• tumor cells
  • At least two possibilities exist for generating CSC niches: either they are manufactured as nascent domains by tumor cells, or CSCs usurp existing tissue-specific stem cell niches. (aacrjournals.org)
  • citation needed] Research on Yoshida Sarcoma, a strain of tumor cells, was also conducted at this institute in the 1950s. (wikipedia.org)
  • Such tumor cells, either "resting" or slowly cycling, may have an increased resistance to therapeutic agents, and some of them are probably potential stem cells. (springer.com)
  • Translation of nonviral and viral mrna's in extracts from uninfected and infected ehrlich ascites tumor cells. (jax.org)
  • The present invention provides an isolated and purified protein derived from Bacillus thuringiensis subspecies thuringiensis, having a molecular weight of approximately 20 kDa of SDS-PAGE, said protein having the partial amino acid sequence shown in SEQ ID No. 1, and wherein said protein displays cytotoxic effects against tumor cells. (freepatentsonline.com)
  • Agents that display antiproliferative properties selectively against tumor cells have potential as anticancer drugs. (freepatentsonline.com)
  • Avoidance of normal proliferative control is a defining characteristic of tumor growth, and the restoration of telomeric repeats by the activation of the telomerase enzyme may be one way in which tumor cells avoid senescence. (aacrjournals.org)
  • Displays oral availability and efficacy towards MDR tumor cells. (tocris.com)
  • Bacher et al (2001) D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo , shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity. (tocris.com)
  • Since that discovery, multiple studies have demonstrated an incidence of approximately 1% in lung cancers, demonstrated oncogenicity, and showed that inhibition of tumor cells bearing ROS1 gene fusions by crizotinib or other ROS1 tyrosine kinase inhibitors was effective in vitro. (wikipedia.org)
  • tumors
  • The cancer stem cell (CSC) hypothesis offers attractive explanations for generation of heterogeneity within tumors, metastatic dissemination, and resistance to therapy. (aacrjournals.org)
  • Considering effective therapy, relatively slowly growing tumors possessing a large fraction of "nonproliferating" cells are of substantial concern. (springer.com)
  • Atkin , N. B. , 1970, Cytogenetic studies on human tumors and premalignant lesions: The emergence of aneuploid Cell. (springer.com)
  • Fifty-three patients with soft tissue tumors (25 soft tissue sarcomas, 19 GIST, 9 desmoids) and 15 healthy controls were included. (readbyqxmd.com)
  • To date, the majority of cancer-related telomerase analyses have been performed on carcinomas that originate from epithelial cells, and few reports have included tumors originating from nonepithelial cells. (aacrjournals.org)
  • The analysis of telomerase activity status has potential clinical utility for diagnosis, screening, and monitoring treatment, but it is yet to be validated in specimens from solid tumors of nonepithelial origin, i.e., sarcomas. (aacrjournals.org)
  • Gene rearrangements involving the ROS1 gene were first detected in glioblastoma tumors and cell lines. (wikipedia.org)
  • Among the top 20 receptor tyrosine kinases identified in this analysis, 15 were identified in both cell lines and tumors, and among these were both ALK and These initial findings paved the way for more expansive analyses of ROS1 kinase fusions in NSCLC and other cancers. (wikipedia.org)
  • Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. (genecards.org)
  • Eribulin is also being investigated by Eisai Co. for use in a variety of other solid tumors, including non-small cell lung cancer, prostate cancer and sarcoma. (wikipedia.org)
  • In addition to its cytotoxic, antimitotic-based mechanisms, preclinical studies in human breast cancer models have shown that eribulin also exerts complex effects on the biology of surviving cancer cells and residual tumors that appear unrelated to its antimitotic effects. (wikipedia.org)
  • gene
  • Prepared cells were analyzed for the presence of gene fusions by fluorescence in situ hybridization, RT-PCR, and karyotyping. (deepdyve.com)
  • Studies using Fgf4 gene knockout mice showed developmental defects in embryos both in vivo and in vitro, revealing that FGF4 facilitates the survival and growth of the inner cell mass during the postimplantation phase of development by acting as an autocrine or paracrine ligand. (wikipedia.org)
  • Although the most preclinical and clinical studies of ROS1 gene fusions have been performed in lung cancer, ROS1 fusions have been detected in multiple other tumor histologies, including ovarian carcinoma, sarcoma, cholangiocarcinomas and others. (wikipedia.org)
  • molecular
  • Moreover, drug screening with chemotherapeutic agents and tyrosine kinase inhibitors revealed that doxorubicin, a subset of tyrosine kinase inhibitors, and several molecular targeting drugs markedly decreased NCC-SS1-C1 cell viability. (deepdyve.com)
  • Molecular models of cell fate specification typically focus on the activation of specific lineage programs. (sdbonline.org)
  • While some insights are glowing, it is clear that more studies are needed to thoroughly understand the molecular mechanism of sarcomagenesis from MSCs and mechanisms determining the sarcoma type, which will potentially give directions for targeted therapies. (biomedcentral.com)
  • murine leuke
  • To examine the immunological relatedness of this enzyme with other retroviral DNA polymerases, remaining Sm-MTV DNA polymerase activity was measured after treatment of this enzyme with various antisera prepared against each of the reverse transcriptases of Mason-Pfizer monkey virus (MPMV), murine mammary tumor virus (MuMTV), simian sarcoma virus-simian sarcoma associated virus (SSV/SSAV), and Rauscher murine leukemia virus (RLV). (curehunter.com)
  • tyrosine kinase activity
  • From a large-scale survey of tyrosine kinase activity in non-small cell lung cancer (NSCLC), and identified more than 50 distinct tyrosine kinases and over 2500 downstream substrates, with the goal of identifying candidate oncogenes. (wikipedia.org)
  • leukemia
  • It blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells. (wikipedia.org)
  • vitro
  • One such anthroposophic pharmaceutical process was evaluated regarding effects on cancer cell toxicity in vitro and on colchicine tumor formation in Lepidium sativum . (hindawi.com)
  • In vitro analyses also confirmed that the established cell line harbored invasive, colony-forming, and spheroid-forming potentials. (deepdyve.com)
  • Microtubule destabilizer that blocks tubulin polymerization (IC 50 = 0.3 μ M). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC 50 values ranging from 0.036 - 0.285 μ M). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo . (tocris.com)
  • Fgf signaling pathway has also been demonstrated to drive hindgut identity during gastrointestinal development, and the up regulation of the Fgf4 in pluripotent stem cell has been used to direct their differentiation for the generation of intestinal Organoids and tissues in vitro. (wikipedia.org)
  • Differentiation
  • Comparison of expression profiles and differentiation capacities between MSCs and sarcoma cells further supports this. (biomedcentral.com)
  • Trilineage differentiation capacity of human MSCs and representative types of sarcomas. (biomedcentral.com)
  • This differentiation spectrum corresponds with the histological spectrum of different types of sarcomas, represented here by osteosarcoma, chondrosarcoma and liposarcoma. (biomedcentral.com)
  • In other studies, eribulin treatment of leiomyosarcoma and liposarcoma cells leads to increased expression of smooth muscle and adipocyte differentiation antigens, respectively. (wikipedia.org)
  • human
  • Moreover, it was found that CB has an inhibitory effect on the uptake of sucrose-3H by chang-strain human liver cells and in CB-treated cells alterations in the appearance and location of microfilaments were observed. (wikipedia.org)
  • Growth of a human leukemic cell line (Molt H) in a cell culture is stopped by mistletoe extract. (editboard.com)
  • Cell surface antigens coded for by the human chromosome 7. (jax.org)
  • Human Nasal squamous cell carc. (clsgmbh.de)
  • human MSC cell culture. (biomedcentral.com)
  • activity
  • Due to their role in maintaining stem cell activity, disrupting CSC-niche interactions may be crucial for overcoming barriers to therapeutic resistance. (aacrjournals.org)
  • Niches are special microenvironments that maintain, or even endow cells with, stem cell activity. (aacrjournals.org)
  • Animal sarcoma cells (Yoshida) are destroyed by mistletoe extract activity on the cell membrance, and causes cytolysis. (editboard.com)
  • Telomerase activation permits extended cell proliferation beyond normal senescence checkpoints, and accordingly, telomerase activity has been detected in a wide range of malignant cells and tissues but is absent in terminally differentiated somatic cells. (aacrjournals.org)
  • extract
  • The high-speed mistletoe extract mixing process investigated thus did not influence toxicity against cancer cells but seemed to sustain morphostasis and to enhance resistance against external noxious influences leading to phenomenological malformations. (hindawi.com)
  • phosphorylation
  • AS160 also contains a calmodulin-binding domain, and this domain mediates phosphorylation-independent glucose uptake in muscle cells. (wikipedia.org)
  • Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. (wikipedia.org)
  • biomedical
  • Research at the Sasaki Institute covers a wide variety of biomedical fields, including biochemistry, cell biology, pathology, and oncology. (wikipedia.org)
  • cellular
  • Primary effusion lymphoma (PEL), strongly linked with latent infection of Kaposi's sarcoma-associated herpesvirus (KSHV), constitutively expresses cellular interferon regulatory factor 4 (IRF4) while suppressing the expression of B cell lymphoma 6 (BCL6). (readbyqxmd.com)
  • motility
  • found that CB causes multinucleation in cells and significantly affects cell motility. (wikipedia.org)
  • Palladin's precise biological role is poorly understood, but it has been shown to play a role in cytoskeletal organization, embryonic development, cell motility, scar formation in the skin, and nerve cell development. (wikipedia.org)
  • embryonic
  • Indeed, embryonic and adult stem and progenitor cell fate decisions are quantifiably flexible in response to combinatorial microenvironments ( 11 - 13 ). (aacrjournals.org)
  • mitotic
  • The multinucleated cells probably arise from failure of mitotic control, leading to variations in size and shape of interphase nuclei. (wikipedia.org)
  • Its cytotoxic effects are related to its antimitotic activities, wherein apoptosis of cancer cells is induced following prolonged and irreversible mitotic blockade. (wikipedia.org)
  • pancreatic cancer
  • have shown that palladin is overexpressed in the non-neoplastic stroma of pancreatic cancer, but only rarely in the cancer cells per se, suggesting that palladin's role in this disease may involve changes in the tumor microenvironmment. (wikipedia.org)
  • Eribulin
  • Fluorescently labeled eribulin has been used to study the pharmacokinetics and pharmacodynamics at single cell level in vivo. (wikipedia.org)
  • tissues
  • A and B, stem cell niches are clearly identifiable in normal tissues. (aacrjournals.org)
  • and (3) experimental approaches have usually neither allowed for any correlation between the structure of neoplastic tissues and therapeutic responses nor revealed the kinetic status of various Cell. (springer.com)
  • However, obtaining quantitative measurements of dynamic shapes and behaviors of cells and tissues in a rapidly developing metazoan embryo using time-lapse 3D microscopy remains technically challenging, with the main hurdle being the shortage of robust imaging processing and analysis tools. (sdbonline.org)
  • lesions
  • Accurate assessment of these lesions is crucial because a misdiagnosis of sarcoma can lead to serious consequences for the patient, such as unnecessary amputation. (aacrjournals.org)
  • transcriptional
  • Recently, it was shown that IRF4, a key transcriptional repressor of BCL6, might be a pivotal regulator of KSHV for balancing between latency and its reactivation in PEL cells. (readbyqxmd.com)
  • This occurs through Tramtrack69-mediated repression in FCMs, whereas Lame duck activates a largely distinct transcriptional program in the same cells. (sdbonline.org)
  • endothelial
  • Circulating endothelial progenitor cells (cEPC) have been proposed as surrogate markers of vasculogenesis in malignancies. (readbyqxmd.com)
  • mouse
  • Isoenzyme transitions of creatine phosphokinase, aldolase and phosphoglycerate mutase in differentiating mouse cells. (jax.org)
  • Selection in the mouse thymus of pha- and con a-responsive cells. (jax.org)
  • Regeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells. (jax.org)
  • analysis
  • further analysis was conducted to identify highly phosphorylated tyrosine kinases in NSCLC from a panel of 41 NSCLC cell lines, and 150 patient samples. (wikipedia.org)
  • myeloma
  • Cell-free translation of messenger rna for a myeloma light chain prepared from synchronised plasmactyoma cells. (jax.org)
  • cancer cell
  • Correspondingly, determination of the toxicity of differently processed mistletoe extracts in cancer cell lines can be seen as first step to study the pharmaceutical process in question. (hindawi.com)