In this randomized control trial (RCT) of patients receiving cefepime or piperacillin-tazobactam, there was no difference in risk of acute kidney injury (AKI) between the two groups. (journalfeed.org)
When a patient with suspected sepsis and risk factors for resistant gram-negative bacteria presents to the hospital, the first-line antibiotics are cefepime and piperacillin-tazobactam. (journalfeed.org)
A potential side effect of piperacillin-tazobactam is AKI, especially when used concomitantly with vancomycin. (journalfeed.org)
Until now, there has been no head-to-head trial comparing the adverse effects of cefepime and piperacillin-tazobactam. (journalfeed.org)
This RCT included adult patients in the ED or medical ICU who were initiated on cefepime or piperacillin-tazobactam within 12 hours of hospital arrival. (journalfeed.org)
Cefepime was given as a 2g push every 8 hours, and piperacillin-tazobactam was given as a 3.375g bolus followed by a 4-hour infusion every 8 hours. (journalfeed.org)
This study has removed my hesitation to administer piperacillin-tazobactam and vancomycin in patients with underlying chronic kidney disease. (journalfeed.org)
For critical patients with peritonitis or concern for intra-abdominal surgical pathology, I will pick piperacillin-tazobactam over cefepime, as piperacillin-tazobactam also offers anaerobic coverage. (journalfeed.org)
In patients with severe infection and suspected polymicrobic infection, vancomycin plus piperacillin/tazobactam is recommended. (medscape.com)
The antimicrobials used to treat acute mastoiditis include vancomycin plus either ceftriaxone, cefepime (for Pseudomonas ), or the combination of a penicillin with a beta-lactamase inhibitor (eg, ampicillin-sulbactam, piperacillin-tazobactam) or a carbapenem. (medscape.com)
Cefepime-enmetazobactam may be more effective than piperacillin-tazobactam in treating complicated UTI and acute pyelonephritis caused by organisms that produce extended-spectrum β-lactamases (ESBL), investigators suggested. (renalandurologynews.com)
Among Gram-negatives more than 20% were resistant to ceftazidime, cefepime, piperacillin-tazobactam and ciprofloxacin while 9% was resistant to meropenem. (uni-frankfurt.de)
Candida albicans, C. tropicalis, C. glabrata, C. parapsilosis and C. guilhermondii were seeded into antibacterial (cefepime, meropenem, vancomycin, and piperacillin- tazobactam) gradient plates produced in Mueller-Hinton Agar. (bvsalud.org)
Intermediate resistance rates are observed against nitrofurantoin, piperacillin/tazobactam, and gentamicin, with increasing resistance observed against tigecycline. (frontiersin.org)
piperacillin/tazobactam (PTZ), cefepime, imipenem/cilastatin and meropenem remained stable. (bvsalud.org)
Pseudomonas1
An aminoglycoside, a third-generation cephalosporin (eg, ceftazidime, cefepime) or a quinolone (in adults) should be considered for coverage of aerobic gram-negative bacilli, including Pseudomonas . (medscape.com)
Cefotaxime1
At variance with this approach, there are reports of therapeutic failures with cefepime associated with MICs of ≤2 μg/ml ( 31 ) and 4 μg/ml in a pediatric patient ( 3 ) and with a cefotaxime MIC of 0.75 μg/ml ( 20 ). (asm.org)