• Examples of recurrent chromosomal imbalances include well characterised conditions such as the common trisomies, which can be studied by classical cytogenetic techniques. (bmj.com)
  • To cover the whole genome, genome wide screening for chromosomal imbalances using microsatellite markers has been reported, 17, 18 as well as metaphase CGH. (bmj.com)
  • Screening for chromosomal imbalances by array CGH, whether using cDNA 23 or BAC clones, 24 has mainly been performed on cancer samples, 25- 30 which usually contain large gene dose alterations. (bmj.com)
  • Genome-wide screening for chromosomal imbalances using comparative genomic hybridization (CGH) revealed a wealth of data on previously unrecognized tumor-specific genomic alterations. (edu.sy)
  • CGH to microarrays of DNA, an approach termed matrix-CGH, allows detection of genomic imbalances at a much higher resolution. (edu.sy)
  • Chromosomal imbalances are associated with increased proliferation and might contribute to bone destruction in cholesteatoma / Ecsedi S., Rákosy Z., Vízkeleti L., Juhász A., Sziklai I., Adány R., Balázs M. (unideb.hu)
  • Constitutional chromosomal imbalance is often associated with learning disability, dysmorphism, congenital anomalies, and abnormalities of growth. (bmj.com)
  • During the scan, chromosomal abnormalities can be detected. (psychesystems.com)
  • FISH is most useful in many pediatric situations to detect chromosomal abnormalities. (psychesystems.com)
  • Producing a pregnancy but resulting in the birth of a baby with a disease because of chromosomal abnormalities. (institutobernabeu.com)
  • Studies show that the overall rate of chromosomal abnormalities in embryos is about 50 percent. (sdfertility.com)
  • As women age, the risk of chromosomal abnormalities increases and so does the risk of miscarriage from these abnormalities. (sdfertility.com)
  • Chromosomal abnormalities cause various disorders. (msdmanuals.com)
  • Chromosomal abnormalities fit into several categories but broadly may be considered as numerical or structural. (msdmanuals.com)
  • More recently, the technique of comparative genomic hybridisation (CGH) using metaphase chromosomes has been applied to this clinical problem. (bmj.com)
  • Both technologies mean that all the chromosomes in an embryo cell can be analysed and it can be determined if there is excess or insufficient genetic material. (institutobernabeu.com)
  • The overall pattern of copy number change was strikingly similar between cell lines and primary cancers with a few obvious exceptions such as loss of chromosome 6 and gain of chromosomes 15 and 12p in the former. (ox.ac.uk)
  • The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. (lookformedical.com)
  • A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. (lookformedical.com)
  • Our aim was to evaluate the copy number alterations of chromosomes 3, 7, 8, and 17 in middle ear cholesteatomas and define the association between the rate of cell proliferation and chromosome number changes. (unideb.hu)
  • CONCLUSIONS: Based on our results, we assume that aneusomy of chromosomes 7, 8, and 17 might play an important role during invasion of the adjacent bony structures of cholesteatoma, as well as associate with increased cell proliferation activity, which might lead to the aggressive behavior of the tissue. (unideb.hu)
  • The main part deals with examples of modern FISH-applications, highlighting unique possibilities of the approach, like the possibility to study individual cells and even individual chromosomes. (frontiersin.org)
  • PGS screens for a number of common embryonic chromosomal disorders, including a condition called aneuploidy - where embryos have too few or too many chromosomes. (sdfertility.com)
  • Karyotype: The full set of chromosomes in a person's cells. (msdmanuals.com)
  • A karyotype analysis involves blocking cells in mitosis during metaphase and staining the condensed chromosomes. (msdmanuals.com)
  • Chromosomes from single cells are photographed, and their images are arranged, forming a karyotype. (msdmanuals.com)
  • For a subset of 29 tumors, comparative genomic hybridization was additionally used to screen for chromosome copy number aberrations. (biomedcentral.com)
  • For a subset of 29 patients with fresh-frozen tisue, CGH was used to screen for chromosomal copy number aberrations. (biomedcentral.com)
  • Although control clones for normalization of the signal ratios can be predicted in cases with defined chromosomal aberrations, in primary tumors such data are often not available, requiring alternative normalization algorithms. (edu.sy)
  • Additionally, comparative genomic hybridization was employed to compare genomic alterations between the CAISMOV24 cell line and its primary malignant cells. (biomedcentral.com)
  • Although the cell line had developed alongside the accumulation of genomic alterations (28 CNV in primary cells and 37 CNV in CAISMOV24), most of them were related to CNVs already present in primary malignant cells. (biomedcentral.com)
  • Our results corroborate with the idea that genomic alterations, depicted by CNVs, can be used for subtyping epithelial ovarian carcinomas. (biomedcentral.com)
  • However, cell lines are known for their susceptibility to genetic and metabolic alterations, which can alter their characteristics in relation to the primary malignant cells. (biomedcentral.com)
  • To begin to define genetic alterations that occur in African-American ESCC we conducted microarray expression profiling in pairs of esophageal squamous cell tumors and matched control tissues. (biomedcentral.com)
  • Oncogenic point mutations in KIT or PDGFRA are recognized as the primary events responsible for the pathogenesis of most gastrointestinal stromal tumors (GIST), but additional genomic alterations are frequent and presumably required for tumor progression. (biomedcentral.com)
  • The use of specialized instrumentation for the generation of DNA chips, their hybridization, scanning, and evaluation required numerous alterations and modifications of the initial protocol. (edu.sy)
  • Using array comparative genomic hybridization to a tiling-resolution microarray encompassing the entire human genome, PMBCL samples were analyzed for genomic copy number alterations. (arizona.edu)
  • Recurrent chromosomal losses were observed at 1p, 3p, 4q, 6q, 7p, and 17p, with a novel event at 1p13.1-p13.2 representing the most frequent at 42% of cases analyzed. (arizona.edu)
  • A minimal level of intra-tumour heterogeneity is a simple consequence of the imperfection of DNA replication: whenever a cell (normal or cancerous) divides, a few mutations are acquired-leading to a diverse population of cancer cells. (wikipedia.org)
  • Stem cell variability is often caused by epigenetic changes, but can also result from clonal evolution of the CSC population where advantageous genetic mutations can accumulate in CSCs and their progeny (see below). (wikipedia.org)
  • In this model, tumours arise from a single mutated cell, accumulating additional mutations as it progresses. (wikipedia.org)
  • Evolution of the initial tumour cell may occur by two methods: Sequentially ordered mutations accumulate in driver genes, tumour suppressor genes, and DNA repair enzymes, resulting in clonal expansion of tumour cells. (wikipedia.org)
  • The CAISMOV24 line was assessed for cell growth, production of soluble biomarkers, expression of surface molecules and screened for typical mutations found in serous ovarian carcinoma. (biomedcentral.com)
  • In addition to clinico-pathological high-risk groups, patients with KIT mutations, genomic complexity, genomic gains and deletions at either 1p or 22q showed a significantly shorter disease-free survival. (biomedcentral.com)
  • Of note, recent genomic studies demonstrate activating, somatic BRAF mutations in the majority of human specimens. (medscape.com)
  • Previous work has documented activating mutations in the KIT receptor tyrosine kinase in testicular germ-cell tumors (TGCT). (ox.ac.uk)
  • Cutaneous T-cell lymphomas (CTCLs) are malignancies of skin-homing lymphoid cells, that have up to now not been investigated thoroughly for common oncogenic mutations. (techblessing.com)
  • Knockdown of NRAS by siRNA induced apoptosis in mutant Hut78 cells however, not in CTCL cell lines missing RAS mutations. (techblessing.com)
  • The pre- and postnatal genetic tests (noninvasive prenatal testing, array comparative genomic hybridization, karyotype in amniotic fluid cells, karyotype in peripheral blood, and uniparental disomy analysis) revealed the fetal chromosomal status and indicated etiology giving rise to the mosaicism, suggesting a prezygotic meiotic error corrected through late trisomic rescue in the zygote. (thieme-connect.com)
  • 35, no prior miscarriage) and normal karyotype seeking elective SET were prospectively randomized into two groups: In Group A, embryos were selected on the basis of morphology and comprehensive chromosomal screening via aCGH (from d5 trophectoderm biopsy) while Group B embryos were assessed by morphology only. (biomedcentral.com)
  • Mapping of the KARYOTYPE of a cell. (lookformedical.com)
  • FISH probes designed to detect subtelomeric rearrangements have given a significant diagnostic yield of around 6% in patients with unexplained learning disability and dysmorphic features, 1- 3 but interstitial chromosomal deletions and duplications are not detectable using this method. (bmj.com)
  • In this concern, methods such as comparative genomic hybridization allow the detection of deletions and duplications of genomic segments, known as copy number variation (CNV). (biomedcentral.com)
  • Similar to CGH is another method known as Array Comparative Genomic Hybridization, or aCGH. (psychesystems.com)
  • This study explored use of comprehensive chromosomal screening by array CGH (aCGH) to provide this advantage and improve pregnancy rate from SET. (biomedcentral.com)
  • Although aCGH followed by frozen embryo transfer has been used to screen at risk embryos (e.g., known parental chromosomal translocation or history of recurrent pregnancy loss), this is the first description of aCGH fully integrated with a clinical IVF program to select single blastocysts for fresh SET in good prognosis patients. (biomedcentral.com)
  • Although ratios of matrix-CGH were highly concordant with results of chromosomal CGH (85%), the dynamic range of the matrix-CGH ratios was highly superior. (edu.sy)
  • Analysis of the results of chromosomal trisomies 21, 18 and 13 screening among 40 628 women by non-invasive prenatal testing]. (cdc.gov)
  • Mutter suggested that these genes or the cells have only the maternal imprint because many teratomas arise from a parthenogenetically activated egg. (medscape.com)
  • The identified DEGs included 20 downregulated genes and 51 upregulated genes, which were highly associated with the cell cycle, organelle fission, chromosome segregation, cell division and spindle stability. (cancerindex.org)
  • Comparative genomic hybridization and LOH analysis using SNP arrays demonstrated that the 13 TGCTs mutationally screened through the 518 protein kinase genes were uniformly aneuploid with consistent chromosomal gains on 12p, 8q, 7, and X and losses on 13q, 18q, 11q, and 4q. (ox.ac.uk)
  • 5′-aza-dC and/or Trichostatin A resulted in transcriptional upregulation of the genes, suggesting that low expression of ECM components, proteoglycan core proteins and HS biosynthetic system is due to epigenetic suppression in type I cells. (oncotarget.com)
  • In another research, repeated deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF in MF was noticed.4 Genomic patterns characteristic of MF differ markedly from SS.5 This may implicate discriminative molecular pathogenesis and various therapeutic requirements. (techblessing.com)
  • Nevertheless, in tumor cells, mutated TCS ERK 11e (VX-11e) (oncogenic) RAS preferentially promotes success and proliferation. (techblessing.com)
  • GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
  • This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
  • Teratomas (from Greek teras, "monster," and - oma, a suffix denoting a tumor or neoplasm) and other germ cell tumors (GCTs) are relatively common solid neoplasms in children. (medscape.com)
  • These tumors are grouped together because they all appear to arise from postmeiotic germ cells. (medscape.com)
  • Normal migration of these germ cells may cause gonadal tumors, whereas abnormal migration produces extragonadal tumors. (medscape.com)
  • In 1965, Teilum first suggested the germ cell origin of gonadal tumors. (medscape.com)
  • In brief, frozen sections of profiled tumors were examined by hematoxylin-and-eosin, and areas rich in neoplastic cells were cut from the frozen blocks. (nature.com)
  • Genomic amplification of FLT3 has been reported in solid tumors including colorectal cancer, breast cancer, and gastric cancer [ 9 ]. (hindawi.com)
  • As with all tumors, whether benign or malignant, the paradigm of comprehension depends on identifying the cell or cell layer of origin. (medscape.com)
  • Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)
  • Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults. (ox.ac.uk)
  • BRAFV600E mutation however, not in wild-type BRAF or tumors having a KRAS mutation.12,14,15 Further, dealing with wild-type BRAF tumors with BRAFV600E specific inhibitors induced tumor growth in vitro and in vivo.14 Thus, MEK inhibitors may be appealing in wild-type BRAF cells. (techblessing.com)
  • B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
  • Multiple types of heterogeneity have been observed between tumour cells, stemming from both genetic and non-genetic variability. (wikipedia.org)
  • The factors influencing the growth of the market include increasing technologies for gene, widespread use of genetic engineering found in developed countries, special attention towards stem cells, increasing use of genetic engineering in medicine and various others. (zupyak.com)
  • The company supplies all the equipments and products required in genetic engineering from bioreactors, cell lines and ultra-pure water of laboratories. (zupyak.com)
  • Array comparative genomic hybridization, with a genome-wide resolution of approximately 1 Mb, has been used to investigate copy number changes in 48 colorectal cancer (CRC) cell lines and 37 primary CRCs. (ox.ac.uk)
  • 1%) of individuals with clinical findings of the 22q11.2 deletion syndrome have chromosomal rearrangements involving 22q11.2, such as a translocation between chromosome 22 and another chromosome. (22q.org)
  • 4, 5 Its sensitivity has been refined to permit detection of chromosomal deletions as small as 3 Mb. (bmj.com)
  • With the matrix-CGH protocol presented here, robust and reliable detection of genomic gains and losses is accomplished in an automated fashion, which provides the basis for widespread application in tumor and clinical genetics. (edu.sy)
  • Expanding the application of non-invasive prenatal testing in the detection of foetal chromosomal copy number variations. (cdc.gov)
  • BACKGROUND: The aim of this study was to evaluate genomic risk of patients with persistent prostate specific antigen (PSA) using mRNA expression analysis and a validated prognostic genomic-risk classifier. (bvsalud.org)
  • In addition to KIT/PDGFRA mutational status, our findings indicate that secondary chromosomal changes contribute significantly to tumor development and progression of GIST and that genomic complexity carries independent prognostic value that complements clinico-pathological and genotype information. (biomedcentral.com)
  • A specific localized, organ-confined, and negative margins sub-population with PSA persistence was compared to a similar sub-population without PSA persistence for genomic differential expression analyses. (bvsalud.org)
  • In patients with normal karyotypes, the clinical features may still suggest appropriate regions to be screened for microscopic imbalance by fluorescent in situ hybridisation (FISH) analysis using locus specific probes. (bmj.com)
  • Fluorescent in situ hybridization, or FISH, is a technique used to identify both acquired and congenital diseases. (psychesystems.com)
  • Spectral karyotyping analysis (also called chromosome painting) uses chromosome-specific multicolor fluorescent in situ hybridization (FISH) techniques that improve the visibility of certain defects, including translocations and inversions. (msdmanuals.com)
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
  • Because of their multi/pluripotency and immunosuppressive properties, mesenchymal stem/stromal cells (MSCs) are important tools for treating immune disorders and for tissue repair. (biomedcentral.com)
  • Amniocentesis and Next Generation Sequencing (NGS)-Based Noninvasive Prenatal DNA Testing (NIPT) for Prenatal Diagnosis of Fetal Chromosomal Disorders. (cdc.gov)
  • Testing such algorithms in a primary high-grade B-cell lymphoma, we show the feasibility of this approach. (edu.sy)
  • For Burkitt's lymphoma cells (BL), serglycin was down-regulated in BL type III cells and perlecan in type I BL cells. (oncotarget.com)
  • Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of diffuse large B-cell lymphoma. (arizona.edu)
  • SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • This is a form of chromosomal identification and analysis. (psychesystems.com)
  • Standard chromosome analysis by G-banding has a limited resolution, but molecular cytogenetic techniques, such as multi-subtelomeric FISH, microdeletion FISH, multicolour FISH and comparative genomic hybridisation (CGH), have played an important role for the diagnosis of MR during the past decade. (bmj.com)
  • PGS, PGT-A and CCS consist of a biopsy on one or more cells in each embryo obtained as a result of in vitro fertilisation, plus the corresponding chromosomal analysis. (institutobernabeu.com)
  • There are two techniques that facilitate this kind of analysis: array CGH (Comparative Genomic Hybridisation) and, more recently, NGS (Next Generation Sequencing). (institutobernabeu.com)
  • METHODS: Our analysis included patients who underwent PN for renal cell carcinoma in 21 French academic centers (2010-2020). (bvsalud.org)
  • Furthermore, genomic complexity was the best predictor of disease progression in multivariate analysis. (biomedcentral.com)
  • Using MCF-7 breast cancer cell line as the proof-of-principle analysis, we have identified 35 palindrome candidates and physically characterized the top 5 candidates and their junctions. (biomedcentral.com)
  • We have explored alternative methods for systematically analyzing palindromes in the genome and here we report our analysis of de novo DNA palindromes from the MCF-7 breast cancer cell line [ 15 ]. (biomedcentral.com)
  • Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas. (ox.ac.uk)
  • However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
  • however, chromosomal losses have been rarely reported. (arizona.edu)
  • An almost equal number of gains and losses of chromosomal material were detected throughout the genome (216 vs. 193, respectively). (arizona.edu)
  • Tumour heterogeneity describes the observation that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. (wikipedia.org)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
  • We aim to evaluate the clinical useful of nephrometry scores for predicting oncological outcomes in a large cohort of patients who underwent PN for renal cell carcinomas. (bvsalud.org)
  • Cell-free DNA screening for trisomy 21 in twin pregnancy: a large multicenter cohort study. (cdc.gov)
  • Comparative Genomic Hybridization, or CGH, is a useful cytogenetic diagnostic tool when a diagnosis is unknown. (psychesystems.com)
  • To explore the entire anatomy of the neoplastic genome in black ESCC, we performed comparative genomic hybridization (CGH) on a panel of 17 matched pairs of tumor and control esophageal tissues [ 13 ]. (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Cells referred to as MSCs originating from various tissues are now used in clinical trials. (biomedcentral.com)
  • The accuracy of chromosomal microarray testing for identification of embryonic mosaicism in human blastocysts. (thieme-connect.com)
  • Often, however, the combination of clinical features is not diagnostic of a particular syndrome but may nevertheless still suggest that a chromosomal imbalance is the likely underlying cause of the abnormality. (bmj.com)
  • The heterogeneity of cancer cells introduces significant challenges in designing effective treatment strategies. (wikipedia.org)
  • These are the cancer stem cell model and the clonal evolution model. (wikipedia.org)
  • The cancer stem cell model asserts that within a population of tumour cells, there is only a small subset of cells that are tumourigenic (able to form tumours). (wikipedia.org)
  • These cells are termed cancer stem cells (CSCs), and are marked by the ability to both self-renew and differentiate into non-tumourigenic progeny. (wikipedia.org)
  • Evidence of the cancer stem cell model has been demonstrated in multiple tumour types including leukemias, glioblastoma, breast cancer, and prostate cancer. (wikipedia.org)
  • Long non-coding RNAs (lncRNAs) can exhibit cell-type and cancer-type specific expression profiles, making them highly attractive as therapeutic targets. (researchgate.net)
  • On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
  • In this study, the new epithelial ovarian cancer cell line CAISMOV24 was described and compared with its original low-grade serous ovarian carcinoma. (biomedcentral.com)
  • The in vitro culture was established with cells isolated from ascites of a 60-year-old female patient with recurrent ovarian cancer. (biomedcentral.com)
  • Group: Triple negative breast cancer (TNBC) cell line. (cellosaurus.org)
  • Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). (cellosaurus.org)
  • Part of: GrayJW breast cancer cell line panel. (cellosaurus.org)
  • Part of: NCI-60 cancer cell line panel. (cellosaurus.org)
  • Characterization of four doxorubicin adapted human breast cancer cell lines with respect to chemotherapeutic drug sensitivity, drug resistance associated membrane proteins and glutathione transferases. (cellosaurus.org)
  • Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability. (ku.dk)
  • The pathogenesis of Langerhans cell histiocytosis (LCH) is unknown. (medscape.com)
  • OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)
  • MTT colorimetric assays, colony formation assays and 5‑ethynyl‑20‑deoxyuridine incorporation assays were also conducted to evaluate ACC cell proliferation. (cancerindex.org)
  • FLT3 (FMS-related tyrosine kinase 3) located on chromosome 13q12.2 encodes a receptor tyrosine kinase (RTK) that activates the Ras and PI3 kinase pathway leading to the increased proliferation and inhibition of apoptosis in hemopoietic progenitor cells [ 7 ]. (hindawi.com)
  • Cell proliferation was characterized with Ki-67 monoclonal antibody on cholesteatoma samples and on postauricular skins as control. (unideb.hu)
  • The NRASQ61K mutation sensitized Hut78 cells toward development inhibition from the MEK inhibitors U0126, AZD6244, and PD0325901. (techblessing.com)
  • CONCLUSIONS: We found unique genomic features of patients with pPSA, whilst confirming previous clinical findings that this condition behaves to a worse prognosis. (bvsalud.org)
  • OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
  • Genomic DNA was purified from the peripheral blood samples using the Maxwell RSC Blood DNA kit (Promega) as per the manufacturer's recommendations. (hindawi.com)
  • Genotype and genomic findings were cross-tabulated and compared with available clinical and follow-up data. (biomedcentral.com)
  • The presence of ≥ 2 cell lines differing in genotype in a person who has developed from a single fertilized egg. (msdmanuals.com)
  • Wu W, Barwacz SA, Bhowmick R, Lundgaard K, Gonçalves Dinis MM, Clausen M, Kanemaki MT, Liu, Y. Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells. (ku.dk)
  • RAD51 protects human cells from transcription-replication conflicts. (ku.dk)
  • Wu, W, Hickson ID, and Liu Y , The prevention and resolution of DNA replication-transcription conflicts in eukaryotic cells. (ku.dk)
  • A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. (lookformedical.com)
  • For example, loss of chromosome 8p was a common event in CIN+ cell lines and cancers but was often found to be gained in MSI+ cancers. (ox.ac.uk)
  • African-Americans have an increased risk for esophageal squamous cell carcinoma (ESCC), the subtype that shows marked variation in geographic frequency. (biomedcentral.com)
  • Adenocarcinoma of the esophagus (EAC) is mostly seen in Western countries [ 3 ] while esophageal squamous cell carcinoma (ESCC) is predominant in Eastern countries and the eastern part of Africa [ 3 ]. (biomedcentral.com)
  • Genomic amplification of FLT3 has not been reported in hematological disease. (hindawi.com)
  • We show that matrix CGH is also feasible from small tissue samples requiring universal amplification of genomic DNA. (edu.sy)
  • Investigation of the two amplicons on 8q24 in COLO320-HSR and HL60, containing the MYC gene, revealed a homogeneous amplicon in COLO320-HSR but a heterogeneous amplification pattern in HL60 cells. (edu.sy)
  • Typically, the clinical presentation of clear cell acanthoma is a solitary nodule in the lower extremities. (medscape.com)
  • The CSC model posits that the heterogeneity observed between tumour cells is the result of differences in the stem cells from which they originated. (wikipedia.org)
  • Different variants of FISH can be used to retrieve information on genomes from (almost) base pair to whole genomic level, as besides only second and third generation sequencing approaches can do. (frontiersin.org)
  • Producing cells according to Good Manufacturing Practices (GMPs) is a global challenge for the production of all cells for use in humans, specifically mesenchymal stem/stroma cells (MSCs), one of the most promising tools in cellular therapy and regenerative medicine. (biomedcentral.com)
  • Its lethality is a consequence of the lack of symptoms or biomarkers enabling the early diagnosis of disease, and the propensity of malignant cells to seed the peritoneal cavity. (biomedcentral.com)