Single-Cell AnalysisPolymorphism, GeneticPolymorphism, Single NucleotideProtein ConformationLaser Scanning CytometryMicrofluidic Analytical TechniquesFlow CytometryCell SeparationImage CytometryCytological TechniquesCellsModels, MolecularGenetic Predisposition to DiseaseGene FrequencyAllelesFluorescent DyesFluorescenceMolecular Sequence DataPolymorphism, Single-Stranded ConformationalHaplotypesLasersCase-Control StudiesStaining and LabelingProtein BindingAmino Acid SequenceGenotypeProtein Structure, SecondaryBinding SitesPolymerase Chain ReactionProtein Structure, TertiaryMicroscopy, FluorescenceCircular DichroismCrystallography, X-RayCell CountMolecular ConformationBase SequenceGenetic Association StudiesThermodynamicsGreen Fluorescent ProteinsEquipment DesignLinkage DisequilibriumMutationGenetic VariationAsian Continental Ancestry GroupKineticsSpectrometry, FluorescenceAlgorithmsCells, CulturedImage Processing, Computer-AssistedTime FactorsLeukocyte CountClone CellsAmino Acid SubstitutionProtein FoldingCell LineMolecular Dynamics SimulationNucleic Acid ConformationSequence Analysis, DNAMagnetic Resonance SpectroscopyReproducibility of ResultsDNALigandsNuclear Magnetic Resonance, BiomolecularSignal TransductionGenetic MarkersHomozygoteProtein DenaturationPhenotypeStructure-Activity RelationshipRisk FactorsModels, ChemicalHydrogen-Ion ConcentrationCell DifferentiationTemperatureComputer SimulationMethylenetetrahydrofolate Reductase (NADPH2)DNA PrimersCell Line, TumorHydrogen BondingEuropean Continental Ancestry GroupAmplified Fragment Length Polymorphism AnalysisEscherichia coliPromoter Regions, GeneticChinaDNA Mutational AnalysisMutagenesis, Site-DirectedHeterozygoteProtein Structure, QuaternaryRecombinant ProteinsExonsTryptophanPoint MutationDimerizationAllosteric RegulationProteinsSolutionsCatalytic DomainBacterial ProteinsGlutathione TransferaseChromosome Mapping