• How is the tissue specificity of immune cells generated and how is it affected by environmental influences, plasticity and the tissue microenvironment? (mdc-berlin.de)
  • Therefore, we investigated the impact of ApoA-I variants on cell physiology and the mechanisms driving the observed tissue specificity. (lu.se)
  • Standardization Program (DASP, 2000, 2002, 2003), organized by WHO, the data were: 76-100% sensitivity, 90-100% specificity (100% specificity 3 times), and 100% validity for GAD65 autoantibodies (3). (cdc.gov)
  • Accuracy of specificity and degree of sensitivity by various methods are assessed. (uclahealth.org)
  • Organisms seen by Gram stain yielded a sensitivity of 96.6%, specificity of 88.9%, positive predictive value of 97.7% and negative predictive value of 84.2% when used to predict positive culture results for bacterial wound infection. (who.int)
  • With any type of laboratory test, the clinical accuracy or reliability depends on performance characteristics such as sensitivity and specificity, as well as the pretest probability that a person has SARS-CoV-2 infection and the prevalence of COVID-19 in the local community. (medscape.com)
  • Greater diagnostic specificity and sensitivity can be achieved by measuring levels of histamine metabolites in random and 24-hour urine specimens than by determining levels of histamine itself. (medscape.com)
  • Notch receptors and Notch ligands were detected in virtually all cells throughout EB development. (karger.com)
  • Notch1 and Notch 2, but not Notch4, were visualized in the nucleus of EB cells, and all these receptors were also observed as patent cytoplasmic foci. (karger.com)
  • Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
  • To do so, cells release signaling molecules that can move around within a tissue and be detected by receptors on other cells. (elifesciences.org)
  • However, random variations (noise) that affect how many of these molecules are produced, how they move through the space between cells and how they bind to receptors makes the reality much more complex. (elifesciences.org)
  • The eye in general and in particular the abundant proteins of the eye lens, which are termed crystallins provided Clayton and her colleague DES Truman with an ideal system in which to investigate the link between gene expression and cell differentiation during embryonic development. (wikipedia.org)
  • Our cells are constantly churning out proteins that they use to carry out their functions. (eurostemcell.org)
  • We demonstrate that RA forms a noisy gradient during critical stages of hindbrain patterning and that cells use distinct intracellular binding proteins to attenuate noise in RA levels. (elifesciences.org)
  • The experiments also show that proteins that interact with retinoic acid help to reduce noise within a cell. (elifesciences.org)
  • These therapeutics work by shuttling mRNA 'instructions' into target cells, providing them with a blueprint to make specific proteins. (nih.gov)
  • Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
  • The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. (cuanschutz.edu)
  • We have established liver cancer cell lines resistant to common chemotherapeutic drugs. (ntu.ac.uk)
  • We have screened 182 small molecule epigenetic modulators on liver cancer cells and found that inhibitors of a specific histone demethylase (KDM) induce cell death. (ntu.ac.uk)
  • 3 μ g/(kg·BW) of AFB 1 can cause significant damage to the DNA of duckling liver cells (Wang et al. (hindawi.com)
  • As the field stands now, mRNA-filled lipid nanoparticles generally reach just a handful of cell types, such as immune cells and cells in the liver or spleen. (nih.gov)
  • Aspergillus -derived mycotoxins, including aflatoxins and ochratoxin A, and fumonisins (members of the fusariotoxin group) can cause pathological damage to vital organs, including the kidney or liver. (frontiersin.org)
  • Liver histological findings included hypertrophy and immune cell infiltration. (cdc.gov)
  • 1973. Substrate-specificity and toxicological significance of pyrethroid-hydrolyzing esterases of mouse liver microsomes. (cdc.gov)
  • The spleen is the organ damaged most commonly, followed by the liver and a hollow viscus (typically the small intestine). (msdmanuals.com)
  • We focused on four ApoA-I amyloidogenic variants and analyzed their cytotoxicity as well as their ability to alter redox homeostasis in cell lines from different tissues (liver, kidney, heart, skin). (lu.se)
  • Cell-free DNA profiling informs all major complications of hematopoietic cell transplantation. (harvard.edu)
  • The pioneering research, presented today at the European Society for Organ Transplantation (ESOT) Congress 2023, opens promising avenues for expanding the organ donor pool and enhancing patient outcomes. (press-news.org)
  • By transplanting older donor organs into younger recipients, researchers from Harvard Medical School and the Mayo Clinic investigated the role of transplantation in inducing senescence, a biological mechanism linked to ageing and age-related diseases. (press-news.org)
  • Throughout Europe, the demand for organ transplantation is on the rise, driven by an increase in chronic diseases. (press-news.org)
  • This research is extremely exciting and clinically so relevant as it may not only help us to improve outcomes but also make more organs available for transplantation," concluded Stefan G. Tullius, the senior and lead author of the study. (press-news.org)
  • The European Society for Organ Transplantation (ESOT) was founded 40 years ago and is dedicated to the pursuit of excellence in organ transplantation. (press-news.org)
  • Solid organ transplantation is an important therapeutic option for children with a variety of end stage diseases. (stanford.edu)
  • High-dimensional profiling of pediatric immune responses to solid organ transplantation. (stanford.edu)
  • This was an important undertaking because tissue typing for organ transplantation, disease studies, and population studies was dependent upon human typing sera obtained in very limited quantities, primarily from multiparous women. (uclahealth.org)
  • PURPOSE OF REVIEW: Fever is a common manifestation of both infectious and noninfectious processes in recipients of hematopoietic cell transplantation (HCT) and chimeric antigen receptor T-cell (CAR-T) therapy. (stanford.edu)
  • Other patients at greater risk because of decreased responsiveness to polysaccharide antigens or more rapid decline in serum antibody include those with functional or anatomic asplenia (e.g., sickle cell disease or splenectomy), Hodgkin's disease, lymphoma, multiple myeloma, chronic renal failure, nephrotic syndrome, and organ transplantation. (cdc.gov)
  • Peripheral tolerance occurs in the secondary lymphoid organs (e.g. spleen, lymph nodes, and mucosal/gut associated lymphoid tissues) and peripheral tissues. (frontiersin.org)
  • Immune phenotyping of the spleen identified that PFHpS altered immune cell subtype abundance, including CD11+ myeloid-derived cells, CD4 T cells, and B cell numbers. (cdc.gov)
  • By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)
  • iNKT cells have been traditionally defined by the expression of an invariant TCR α-chain (Vα14-Jα18 in mice or Vα24-Jα18 in humans) and their capacity to recognise the glycolipid antigen α-galactosylceramide (αGalCer) presented on CD1d. (elifesciences.org)
  • γ-secretase inhibitors (GSIs) have been recently proposed as chemopreventive agents in gastrointestinal neoplasia, because they lead, through inhibition of the Notch signaling pathway, to goblet cell conversion in some intestinal adenomas of the Apc Min mice, and halt epithelial cell proliferation. (biologists.com)
  • Consistent with this, iNKT cells from different organs show distinct basal activation, proliferation and clonal expansion. (elifesciences.org)
  • Cells seeded on laminin-incorporated OSCMs displayed evidence of adherence to substrate, proliferation, and enhanced survival. (techbriefs.com)
  • First, we are interested in Epstein Barr Virus-mediated mechanisms of immune evasion with particular emphasis on pathways that promote survival and proliferation of EBV B cell lymphomas, the characterization of the human T cell and NK cell response to EBV and the identification of novel therapeutics for treatment of EBV B cell lymphomas. (stanford.edu)
  • pointed out that Mage-D1 may participate in the proliferation of bone marrow mesenchymal stem cells (BMSCs) and the differentiation of odontoblasts through the NF-κB signalling pathway 21 . (researchsquare.com)
  • These included 8/14 members of let-7 family of miRNAs that have been widely implicated in the control of androgen signaling and the repression of cell proliferation and oncogenic pathways. (edu.au)
  • or physiological or as a description of key events and processes starting toxic effects that affect cell proliferation. (cdc.gov)
  • Mastocytosis is a rare disorder characterized by functional secretion or abnormal proliferation of tissue mast cells. (medscape.com)
  • CGNRs were extensively endocytosed by GD2+ stNB-V1 neuroblastoma cells via antibody-mediated endocytosis. (phytid.org)
  • We have applied the lectin Amaranthin, having a nominal specificity for Galβ1,3GalNAcR and Neu5Ac2,3Galβ1,3GalNAcα-R, and a monoclonal antibody raised against Galβ1,3GalNAcαR to examine the distribution of these simple O-glycans in adult rat kidney. (uzh.ch)
  • As the complexity of the HLA system defined by antibody reagents grew, the Cell Exchange focused its efforts on providing challenging cell types - those that included "rare" HLA antigens or unusual combinations of antigens that might be difficult to discriminate. (uclahealth.org)
  • A serum exchange was added in 1981, to check for anti-HLA antibody specificities. (uclahealth.org)
  • Recipients that had received old hearts showed augmented frequencies of senescent cells in draining lymph nodes, livers, and muscles, in addition to augmented systemic mt-DNA levels, when compared to recipients that had received young grafts. (press-news.org)
  • Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ specific autoimmune diseases confers high specificity for insulin- dependent diabetes mellitus. (cdc.gov)
  • Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
  • Sequestration of Plasmodium falciparum -infected erythrocytes in vital organs and the associated inflammation leads to organ dysfunction. (cdc.gov)
  • Since antigen-specific TGF-beta1 secreting cells localize to the target organ and then suppress inflammation in the local microenvironment, oral tolerization with self antigens may provide a therapeutic approach for the treatment of cell-mediated autoimmune disease which does not depend upon knowledge of the antigen specificity of the original T cell clone triggering the autoimmune cascade. (jci.org)
  • One of the research areas at the MDC is immunology and inflammation, which covers tumor immunology, DNA repair in B lymphocytes, the role of tumor stroma-immune cell interaction in cancers, the role of innate immune cells in gliomas and neurodegenerative diseases, and the development of immunotherapy strategies. (mdc-berlin.de)
  • Inflammation occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight the invaders and facilitate tissue repair. (medlineplus.gov)
  • In addition to inflammation, the OTULIN protein is thought to be involved in regulating development before birth and controlling cell death. (medlineplus.gov)
  • Sequestration of P. falciparum -infected erythrocytes (iEs) ( 3 ) in vital organs is considered a key pathogenic event leading to SM, as has been shown in postmortem parasite counts in patients who died with cerebral malaria ( 4 , 5 ). (cdc.gov)
  • Langerhans cells (LCs) populate the mucosal epithelium, a major entry portal for pathogens, yet their ontogeny remains unclear. (nih.gov)
  • Most anatomical compartments, including mucosal surfaces and solid organs, host large populations of tissue-resident lymphocytes which are uniquely placed to provide local networks for immune surveillance and defence against infection ( Fan and Rudensky, 2016 ). (elifesciences.org)
  • These results suggest that the oral administration of antigens generates antigen specific TGF-beta1 secreting Th3 cells of presumed mucosal origin that represent a distinct lineage of T cells. (jci.org)
  • Select organ toxicity potentially results from compound accumulation in a particular tissue, cell types within organs, metabolism, and off-target effects. (nih.gov)
  • for example, they provide structural stability to cells and tissues, give motility to individual cells, carry messages within and between cells, and regulate gene expression and metabolism. (biologists.com)
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
  • Importantly, to provide insight into human disease we will investigate the therapeutic potential of targeting KDM by employing a novel organ-on-a-chip technology. (ntu.ac.uk)
  • We will develop nanoparticles to improve efficacy and target specificity of the therapeutic combinations. (ntu.ac.uk)
  • As part of our strategy, we are building new therapeutic platforms including cell and gene therapies," said Stefan Oelrich, Member of the Board of Management, Bayer AG and President of Bayer's Pharmaceuticals Division. (askbio.com)
  • On the basis of these and other studies she developed and advocated the view that the differences in gene expression that underlie cell differentiation are quantitative in nature and combinatorial in effect. (wikipedia.org)
  • The epigenetic landscape model of Waddington's proposed that development proceeds by progressive restriction of cell fate, commitment and subsequent differentiation to a range of well-defined cell types. (wikipedia.org)
  • Kim YH, Larsen HL, Rué P, Lemaire LA, Ferrer J, Grapin-Botton A (2015) Cell Cycle-Dependent Differentiation Dynamics Balances Growth and Endocrine Differentiation in the Pancreas. (eurostemcell.org)
  • The classic organ systems are influenced by ters DNA repair or causes genomic mutation theory of cancer no longer mechanistic events associated with instability, (4) induces epigenetic fully encompasses the mechanistic cancer induction. (who.int)
  • This suggests that unique tissue-specific factors (including local lipid antigens, cytokines and/or hormones) may shape the population of iNKT cells resident in those tissues, ultimately regulating local immune responses. (elifesciences.org)
  • The discovery and characterization of new antigens implicated in the pathogenesis of T1D is a high priority as it can lead to new diagnostic tools and anticipate that studies proposed by Dr. Baker will provide critical information to target autoreactive T cells though antigen-specific therapies. (cuanschutz.edu)
  • The second area of study is to understand the regulation of the immune response to cellular and solid organ grafts. (stanford.edu)
  • By histochemistry glycosyltransferases and their products can be localized to specific cell types in organs of complex cellular composition. (uzh.ch)
  • Precisely how the changes in cellular structure due to storage translates into adverse effects on cell function remains enigmatic. (medscape.com)
  • Shock Shock is a state of organ hypoperfusion with resultant cellular dysfunction and death. (msdmanuals.com)
  • It is cells of the pancreas that produce the insulin we need to control blood sugar levels. (eurostemcell.org)
  • Perhaps we could incite cells that haven't specialized to make insulin, to secrete it. (eurostemcell.org)
  • This extensive sequestration of parasitized erythrocytes in the microvasculature, together with the production of inflammatory mediators, leads to the dysfunction of one or more peripheral organs, such as the lungs (acute respiratory distress syndrome), kidneys (acute kidney injury) or brain (coma) ( 6 , 7 ). (cdc.gov)
  • Within peripheral tissues iNKT cell recent thymic emigrants exhibit a different TCR repertoire than mature cells, suggesting that the iNKT population is shaped after arrival to the periphery. (elifesciences.org)
  • Since iNKT cell activation can prevent or promote immunopathology in diverse disease contexts, the strict control of peripheral iNKT cell homeostasis is vital to regulate local immunity. (elifesciences.org)
  • Peripheral tolerance evolved to counteract autoantigen-recognizing T or B cells that escape central tolerance. (frontiersin.org)
  • Mechanisms of peripheral tolerance include inactivation of autoantigen-recognizing T and B cells by the induction of apoptosis, anergy or conversion into immunosuppressive regulatory cells. (frontiersin.org)
  • MRI utilizes magnetic properties of ions in the body along with computer-generated radio waves to create detailed images of the body's organs and tissues 4 . (tufts.edu)
  • Here, we investigated whether in MS patients oral myelin treatment, containing both myelin basic protein (MBP) and proteolipid protein (PLP), induced antigen specific MBP or PLP reactive T cells that either secreted IL4, TGF-beta1, or alternatively did Th1 type sensitization occur as measured by IFN-gamma secretion. (jci.org)
  • Designing such lipid nanoparticles that can target hard-to-reach organs, such as the heart or pancreas, could revolutionize treatment options for a wide range of conditions. (nih.gov)
  • Lipid nanoparticles are essentially tiny spheres of fat, and fats have all kinds of chemical properties that can affect their ability to travel through the body and target specific organs," explained Luisa Russell, Ph.D., a program director in the Division of Discovery Science & Technology at the National Institute of Biomedical Imaging and Bioengineering (NIBIB). (nih.gov)
  • Within the past couple of years, there's been much more appreciation for how the lipids in nanoparticles can redirect mRNA delivery to different cells and organs," said first study author Jilian Melamed, Ph.D., a postdoctoral researcher at the University of Pennsylvania. (nih.gov)
  • Organ Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • From this colorful three-dimensional clip, Kim and her team looked at whether the cells of the pancreas are ones that can produce hormones, or cells that have not specialized to this function. (eurostemcell.org)
  • They investigated mRNA delivery via intraperitoneal injection, which involves injecting a drug directly into the fluid that surrounds the organs of the peritoneal cavity (including the kidneys, intestines, and pancreas). (nih.gov)
  • Her work on the T cell tyrosine kinase ITK has revealed a critical role for this TCR signaling protein in autoreactive T cell trafficking into tissues such as the pancreas and the intestine. (cuanschutz.edu)
  • In addition, suppressor immune cells such as FOXP3 + regulatory T cells (Tregs) exert dominant immune suppression to control autoreactive T and B cells. (frontiersin.org)
  • The laboratory course provides insight into the isolation and study of fish immune cells, selected cell markings, functional analysis and measurement of appropriate immune responses in fish. (uib.no)
  • The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. (ncsu.edu)
  • A novel study has shown that Senolytics, a new class of drugs, have the potential to prevent the transfer of senescence, a key mechanism of ageing, and the associated physical and cognitive impairments in recipients of older donor organs. (press-news.org)
  • Press-News.org) (18 September 2023, Athens, Greece) A novel study has shown that Senolytics, a new class of drugs, have the potential to prevent the transfer of senescence*, a key mechanism of ageing, and the associated physical and cognitive impairments in recipients of older donor organs. (press-news.org)
  • Recipients who received old organs treated with Senolytics showed improved physical fitness that was comparable to observations in recipients of young organs. (press-news.org)
  • Maximillian J. Roesel, presenting the study as part of the group at Brigham and Women's Hospital, Harvard Medical School, commented, "Donor age plays a crucial role in the success of transplantations, with recipients of older organs facing worse short- and long-term outcomes. (press-news.org)
  • Before the 1980s, fewer than 100 cases of PJP were reported annually in the United States, occurring in patients who were immunosuppressed (eg, cancer patients receiving chemotherapy and solid-organ transplant recipients receiving immunosuppressants). (medscape.com)
  • Two cells in the same position can have very different retinoic acid levels, and the levels in a particular cell can vary from one minute to the next. (elifesciences.org)
  • Blunt injury may alternatively cause only a hematoma in a solid organ or the wall of a hollow viscus. (msdmanuals.com)
  • Hemorrhage due to low-grade solid organ injury, minor vascular laceration, or hollow viscus laceration is often low-volume, with minimal physiologic consequences. (msdmanuals.com)
  • Third, IL-2 therapies aiming at expanding immunosuppressive regulatory T cells in vivo . (frontiersin.org)
  • Whole-body PD-L1 expression PET imaging may potentially allow for a better prediction of response to programmed cell death protein-1-targeted therapies. (snmjournals.org)
  • We anticipate that these MPL-compatible OS composite resins will pave the path towards production of soft, bioactive, and conductive microstructures for various applications in the emerging fields of flexible bioelectronics, biosensors, nanoelectronics, organ-on-chips, and immune cell therapies. (techbriefs.com)
  • Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin. (harvard.edu)
  • We further demonstrated that similar to non-lymphoid dendritic cells (DCs), CD103(+) LCs originate from pre-DCs, whereas CD11b(+) LCs differentiate from both pre-DCs and monocytic precursors. (nih.gov)
  • Large quantities of histamine can also be produced by dendritic cells and T cells, though these cells do not store histamine. (medscape.com)
  • Several publications have aimed to predict specific organ toxicities. (nih.gov)
  • Here, we investigated the utility of hepatic-, cardiac-, and kidney-derived cell lines to (1) accurately predict cytotoxicity and (2) to accurately predict specific organ toxicities. (nih.gov)
  • Our results suggest that from a general screening perspective, different cell lines have relatively equal value in assessing general cytotoxicity and that specific organ toxicity cannot be accurately predicted using such a simple approach. (nih.gov)
  • Crystallin gene expression was further explored in a detailed series of studies using long-term cell culture models in which progenitor chick lens cells continuously differentiated into lens fibre cells in controlled laboratory conditions. (wikipedia.org)
  • Despite this prototypical TCR repertoire gene usage, in recent years it has become apparent that there are variations within the iNKT cell repertoire that ultimately impact the antigen recognition capacity and consequently the functional outcomes during an immune response. (elifesciences.org)
  • Morphogen gradients induce sharply defined domains of gene expression in a concentration-dependent manner, yet how cells interpret these signals in the face of spatial and temporal noise remains unclear. (elifesciences.org)
  • The addition of AskBio to Bayer's emerging cell and gene therapy (CGT) business strengthens Bayer's commitment to the field. (askbio.com)
  • With this acquisition, Bayer significantly advances the establishment of a cell and gene therapy platform that can be at the forefront of breakthrough science contributing to, preventing, or even curing diseases caused by gene defects and further driving company growth in the future. (askbio.com)
  • In 2005, the International KIR Exchange was integrated within the framework of the International Cell Exchange, by offering reference DNA samples for KIR gene typing. (uclahealth.org)
  • We demonstrate that DBZ elicits a homogeneous goblet cell conversion all along the mouse intestinal tract, associated with an overexpression of the gene Muc2 without ectopic expression of the gastric genes Muc5ac and Muc6 , and with the emergence of lysozyme-positive 'intermediate cells' in the colon. (biologists.com)
  • Methods: Following a 28-day sub-chronic dermal exposure to PFHpS (0.3125%, 0.625%, and 1.25% or 7.8-15.6mg/kg/day) organ weight, serum chemistry, histology, immune phenotype, and gene expression were analyzed. (cdc.gov)
  • Kupka S, Reichert M, Draber P, Walczak H. Formation and removal of poly-ubiquitin chains in the regulation of tumor necrosis factor-induced gene activation and cell death. (medlineplus.gov)
  • D) Calcium-activated chloride channels were activated by UTP (100 M) in cystic fibrosis (CFTR-deficient) human bronchial epithelial cells, with PPQ-102 added as indicated. (phytid.org)
  • An impressive profile of some 370 miRNAs were detected in the mouse epididymis, with a subset of these specifically identified within the epithelial cells that line the tubule (218). (edu.au)
  • Cells responding to signals need to be able to distinguish these signals from random fluctuations (i.e., noise) and presumably have evolved mechanisms to do so. (elifesciences.org)
  • His work has ranged from exploring the mechanisms contributing to T cell effector function to investigating the role of new beta-cell autoantigens. (cuanschutz.edu)
  • A major focus has been understanding the role of intra-islet communication and functional sub-populations of cells in islet function, and how disruption to intra-islet communication mechanisms and changes in sub-populations occur in diabetes and may contribute to islet decline. (cuanschutz.edu)
  • However, the factors leading to cell/tissues damage, as well as the mechanisms behind the observed organ specificity are mostly unknown. (lu.se)
  • In our previous studies, EMSCs were obtained from rat embryonic facial process tissue by fluorescence p75 neurotrophin receptor (p75NTR) activated cell sorting, providing a good stem cell model for studies of dental mineralization. (researchsquare.com)
  • Nevertheless, the use of older donor organs is essential to tackle the global organ shortage, and this research illuminates fundamental challenges and potential solutions for utilising older organs. (press-news.org)
  • The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. (harvard.edu)
  • As we develop from wads of cells to fully formed humans, each of our organs goes through intricate processes to achieve the right combination and number of cells arranged in the proper way. (eurostemcell.org)
  • Examples are CRISPR/Cas9-mediated mutagenesis, genetic mouse models, cell-fate-mapping, organoids and tumor explants, as well as GMP production of pharmaceuticals and many years of experience in conducting clinical studies. (mdc-berlin.de)
  • Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)
  • While immune checkpoint inhibitors are very effective in cancer treatment, their effect is not only limited to tumor cell and they have many autoimmune side effects. (cuanschutz.edu)
  • Cell Freezing Medium-DMSO Serum free media, contains 8.7% DMSO in MEM supplemented with methyl cellulose. (abcam.com)
  • Fourier-transform mid-infrared (FT-MIR) spectroscopy is a powerful technique that probes intramolecular vibrations of almost any molecule, enabling the acquisition of metabolic fingerprint of cells, tissues and biofluids (e.g. serum, urine and saliva, etc.), in a rapid (in minutes), simple (without or with minimum sample processing), economic (without consumption of reagents), label-free and highly sensitive and specific mode. (benthamscience.com)
  • Although multiple PFAS are detectable in human serum, research is needed to identify and characterize the potential biological effects of each PFAS and the specificity pf these effects to the exposure route. (cdc.gov)
  • PD-L1 binding assays were performed using the transduced PD-L1-expressing lymphoma cell line U-698-M and wild-type U-698-M cells as a negative control. (snmjournals.org)
  • 3 Moreover, this growing need far surpasses the available supply of organs, with recent data demonstrating that across Europe an average of 21 people die each day waiting for a transplant. (press-news.org)
  • Epidemiology of lower respiratory tract infections and community-acquired respiratory viruses in patients with bronchiolitis obliterans syndrome after hematopoietic cell transplant: a retrospective cohort study. (stanford.edu)
  • After seven days of culture, OS composite polymers did not induce cell mortality with approximately 94 percent cell viability compared to the control surfaces," Abidian said. (techbriefs.com)
  • When old donors were treated with Senolytics (Dasatinib and Quercetin) prior to organ procurement, the transfer of senescence was significantly reduced through a diminished accumulation of senescent cells and mt-DNA. (press-news.org)
  • Cell damage was assessed using MTT assays, and the lactate dehydrogenase (LDH) release rate and flow cytometry were used to detect the accumulation of reactive oxygen species (ROS) and mitochondrial membrane potential respectively. (sdbonline.org)
  • It was found that GSOs reversed GLU-induced reductions in cell viability and the LDH release rate, and rescued ROS accumulation. (sdbonline.org)
  • The specificity of these accumulated materials to the distinct enzyme defect is striking in the lysosomal disorders, and the accumulation then leads to abnormal cell architecture. (medscape.com)
  • Data indicated that ApoA-I variants exerted a cytotoxic effect in a time and cell-type-specific manner that seems to be due to protein accumulation in lysosomes. (lu.se)
  • Mage-D1 (MAGE family member D1) is involved in a variety of cell biological effects. (researchsquare.com)
  • Many of these extracts were from the reference cells sequenced for rare alleles, thus giving laboratories the opportunity to type them, whereas they may not detect them in routine typing them in their local populations. (uclahealth.org)
  • Transcriptomic profiling revealed the deregulation of histone-modifying enzymes in chemoresistant cells. (ntu.ac.uk)
  • High and specific binding of 68 Ga-BMS-986192 to human PD-L1-expressing cancer cells was confirmed, which closely correlates with the respective PD-L1 expression level determined by flow cytometry and immunohistochemistry staining. (snmjournals.org)
  • The DKFZ is a multidisciplinary center covering cancer biology from basic molecular and cell biology to clinical research and care. (mdc-berlin.de)
  • TCF7L2 and JMJD6 and c-Myc overexpression mechanistically regulate BETi resistance in human being BETi-P/R sAML cells We next identified effects of specific lead RNA (gRNA)-directed CRISPR/Cas9-mediated knockout of TCF7L2 in BETi-P/R vs their sensitive control sAML cells. (phytid.org)
  • Please note a wild-type cell line is not automatically included with a knockout cell line order, if required please add recommended wild-type cell line at no additional cost using the code WILDTYPE-TMTK1. (abcam.com)
  • Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)
  • The development of teeth is initiated by epithelial-mesenchymal interactions, which form dental papilla cells and dental sac cells, subsequently forming pulp, dentin, cementum, periodontal ligament and proper alveolar bone, except enamel 1 - 4 . (researchsquare.com)
  • dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
  • This research is from the lab of Anne Grapin-Botton, Danstem , part of the HumEn consortium , working towards making fully functional beta cells for diabetes therapy. (eurostemcell.org)
  • The functional maturation of mammalian spermatozoa is accomplished as the cells descend through the highly specialized microenvironment of the epididymis. (edu.au)
  • Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen. (harvard.edu)
  • GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
  • This observation is consistent with the B-cell dysfunction noted in patients with AIDS (9,10). (cdc.gov)
  • We tend to assume that the signaling molecules are evenly distributed across a tissue and affect all the receiving cells in the same way. (elifesciences.org)
  • Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)
  • In 1994, the Cell Exchange initiated offering the same cells for molecular typing as for serologic typing for Class I. The data from the parallel typings is instrumental in identifying serologic equivalents for Class I and Class II alleles that previously had little or no serologic information. (uclahealth.org)
  • Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types. (harvard.edu)
  • Cells in developing organs begin without specificity and over time turn into various cell types upon receiving the right signals. (eurostemcell.org)
  • Having these cells typed by numerous laboratories will help to achieve standardization in the typing of rare types. (uclahealth.org)
  • The goal of providing unusual types or combinations to participants was often accomplished by identifying cells that gave ambiguous or incomplete results. (uclahealth.org)