• Immune
  • The best developed version of immune network theory is called the symmetrical network theory, in which the distinction between idiotype and paratope plays no role. (wikipedia.org)
  • Tumors have several potential mechanisms for immune evasion, such as downregulation of MHC, lack of costimulatory signal, deficiency of antigen processing or expression, and creating an immunosuppressive microenvironment by production of tumor cytokines or by induction of regulatory T cells ( 1 ). (aacrjournals.org)
  • malignancies
  • However, a low but significant percentage of patients with monoclonal gammopathy develop frank B-cell malignancies each year.7,8,9,10 and 11 For this reason, the term benign monoclonal gammopathy largely has been replaced by the term essential monoclonal gammopathy (see Chap. 105). (wordpress.com)
  • T-cell Acute Lymphoblastic Leukemia and advanced stage Lymphoblastic Lymphoma are rare malignancies which affect pre-teen and teen-aged children with a male preponderance. (stanford.edu)
  • These entities are closely related biologically, and probably represent different ends of a spectrum of T-cell malignancies. (stanford.edu)
  • autoimmunity
  • In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like. (freepatentsonline.com)
  • stem cells
  • Identification of appropriate marrow donors (within or outside of the family) and the increasing use of autologous stem cells with or without purging have made this treatment approach available to more and more patients. (stanford.edu)
  • mast
  • For example, IgE is responsible for an allergic response consisting of mast cell degranulation and histamine release. (wikipedia.org)
  • Therapies
  • This validates these second-generation anti-GD3 designer T cells as the preferred format for human clinical trials and provides a rationale for IL2 supplementation in designer T-cell therapies. (aacrjournals.org)
  • methods
  • The power and versatility of cell-free methods coupled with careful evaluation and engineering of these new systems enables a whole new range of applications and scientific investigation. (stanford.edu)
  • Even though these are very complex enzymes, we have produced active hydrogenases with our cell-free methods. (stanford.edu)
  • Methods and computer systems are provided for analyzing cell proteomes to characterize proteins that are up- or down-regulated under different conditions, such as under abnormal or compound treated conditions, including drug screening and testing, as well as proteins and encoding or complementary nucleic acids characterized using such methods and computer systems. (patents.com)
  • complete
  • In an adoptive transfer model using established melanoma tumors, designer T cells with CD28 showed a 50% rate of complete remissions but only where IL2 was supplemented. (aacrjournals.org)
  • Treatment
  • Allogeneic hematopoietic stem cell transplantation (HSCT) is a standard treatment for a variety of hematologic conditions. (stanford.edu)
  • expression
  • Further, the present invention also relates to processes of identifying compounds that modulate, i.e., act as agonists or antagonists, of NHP expression and/or NHP product activity that utilize purified preparations of the described NHPs and/or NHP product, or cells expressing the same. (google.com)
  • Another (disialo)ganglioside, GD3, has low expression on retina pigment cells, central nervous system, and normal melanocytes ( 4 ). (aacrjournals.org)
  • develop
  • The first task is to develop an oxygen tolerant hydrogenase using cell-free technology to express libraries of mutated enzymes that can be rapidly screened for improved function. (stanford.edu)
  • effects
  • Osmotic IL2 pumps were used to deliver the maximum tolerated dose of IL2 to enhance the antitumor effects of designer T cells on subcutaneous established melanoma in nude mice. (aacrjournals.org)