• IFN-α 2A enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T cells. (sigmaaldrich.com)
  • CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
  • By promoting cell differentiation and proliferation, the FGF family of proteins plays a central role in prenatal development, postnatal growth and various tissue regeneration processes. (fujifilm.com)
  • In some cases, production of biomass itself is the objective, as is the case for single-cell proteins, baker's yeast, and starter cultures for lactic acid bacteria used in cheesemaking. (wikipedia.org)
  • BioLegend carrier-free recombinant proteins provided in liquid format are shipped on blue-ice. (biolegend.com)
  • Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. (peprotech.com)
  • Recently, research into recombinant protein production revealed a more attractive expression system based on the microalgae, C. reinhardtii, for significant savings in cost and production of correctly folded recombinant proteins. (bl.uk)
  • This review summarizes evidence for the role of proteolytic enzymes that degrade and inactivate insulin-like growth factor binding proteins (IGFBP) during follicular development in mammals. (bioone.org)
  • And you instruct the cells to make the protein or proteins that you need. (medscape.com)
  • Serial dilutions of Mouse IL-11 Recombinant Protein were added to B9 cells. (cellsignal.com)
  • The purity of Mouse IL-11 Recombinant Protein was determined by SDS-PAGE of 1 µg reduced (+) and non-reduced (-) recombinant mIL-11 and staining with Coomassie Blue. (cellsignal.com)
  • Mouse IL-11 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/ml which can be further diluted in aqueous solutions as needed. (cellsignal.com)
  • Interferon α 2A (IFN-α 2A) belongs to the type I interferon protein family and is produced by many cell types in response to viral infection. (sigmaaldrich.com)
  • Production of rhGH in CHO cells is an alternative to production in Escherichia coli, with the advantage that rhGH is secreted into protein-free production media, facilitating a more simple purification and avoiding resolubilization of inclusion bodies and protein refolding. (edu.au)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human TPP1. (novusbio.com)
  • Compared to grains, microalgae have higher growth capacity and usable protein content in their biomass. (nature.com)
  • Recombinant fusion protein containing a sequence corresponding to amino acids 169-300 of human SOX9 (P48436). (thermofisher.com)
  • The 148 amino acid recombinant protein (with ADL-His9-SSGIEGR at N-terminus) has a predicted molecular mass of approximately 17 kD. (biolegend.com)
  • Recombinant Human FGF-6 is an 18.7 kDa protein consisting of 168 amino acid residues. (peprotech.com)
  • Even though EIF4EBP2 protein binds eIF4E and inhibits translation initiation, growth factors can release this inhibition by a phosphorylation-dependent disruption. (prospecbio.com)
  • EIF4EBP2 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway. (prospecbio.com)
  • Regulation of this protein is associated to cell proliferation, cell differentiation and viral infection. (prospecbio.com)
  • PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit a) is one of the four catalytic subunits of PI3K protein, which plays an essential role in extracellular growth signaling. (sigmaaldrich.com)
  • In abstract, a framework was developed to supply useful human full-length GLP-1R by recombinant expression in E. coli as a prerequisite for eventual construction willpower and a rigorous biophysical characterization together with protein variants. (ncbcs.org)
  • Recombinant Active Human CXCL1 Protein with His tag (N-ter) was expressed in E. coli. (creativebiomart.net)
  • The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. (creativebiomart.net)
  • Aberrant expression of this protein is associated with the growth and progression of certain tumors. (creativebiomart.net)
  • HERZUMA (trastuzumab-pkrb) is a humanized IgG1 kappa monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 protein, HER2 . (rxlist.com)
  • Several expression systems for recombinant protein production, essentially cells or whole organisms are currently in use today. (bl.uk)
  • Using the expression of E. coli β-glucuronidase (gus) in C. reinhardtii chloroplast, the overall aim of the project was to address if the low recombinant gus yield in C. reinhardtii was due to limitations that affect growth and protein production, and if the fluxes for recombinant gus production were suboptimal (limiting). (bl.uk)
  • The finding was used to implement a strategy for a more predictable recombinant protein yield in C. reinhardtii. (bl.uk)
  • No detectable protein burden was observed for expression of recombinant gus in autotrophic and mixotrophic conditions, but protein burden was significant in heterotrophic condition (15 - 18% reduction in growth rate). (bl.uk)
  • Furthermore, this research presented a framework for identifying, analysing and understanding the effect of the uptake of individual amino acid towards recombinant protein yield. (bl.uk)
  • Using a preterm rabbit pup model, we investigated the uptake of systemic recombinant human (rh) IGF-1 in complex with its main binding protein IGF-binding protein 3 (BP-3) to the brain parenchyma via the choroid plexus. (lu.se)
  • Moreover, using choroid plexus in vitro cell cultures, gene expression and protein synthesis were further investigated upon rhIGF-1/rhIGFBP-3 stimulation as compared to rhIGF-1 alone, and found not to be differently altered. (lu.se)
  • Even if a protein is very complex in structure, which could be a limitation in recombinant, because your body makes it, it knows how to do it. (medscape.com)
  • This recombinant antigen is only intended to be used as a blocking agent to confirm antibody specificity with the corresponding antibody, catalog number NBP1-85561. (novusbio.com)
  • August 16, 2021- A new CDC study showed that flu shots made using recombinant technology produced a better antibody response among health care personnel compared with both cell-based and traditional flu shots. (cdc.gov)
  • The study, conducted during the 2018-2019 flu season, compared antibody responses among health care personal one month and six-months post-vaccination between recombinant (RIV), cell-based (ccIV), and traditional egg-based flu shots (IIV). (cdc.gov)
  • The following product was used in this experiment: SOX9 Recombinant Rabbit Monoclonal Antibody (5Y4J8) from Thermo Fisher Scientific, catalog # MA5-42728, RRID AB_2911869. (thermofisher.com)
  • This antibody gave a positive result when used in the following formaldehyde fixed cell lines: DU145. (abcam.com)
  • This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. (abcam.com)
  • The SCGFs are non-glycosylated, species-specific cytokines that can support growth of primitive hematopoietic cells, and, in combination with EPO or GM-CSF, promote proliferation of erythroid or myeloid progenitors, respectively. (peprotech.com)
  • The culture supernatant of animal cells, also known as 'conditioned medium' (CM), contains various factors secreted by the cells themselves, such as growth factors and cytokines. (nature.com)
  • Utilizing the upstream regulator (i.e. transcription factors, cytokines, growth factors) analysis, the lung had 285, blood cells 30, aorta 39, and heart 32 significantly altered mediators 4 h post-exposure. (cdc.gov)
  • CAFs and normal fibroblasts differ with respect to the expression of various markers, such as fibrotic markers, growth factors, chemokines and cytokines ( 9 ). (spandidos-publications.com)
  • Growth factors and cytokines involved in their migration, development and survival could be absent in this tissue and need further investigations. (bvsalud.org)
  • Recombinant mouse IL-11 was expressed in E. coli and is supplied in a lyophilized form. (cellsignal.com)
  • For efficient production of P4HB recombinant Escherichia coli has been employed. (biomedcentral.com)
  • E. coli JM109 was found to be the best strain regarding the specific growth rate and the P4HB content. (biomedcentral.com)
  • The effect of growth conditions such as temperature and physiological stage of Na-4HB addition on P4HB synthesis was also studied in E. coli JM109 recombinant in batch culture. (biomedcentral.com)
  • The response of a B cell to antigen is dependent on the surface expression of a clonotypic B-cell receptor complex (BCR) consisting of membrane-bound Ig and disulfide-linked heterodimers of Ig alpha/beta. (nih.gov)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • A plethora of biological agents are currently available in the market, including insulins, vaccines, human growth hormone, erythropoietin, interleukins, interferon, clotting factors and monoclonal antibodies 3 4 . (lww.com)
  • In the first phase of the project cell lines of specific leukocyte subsets (THP-1/monocyte, IM-9/T lymphocyte, H9/B lymphocyte), PBMCs (peripheral blood mononuclear cells) from healthy donors, respectively will be treated in vitro with hgh to identify candidate genes influenced by hghapplication. (wada-ama.org)
  • To this purpose cell lines of specific leukocyte subsets (THP-1/ monocyte, IM-9/ B- lymphocyte, H9/ T-lymphocyte) and PBMCs (peripheral blood mononuclear cells) from healthy donors, respectively were treated in vitro with hgh to identify candidate hgh-sensitive genes. (wada-ama.org)
  • Cultured meat is produced by culturing/proliferating animal muscle cells in vitro. (nature.com)
  • In vitro, most HRVs and HEVs differ by their optimal growth temperature, acid tolerance, receptor usage, and cell tropism. (cdc.gov)
  • We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
  • Recombinant expression, in vitro refolding, and biophysical characterization of the human glucagon -like peptide-1 receptor. (ncbcs.org)
  • Optimizing the growth environment for a recombinant myeloma cell line used in the production of new cancer vaccines (Master's thesis, University of Calgary, Calgary, Canada). (ucalgary.ca)
  • Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes. (joplink.net)
  • SOX9 has a role in sex determination and differentiation of Sertoli cells. (thermofisher.com)
  • IL-7 is necessary to specify CD8 lineage differentiation during CD4/CD8 cell fate choice in the thymus by inducing expression of the transcription factor Runx3. (biolegend.com)
  • FGF-6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. (peprotech.com)
  • IL-5 is a potent T-cell derived factor that stimulates the growth of certain B cells and the differentiation of eosinophils. (biovision.com)
  • Recombinant Human SCGF-α is a 33.9 kDa polypeptide containing 305 amino acid residues. (peprotech.com)
  • Mouse IL-7, amino acids Glu26 -Ile154 (Accession# NM_008371.4) was expressed in insect cells. (biolegend.com)
  • IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) α subunit. (cellsignal.com)
  • The Flt-3 ( fms- like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the receptor for SCF and FMS, the receptor for M-CSF. (rndsystems.com)
  • The B lymphocyte cell line RA-1 showed gene upregulation in the categories opioid receptor, oxidoreductase and GMP-reductase activity. (wada-ama.org)
  • Therefore, we developed a novel system in which we could form and then aggregate dimers, representative of partial receptor complexes, which contained either Ig alpha alone, Ig beta alone, or the two chains together and then examine their ability to induce apoptosis in the immature B-cell line, WEHI-231. (nih.gov)
  • This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. (prospecbio.com)
  • Activation of the glucagon-like peptide-1 receptor (GLP-1R) upon ligand binding results in the discharge of insulin from pancreatic cells. (ncbcs.org)
  • A particle according to claim 1 or 2, wherein the heterologous polypeptide has specific binding affinity for a cognate receptor on die surface of an eukaryotic cell, binding to which does not allow infection of the cell by the viral particle. (sumobrain.com)
  • A particle according to any one of the preceding claims, wherein the heterologous polypeptide sterically hinders binding of d e viral glycoprotein to its cognate receptor on the eukaryotic cell. (sumobrain.com)
  • A particle acording to claim 11 , wherein the protease cleavage site becomes accessible after the heterologous polypeptide has bound to its cognate receptor on the eukaryotic cell. (sumobrain.com)
  • Kim and Morshead, 2003), and the fibroblast that SSEA4 associated with CD133 can be used for growth factor (FGF) receptor 4 (Cai et al. (lu.se)
  • SCGF-α and -β are hematopoietic growth factors that exert their activity at early stages of hematopoiesis. (peprotech.com)
  • Here, we developed a novel medium containing nutrients extracted from microalga and cell-secreted growth factors. (nature.com)
  • The supernatant, containing the RL34 cell-secreted growth factors, was used as the conditioned medium (CM). This CM, with CVE added as a nutrient source, was applied to primary bovine myoblast cultures. (nature.com)
  • Animal cells are generally cultured in basal media supplemented with fetal bovine serum (FBS) which provides the various factors essential for cell growth. (nature.com)
  • Here, we propose a new approach wherein the nutrients in the culture medium are provided by a microalgae extract, and the FBS is replaced by growth factors in the CM. Figure 1 illustrates the preparation process of our serum-free and grain-derived-nutrient-free medium. (nature.com)
  • The growth of C. reinhardtii cultures were characterized in autotrophic, heterotrophic and mixotrophic conditions to identify factors that limit growth and recombinant gus yields. (bl.uk)
  • The process of secreting organic anions through the proximal tubule cells is achieved via unidirectional transcellular transport involving the uptake of organic anions into the cells from the blood across the basolateral membrane, followed by extrusion across the brush-border membrane into the proximal tubule fluid. (aspetjournals.org)
  • Anemia in pregnancy and the puerperium should be treated according to a staged regimen, administering either iron alone or in combination with an off-label use of human recombinant erythropoietin in selected patients. (karger.com)
  • It stimulates the growth of linear bone, skeletal muscle, and organs and stimulates erythropoietin, increasing red blood cell mass. (medscape.com)
  • The bioactivity of recombinant mIL-11 was determined in a B9 cell proliferation assay. (cellsignal.com)
  • Determined by a cell proliferation assay using Balb/c 3T3 cells. (peprotech.com)
  • Suppressed red blood cell production, for example, can lower your body's production of peptides that regulate iron uptake and storage within cells. (healthline.com)
  • Whole genome cDNA microarrays as well as oligonucleotide microarrays including leukocyte-relevant genes will be used to characterize potential hgh-specific genes by comparing gene expression profiles of treated and untreated cells. (wada-ama.org)
  • Genes clustering in the categories fatty acid beta oxidation, cell adhesion, DNA replication and polyamine biosynthesis were up-regulated indicating increased lipolysis, cell attachment, proliferation and growth. (wada-ama.org)
  • Genes for non-apoptotic cell death and regulation of osmotic pressure were down-regulated. (wada-ama.org)
  • Genes of groups similar to those detected as repressed in H9 cells were also down-regulated in the RA-1 cell line along with genes responsible for muscle development. (wada-ama.org)
  • 2, 3, 4] Mutations in at least 11 genes that play a role in regulating beta-cell insulin secretion have been implicated in the pathogenesis of HI. (medscape.com)
  • In adult mice, IL-7/IL-7R signaling up regulates expression of early B cell factor (EBF), and EBF in turn regulates expression of B cell-specific genes required for the transition from lymphoid progenitor to pro-B cells. (biolegend.com)
  • The immune responses generated by recombinant vaccine outperformed those of both the cell-based and the standard dose flu vaccines made using traditional egg-based technology. (cdc.gov)
  • While not definitive, this suggests that vaccine effectiveness may be higher for recombinant flu vaccines. (cdc.gov)
  • This production technology has some drawbacks including the fact that growth in eggs can cause mutations in the vaccine viruses that can impact how well the vaccines work. (cdc.gov)
  • Recombinant and cell-based vaccines are produced using a different production process that does not require growth in eggs. (cdc.gov)
  • These findings support a possible additional benefit from flu vaccination with recombinant flu vaccines. (cdc.gov)
  • Herpesvirus of turkeys (HVT), used originally as a vaccine against Marek's disease (MD), has recently been shown to be a highly effective viral vector for generation of recombinant vaccines that deliver protective antigens of other avian pathogens. (mdpi.com)
  • This study demonstrates the ability of Gradiflow preparative electrophoresis technology to purify rhGH from mammalian cell culture supernatant in a one-step process with high purity and yield. (edu.au)
  • It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
  • A particle according to any one of the preceding claims, wherein heterologous polypeptide sterically hinders fusion of an enveloped viral particle with an eukaryotic cell to which it is bound. (sumobrain.com)
  • A particle according to any one of the preceding claims, wherein the protease cleavage site is accessible to the relevant protease (i.e. that which recognises the cleavage site) before the viral particle becomes bound to an eukaryotic cell. (sumobrain.com)
  • A particle according to any one of claims 1 to 9, wherein the protease cleavage site becomes accessible to die relevant protease only after the viral particle has become bound to an eukaryotic cell. (sumobrain.com)
  • In addition, IL-7 controls T-cell size and metabolism through the activation of PI3 kinase-dependent pathways and regulation of glucose metabolism. (biolegend.com)
  • Interleukin-11 (IL-11) was initially cloned as a mediator of plasmacytoma cell proliferation and was later found to exhibit a wide variety of biological effects in neural cells as well as in the hematopoietic and immune systems (1). (cellsignal.com)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
  • Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
  • Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
  • Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
  • There are no contraindications to autologous hematopoietic stem cell transplantation. (msdmanuals.com)
  • Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
  • The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)
  • Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
  • As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
  • Primary antibodies are available for the characterization of neural stem cells, neural progenitor cells and their progeny. (stemcell.com)
  • The labeled cells can be visualized using fluorescent imaging, quantified using flow cytometry, and isolated using fluorescence-activated cell sorting (FACS).The ALDEFLUOR™ fluorescent reagent system offers a novel approach to the non-immunological identification, evaluation and isolation of neural stem and progenitor cells. (stemcell.com)
  • Melero-Martin JM , Khan ZA , Picard A , In vivo vasculogenic potential of human blood-derived endothelial progenitor cells . (avma.org)
  • Edwards N , Langford-Smith AWW , Wilkinson FL , Endothelial progenitor cells: new targets for therapeutics for inflammatory conditions with high cardiovascular risk . (avma.org)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • The organisms used are typically microorganisms, particularly bacteria, algae, and fungi, such as yeasts and molds, but industrial fermentation may also involve cell cultures from plants and animals, such as CHO cells and insect cells. (wikipedia.org)
  • Glycosylation contributes to stability in cell growth media and other applications. (sigmaaldrich.com)
  • Mouse IL-7 was initially described as a pre B-cell grow factor expressed in bone marrow stromal cells. (biolegend.com)
  • TP53‑deficiency in cancer cells is associated with robust stromal activation. (spandidos-publications.com)
  • The mutational inactivation of the TP53 gene in tumor cells has been reported to affect not only tumor cells but also the surrounding cells in the tumor microenvironment and to promote tumor-stromal activation and subsequent tumor growth ( 11 , 12 ). (spandidos-publications.com)
  • Whether you're starting from primary cells, tissue samples, or pluripotent stem cells, explore our complete portfolio of products to support your neural culture workflow. (stemcell.com)
  • Various genetic abnormalities such as wingless and int-1 (Wnt) signaling, tissue growth factor beta (TGFβ) signaling, or TP53 signaling have been known in the carcinogenesis of colorectal cancer ( 2 , 3 ). (spandidos-publications.com)
  • The tumor microenvironment consists of various cell types and fibroblasts in the tumor tissue, called cancer-associated fibroblasts (CAFs), which play pivotal role in tumor progression ( 7 , 8 ). (spandidos-publications.com)
  • The activation of these cells leads to the release of chemical mediators such as histamine and arachidonic acid metabolites, which increase vascular permeability and tissue swelling 9 . (bvsalud.org)
  • Since mGLP-1 remedy elevated cytosolic cAMP focus in SH-SY5Y cells, we postulate that mGLP-1 could exert its affect through binding to GLP-1 receptors in SH-SY5Y cells and stimulating the manufacturing of cAMP. (ncbcs.org)
  • fication and isolation via fluorescence-activated cell sort- ing (FACS). (lu.se)
  • Fluorescence-activated cell sorting is used to identify and separate stem cells from other cells. (msdmanuals.com)
  • HumanKine IFN-α 2A, expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 16 kDa. (sigmaaldrich.com)
  • The pair thought it might be transplanted into rats to relieve Parkinson- to join the medical school at the Univer- possible to implant immature cells into like symptoms, Björklund and former stu- sity of Lund, where he would stay for his damaged brain areas, where the new cells dent Olle Lindvall initiated the first clinical entire career. (lu.se)
  • 2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)
  • Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
  • The role of exosomes collected by ultracentrifugation were also analyzed as mediators of p53 expression in cancer cells and APJ expression in fibroblasts. (spandidos-publications.com)
  • MicroRNA 5703 enriched in exosomes derived from HCT116 sh p53 cells inhibited APJ expression, and inhibition of miR‑5703 diminished APJ suppression in fibroblasts caused by cancer cells. (spandidos-publications.com)
  • APJ suppression from a specific microRNA in cancer cell‑derived exosomes induced CAF‑like properties in fibroblasts. (spandidos-publications.com)
  • In this study, we aimed to investigate the physiology of P4HB synthesis, and to reduce the total production cost by using cheap and widely available xylose as the growth substrate and sodium 4-hydroxybutyrate (Na-4HB) as the precursor for P4HB synthesis. (biomedcentral.com)
  • The antitumor efficacy of the recombinant virus on hepatoma was examined both in cell cultures and in mice. (usda.gov)
  • High conversion rate and P4HB contents from xylose and precursor were achieved here by simple batch culture, which was only possible previously through fed-batch high cell density cultures with glucose. (biomedcentral.com)
  • Myelodysplastic syndromes (MDS) are rare bone marrow disorders that impair how well your body creates new blood cells. (healthline.com)
  • MDS prevent your bone marrow from making the necessary level of red blood cells, which help transport oxygen throughout the body. (healthline.com)
  • In this fashion, IL-7 induces cell activation, survival, and proliferation of T lymphocytes. (biolegend.com)
  • Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. (prospecbio.com)
  • Purification of recombinant human growth hormone (rhGH) from Chinese hamster ovary (CHO) cell culture supernatant by Gradiflow large-scale electrophoresis is described. (edu.au)
  • Trastuzumab-pkrb is produced by recombinant DNA technology in a mammalian cell (Chinese Hamster Ovary) culture. (rxlist.com)
  • The present project aims to introduce microarray technology as a new analytical tool into the field of doping control analysis to gain insight in specific effects of recombinant human growth hormone (hgh) on blood cells (leukocytes). (wada-ama.org)
  • Microarray technology will be used to search for changes in leukocyte gene expression which are directly related to the application of human growth hormone (hgh). (wada-ama.org)
  • The aim was to establish a selective human Growth Hormone (hgh) microarray which can be used in hgh doping control by detecting the specific effects of hgh administration rather than the presence of the hormone itself as its very short half-life complicates direct detection. (wada-ama.org)
  • FGF10 is known to be significantly involved with FGF7 (also known as keratinocyte growth factor or KGF). (fujifilm.com)
  • APJ expression in fibroblasts co‑cultured with p53‑suppressed colon cancer cells (HCT116 sh p53 cells) was significantly lower than in control colon cancer cells (HCT116 sh control cells). (spandidos-publications.com)
  • NDV/Anh-EGFP significantly inhibited liver cancer development both in cancer cell lines and in mice. (usda.gov)
  • A strategy that significantly increased growth and cell productivity (>3 fold) in heterotrophic condition was identified. (bl.uk)
  • Using FBA modelling, model verifications and corrections, a strategy that significantly increased the yield of recombinant gus in each cell (~2 fold) was identified. (bl.uk)
  • Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
  • Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • A potential future source of stem cells is induced pluripotent stem cells (certain cells taken from adults and reprogrammed to act like stem cells). (msdmanuals.com)
  • Human breast carcinoma, T47D cell lysate. (abcam.com)
  • However, ST6GAL1 is also released into the extracellular milieu and extracellularly remodels cell surface and secreted glycans. (nature.com)
  • We hypothesize that ST6GAL1 action is the combined effect of natively expressed sialyltransferase acting cell-autonomously within the ER-Golgi complex and sialyltransferase from extracellular origins acting extrinsically to remodel cell-surface glycans. (nature.com)
  • Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
  • Mast cells play an important role in a variety of biological processes and actively participate in the inflammatory response. (bvsalud.org)
  • Mast cells play an important role in a variety of biological processes including allergic reactions, atherosclerosis and inflammation 7,8 . (bvsalud.org)
  • It is recommended to reconstitute the lyophilized IL-7 in sterile PBS containing 0.1% endotoxin-free recombinant HSA. (prospecbio.com)
  • During a transfusion, you're given blood cells from a healthy donor through an IV. (healthline.com)
  • IL-7 Human Recombinant produced in HEK cells is a glycosylated monomer, having a molecular weight range of 19-30kDa due to glycosylation. (prospecbio.com)
  • These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. (thermofisher.com)
  • In addition, xenografts of HCT116 cells with APJ‑suppressed fibroblasts showed accelerated tumor growth. (spandidos-publications.com)
  • Successful expression depended on the use of strictly anaerobic conditions for both growth and enzyme preparation, since FldZ was oxygen-sensitive. (microbiologyresearch.org)
  • The availability of an expression system for this recombinant clostridial 2-enoate reductase will facilitate future characterisation of this unusual class of 'ene'-reductases, and expand the biocatalytic toolbox available for enantioselective hydrogenation of carbon-carbon double bonds. (microbiologyresearch.org)
  • CD4 T cell lymphopenia increases the expression of circulating IL-7, and TGFb induces IL-7 downregulation. (biolegend.com)
  • GDNF, but not nerve growth factor (NGF), can prevent several axotomy-induced changes in these neurons, including the downregulation of IB4 binding, TMP activity, and somatostatin expression. (jneurosci.org)
  • A non-live, recombinant influenza virus vaccine not requiring isolation or growth in hen's eggs was licensed in 2013. (cdc.gov)