm ProteinsPrognosisAutophagyNeoplasmsProtein BindingCaspasesReverse Transcriptase Polymerase Chain ReactionLeukemia P388FibroblastsNF-kappa BMice, TransgenicMice, Inbred BALB CDrug ResistanceModels, BiologicalRNA InterferenceApoptosis Regulatory ProteinsFlow CytometryBase SequenceAdenocarcinomaProto-Oncogene Proteins c-mycUp-RegulationNeoplasm MetastasisNeoplasm Recurrence, LocalIn Situ Nick-End LabelingPhenotypeCell NucleusCell Transformation, NeoplasticCisplatinTumor Markers, Biological