• 2001
  • In the 'extrusion-capture' model, replication through an anchored replisome provides the force to move daughter chromosomes to the poles ( Lemon and Grossman, 2001 ). (wiley.com)
  • mechanism
  • The mechanism by which specific regions of the chromosome are organized and segregated prior to division remains a mystery. (wiley.com)
  • The selected Xi becomes the target of a chromosome‐wide mechanism of transcriptional silencing, which constitutes an exciting paradigm for epigenetic regulations and confirms interest in the molecular dissection of the X‐inactivation centre ( Xic ), a locus on the X chromosome that contains the Xist gene and the elements involved in counting, choice and silencing. (embopress.org)
  • specific
  • Furthermore, we show that the 65 kb deletion also leads to inappropriate XCI in XY differentiated ES cells, which excludes the involvement of sex‐specific mechanisms in the initiation of XCI. (embopress.org)
  • normal
  • Cells lacking ObgE continue to initiate replication, with a normal ratio of the origin to terminus. (wiley.com)
  • We show here that normal counting can be rescued in these deleted ES cells using cre/ lox P re‐insertion, and refine the location of elements controlling counting within a 20 kb bipartite domain. (embopress.org)