• Biology
  • Journal of Cell Science publishes cutting-edge science, e ncompassing all aspects of cell biology. (biologists.org)
  • they are supported by an outstanding Editorial Advisory Board that reflects all relevant areas in cell biology, including recently emerging fields. (biologists.org)
  • We are pleased to accept submissions for our upcoming Special Issue on Reconstituting Cell Biology , guest edited by Manuel Théry. (biologists.org)
  • Have you seen our latest special issue on Plant Cell Biology , guest edited by Jenny Russinova? (biologists.org)
  • Schwann cells are involved in many important aspects of peripheral nerve biology-the conduction of nervous impulses along axons, nerve development and regeneration, trophic support for neurons, production of the nerve extracellular matrix, modulation of neuromuscular synaptic activity, and presentation of antigens to T-lymphocytes. (wikipedia.org)
  • Protein & Cell is a monthly peer-reviewed open access journal covering protein and cell biology. (wikipedia.org)
  • Cell Calcium is a monthly peer-reviewed scientific journal published by Elsevier that covers the field of cell biology and focuses mainly on calcium signalling and metabolism in living organisms. (wikipedia.org)
  • In cellular biology, labile cells are cells that multiply constantly throughout life. (wikipedia.org)
  • Biology portal Stable cells, which only multiply when receiving external stimulus to do so Permanent cells, which don't have the ability to multiply Encyclopædia Britannica Online: labile cell McConnell, Thomas H. (2007-01-01). (wikipedia.org)
  • Cell Research is a monthly peer-reviewed scientific journal covering cell biology. (wikipedia.org)
  • It is published by the Nature Publishing Group on behalf of the Shanghai Institutes for Biological Sciences (Chinese Academy of Sciences) and is affiliated with the Chinese Society for Cell Biology. (wikipedia.org)
  • epithelium
  • The dark cell epithelium consists of cells with a multitude of pinocytotic vesicles near their luminal surface. (wikipedia.org)
  • M cells are exploited by several pathogenic gram-negative bacteria including Shigella flexneri, Salmonella typhimurium, and Yersinia pseudotuberculosis, as well as infectious prions, such as in bovine spongiform encephalitis (Mad-cow disease), as a way of penetrating the intestinal epithelium. (wikipedia.org)
  • CXCR4 tropic but not CCR5 tropic HIV has been noted to be able to bind to M cells and get transported across the epithelium by them. (wikipedia.org)
  • B cells have been implicated in the developmental of M cells, since they are also localized in high numbers in the follicular-associated epithelium (FAE). (wikipedia.org)
  • Interestingly, microbes found on intestinal epithelium are known to direct M cell development. (wikipedia.org)
  • lymphocytes
  • However, a lack of particular co-stimulated molecules that aid in the way antigens react with lymphocytes can impair the natural killer cells' function, ultimately leading to cancer. (wikipedia.org)
  • The lesions may include certain distinctive Langerhans cells involved in certain immune responses, as well as other white blood cells (e.g.,lymphocytes, monocytes, eosinophils). (webmd.com)
  • The main function of M cells is the selective endocytosis of antigens, and transporting them to intraepithelial macrophages and lymphocytes, which then migrate to lymph nodes where an immune response can be initiated. (wikipedia.org)
  • basolateral
  • As mentioned in dark cell structure, the basolateral membranes of vestibular dark cells are highly folded, allowing the enclosure of the numerous large mitochondria, and they contain high levels of Na+/K+-ATPase in both alpha and beta isoforms, transporting potassium into the cell in exchange for sodium while consuming ATP. (wikipedia.org)
  • The basolateral membrane also contains a Na+/K+/Cl--co-transporter, (NKCC1) which transports all three ions into the cell. (wikipedia.org)
  • When they present microvilli, they are short, irregular, and present on the apical surface or pocket-like invagination on the basolateral surface of these cells. (wikipedia.org)
  • Type
  • Langerhans cell histiocytosis (LCH) is a spectrum of rare disorders characterized by overproduction (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the various tissues and organs of the body (lesions). (webmd.com)
  • In other words, they can develop into each of the more than 200 cell types of the adult body when given sufficient and necessary stimulation for a specific cell type. (slideshare.net)
  • Charcot-Marie-Tooth disease (CMT), Guillain-Barré syndrome (GBS, acute inflammatory demyelinating polyradiculopathy type), schwannomatosis, and chronic inflammatory demyelinating polyneuropathy (CIDP), and leprosy are all neuropathies involving Schwann cells. (wikipedia.org)
  • It is possible that they share the same origin as supporting cells such as pericytes and vascular smooth muscle cells, or even be a type of specialised vascular smooth muscle cell. (wikipedia.org)
  • Labile cells are one type of the cells that are involved in the division of cells. (wikipedia.org)
  • Each of these type of cells respond to injuries of the cells they occupy differently. (wikipedia.org)
  • A somatomammotroph or somatomammotrophic cell, also known as a somatolactotroph or somatolactotrophic cell, is a type of cell of the anterior pituitary gland that produces both somatotropin (growth hormone) and prolactin. (wikipedia.org)
  • For example, the type III secretion system effector protein SopB activates the transition of M cells from enterocytes. (wikipedia.org)
  • tissues
  • With this ability, they have been used to replace defective cells/tissues in patients who have certain diseases or defects. (slideshare.net)
  • Only cells from an earlier stage of the embryo, known as the morula, are totipotent, able to become all tissues in the body and the extraembryonic placenta. (slideshare.net)
  • Following the blastocyst stage, the tissues of the embryo start to form and the cells become multipotent. (slideshare.net)
  • gastrointestinal tract
  • Microfold cells (or M cells) are found in the gut-associated lymphoid tissue (GALT) of the Peyer's patches in the small intestine, and in the mucosa-associated lymphoid tissue (MALT) of other parts of the gastrointestinal tract. (wikipedia.org)
  • cellular
  • This special issue brings a comprehensive collection of reviews highlighting diverse non-lethal functions of caspases in a variety of organisms, cell types, and cellular processes, such as signaling, proliferation, differentiation, remodeling and neuronal plasticity. (nature.com)
  • occurs
  • If damage occurs to a nerve, the Schwann cells will aid in digestion of its axons (phagocytosis). (wikipedia.org)
  • This occurs so then that daughter cell can end up restoring the population of the stem cells that were lost. (wikipedia.org)
  • A numerable portion of infoldings occurs at the basal end of the dark cell toward the basal membrane. (wikipedia.org)
  • developmental
  • In addition, this issue also includes several reviews on tangential topics, such as viral hijacking of host caspases, metacaspase functions, non-lethal functions of BCL-2 family proteins, and alternative, caspase-independent developmental cell death pathways. (nature.com)
  • protein
  • The primary function of mesangial cells is to remove trapped residues and aggregated protein from the basement membrane thus keeping the filter free of debris. (wikipedia.org)
  • The apical membranes of the dark cells also have a k+ channel which is formed of two subunits, the KCNE1 regulatory protein and the KCNQ1 channel proteins. (wikipedia.org)
  • Carcinoma
  • The safety and efficacy of nivolumab for treating metastatic renal cell carcinoma is comparable to that found in the CheckMate 025 trial. (renalandurologynews.com)
  • In a phase Ib study, dual therapy with axitinib and pembrolizumab was well tolerated and demonstrated antitumor activity in treatment-naïve patients with advanced renal cell carcinoma. (renalandurologynews.com)
  • Immunotherapy with atezolizumab plus targeted therapy with bevacizumab improves progression-free survival better than sunitinib in patients with untreated metastatic renal cell carcinoma. (renalandurologynews.com)
  • Partial nephrectomy was associated with decreased odds of death versus radical nephrectomy among patients with cT1b but not cT2 renal cell carcinoma. (renalandurologynews.com)
  • Carcinoma Leukaemia Lymphoma Myeloma Sarcoma Mesothelioma Cancer cells have distinguishing histological features visible under the microscope. (wikipedia.org)
  • These stem cells were named embryonal carcinoma P19 cells. (wikipedia.org)
  • basement membrane
  • The anchor cell next removes the basement membrane that separates the uterus and vulva and invades, initiating the connection between the uterus and the vulva. (wikipedia.org)
  • The anchoring filaments from mesangial cells to the glomerular basement membrane can alter capillary flow by changing glomerular ultrafiltration surface area. (wikipedia.org)
  • irregular
  • In normal cells, the nucleus is often round or ellipsoid in shape, but in cancer cells the outline is often irregular. (wikipedia.org)
  • citation needed] Mesangial cells have irregular shapes with flattened-cylinder-like cell bodies and processes at both ends containing actin, myosin and actinin, giving mesangial cells contractile properties. (wikipedia.org)
  • molecular
  • Over the last two decades, targeted therapies like imatinib (Gleevec®) and trastuzumab (Herceptin®) -drugs that target cancer cells by homing in on specific molecular changes seen primarily in those cells-have also cemented themselves as standard treatments for many cancers. (cancer.gov)
  • With the Nissl-method, Fañanas cells can be identified by their slightly bigger, roundish and ovally shaped nuclei, scattered in the molecular and granular layer. (wikipedia.org)
  • Mesangial cells form a glomerular functional unit with glomerular endothelial cells and podocytes through interactions of molecular signalling pathways which are essential for the formation of the glomerular tuft. (wikipedia.org)
  • Though many studies have shown various cell types directing the differentiation of M cells, new research characterizes the molecular pathways that guide M cell differentiation. (wikipedia.org)
  • Golgi
  • Plasma cell with distinct clear perinuclear region of the cytoplasm containing a large number of Golgi bodies . (wikipedia.org)
  • astrocytes
  • However, the results of the study did not point at significant mutations in Fañanas cells but rather described the possible importance of astrocytes in general in the aetiology of CJD. (wikipedia.org)
  • histological
  • however, studies indicate an earlier histological and immunohistological maturity in the dark-cell areas compared to the stria vascularis. (wikipedia.org)
  • oligodendrocytes
  • Moreover, oligodendrocytes also developed and migrated into fiber bundles in mice when the RA-induced cells were transplanted into the brains. (wikipedia.org)
  • In this sense, Schwann cells are the peripheral nervous system's analogues of the central nervous system's oligodendrocytes. (wikipedia.org)
  • However, unlike oligodendrocytes, each myelinating Schwann cell provides insulation to only one axon (see image). (wikipedia.org)
  • Damage
  • Damage to mesangial cells using Thy 1-1 antibody specific to mesangial cells causes the vasoconstriction of arterioles mediated by tubuloglomerular feedback to be lost. (wikipedia.org)
  • actin
  • Human foetal and infant kidneys stained for alpha smooth muscle actin (α-SMA), a marker for mesangial cells, demonstrated that α-SMA-positive mesenchymal cells migrate towards the glomerulus and during a later stage they can be found within the mesangium. (wikipedia.org)
  • These cells can also be identified by cytoskeletal and extracellular matrix components expressed at the edge of cells or on their cell surfaces, such as actin, villin, cytokeratin, and vimentin. (wikipedia.org)
  • therapies
  • In 2017, two CAR T-cell therapies were approved by the Food and Drug Administration (FDA), one for the treatment of children with acute lymphoblastic leukemia (ALL) and the other for adults with advanced lymphomas. (cancer.gov)
  • In just the last few years, progress with CAR T cells and other ACT approaches has greatly accelerated, with researchers developing a better understanding of how these therapies work in patients and translating that knowledge into improvements in how they are developed and tested. (cancer.gov)
  • A growing number of CAR T-cell therapies are being developed and tested in clinical studies. (cancer.gov)
  • This may make them potentially useful sources of transplant tissue and cell-based therapies. (slideshare.net)
  • development
  • There are several types of ACT (see "ACT: TILs, TCRs, and CARs"), but, thus far, the one that has advanced the furthest in clinical development is called CAR T-cell therapy. (cancer.gov)
  • Langerhans cell histiocytosis was chosen because it seemed that the Langerhans cells might play a central role in the development of these disorders. (webmd.com)
  • It is important in the development of the reproductive system, as it is required for the production of the tube of cells that allows embryos to pass from the uterus through the vulva to the outside of the worm. (wikipedia.org)
  • However, researchers utilize these cells to study the development of cancer cells in order to find more specific treatments. (wikipedia.org)
  • Some group around smaller axons (External image here) and form Remak bundles Myelinating Schwann cells begin to form the myelin sheath in mammals during fetal development and work by spiraling around the axon, sometimes with as many as 100 revolutions. (wikipedia.org)
  • During development mesangial cells are important in the formation of convoluted capillaries allowing for efficient diffusion to occur. (wikipedia.org)
  • The transcription factor for PDGFRβ, Tbx18, is crucial for the development of mesangial cells. (wikipedia.org)
  • Without Tbx18 the development of mesangial cells is compromised and results in the formation of dilated loops. (wikipedia.org)
  • In 2006, 5th Cell transitioned into Nintendo DS and casual game development. (wikipedia.org)
  • adjacent
  • The gaps between adjacent Schwann cells are called nodes of Ranvier. (wikipedia.org)
  • The extraglomerular mesangial cells are adjacent to the intraglomerular mesangial cells that are located inside the glomerulus and in between the capillaries. (wikipedia.org)
  • cancer
  • Nevertheless, researchers caution that, in many respects, it's still early days for CAR T cells and other forms of ACT, including questions about whether they will ever be effective against solid tumors like breast and colorectal cancer. (cancer.gov)
  • The different forms of ACT "are still being developed," said Steven Rosenberg, M.D., Ph.D., chief of the Surgery Branch in NCI's Center for Cancer Research (CCR), an immunotherapy pioneer whose lab was the first to report successful cancer treatment with CAR T cells . (cancer.gov)
  • CAR T cells are the equivalent of "giving patients a living drug," explained Renier J. Brentjens, M.D., Ph.D., of Memorial Sloan Kettering Cancer Center in New York, another early leader in the CAR T-cell field. (cancer.gov)
  • Cancer cells are cells that divide relentlessly, forming solid tumours or flooding the blood with abnormal cells. (wikipedia.org)
  • Healthy cells stop dividing when there is no longer a need for more daughter cells, but cancer cells continue to produce copies. (wikipedia.org)
  • Cancer cells are created when the genes responsible for regulating cell division are damaged. (wikipedia.org)
  • In fact, a series of several mutations to certain classes of genes is usually required before a normal cell will transform into a cancer cell. (wikipedia.org)
  • These work to help the white blood cells to detect and kill cancer cells. (wikipedia.org)
  • Cancer cells have unique features that make them "immortal" according to some researchers. (wikipedia.org)
  • Constantly dividing cells have a higher risk of becoming malignant and develop cancer, dividing uncontrollably. (wikipedia.org)
  • This is why muscle cancer is very rare, even though muscle tissue accounts for ~50% of total body weight, since muscle cells are not constantly dividing cells, and therefore not considered labile. (wikipedia.org)
  • genes
  • EPEC (see Pathogenic Escherichia coli) containing plasmids with genes for EAF (Escherichia coli adherence factor) will adhere to M cells. (wikipedia.org)
  • pathways
  • Moreover, signaling pathways related to neurogenesis and myogenesis were also investigated by studying gene expression or generating mutants of P19 cells. (wikipedia.org)
  • However
  • However, new research (Allen 2010) has shown that the skin Langerhans cell is not the cell of origin, but a myeloid dendritic cell. (webmd.com)
  • Successful axons can therefore reconnect with the muscles or organs they previously controlled with the help of Schwann cells, however, specificity is not maintained and errors are frequent, especially when long distances are involved. (wikipedia.org)
  • form
  • Rigorous peer review and fair decisions form the bedrock of the journal and maintain Journal of Cell Science as a solid forum for communicating the best research. (biologists.org)
  • A band cell (also called band neutrophil, band form or stab cell) is a cell undergoing granulopoiesis, derived from a metamyelocyte, and leading to a mature granulocyte. (wikipedia.org)
  • The fertilized egg (day 1) undergoes cell division to form a 2-cell embryo, followed by 4-cell, etc. until a ball of cells is formed by the fourth day. (slideshare.net)
  • Finally the anchor cell fuses with eight of the π cells to form the uterine seam cell. (wikipedia.org)
  • Kupffer cells, also known as stellate macrophages and Kupffer-Browicz cells, are specialized macrophages located in the liver, lining the walls of the sinusoids that form part of the mononuclear phagocyte system. (wikipedia.org)
  • In myelinated axons, Schwann cells form the myelin sheath. (wikipedia.org)
  • Hepatocytes of the liver are thought to be a form of a labile cell because they can regenerate after they become injured. (wikipedia.org)
  • Morphological and immunohistochemical studies in several species have indicated that these dark cell areas also form a single layer resting on top of pigmented cells at the base of the cristae ampullaris in the semi-circular canals and around the utricular macula. (wikipedia.org)