CD40 ligand (CD40L) deficiency or X-linked Hyper-IgM syndrome is a severe primary immunodeficiency caused by mutations in the CD40L gene. (nih.gov)
Description: The 24-31 monoclonal antibody reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). (thermofisher.com)
CD40 ligand (CD40L) plays an important role in inflammation, platelet activation, and clotting system activation. (psychiatrist.com)
This pilot study shows that CD40/CD40L pathway up-regulation in MDD patients relates increased levels of sCD40L to a prothrombotic state and, preliminarily, indicates that SSRI therapy may significantly reduce sCD40L and CD40L levels associated with proinflammatory and prothrombotic states. (psychiatrist.com)
The CD40 ligand (CD40L) is a member of the tumor necrosis factor (TNF) family of proteins and is transiently expressed on the surface of activated T cells. (nih.gov)
The binding of CD40L to CD40, which is expressed on the surface of B cells, provides a critical and unique pathway of cellular activation resulting in antibody isotype switching, regulation of apoptosis, and B cell proliferation and differentiation. (nih.gov)
CD40 ligand (CD40L, CD154) is expressed on T cells and serves to stimulate APCs, including B cells, through the interaction with its ligand CD40. (medscape.com)
We have shown that interaction of CD40 with CD40L enables microglial activation in response to amyloid-beta peptide (Abeta), which is associated with Alzheimer's disease (AD)-like neuronal tau hyperphosphorylation in vivo. (nih.gov)
Conversely, in neuroblastoma cells overexpressing wild-type human APP, the CD40-CD40L interaction resulted in amyloidogenic APP processing. (nih.gov)
These findings suggest several possible mechanisms underlying mitigation of AD pathology in response to CD40L depletion and validate the CD40-CD40L interaction as a target for therapeutic intervention in AD. (nih.gov)
CD40 ligand (CD40L), a tumor necrosis factor (TNF) family member, plays a critical role in antigen-specific T cell responses in vivo. (ox.ac.uk)
However, CD40L- or CD40-deficient mice challenged with viruses mount protective CD4+ T cell responses that produce normal levels of interferon γ, suggesting a CD40L/CD40-independent mechanism of CD4+ T cell priming that to date has not been elucidated. (ox.ac.uk)
Thus, the TRANCE/TRANCE-R interaction provides costimulation required for efficient CD4+ T cell priming during viral infection in the absence of CD40L/CD40. (ox.ac.uk)
CD40 ligand (CD40L, also known as CD154) is an important costimulatory molecule found on the T-cell and is critical for the development of immunity. (nih.gov)
CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the cytokine TNF-alpha, was originally identified on stimulated CD4+ T cells, and later on stimulated mast cells and basophils. (mdc-berlin.de)
Interaction of CD40L on T cells with CD40 on B cells is of paramount importance for the development and function of the humoral immune system. (mdc-berlin.de)
CD40 is not only constitutively present on B cells, but it is also found on monocytes, macrophages and endothelial cells, suggesting that CD40L has a broader function in vivo. (mdc-berlin.de)
Antibodies preventing the interaction between CD40 and its T cell-based ligand CD154 (CD40L) have been shown in rodents to act synergistically with CTLA4-Ig. (usuhs.edu)
History Compact disc40 an associate of the tumour necrosis factor receptor (TNFR) superfamily and its ligand (CD40L/CD154) play Rolipram a fundamental role in co-ordinating immune responses [1]. (scienceexhibitions.org)
As a means of delivering membrane-bound CD40L in a form that may be clinically applicable we have generated a replication-deficient recombinant adenovirus encoding human CD40L (RAdCD40L) which results in expression of ligand at the cell membrane. (scienceexhibitions.org)
The direct aftereffect of cleavage-resistant and wild-type CD40L on cell survival was examined in CD40-positive carcinoma cell lines. (scienceexhibitions.org)
CD40-CD40 ligand (CD40L) interaction is required for the generation of antibody responses to T-dependent antigens as well as for the development of germinal centers and memory B cells. (jenner.ac.uk)
The role of the CD40-CD40L interaction in the induction of antigen-specific. (jenner.ac.uk)
Using CD40- and CD40L-deficient mice together with lymphocytic choriomeningitis virus and vesicular stomatitis virus as viral model antigens, this study corroborates earlier findings that no lg isotype switching of virus-specific antibodies was measurable upon infection of CD40- or CD40L-deficient mice. (jenner.ac.uk)
In contrast, in vivo induction of virus-specific CD4+ T cells measured by proliferation and cytokine secretion of primed virus-specific Th cells in vitro was not crucially dependent on the CD40-CD40L interaction. (jenner.ac.uk)
Thus, CD40-CD40L interaction plays a crucial role in T-B interactions for Th-dependent activation of B cells but not, or to a much lesser extent, in T cell activation, antigen-specific Th cell responses in vitro, and for interleukin-mediated Th cell effector functions in vivo. (jenner.ac.uk)
Mecanismos de modulação da via de sinalização CD40/CD40L. (usp.br)
Demonstramos que angiotensina II é indutor da expressão de CD40, mas não de CD40L, na parede vascular e espécies reativas de oxigênio agem como segundos mensageiros nesse fenômeno. (usp.br)
Descrevemos um aumento importante da expressão de CD40 e CD40L em leucócitos circulantes de pacientes em sepse grave ou choque séptico e por último, mostramos que o receptor CD40 pode sofrer ntirosilação em resíduo de cisteína, diminuido sua atividade, tanto in vitro, quanto in vivo. (usp.br)
Devido à importância da via de sinalização CD40/CD40L e a ausência de uma terapêutica direta eficaz para seu controle, o conhecimento sobre os meios de manipulação dessa via por meios indiretos é essencial. (usp.br)
Control mechanisms of CD40/CD40L signaling pathway. (usp.br)
Dysfunction in CD40/CD40L function is reported in autoimmune diseases, atherosclerosis and sepsis. (usp.br)
We demonstrate that angiotensin II induces CD40, but not CD40L expression in vascular cells, and that reactive oxygen species act as seconfd messengers in this phenomenon. (usp.br)
We also show that there is a functional crosstalk between CD40/CD40L and peroxisome proliferator activated receptors signaling, both in cell cultures and in monocytes from patients with diagnosis of systemic eritematous lupus. (usp.br)
We describe a marked increase in CD40 and CD40L expression in leukocytes from patients in severe sepsis and that the receptor CD40 can be moduylated by nitrosylation of cysteine residues in its extracellular domain, which decreases its activity. (usp.br)
Due to its importance and absence of a direct approach to control its function, knowledge about indirect manners to modulate CD40/CD40L function is essential. (usp.br)
The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis. (biolegend.com)
Additional reported applications (for the relevant formats) include: costimulation of B cell proliferation 1 , partial inhibition of CD40 binding to CD40L 3 , and B cell rescue from apoptosis 1 . (biolegend.com)
CD154 , takođe poznat kao CD40 ligand ili CD40L, je protein koji je prvenstveno izražen u aktiviranim T ćelijama . (wikipedia.org)
CD40L može da se veže za tri molekula: CD40, α5β1 integrin i αIIbβ3 . (wikipedia.org)
Sekundarni signal je CD40L na T ćelijama, koji se vezuje za CD40 na ćelijskoj površini makrofaga . (wikipedia.org)
CD40L se vezuje za B ćelijski CD40 receptor, prouzrokujući zaustavljanje B ćelijske aktivacije. (wikipedia.org)
Dapirolizumab pegol is an investigational humanised monovalent pegylated Fab antibody fragment against the CD40 ligand (CD40L). (ucb.com)
Through interactions with its receptor, CD40, CD40L plays an important role in regulating interactions between T cells and other immune cells and thus affects several important functional events thought to be involved in autoimmune disease. (ucb.com)
As the company notes, HERA-CD40L-in contrast to antibodies-does not depend on Fcγ receptor-mediated crosslinking for activity, adding, "As the first pure CD40 receptor agonist with a well-defined mechanism of action, HERA-CD40L is not restrained by dose-limiting toxicities observed with anti-CD40 antibodies. (drugdiscoverynews.com)
HERA-CD40L is a novel TNF [tumor necrosis factor] superfamily receptor agonist based on our proprietary HERA-ligand technology platform that has demonstrated a strong antitumor efficacy in preclinical tumor models," said Dr. Harald Fricke, chief medical officer of Apogenix. (drugdiscoverynews.com)
CD15412
The following product was used in this experiment: CD154 (CD40 Ligand) Monoclonal Antibody (24-31), PerCP-eFluor™ 710, eBioscience™ from Thermo Fisher Scientific, catalog # 46-1548-42, RRID AB_10670357. (thermofisher.com)
Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. (thermofisher.com)
CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. (thermofisher.com)
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. (thermofisher.com)
CD40-ligand is also known as CD154, the T cell-B cell activating molecule (T-BAM), TRAP and gp39. (tonixpharma.com)
Immunoglobulin class switching from immunoglobulin M (IgM) to IgG and IgA is central to immunity against viruses and requires the activation of B cells by T cells via CD154 (CD40 ligand) and cytokines. (nih.gov)
CD154 is a 39 kDa type II membrane glycoprotein that is a member of the tumor necrosis factor superfamily, Tumor necrosis factor ligand superfamily member 5 (TNFSF5). (bdbiosciences.com)
The expression of CD154 by activated T-helper cells costimulates B-cell activation and proliferation through binding to CD40 expressed on B cells. (bdbiosciences.com)
In response to T-dependent antigens, the CD154 and CD40 interaction is required for B-lymphocyte differentiation, including immunoglobulin production and isotype switching and memory B cell generation. (bdbiosciences.com)
The ligand of CD40 is CD154 (CD40 ligand). (biolegend.com)
CD154 se vezuje za CD40 na antigen-prezentirajućim ćelijama (APC), posledica čega su mnogobrojni efekti koji zavise of tipa ciljne ćelije. (wikipedia.org)
Most cases are X-linked and caused by mutations in a gene on the X chromosome that encodes a protein (CD154, or CD40 ligand) on the surfaces of activated helper T cells. (merckmanuals.com)
CD40 Rolipram is expressed on normal B cells monocytes and dendritic cells (DC) and conversation with its ligand promotes dendritic cell maturation Rolipram upregulation of co-stimulatory molecules and secretion of immunostimulatory cytokines. (scienceexhibitions.org)
In the presence of cytokines, normal CD40 ligand interacts with B cells and thus signals them to switch from producing IgM to producing IgA, IgG, or IgE. (merckmanuals.com)
Soluble CD405
It's really novel, a new soluble CD40 ligand. (newshealth.biz)
The role of soluble CD40 ligand (sCD40L) as a potential initiator of inflammation after stenting has not been described. (biu.ac.il)
On this basis engagement of CD40 on DC to induce anti-tumour immune responses is a prolific area of research and both recombinant soluble CD40 ligand and CD40 agonist antibodies have entered clinical trials. (scienceexhibitions.org)
The relationship of platelet number to soluble CD40 Ligand, Interleukin-6 and C-reactive protein blood levels was studied. (scirp.org)
Expression of CD40 Ligand on T Cells and Soluble CD40 Ligand in Children With Kawasaki Disease: A Single-Center Preliminary Study From North India. (nih.gov)
Receptor7
The most important ligand-receptor pair is CD28 on T cells and B7 molecules (CD 80/86) on APCs. (medscape.com)
FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. (biovisi.com)
Dr. Lederman continued, "Despite the recognized promise of anti-CD40-ligand mAb therapy, first generation anti-CD40-ligand mAbs were limited because their crystallizable fragment (Fc) domain interacted with a cell surface receptor called FcγRII, which resulted in an increased risk of thrombosis. (tonixpharma.com)
Here we show that CD4+ T cell responses to viral infection were greatly diminished in CD40-deficient mice by administration of a soluble form of TNF-related activation-induced cytokine receptor (TRANCE-R) to inhibit the function of another TNF family member, TRANCE. (ox.ac.uk)
O receptor de membrana CD40 é expresso em células do sistema imune, (linfócitos, macrófagos, células dendríticas) e em células da parede vascular (células endoteliais, musculares lisas). (usp.br)
The membrane receptor CD40 is expressed in cells from the immune system (monocytes, lymphocytes, macrophages, dendritic cells) and from the vascular wall (endothelia and smooth muscle cells). (usp.br)
Apogenix has developed a proprietary technology platform for the construction of novel hexavalent TNF superfamily receptor agonists (HERA-ligands). (drugdiscoverynews.com)
Antibody4
Collaborating with a team at Biogen Inc., we determined the crystal structure of CD40-ligand 2 , developed a humanized version of our antibody (hu5c8, ruplizumab, or Antova®) and tested it in human trials for preventing organ transplant rejection and autoimmunity. (tonixpharma.com)
17. TLR9 Ligand (CpG Oligodeoxynucleotide) Induces CLL B-Cells to Differentiate into CD20(+) Antibody-Secreting Cells. (nih.gov)
Anti-human CD3 monoclonal antibody OKT3, combined with 5C3 antibody against CD40, was used as stimulant. (hindawi.com)
SCD40L2
RÉSUMÉ L'objectif de l'étude était d'évaler l'importance clinique du ligand de CD40 soluble (sCD40L) chez des patients atteints d'un carcinome hépatocellulaire (CHC) associé au virus de l'hépatite C (VHC). (who.int)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
Antigens1
Furthermore, the ability of mCD40L to also directly induce cell death in CD40-expressing carcinomas, subsequently releasing tumour-specific antigens into the tumour microenvironment highlights the potential for mCD40L as a multi-faceted anti-cancer immunotherapeutic. (whiterose.ac.uk)
Anti-CD40-ligand4
Tonix's President and Chief Executive Officer, Seth Lederman, M.D. said, "Nearly 30 years ago my laboratory at Columbia University generated the first anti-CD40-ligand mAb (5c8), discovered and characterized human CD40-ligand and elucidated the molecular basis of T cell helper function 1 . (tonixpharma.com)
Our studies and those of others generated a substantial body of evidence in humans and animals that indicates anti-CD40-ligand mAbs have the potential to be an important therapeutic option for preventing or treating transplant organ rejection and for treating autoimmune disorders. (tonixpharma.com)
Second generation anti-CD40-ligand mAbs had dramatically reduced binding to FcγRII, but had other issues, including decreased efficacy 3-5 . (tonixpharma.com)
TNX-1500 is a third generation anti-CD40-ligand mAb that has been designed by protein engineering to decrease FcγRII binding and the potential for thrombosis, while retaining efficacy. (tonixpharma.com)
Superfamily1
We will continue to apply our HERA-ligand technology to address other TNF superfamily receptors that play a critical role in the antitumor immune response and evaluate the synergistic potential of these development candidates in combination with traditional cancer therapies as well as other immuno-oncology therapeutics. (drugdiscoverynews.com)
Protein2
CD40-ligand is a protein expressed on the surface of activated T lymphocytes that mediates T cell helper function. (tonixpharma.com)
CDC researchers have developed methods and adjuvants for enhancing a subject's immune response to respiratory syncytial virus (RSV) by inclusion of a CD40 binding protein. (nih.gov)
Cells11
We and others have demonstrated that in addition to immune cells CD40 is expressed in malignant haemopoietic cells and a number Rolipram of carcinomas [2]. (scienceexhibitions.org)
In carcinoma cells the level of CD40 engagement influences the physiological end result with COL27A1 low levels of ligation promoting cell survival/proliferation and high levels inducing growth arrest/apoptosis [3-5]. (scienceexhibitions.org)
In addition, virus-specific Th cells primed in a CD40-deficient environment, adoptively transferred into CD40-competent recipients, were able to mediate lg isotype switch. (jenner.ac.uk)
Henn, V., Slupsky, J.R. and Grafe, M. (1998) CD40 lig- and in activated platelets triggers an inflammatory reaction of endothelial cells. (scirp.org)
In antigen presenting cells, CD40 activation is necessary for the immune system to decide between an efficient immune response or tolerance. (usp.br)
4. Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors. (nih.gov)
In X-linked hyper-IgM syndrome, T cells lack functional CD40 ligand and cannot signal B cells to switch. (merckmanuals.com)
Lymphoid tissue is very small because deficient CD 40 ligand signaling does not activate B cells. (merckmanuals.com)
The specific molecular structure of Apogenix's HERA-ligands induces a well-defined clustering of functional TNF receptors on the surface of target immune cells. (drugdiscoverynews.com)
Lymphocytes1
Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. (bdbiosciences.com)
Deficiency1
King Nazir Leon, age 2, has CD40 Ligand deficiency, a rare disease that affects his immune system and this disease is life-threatening. (saveoneperson.org)
Blockade1
Gray D, Dullforce P, Jainandunsing S. Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction. (bdbiosciences.com)
Vivo1
Since transgene appearance via replication-deficient adenovirus vectors in vivo is certainly low we've also built a conditionally replicating E1A-CR2 removed adenovirus expressing mutant Compact disc40L leading to significant amplification of ligand appearance and consequent improvement of its healing effect. (scienceexhibitions.org)
Membrane bound1
1999) Enhanced levels of soluble and membrane bound CD40 ligand in patients with unstable angina: Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes. (scirp.org)
Investigational1
Treatment with the investigational CD40 ligand inhibitor frexalimab significantly reduced new MRI lesions i n relapsing multiple sclerosis (MS) by week 24, according to data presented at the joint meeting of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS). (newshealth.biz)
Induce1
CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. (thermofisher.com)
Hyper-IgM synd3
The structure suggests that most of the hyper-IgM syndrome mutations affect the folding and stability of the molecule rather than the CD40-binding site directly. (nih.gov)
Despite the fact that the hyper-IgM syndrome mutations are dispersed in the primary sequence, a large fraction of them are clustered in space in the vicinity of a surface loop, close to the predicted CD40-binding site. (nih.gov)
In autosomal recessive hyper-IgM syndrome with CD40 mutation, manifestations are similar to those of the X-linked form. (merckmanuals.com)
Apoptosis1
Right here we show the fact that mutated cleavage-resistant type of Compact disc40L is a far more powerful inducer of apoptosis than wild-type ligand in Compact disc40-positive carcinoma cell lines. (scienceexhibitions.org)
Fragment1
TNX-1500 incorporates the antigen binding fragment (Fab) region of hu5c8, which has been extensively characterized including at the atomic level in complex with CD40-ligand 6 . (tonixpharma.com)
Activation1
Thus CD40 activation can effect the key elements required for generation of antigen-specific cytotoxic T-cell responses. (scienceexhibitions.org)
Interactions2
CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions. (jenner.ac.uk)
Additionally, CD40 is important for T cell-B cell interactions. (biolegend.com)
Antigen1
CD40 is a key target because it has a unique role in initiating an antigen-specific immune response against tumors. (drugdiscoverynews.com)
Carcinomas1
In carcinomas, the nature of CD40 ligand shapes the outcome of CD40 ligation. (whiterose.ac.uk)
Immune2
Background CD40 and its own ligand (Compact disc40L) play a crucial function in co-ordinating immune system replies. (scienceexhibitions.org)
By stimulating different TNF signaling pathways, these HERA-ligands can increase the antitumor immune response. (drugdiscoverynews.com)
Cell2
expressing a mutant Compact disc40L that's resistant to metalloproteinase cleavage in a way that ligand appearance is retained on the cell membrane. (scienceexhibitions.org)
Further based on our previous observation that Fas ligand mutated to resist cleavage from your cell membrane delivers a far more powerful apoptotic stimulus than wild-type FasL we've produced a mutant Compact disc40L that's resistant to cleavage by matrix metalloproteinases. (scienceexhibitions.org)
Human2
Immobilized Human CD40 Ligand, His Tag at 5 μg/mL (100 μl/well) can bind Human CD40, Fc Tag with a linear range of 0.156-5 μg/ml. (biovisi.com)
The newly published patent application includes claims related to proprietary anti-human CD40-ligand mAbs that were engineered to have modified effector function, including TNX-1500, which have reduced potential for Fc binding to FcγRII. (tonixpharma.com)
Glycoprotein1
CD40 is a 48 kD type I glycoprotein also known as BP50. (biolegend.com)