• Principal mechanisms of resistance include high levels of bleomycin hydrolase, cell mutations altering DNA sequences to prevent intercalation, poor cell accumulation of drug, and rapid plasma removal. (medscape.com)
  • Bleomycin inhibits the uncontrolled cell division in cancer-causing cells by inhibiting DNA synthesis. (yashodahospitals.com)
  • Bleomycin is therapeutically used to treat malignant neoplasms such as sarcomas, lymphomas, melanomas, and germinal cell cancers. (yashodahospitals.com)
  • Bleomycin interacts with cancerous cells and binds with the DNA, and inhibits cell synthesis by breaking DNA strands. (yashodahospitals.com)
  • 5. Is Bleomycin an antibiotic? (yashodahospitals.com)
  • Most antibiotic antitumor drugs are cell-cycle nonspecific except Bleomycin which shows significant effects in G2 and M phases. (yashodahospitals.com)
  • Development of a best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours in the UK. (ox.ac.uk)
  • Bleomycin, a cytotoxic chemotherapy agent, forms a key component of curative regimens for lymphoma and germ cell tumours. (ox.ac.uk)
  • We surveyed 63 germ cell cancer physicians from 32 cancer centres across the UK to understand their approach to using bleomycin. (ox.ac.uk)
  • A best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours has been developed and includes recommendations regarding baseline investigations, the use of pulmonary function tests, route of administration, monitoring and patient advice. (ox.ac.uk)
  • Bleomycin-Sulfate is a type of antibiotic that works by stopping the growth of cancer cells. (rxguide.org)
  • Bleomycin-Sulfate is an antibiotic drug used to treat a variety of cancers. (rxguide.org)
  • A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. (umassmed.edu)
  • It is an antibiotics agent which exhibits antineoplastic activity and is used primarily in chemotherapy as an anticancer agent. (yashodahospitals.com)
  • hence it is classified as an 'Anticancer antibiotic. (yashodahospitals.com)
  • hence it is classified as an anticancer antibiotic and is used to treat cancer. (yashodahospitals.com)
  • Various types of anticancer medications kill cancer cells in different ways. (lls.org)
  • Cytotoxic drugs - sometimes known as antineoplastic, anticancer, hazardous or cancer chemotherapy drugs - include a wide range of chemical compounds. (cleanroom.com.au)
  • An anticancer drug that inhibits the transformation of normal cells to cancer cells. (medindex.am)
  • Antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
  • Platinum compounds inhibit cell growth and proliferation. (medscape.com)
  • A protein kinase inhibitor of the m ammalian t arget o f r apamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. (ebi.ac.uk)
  • Vitamin F deficiency allows the cell proliferation found in tumors and cancer. (medicalmarijuana411.com)
  • Signal transduction plays an important role in activating cellular functions, cell differentiation , and cell proliferation . (lookformedical.com)
  • Ren F, Shi Q, Chen Y, Jiang A, Ip YT, Jiang H, Jiang J. Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration. (umassmed.edu)
  • Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm′s tumour and the sarcomas. (gendepot.com)
  • The aminoglycosides are bactericidal antibiotics that bind to the 30S ribosome and inhibit bacterial protein synthesis. (medscape.com)
  • Actinomycin D, an antineoplastic antibiotic, inhibits RNA synthesis. (enzolifesciences.com)
  • Cycloheximide, an active antibiotic against many yeast and fungi, inhibits protein synthesis. (enzolifesciences.com)
  • 5-FU inhibits tumor cell growth through at least 3 different mechanisms that ultimately disrupt DNA synthesis or cellular viability. (medscape.com)
  • Doxorubicin is an anthracycline antibiotic that inhibits DNA and RNA synthesis. (medscape.com)
  • Antitumor antibiotics prevent cell division by either binding to DNA to prevent the cells from duplicating or inhibiting RNA synthesis. (lls.org)
  • D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. (medindex.am)
  • Mitomycin inhibits DNA synthesis by producing DNA cross-links, which halt cell replication and eventually cause cell death. (growthmarketreports.com)
  • Mitomycin C is known for its ability to inhabit the growth of cancer cells by interfering with their DNA synthesis. (growthmarketreports.com)
  • Aim of this study was to evaluate possible in vitro cytotoxic effects of two new-generation antiepileptic drugs on a human glioma cell line U87MG. (biomedcentral.com)
  • As these drugs cause damage to cells they are termed cytotoxic . (wikidoc.org)
  • Cisplatin IUPAC nomenclature (SP-4-2)-diamminedichloroplatinum(II) Classification Cisplatin falls under the category of Antineoplastic cytotoxic drug. (gpatindia.com)
  • Classification Mitomycin C falls under the category of antibiotic Antineoplastic cytotoxic drug. (gpatindia.com)
  • Cytotoxic activity of this nanocomplex was studied in vitro towards two cancer cell lines in comparison to human mesenchymal stem cells (hMSCs) using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) test and a live/dead assay. (uky.edu)
  • Hazardous drugs include cytotoxic (chemotherapy) drugs, antibiotics, and radiopharmaceuticals. (cleanroom.com.au)
  • By interfering with cell division, cytotoxic drugs not only have the ability to kill tumour cells, but also, if physical contact is made with the drugs for long periods of time, normal, healthy cells. (cleanroom.com.au)
  • It is critical to be aware of why personal protective equipment (PPE) is required to be worn at all times during administration or preparation of cytotoxic drugs, antibiotics and radiopharmaceuticals and also to be aware of the safe and proper procedures for spill cleanups to reduce personal exposure. (cleanroom.com.au)
  • The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
  • Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)
  • DNA-repair enzyme inhibitors attack the cancer cell proteins (enzymes) that normally repair damage to DNA. (lls.org)
  • Histone deacetylase inhibitors attack cancer cells by targeting the proteins that support DNA in the cell nucleus. (lls.org)
  • JAK inhibitors block the enzymes JAK1, JAK2, JAK3 and tyrosine kinase 2, which play a role in the cell-signaling process that leads to the inflammatory and immune responses seen in certain diseases. (lls.org)
  • Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma (NHL)? (medscape.com)
  • In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
  • Broadly, most chemotherapeutic drugs work by impairing mitosis ( cell division ), effectively targeting fast-dividing cells . (wikidoc.org)
  • With succeeding generations of tumor cells, differentiation is typically lost, growth becomes less regulated, and tumors become less responsive to most chemotherapeutic agents. (wikidoc.org)
  • CFU-Leuk), which we have shown are predictive for hematopoietic engraftment and AML log-kill in rats given syngeneic marrow and/or AML cells incubated ex vivo with selected chemotherapeutic agents, will be used in these dose-response studies. (arizona.edu)
  • Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
  • The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
  • By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
  • Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. (bvsalud.org)
  • have identified a subset of breast and ovarian cancer cell lines that show synergistic response to the combination of doxorubicin and GDC-0941, a class IA phosphatidylinositol 3-kinase (PI3K) inhibitor. (nih.gov)
  • An analogue of the anthracycline antineoplastic antibiotic doxorubicin. (wikipedia.org)
  • This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (wikipedia.org)
  • Five leads were tested in additional cancer cell lines of which, doxorubicin, mitoxantrone, and mithramycin demonstrated synergy in all lines. (biomedcentral.com)
  • Bloodstream infections (BSI) are a severe complication of antineoplastic chemotherapy or hematopoietic stem cell transplantation (HSCT), especially in the presence of antibiotic resistance (AR). (uni-frankfurt.de)
  • Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (merckmanuals.com)
  • The precise mechanism remains unclear, but in the majority of acquired cases, the mechanism involves an immune attack on the hematopoietic stem cell. (merckmanuals.com)
  • To overcome this problem, methods of ex vivo treatment ('purging') of autologous marrow must be developed that optimally eradicate AML cells but spare normal hematopoietic stem cells. (arizona.edu)
  • After incubation, cells will be plated for CFU-GM and CFU-Leuk assays to determine survival of committed hematopoietic progenitors and log-kill of AML cells, and optimal conditions for antileukemic effect with stem-cell sparing. (arizona.edu)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • Hematopoietic Stem Cell Transplantation. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • Germinal cell tumors. (yashodahospitals.com)
  • As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)
  • Drugs affect "younger" tumors (i.e. more differentiated) more effectively, because mechanisms regulating cell growth are usually still preserved. (wikidoc.org)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. (umassmed.edu)
  • Camptothecin, an inhibitor of nuclear topoisomerase, induces apoptosis in many types of cells. (enzolifesciences.com)
  • As far as LEV is concerned, in 2010 Bobustuc hypothesized that AED may modulate O-6 methylguanine-DNA methyltransferase (MGMT), a DNA repair protein that has an important role in tumor cell resistance to alkylating agents, and LEV was reported as the most potent MGMT inhibitor among several AED [ 10 ]. (biomedcentral.com)
  • This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
  • The method may further comprise administering to the subject a cell growth inhibitor. (justia.com)
  • Another method of the invention comprises administering a cell growth inhibitor to the subject and administering to the subject a chemotherapy agent. (justia.com)
  • When the cancer cell uses an antimetabolite instead of the natural substances, it can't produce normal DNA or RNA and the cell dies. (lls.org)
  • EPIRUBICIN is a Schedule H antibiotic. (mtatva.com)
  • Epirubicin is a cancer medication that interferes with the growth and spread of cancer cells in the body. (mtatva.com)
  • Particular groups of patients, including those with cystic fibrosis , immune dysfunction, and certain chronic infectious disease, are more likely to be treated with this class of antibiotics. (medscape.com)
  • We recommend using 1,000x dilutions for inducing apoptosis in cell cultures. (enzolifesciences.com)
  • Activation of TRPV1 by capsaicin caused significant inhibition of cancer cell growth and induced apoptosis and necrosis. (dovepress.com)
  • 10 TRPV1 agonist, capsaicin, is capable of inducing apoptosis 11 , 12 and inhibiting cancer cell growth by cell cycle arrest in many different types of cancer, for example, osteosarcoma, colon, and pancreatic cancer cells, while normal cells remained unharmed. (dovepress.com)
  • To investigate the putative anti-proliferative effect, apoptosis assay, microRNA expression profile and study of cell cycle were performed. (biomedcentral.com)
  • Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
  • T umor Necrosis Factor-α R elated A poptosis I nducing L igand (TRAIL) and agonistic antibodies to death receptor 4 and 5 are promising candidates for cancer therapy due to their ability to induce apoptosis selectively in a variety of human cancer cells, while demonstrating little cytotoxicity in normal cells. (biomedcentral.com)
  • Although TRAIL and agonistic antibodies to DR4 and DR5 are considered safe and promising candidates in cancer therapy, many malignant cells are resistant to DR-mediated, TRAIL-induced apoptosis. (biomedcentral.com)
  • In the current work, we screened a small library of fifty-five FDA and foreign-approved anti-neoplastic drugs in order to identify candidates that sensitized resistant prostate and pancreatic cancer cells to TRAIL-induced apoptosis. (biomedcentral.com)
  • Sequential and simultaneous dosing modalities were investigated and the annexin V/propidium iodide assay, in concert with fluorescence microscopy, was employed to visualize cells undergoing apoptosis. (biomedcentral.com)
  • TRAIL has attracted significant attention in recent years due to its ability to selectively induce apoptosis in transformed (malignant) cells while demonstrating little cytotoxicity in normal cells [ 2 - 7 ]. (biomedcentral.com)
  • The proteolytic activation of initiator caspases leads to the subsequent activation of executioner caspases (e.g. caspase-3), which ultimately results in apoptosis in Type I Cells. (biomedcentral.com)
  • Activation of caspase-8 engages the mitochondria-amplified apoptosis machinery in Type II cells [ 7 ]. (biomedcentral.com)
  • Although TRAIL and agonistic antibodies to death receptors 4 and 5 are promising candidates for cancer therapy, many tumor cells are inherently resistant or acquire resistance to TRAIL-mediated apoptosis. (biomedcentral.com)
  • In conclusion, the current study revealed the expression profiles of human TRP channels in 60 different breast cancer tissues and cell lines and furthermore validated the antitumor activity of TRPV1 against SUM149PT breast cancer cells, indicating that activation of TRPV1 could be used as a therapeutic target, even in the most aggressive breast cancer types. (dovepress.com)
  • Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: A preliminary study. (medscape.com)
  • Mutated and wild-type p53 expression and HPV integration in proliferative verrucous leukoplakia and oral squamous cell carcinoma. (medscape.com)
  • Here we found that netrin-1 is upregulated in a primary mouse model of skin squamous cell carcinoma (SCC) exhibiting spontaneous EMT. (bvsalud.org)
  • Introduction: Landomycins are a subgroup of angucycline antibiotics that are produced by Streptomyces bacteria and possess strong antineoplastic potential. (uky.edu)
  • Cancerous cells are characterized by uncontrolled cell division. (yashodahospitals.com)
  • In this case, your doctor may prescribe different drugs to target and kill the cancerous cells. (lls.org)
  • Chemotherapy , in its most general sense, is the treatment of a disease by chemicals especially by killing micro-organisms or cancerous cells. (druginformer.com)
  • Seroepidemiology of Hepatitis Klisyri 1 Topical identifiable only as Antineoplastic Alkylating Agents Use this medication FDA given the experiencing a burst chronically infected in. (ripyard.com)
  • This last topic is particularly relevant since pregnant women normally do not take part in clinical trials, making this human cell-based in vitro platform the only viable alternative to assess developmental cardiotoxicity. (scoop.it)
  • Cells grown in vitro from neoplastic tissue. (lookformedical.com)
  • Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
  • Short hairpin RNA knockdown of netrin-1 and its receptor UNC5B in EPCAM+ tumour cells inhibited EMT in vitro in the absence of stromal cells and regulated a common gene signature that promotes tumour epithelial state and restricts EMT. (bvsalud.org)
  • Variables to be examined include agent concentrations, incubation duration and temperature, cell density, sequence of treatment, and number of cycles of in vitro treatment. (arizona.edu)
  • DNA-damaging agents (antineoplastics) and alkylating agents react with DNA to change it chemically and keep it from allowing cell growth. (lls.org)
  • Hypomethylating (demethylating) agents interfere with cancer cell duplication by slowing or reversing hypermethylation. (lls.org)
  • Hopkins Oncology Center (JHOC), Baltimore, MD, will evaluate novel ex vivo marrow purging regimens by comparison of the effects of incubation with graded concentrations of immunologic and/or pharmacologic agents on the growth of normal marrow and leukemic cells, using an authentic animal model of human AML (the LBN hybrid rat). (arizona.edu)
  • Agents in this class halt the cell cycle at the G1 phase in tumor cells. (medscape.com)
  • Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)
  • We have noticed through our daily practice that insisted upon using camel urine instead of established many of our patients use this type of therapy on the antineoplastic agents. (who.int)
  • Mitoxantrone is a member of the antibiotics/antineoplastics drug class and is commonly used for Acute Nonlymphocytic Leukemia, Mantle Cell Lymphoma, Multiple Sclerosis, and others. (drugs.com)
  • It acts throughout the entire cell cycle and by direct intercalating into DNA triggers DNA breakage by topoisomerase II, causing subsequent cytocydal activity. (medscape.com)
  • Cell cycle-specific with activity in the S-phase as single agent and has for many years been combined with biochemical modulator leucovorin.Has activity as single agent that inhibits DNA replication and transcription. (medscape.com)
  • Methylation is a critical part of cell growth and replication. (lls.org)
  • One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
  • The production of secondary metabolites with antibiotic properties is a common characteristic to entomopathogenic bacteria Xenorhabdus spp. (biomedcentral.com)
  • Pharmacological inhibition of netrin-1 by administration of NP137, a netrin-1-blocking monoclonal antibody currently used in clinical trials in human cancer (ClinicalTrials.gov identifier NCT02977195 ), decreased the proportion of EMT tumour cells in skin SCC, decreased the number of metastases and increased the sensitivity of tumour cells to chemotherapy. (bvsalud.org)
  • Fourteen drugs were identified as having synergy with TRAIL, including those whose TRAIL sensitization activities were previously unknown in either prostate or pancreatic cancer cells or both. (biomedcentral.com)
  • A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
  • Single-cell RNA sequencing revealed the presence of different EMT states, including epithelial, early and late hybrid EMT, and full EMT states, in control SCC. (bvsalud.org)
  • By contrast, administration of NP137 prevented the progression of cancer cells towards a late EMT state and sustained tumour epithelial states. (bvsalud.org)
  • Drugs demonstrating the highest synergy were selected as leads and tested in different prostate and pancreatic cancer cell lines, and one immortalized human pancreatic epithelial cell line. (biomedcentral.com)
  • At these low concentrations, mitoxantrone demonstrated selectivity toward malignant cells over normal pancreatic epithelial cells. (biomedcentral.com)
  • Lymphoma b cell. (lookformedical.com)
  • B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
  • A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
  • Serum Levels of the Chemokine CXCL13, Genetic Variation in CXCL13 and Its Receptor CXCR5, and HIV-Associated Non-Hodgkin B-Cell Lymphoma Risk. (medscape.com)
  • It is an antibiotic, immunosupressive and antineoplastic agent. (ebi.ac.uk)
  • It was reasoned that an agent that damaged the rapidly growing white blood cells might have a similar effect on cancer. (wikidoc.org)
  • MoAbs) AP64, RM124, and RM152, or with bruneomycin (an antineoplastic antibiotic with potential utility as a marrow chemopurging agent), or the alkylating agent 4-hydroperoxycyclophosphamide (4HC). (arizona.edu)
  • In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)
  • Drug therapy can speed up cancer cell death. (lls.org)
  • Based on antineoplastic effect of brivaracetam and lacosamide on glioma cells, we assume that patients with glioma could benefit by the treatment with these two molecules, in addition to standard therapeutic options. (biomedcentral.com)
  • However, the presence of residual occult viable leukemic cells in the marrow autograft limits the therapeutic effectiveness of ABMT in AML. (arizona.edu)
  • This complex inhibits mammalian target of rapamycin (mTOR) kinase, a key protein in cells that regulate the gene translation responsible for cell-cycle regulation. (medscape.com)
  • In this study, stimulation by the TRPV1 agonist, capsaicin, of SUM149PT cells, a model system for the most aggressive breast cancer subtype, triple-negative breast cancer, led to intracellular calcium signals that were diminished by the specific TRPV1 antagonist, capsazepin. (dovepress.com)
  • Transient receptor potential (TRP) channels, which are membranous ion channels that conduct calcium and sodium ions, have been shown to influence cancer cell growth. (dovepress.com)
  • Unlike normal cells, cancer cells lose the ability to stop division. (yashodahospitals.com)
  • Drugs used in chemotherapy halts this division and kills cancer cells. (yashodahospitals.com)
  • Targeted therapy is a cancer treatment that targets specific genes and proteins responsible for cancerous cell growth and survival. (yashodahospitals.com)
  • Blocks or turn off signals that tell cancer cells to grow and divide. (yashodahospitals.com)
  • Destroy cancer cells. (yashodahospitals.com)
  • Chemotherapy , in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer . (wikidoc.org)
  • In popular usage, it usually refers to antineoplastic drugs used to treat cancer or the combination of these drugs into a standardized treatment regimen . (wikidoc.org)
  • Cancer is the uncontrolled growth of cells coupled with malignant behavior: invasion and metastasis . (wikidoc.org)
  • To assess the relevance of these findings to human cancers, we treated mice transplanted with the A549 human cancer cell line-which undergoes EMT following TGFß1 administration8,9-with NP137. (bvsalud.org)
  • Cancer cells can grow too fast or fail to die quickly. (lls.org)
  • However, many conventional and investigational drug therapies combine drugs that attack cancer cells at different points in their growth cycles. (lls.org)
  • This approach often makes therapy more effective and reduces the chance that the cancer cells will become resistant to a particular drug. (lls.org)
  • Sometimes cancer cells may be resistant to the initial drugs used or can become resistant to the drugs after a period. (lls.org)
  • Antimetabolites mimic the building blocks of DNA or RNA that cancer cells need to survive and grow. (lls.org)
  • Antimitotics damage cancer cells by blocking a process called mitosis (cell division), which prevents cancer cells from dividing and multiplying. (lls.org)
  • Some enzymes can prevent cancer cells from surviving. (lls.org)
  • Without this repair process, the cancer cell is much more susceptible to damage and cannot grow. (lls.org)
  • This process sometimes speeds up in cancer cells. (lls.org)
  • With some chemotherapy drugs being mutagenic, they may cause changes in cell DNA which can result in cancer, miscarriage and/or birth defects. (cleanroom.com.au)
  • Antineoplastic Drugs Part 1: Cancer Overview and Cell Cycle-Specific Drugs 46. (barmerit.com)
  • It is a part of a group of drugs called antineoplastics, which are used to treat cancer. (rxguide.org)
  • It is a type of antibiotic that works by interfering with the DNA of cancer cells, preventing them from growing and dividing. (rxguide.org)
  • FDA-approved drugs were screened for their ability to sensitize TRAIL resistant prostate cancer cells to TRAIL using an MTT assay for cell viability. (biomedcentral.com)
  • In particular, mitoxantrone and mithramycin demonstrated significant synergy with TRAIL and led to reduction of cancer cell viability at concentrations lower than 1 μM. (biomedcentral.com)
  • Mitomycin C (C15H18N4O5) is an antineoplastic antibiotic drug used as a treatment for a number of different types of cancer, such as anal carcinoma, bladder carcinoma, breast carcinoma, and some other gastrointestinal carcinomas. (growthmarketreports.com)
  • The cell damage slows or stops the growth of cancer cells in the body. (growthmarketreports.com)
  • In a recently published Nature Communications paper, a iBB team led by Margarida Diogo, in collaboration with Perpetua Pinto do Ó at i3S, engineered a unique organ-like model from stem cells that recreates several stages of embryonic development of the human heart. (scoop.it)
  • Cisplatin is a platinum-containing compound that exerts an antineoplastic effect by covalently binding to DNA, with preferential binding to N-7 position of guanine and adenosine. (medscape.com)
  • Expression of chemoresistance molecules was evaluated using flow cytometry in U87MG and human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • Previous exposure to antibiotics, especially to carbapenems, was significantly associated with resistant Gram-negative BSI while previous colonization with methicillin-resistant S. aureus was associated with BSI due to this pathogen. (uni-frankfurt.de)
  • Sulfasalazine Sulfasalazine [Azulfidine] belongs to the same chemical family as the sulfonamide antibiotics. (spiritsong.org)
  • Brodeur TY, Robidoux TE, Weinstein JS, Craft J, Swain SL, Marshak-Rothstein A. IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells. (umassmed.edu)
  • Atthetissuelevel,vitaminC is required for production of collagen and other compounds that comprise the intercellular matrix that binds cells together. (spiritsong.org)
  • is known, and several compounds with antibiotic activity have been isolated and identified. (biomedcentral.com)
  • Cytotoxicity is cell-cycle nonspecific. (medscape.com)
  • Antineoplastic Drugs Part 2: Cell Cycle-Nonspecific Drugs and Miscellaneous Drugs 47. (barmerit.com)
  • Optimal doses may vary for different cells and culture conditions and must be determined individually. (enzolifesciences.com)
  • The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. (lookformedical.com)
  • It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION . (lookformedical.com)
  • They're believed to work by blocking cell metabolism through their effect on specific genes. (lls.org)