• Neurogenic heterotopic ossification - This condition is the one that comes to mind when the generic phrase heterotopic ossification is used. (medscape.com)
  • Neurogenic heterotopic ossification (NHO) is the formation of ectopic bone generally in muscles surrounding joints following spinal cord or brain injury. (jci.org)
  • A ) CD34 + cells from human neurogenic heterotopic ossification (NHO) were isolated using immunomagnetic cell separation and induced to differentiate into macrophages for 2 weeks in specific medium. (jci.org)
  • Despite many investigations, the etiology and pathogenesis of neurogenic heterotopic ossification remain unknown. (medscape.com)
  • citation needed] Heterotopic ossification often develops in patients with traumatic brain or spinal cord injuries, other severe neurologic disorders or severe burns, most commonly around the hips. (wikipedia.org)
  • Another finding, often misinterpreted as early heterotopic bone formation, is an increased (early) uptake around the knees or the ankles in a patient with a very recent spinal cord injury. (wikipedia.org)
  • Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue following a neurological condition, of which the most common are brain and spinal cord injuries. (monash.edu)
  • Heterotopic ossification may occur for no known reason as in myositis ossificans progressiva or may follow a wide variety of surgical, occupational, and sports trauma (e.g., hip arthroplasty, spinal cord injury, head injury, burns, and severe thigh bruises). (nih.gov)
  • Clinical trials have demonstrated the efficacy of etidronate disodium in heterotopic ossification following total hip replacement or due to spinal cord injury. (nih.gov)
  • Heterotopic ossification due to spinal cord injury typically develops radiographically 1 to 4 months after injury. (nih.gov)
  • Etidronate disodium tablets, USP are indicated for the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury. (nih.gov)
  • Heterotopic ossification following traumatic brain injury and spinal cord injury. (trdizin.gov.tr)
  • Garland DE, Shimoyama ST, Lugo C, Barras D, Gilgoff I. Spinal cord insults and heterotopic ossification in the pediatric population. (trdizin.gov.tr)
  • Regional anesthesia was to be avoided due to concerns of additional spinal ossification and inability to secure the airway in an emergency. (ispub.com)
  • abstract = "Heterotopic ossification (HO) refers to the formation of mature lamellar bone in nonosseous tissue. (usuhs.edu)
  • citation needed] Heterotopic ossification of varying severity can be caused by surgery or trauma to the hips and legs. (wikipedia.org)
  • Sullivan MP, Torres SJ, Mehta S, Ahn J. Heterotopic ossification after central nervous system trauma: A current review. (trdizin.gov.tr)
  • Heterotopic ossification (HO) is a dynamic, complex pathologic process that often occurs after severe polytrauma trauma, resulting in an abnormal mesenchymal stem cell differentiation leading to ectopic bone growth in soft-tissues including tendons, ligaments, and muscles. (nih.gov)
  • Recently, we observed that NGF (Nerve growth factor)-responsive TrkA (Tropomyosin receptor kinase A)-expressing nerves invade sites of soft-tissue trauma, and this is a necessary feature for heterotopic bone formation at sites of injury. (nih.gov)
  • Here, we assayed the effects of the partial TrkA agonist Gambogic amide (GA) in peritendinous heterotopic bone after extremity trauma. (nih.gov)
  • In summary, these studies further link injury site hyper-innervation with increased vascular ingrowth and ultimately heterotopic bone after trauma. (nih.gov)
  • In the future, modulation of TrkA signaling may represent a potent means to prevent the trauma-induced heterotopic bone formation and improve tissue regeneration. (nih.gov)
  • Ossification can occur either spontaneously or as a result of tissue trauma beginning in childhood. (ispub.com)
  • Also, trauma from needle placement can lead to further progression of their disease and lead to additional painful ossification. (ispub.com)
  • At this time our preoperative concerns included: difficulty obtaining an airway, difficulty with ventilation, difficulty with positioning and prevention of trauma or ossification, difficulty and risk vs. benefit of IV and arterial access, unknown surgical conditions and potential for increased length of surgery and bleeding. (ispub.com)
  • About every third patient who has total hip arthroplasty (joint replacement) or a severe fracture of the long bones of the lower leg will develop heterotopic ossification, but is uncommonly symptomatic. (wikipedia.org)
  • Symptomatic heterotopic ossification after very severe traumatic brain injury in 114 patients: incidence and risk factors. (trdizin.gov.tr)
  • aur A, Sinclair M, Caruso E, Peretti G, Zaleske D. Heterotopic ossification around the elbow followHeterotopic ing burns in children: results after excision. (trdizin.gov.tr)
  • Coexistence of Heterotopic Ossification of the Elbow and Vitamin D Deficiency Following Stroke: Can Calcium and Vitamin D Treatment Aggravate Ossification? (uwi.edu)
  • In traumatic heterotopic ossification (traumatic myositis ossificans), the patient may complain of a warm, tender, firm swelling in a muscle and decreased range of motion in the joint served by the muscle involved. (wikipedia.org)
  • The term myositis ossificans is not used anymore because primary muscle inflammation is not a necessary precursor and ossification does not always occur in muscle tissue. (ruralneuropractice.com)
  • Myositis ossificans is a misnomer, although the term myositis ossificans circumscripta continues to be used to describe nonhereditary forms of heterotopic ossification. (medscape.com)
  • Although the inciting events and the definitive cell(s) of origin continue to remain elusive, animal models and human histology samples suggest that HO formation follows a predictable sequence of events culminating in endochondral ossification. (usuhs.edu)
  • Two groups of resident progenitors, the skeletal muscle satellite cells (SCs) and vascular endothelium (VE)/vascular endothelial progenitors (VEPs), have been considered to be putative cell sources for ectopic lesions of heterotopic ossification due to their reported multipotent characteristics. (uconn.edu)
  • Patients with traumatic neurological injuries, severe neurologic disorders or severe burns who develop heterotopic ossification experience limitation of motion in the areas affected. (wikipedia.org)
  • Note the severe kyphoscoliosis and the heterotopic calcifications present throughout her body. (ispub.com)
  • There are also rare genetic disorders causing heterotopic ossification such as fibrodysplasia ossificans progressiva (FOP), a condition that causes injured bodily tissues to be replaced by heterotopic bone. (wikipedia.org)
  • Excess inflammation and canonical BMP receptor (BMPR) signaling are coinciding hallmarks of the early stages of injury-induced endochondral heterotopic ossification (EHO), especially in the rare genetic disease fibrodysplasia ossificans progressiva (FOP). (ozgene.com)
  • Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disease characterized by progressive ossification of tendons, ligaments, fascia, and skeletal muscle. (ispub.com)
  • Fibrodysplasia ossificans progressiva (FOP) is a rare and disabling genetic condition characterized by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomic patterns. (medscape.com)
  • Extensive heterotopic ossification on the back of a patient with fibrodysplasia ossificans progressiva. (medscape.com)
  • Fibrodysplasia ossificans progressiva is the most catastrophic disorder of heterotopic ossification in humans. (medscape.com)
  • Progressive postnatal heterotopic ossification in fibrodysplasia ossificans progressiva usually appears within the first decade of life as spontaneous or injury-induced exacerbations. (medscape.com)
  • The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. (medscape.com)
  • Age- and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. (medscape.com)
  • Heterotopic ossification (HO), the development of abnormal bone in the soft tissue, is a rare but severely debilitating complication of burn injuries. (spauldingrehab.org)
  • Heterotopic ossification (HO) is the abnormal bone formation within skeletal soft tissues. (ruralneuropractice.com)
  • Periarticular heterotopic ossification in head-injured adults. (trdizin.gov.tr)
  • Inan M, Chan G, Dabney K, Miller F. Heterotopic ossification following hip osteotomies in cerebral palsy: incidence and risk factors. (trdizin.gov.tr)
  • citation needed] Another rare genetic disorder causing heterotopic ossification is progressive osseous heteroplasia (POH), is a condition characterized by cutaneous or subcutaneous ossification. (wikipedia.org)
  • Heterotopic ossification (HO) is the abnormal growth of bone in soft connective tissues that occurs as a frequent complication in individuals with traumatic brain injury (TBI) and in rare genetic disorders. (mdpi.com)
  • Genetic and Acquired Heterotopic Ossification: A Translational Tale of Mice and Men. (cdc.gov)
  • Between 50% and 90% of patients who developed heterotopic ossification following a previous hip arthroplasty will develop additional heterotopic ossification. (wikipedia.org)
  • This study was to identify the risk factors of heterotopic ossification (HO) after total hip arthroplasty (THA) in ankylosing spondylitis. (amrita.edu)
  • A known local response is "heterotopic ossification," defined as the formation of bone tissue in damaged soft tissue and muscle. (health.mil)
  • X-ray films of multiple joints revealed heterotopic ossification over left shoulder, hip and knee joint with bony ankylosis of left hip and soft tissue contractures. (ruralneuropractice.com)
  • In this regard, we have concentrated on the tissue resident adult progenitors in skeletal muscle and specifically, their role in soft tissue associated heterotopic ossification. (uconn.edu)
  • Skeletal muscle, a known and plentiful source of progenitor cells is commonly associated with extraskeletal pathologies such as muscular dystrophy and heterotopic ossification. (uconn.edu)
  • In conclusion, these data decisively establish degrees of potency for skeletal muscle resident progenitors and identify the putative cell-of-origin for the ectopic skeletal anlagen of heterotopic ossification. (uconn.edu)
  • Nine weeks after injury, this culminated in higher overall levels of heterotopic bone among GA-treated animals. (nih.gov)
  • Relative to immediate amputation groups, the groups with simulated tourniquets had more heterotopic bone, a heightened and prolonged systemic inflammatory response, and increased evidence of injury to the kidneys, liver, and lungs. (health.mil)
  • Tourniquet use following blast-associated complex lower limb injury and traumatic amputation promotes end organ dysfunction and amplified heterotopic ossification formation. (health.mil)
  • Studies have shown that AlkP may have an important role in ectopic calcification and ossification of soft tissues. (medscape.com)
  • citation needed] The only definitive diagnostic test in the early acute stage is a bone scan, which will show heterotopic ossification 7 - 10 days earlier than an x-ray. (wikipedia.org)
  • It is not clear exactly what this means, because these patients do not develop heterotopic bone formation. (wikipedia.org)
  • The records of 3,693 adult burn patients were analyzed for potential predictors of the development of heterotopic ossification (HO). (spauldingrehab.org)
  • Legosz P, Drela K, Pulik L, Sarzynska S, Maldyk P. Challenges of Heterotopic Ossification - molecular background and current treatment strategies. (trdizin.gov.tr)
  • Very few reports have been published in the literature for association of heterotopic ossification with tubercular meningitis with such extensive joint involvement which compels us to report this clinical association of tubercular meningitis. (ruralneuropractice.com)
  • Heterotopic ossification complicating total hip replacement typically develops radiographically 3 to 8 weeks postoperatively in the pericapsular area of the affected hip joint. (nih.gov)
  • Apart from neurological deficits, musculoskeletal involvement is also seen in very few cases in the form of heterotopic ossification around immobile joints. (ruralneuropractice.com)
  • Individuals with FOP will frequently have ossification of their temporomandibular joint (TMJ) resulting in jaw immobility. (ispub.com)
  • This report describes the case of a 69-year-old man with adenocarcinoma of the transverse colon who developed heterotopic ossification in a metastatic axillary lymph node. (nih.gov)
  • Prophylactic radiation therapy for the prevention of heterotopic ossification has been employed since the 1970s. (wikipedia.org)
  • Immunostaining for alkaline phosphatase revealed a significant concentration of this enzyme in these cells and, to a lesser degree, on the apical membrane of the glandular cells of the adenocarcinoma adjacent to the ossification centers. (nih.gov)
  • We use extensively, the Cre/loxP lineage tracing system to label putative plastic cell types and assess the inherent plasticity of these cells in biologically relevant mouse-chick chimeric models of developmental potency and bioassays of heterotopic ossification. (uconn.edu)
  • Heterotopic ossification (HO) is the process by which bone tissue forms outside of the skeleton in muscles and soft tissue. (wikipedia.org)
  • Predicting Heterotopic Ossification Early After Burn Injuries: A Risk Scoring System. (spauldingrehab.org)
  • Background: There are multiple etiologies of heterotopic ossification (HO) and limited information regarding the outcome of HO complicating specific injuries in children. (trdizin.gov.tr)
  • Dive into the research topics of 'Heterotopic ossification in wartime wounds. (usuhs.edu)
  • Krum SD, Miller F. Heterotopic ossification after hip and spine surgery in children with cerebral palsy. (trdizin.gov.tr)
  • The histopathological study revealed a moderately differentiated adenocarcinoma with ossification. (journalmc.org)
  • Heterotopic bone formation in the colon is rare, and its mechanism is still unclear. (journalmc.org)
  • In group AT, both at 7 and 90 post-operative days, the main healing type was the presence of dense conjunctive tissue exhibiting bundles of collagen fibers disposed in beams permeating the remaining adipose tissue with rare heterotopic bone formation associated to fibrosis and different types of tissue necrosis. (bvsalud.org)
  • It may be necessary to do both a bone scan and a venogram to differentiate between heterotopic ossification and thrombophlebitis, and it is even possible that both could be present simultaneously. (wikipedia.org)
  • 3) Spontaneous flare-ups present as large, painful swellings resulting in heterotopic ossification. (ispub.com)