• Antigen
  • Experimental observations suggest that antigen and CD40 Ligand act during cognate T/B cell interaction and are crucial for germinal center B-cell maturation generating marginal-zone B cells. (hindawi.com)
  • 1-3 doses of an interleukin-2 immunotoxin directed to the CD25 antigen (denileukin diftitox, ONTAK) in chronic lymphocytic leukemia (B-CLL) patients, followed by six subcutaneous (SC) injections of autologous leukemic cells modified ex vivo to secrete human interleukin-2 (hIL-2) and to express human CD40 ligand (hCD40L). (knowcancer.com)
  • Thus, CD40-CD40 ligand interactions in vivo regulate the migration of antigen-bearing DCs from the skin to DLNs via TNF-α production and play a vital role in the initiation of acquired T cell-mediated immunity. (rupress.org)
  • The secondary response was not readily blocked by sCD40-gamma 1 treatment, indicating a relative independence of CD40 ligation of antigen-experienced B cells. (rupress.org)
  • It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. (wikipedia.org)
  • CD40LG
  • Das vom CD40LG Gen kodierte Protein ist der Ligand des CD40 auf den T-Lyphozyten. (moldiag.com)
  • Die kopplung des CD40 auf den B-Lymphozyten mit dem CD40LG ist für eine reife Immunantwort insbesondere dem Klassenwechsel unerlässlich. (moldiag.com)
  • The diagnosis of hyper IgM syndrome can be done via the following methods and tests: MRI Chest radiography Pulmonary function test Lymph node test Laboratory test (to measure CD40) Five types of hyper IgM syndrome have been characterized: Hyper-IgM syndrome type 1 (X-linked), characterized by mutations of the CD40LG gene. (wikipedia.org)
  • pathway
  • Objective- The CD40/CD40 ligand pathway mediates inflammatory processes important in atherogenesis and the formation of the intraplaque lipid pool. (ahajournals.org)
  • The latter observation suggests that there is a T-dependent, CD40 ligand-independent pathway of B cell activation that leads to IgM responses and that a significant component of the IgM in HIMG1 patients is derived from T-dependent responses. (rupress.org)
  • Whereas entry of B cells into the memory cell pathway is dependent on CD40 ligation, the clonal expansion of the potential memory precursors in germinal centers seems not to require a CD40 signal. (rupress.org)
  • mice
  • We analyzed the DC status of CD40 ligand −/− mice using a contact hypersensitivity (CHS) model system that enables multiple functions of DCs to be assessed in vivo. (rupress.org)
  • Immunohistochemistry of skin sections revealed no differences in terms of numbers and morphology of dendritic epidermal Langerhans cells (LCs) in unsensitized CD40 ligand −/− mice as compared with wild-type C57BL/6 mice. (rupress.org)
  • However, after contact sensitization of CD40 ligand −/− mice, LCs failed to migrate out of the skin and substantially fewer DCs accumulated in draining lymph nodes (DLNs). (rupress.org)
  • Likewise, development of experimental allergic encephalomyelitis (EAE) in myelin basic protein (MBP)-TCR-transgenic mice is also blocked when these animals lack CD40 ligand ( 5 ). (rupress.org)
  • Interestingly, Ag-specific responses are intact in MBP-TCR CD40 ligand −/− T cells in vitro, and the inability to induce EAE in these mice is corrected by reconstituting them with B7.1-transgenic APCs. (rupress.org)
  • defective
  • This raises the possibility that the immunological abnormalities seen as a result of mutated CD40 or CD40 ligand are in fact due to defective upstream events in the initiation of acquired immunity, i.e., during the presentation of Ag and priming of naive T cells. (rupress.org)
  • ligation
  • To explore CD40 ligation as a strategy to activate tolerogenic DCs, systemic administration of agonist anti-CD40 Abs has been investigated. (jimmunol.org)
  • Based on these observations, CD40 ligation has been used to boost the CD8 + T cell response to tumors and to break peripheral self-tolerance ( 15 - 17 ). (jimmunol.org)
  • vitro
  • The in vitro proliferation response of all low-grade MALT-type lymphomas was dependent on anti-CD40- mediated signals and cytokines. (hindawi.com)
  • Blocking CD40-CD40 ligand interplay dramatically prolongs cardiac and skin allograft survival and inhibits T cell-proliferative responses both in vitro and in vivo ( 7 ). (rupress.org)
  • In in vitro studies, it inhibited cell proliferation induced by CD40 ligands and induced cell lysis. (wikipedia.org)
  • systemic
  • Although the initial phase I clinical results have shown significant objective antitumor responses ( 30 ), and no major systemic toxicity has been observed, transient cytokine release syndrome has been a side effect with several of the agonist anti-CD40 mAbs ( 30 ). (jimmunol.org)
  • Because elevated CD40 activation has also been implicated in the progression of systemic lupus erythematosus ( 31 ), rheumatoid arthritis ( 32 ), type 1 diabetes ( 33 ), neurodegenerative disorders ( 34 , 35 ), and allograft rejection ( 36 - 38 ), systemic activation of CD40 could potentially induce autoimmunity. (jimmunol.org)
  • Cells
  • There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. (google.com.au)
  • Moreover, naive T cells from CD40 ligand −/− animals display normal polyclonal as well as Ag-specific responses ( 8 ). (rupress.org)
  • This gene codes for the CD40 ligand, which is expressed on T cells. (wikipedia.org)
  • More specifically, Lentiviruses attach to the CD40 ligand glycoproteins on the surface of T-lymphocyte cells. (wikipedia.org)
  • In this type, B cells cannot recombine genetic material to change heavy chain production Hyper-IgM syndrome type 3 characterized by mutations of the CD40 gene. (wikipedia.org)
  • regulation
  • It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). (wikipedia.org)
  • activation
  • As a result, the macrophage expresses more CD40 and TNF receptors on its surface, which helps increase the level of activation. (wikipedia.org)