• tumor
  • Outside stimuli such as reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-α) activate cell surface receptors such as Toll-Like Receptors (TLRs) and Receptor Activators of NF-κB (RANK). (aacrjournals.org)
  • Because of the tumor promoting characteristics of NF-κB activation, a focus of current research is to find methods of suppressing NF-κB to kill cancer cells or slow their growth. (aacrjournals.org)
  • mice
  • In the epidermis of mice lacking NF-κB activity, initiation of primary hair follicle pre-placode formation is observed, but these primitive structures fail to proliferate and generate placodes. (biologists.org)
  • We examined LV remodeling following permanent coronary ligation (or sham-operation) in adult male transgenic (TG) mice with NF-κB abrogation in the heart via the cardiac-specific overexpression of a phosphorylation-resistant IκBα (n=16), or in non-transgenic (NTG) littermates (n=16). (ahajournals.org)
  • active
  • When the upstream signaling is active, an IkBa kinase (IKK) complex consisting of catalytic kinase subunits IKKa and/or IKKb and the scaffold protein NEMO will be recruited to the cytoplasmic adaptor of certain cell surface receptor and stay activated. (allelebiotech.com)
  • protein
  • We designed a 3D-printed model of the p50/RelA NF-κB protein using Jmol to highlight the relationship between its structure and function. (aacrjournals.org)
  • activation
  • We tested the hypothesis that sustained activation of NF-κB exacerbates LV remodeling in heart failure (HF). (ahajournals.org)
  • Persistent NF-κB activation imparts detrimental effects in post-infarction HF and worsens LV remodeling, related, at least in part, to augmentation of inflammatory cytokine expression and apoptosis. (ahajournals.org)
  • Find
  • Consistent with this, we find that TGFβ2 signaling is deficient in embryos with either inhibited NF-κB signaling or loss of LHX2. (biologists.org)
  • rate
  • Importantly, as compared to TG sham, TG HF showed only a mild increase in apoptotic rate (0.4 ± 0.3 %) that was not statistically significant (p = 0.45), suggesting that differences in the rate of cell loss between NTG and TG HF may account for comparable degrees of chamber hypertrophy despite differences in LV dilatation. (ahajournals.org)