AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentTechnology, Industry, Agriculture
Acne VulgarisPropionibacterium acnesDermatologic AgentsSebumBenzoyl PeroxideIsotretinoinFolliculitisSebaceous GlandsProteus vulgarisIce CreamMite InfestationsAdministration, TopicalKeratolytic AgentsPropionibacteriumRosaceaDesulfovibrio vulgarisOintmentsGelsClindamycinChlorella vulgarisGram-Positive Bacterial InfectionsBeta vulgarisPhaseolus
2023Moderate-to-severe acneDisease of the pilosebaceousDisorder of the pilosebaceousDermatologyTherapiesTreatmentMenlo TherapeuticsHyperpigmentationMinocyclinePropionibacteriumEpidemiologyBacteriaAffectsPilosebaceousNodulesAdapalenePrevalenceEfficacyLesionsPatients with acnePathogenesisTherapyPharmaSeverityFacial acneHistorical and forecastedClinicalSebum productionPipelineMalesScarsRosaceaPhaseDapsonePopulationsSkinAbstractProvenTreat acneFollicleYoung adultsStudy
20231
  • SAN DIEGO, CA / ACCESSWIRE / November 16, 2023 / Dermata Therapeutics, Inc. (NASDAQ:DRMA)(NASDAQ:DRMAW) ('Dermata' or the 'Company'), a clinical-stage biotechnology company focusing on the treatment of medical and aesthetic skin conditions, announces agreement with the U.S. Food and Drug Administration (FDA) on the DMT310 Phase 3 clinical protocols for the treatment of acne. (statenews.net)
Moderate-to-severe acne10
  • Study FX2016-40 is a prospective, randomized, double-blind, vehicle-controlled Phase 2 trial that enrolled patients aged 12 years and older with a clinical diagnosis of moderate-to-severe acne vulgaris. (sec.gov)
  • Previously, a 4% topical minocycline foam (Amzeeq) developed by Menlo's now wholly-owned subsidiary Foamix Pharmaceuticals Ltd. was approved by the FDA for treatment of inflammatory lesions of non-nodular moderate-to-severe acne vulgaris in pediatric patients and adults on Oct. 18, 2019. (dermatologytimes.com)
  • We look forward to enrolling the first patients in the STAR-1 trial by the end of this year, which we believe may provide further evidence of the significant efficacy of DMT310 seen in moderate-to-severe acne patients. (statenews.net)
  • If approved, we believe DMT310 has the potential to cause a paradigm shift in the treatment of moderate-to-severe acne, becoming a first in class treatment option for the approximately 50 million patients suffering with acne in the US,' concluded Mr. Proehl. (statenews.net)
  • DMT310 has previously shown its treatment effect in moderate-to-severe acne in a Phase 2b study where DMT310 applied once weekly, achieved statistically significant results at all timepoints for all primary and secondary endpoints. (statenews.net)
  • SB204 was generally well-tolerated and not associated with any significant safety issues under maximal use conditions in a Phase 1 clinical study in adults with moderate-to-severe acne. (plasticsurgerypractice.com)
  • The Phase 1 study assessed the pharmacokinetics and safety of SB204 Gel applied topically to the chest, back, and face of adults with moderate to severe acne vulgaris. (plasticsurgerypractice.com)
  • Foamix recently received FDA approval for AMZEEQ™ (minocycline) topical foam, 4%, for the treatment of inflammatory lesions of non-nodular moderate-to-severe acne vulgaris in adults and pediatric patients 9 years of age and older. (globenewswire.com)
  • Foamix is also conducting a Phase II trial for FCD105, a topical combination foam of minocycline and adapalene, currently being evaluated for the treatment of moderate-to-severe acne vulgaris. (globenewswire.com)
  • A 12-week phase 3 study was conducted in subjects aged ≥9 years with moderate to severe acne, followed by 9-month open label safety extension. (aadhighlights.com)
Disease of the pilosebaceous2
  • Acne, or Acne Vulgaris (AV), is a chronic inflammatory disease of the pilosebaceous unit. (industrytoday.co.uk)
  • Acne vulgaris is a disease of the pilosebaceous follicle characterized by non-inflammatory (open and closed comedones) and inflammatory lesions. (skintherapyletter.com)
Disorder of the pilosebaceous2
  • Acne vulgaris is an inflammatory disorder of the pilosebaceous unit, which runs a chronic course and it is self-limiting. (mithilasamachar.in)
  • Acne vulgaris is a common disorder of the pilosebaceous follicle with multiple pathogenic factors. (skintherapyletter.com)
Dermatology5
  • Atacama was founded by a team of experienced life science professionals to test treatments for serious dermatology conditions with initial focus on a proof-of-concept trial for AT-5214 in Acne Vulgaris, a disease with a significant unmet medical need where few treatments have been approved by regulatory authorities. (atacamatherapeutics.com)
  • Novan Therapeutics nitric oxide-based acne gel SB204 is safe, according to data presented at the 23rd World Congress of Dermatology in Vancouver, Canada. (plasticsurgerypractice.com)
  • Be sure to consult your dermatology professional regarding dosage, before you start taking vitamin A for acne (3). (clearskinregime.com)
  • Trade Setup VYNE Therapeutics Inc., a pharmaceutical company, focuses on developing and commercializing various therapeutics for dermatology. (traderspro.com)
  • REHOVOT, Israel, BRIDGEWATER, N.J. and REDWOOD CITY, Calif., Nov. 11, 2019 (GLOBE NEWSWIRE) -- Foamix Pharmaceuticals Ltd. (Nasdaq: FOMX ) ("Foamix") and Menlo Therapeutics Inc. (Nasdaq: MNLO) ("Menlo") today announced that they have signed a definitive merger agreement to create a combined biopharmaceutical company focused on the commercialization and development of therapeutics to serve patients in the dermatology space. (globenewswire.com)
Therapies7
  • The Acne Vulgaris market report covers emerging drugs, current treatment practices, market share of the individual therapies, and current & forecasted market size from 2019 to 2032. (mithilasamachar.in)
  • The Acne Vulgaris market report provides insights on the current and emerging therapies. (mithilasamachar.in)
  • The dynamics of the Acne Vulgaris market are anticipated to change in the coming years owing to the expected launch of emerging therapies and others during the forecasted period 2019-2032. (mithilasamachar.in)
  • Some blue light treatments have approval from the Food and Drug Administration (FDA) for moderate acne vulgaris that has not responded to other therapies. (weeklyradioaddress.com)
  • This article delves into appropriate use of topical therapies for acne treatment. (skintherapyletter.com)
  • Jon is Associate Editor of two international peer-reviewed CAM journals, Complementary Therapies in Medicine and the Journal of Acupuncture and Meridian Studies , he sits on the International Editorial Advisory Board for the Journal of Manipulative and Physiological Therapeutics and is regular reviewer for a wide range of international peer-reviewed health research journals. (norphcam.org)
  • It has been shown to enhance or complement some acne therapies. (avantilipids.com)
Treatment25
  • The data suggests FCD105 has the potential to be a best-in-class treatment for patients with acne and could provide an important new treatment option for this challenging condition," said Dr. Iain Stuart, Chief Scientific Officer of Menlo. (sec.gov)
  • Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. (wikipedia.org)
  • Due to its effects on keratinocyte proliferation and differentiation, adapalene is superior to tretinoin for the treatment of comedonal acne and is often used as a first-line agent. (wikipedia.org)
  • Per the recommendations of the Global Alliance on Improving Outcomes of Acne, retinoids such as adapalene are considered first-line therapy in acne treatment and are to be used either independently or in conjunction with benzoyl peroxide and/or an antimicrobial agent, like clindamycin, for maximum efficacy. (wikipedia.org)
  • Dapsone 7.5% gel is indicated for the topical treatment of acne vulgaris in patients nine years of age or older. (mssm.edu)
  • The U.S. Food and Drug Administration has approved FMX103 (ZILXI, Menlo Therapeutics), a topical 1.5% minocycline foam for the treatment of inflammatory lesions of rosacea in adult patients. (dermatologytimes.com)
  • Another topical rosacea treatment enters the market with the United States Food and Drug Administration (FDA) approval of FMX103 (ZILXI, Menlo Therapeutics), a 1.5% minocycline foam, equipped with the company's proprietary Molecule Stabilizing Technology (MST), for the treatment of inflammatory lesions of rosacea in adult patients. (dermatologytimes.com)
  • 1. Menlo Therapeutics Receives FDA Approval of ZILXI™ (minocycline) topical foam, 1.5%, the First Topical Minocycline Treatment for Rosacea. (dermatologytimes.com)
  • Objective: We sought to provide evidence of the superiority of adapalene gel 0.3% over adapalene gel 0.1% and gel vehicle in the treatment of acne. (psu.edu)
  • Conclusions: Adapalene gel 0.3% was effective and well tolerated in the treatment of acne. (psu.edu)
  • Effects of Diet on Acne and Its Response to Treatment. (kivh.nl)
  • The role of zinc in the treatment of acne: A review of the literature. (kivh.nl)
  • Fixed combination adapalene 0.3% and benzoyl peroxide 2.5% gel was approved for the once-daily, topical treatment of acne vulgaris. (skintherapyletter.com)
  • This partnership is aimed at advancing Eligo biotics for the treatment or prevention of acne vulgaris with a pioneering CRISPR-based therapeutic for strain-specific microbiome modulation. (biospace.com)
  • A Review of the Use of Adapalene for the Treatment of Acne Vulgaris. (veeprho.com)
  • It is frequently used early in the treatment of acne to help unclog pores and remove blackheads, whiteheads, and slightly irritated patches. (veeprho.com)
  • The 1800s: Nineteenth-century dermatologists used sulfur in the treatment of acne. (wikidoc.org)
  • It is a combination of well balanced formula of homoeopathic therapeutics for the treatment of conjunctivitis and other inflammatory conditions of eyes. (madanapalas.com)
  • Identify sub-populations within Acne Vulgaris which require treatment. (industrytoday.co.uk)
  • Vitamin E is well represented in a typical multivitamin but is most commonly used topically in skin care ingredients to help you achieve clearer skin, however, taking a vitamin E capsule could potentially help with acne treatment. (clearskinregime.com)
  • Red light therapy (RLT) is a treatment that uses low wavelength red light to reportedly improve your skin's appearance, such as reducing wrinkles, scars, redness and acne. (weeklyradioaddress.com)
  • What's New in Acne Treatment in Canada? (skintherapyletter.com)
  • This article discusses combination therapy, and simplifying treatment plans in order to increase patient adherence, which is often a critical problem in treating acne. (skintherapyletter.com)
  • Clascoterone is a topical androgen receptor inhibitor under investigation for the treatment of acne. (aadhighlights.com)
  • The primary purpose of the study was to assess the efficacy of clascoterone topical 1% cream for the treatment of facial acne vulgaris in adult and pediatric populations. (aadhighlights.com)
Menlo Therapeutics1
Hyperpigmentation2
  • Furthermore, adapalene, like other retinoids, increases the efficacy and penetration of other topical acne medications that are used in conjunction with topical retinoids as well as hastens the improvement of the post-inflammatory hyperpigmentation caused by acne. (wikipedia.org)
  • Using its Penetrating Therapeutics™ technologies, the company's products are designed to improve penetration of prescription and cosmetic agents across the skin barrier for common and visible skin conditions in adult skin including photo damage, hyperpigmentation (chloasma, melasma and freckles), senile lentigines, acne vulgaris, sun damage and rosacea. (bendoralsurgery.com)
Minocycline4
Propionibacterium2
Epidemiology4
  • DelveInsight's "Acne Vulgaris Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Acne Vulgaris , historical and forecasted epidemiology as well as the Acne Vulgaris market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. (meghalayamagazine.in)
  • DelveInsight launched its new report on Acne Vulgaris - Market Insights, Epidemiology, and Market Forecast-2032 . (meghalayamagazine.in)
  • Acne Vulgaris market report covers a descriptive overview and comprehensive insight of the Acne Vulgaris Epidemiology and Acne Vulgaris market in the 7MM (the United States, EU5 (Germany, Spain, France, Italy, UK) & Japan. (mithilasamachar.in)
  • Acne vulgaris in the United States: a descriptive epidemiology. (jofskin.org)
Bacteria3
  • Sebum supports the growth of the bacteria P.acnes , and as such acne cannot occur without the presence of sebum. (positivehealth.com)
  • After processing, the sponge powder contains precisely sized and shaped silica spicules that upon application may help exfoliate the skin, promote collagen production, open closed comedones (creating an aerobic environment to help kill C. acne bacteria), and create microchannels to facilitate penetration of the sponge's naturally occurring chemical compounds. (statenews.net)
  • LED light masks and devices are best used to help stimulate collagen production and kill the bacteria that cause acne breakouts, though they don't replace your regular skin-care routine. (weeklyradioaddress.com)
Affects6
  • Acne is a chronic, inflammatory skin condition that affects the skin's oil glands and hair follicles. (sec.gov)
  • Mild acne affects many teenagers at some point but also adults. (positivehealth.com)
  • Acne is a hormonally driven condition which affects your pilosebaceous glands. (positivehealth.com)
  • 1. Acne Vulgaris affects ~85% of young adults aged 12-25 years. (meghalayamagazine.in)
  • Acne affects approximately 50 million people in the U.S., with about 85% of teenagers experiencing some form of acne, and some individuals suffering from acne well into their 30s, 40s, and beyond. (statenews.net)
  • Although acne can develop at any age, it most commonly affects adolescents and is triggered by the overproduction of sebum in the sebaceous glands. (industrytoday.co.uk)
Pilosebaceous3
  • Acne Vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). (meghalayamagazine.in)
  • Acne vulgaris is a common chronic inflammatory cutaneous disease involving the pilosebaceous unit. (skintherapyletter.com)
  • This agent targets androgen receptors in sebocytes and hair papilla cells within the skin's pilosebaceous unit, intervenes at multiple and different points in acne pathogenesis, and inhibits dihydrotestosterone-stimulated signaling downstream of the androgen receptors. (aadhighlights.com)
Nodules1
  • Moderate-to-severe inflammatory acne is characterized by the presence of nodules and cyst. (meghalayamagazine.in)
Adapalene4
  • A study with six acne patients treated once daily for five days with two grams of adapalene cream applied to 1,000 cm2 (160 sq in) of skin found no quantifiable amounts, or less than 0.35 ng/mL of the drug, in the patients' blood plasma. (wikipedia.org)
  • Adapalene is also regarded as an anti-inflammatory agent, as it suppresses the inflammatory response stimulated by the presence of Cutibacterium acnes, and inhibits both lipoxygenase activity and the oxidative metabolism of arachidonic acid into prostaglandins. (wikipedia.org)
  • Acne is treated with adapalene. (veeprho.com)
  • Is adapalene effective for acne? (veeprho.com)
Prevalence2
Efficacy2
  • The DMT310 Phase 3 clinical program will include two Phase 3 clinical trials to evaluate the efficacy, safety, and tolerability of DMT310 in patients with moderate-to-severe facial acne. (statenews.net)
  • Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. (avantilipids.com)
Lesions6
  • Microcomedones are non-inflammatory lesions, which are the first signs of acne. (positivehealth.com)
  • It can take as long as 2 to 3 years before they become significant acne lesions. (positivehealth.com)
  • These are always the precursor lesions to acne. (positivehealth.com)
  • We believe patients and physicians are eagerly awaiting a novel product like DMT310 that only requires once-weekly applications with a demonstrated 45% reduction in inflammatory lesions after only 4 treatments as seen in our Phase 2b acne study. (statenews.net)
  • Its pathogenesis is multifactorial - the interplay of hormonal, bacterial, and immunological (inflammatory) factors results in the formation of acne lesions. (skintherapyletter.com)
  • The primary outcome measure was evaluation of any change in facial acne vulgaris, as reflected in the percent change in inflammatory lesions at week 12, to identify a change from baseline and to determine if there was a statistically significant difference between clascoterone topical 1% cream and vehicle. (aadhighlights.com)
Patients with acne2
  • METHODS: This was a Phase IV, multicenter, open-label study in patients with acne aged 9 to 11 years. (mssm.edu)
  • CONCLUSION: Once-daily topical dapsone 7.5% gel used for 12 weeks was safe, effective, and well tolerated in preadolescent patients with acne. (mssm.edu)
Pathogenesis1
  • 2016). Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis. (kivh.nl)
Therapy3
  • Acne: The Role of Medical Nutrition Therapy. (kivh.nl)
  • Because of its ability to reduce the bacterial population of P. acnes, the antimicrobial BPO, an oxidizing agent with antibacterial and keratolytic properties, is commonly used in acne therapy. (veeprho.com)
  • Red light therapy helps promote healing and may work to decrease the visibility of acne scarring. (weeklyradioaddress.com)
Pharma1
  • Companies such MaaT Pharma, AOBiome, Seres Therapeutics, Inc and others have been implementing various strategies that have helped the growth of the company and in turn have brought about various changes in the market. (biospace.com)
Severity1
  • It may reduce the amount and severity of acne pimples while also promoting rapid healing of pimples that do form. (veeprho.com)
Facial acne1
  • RESULTS: After 12 weeks, facial acne was clear or almost clear in about 47 percent of patients. (mssm.edu)
Historical and forecasted1
  • Acne Vulgaris market report provides a global historical and forecasted market covering drug outreach in 7MM. (mithilasamachar.in)
Clinical2
  • 21 September 2017 - Realm Therapeutics plc (AIM: RLM), a clinical stage biopharmaceutical company focused on leveraging its proprietary immunomodulatory technology, is pleased to announce today that it has successfully secured funding commitments to raise gross proceeds of approximately £19.3 million ($26 million) through a proposed placing (the "Placing") with new and existing investors, including several healthcare specialist funds based in the US and UK. (mtspartners.com)
  • Therapeutics and Clinical Risk Management, vol. 3, no. 4, 2007, pp. 621-24, www.ncbi.nlm.nih.gov/pmc/articles/PMC2374937/ . (veeprho.com)
Sebum production2
  • Vitamin A can help decrease sebum production which is obviously a good thing for acne prone patients. (clearskinregime.com)
  • This article discusses pathophysiology, sebum production, keratinization, and the role of P.acnes in acne formation. (skintherapyletter.com)
Pipeline1
Males1
Scars4
Rosacea1
  • They are thought to help with several inflammatory conditions of the skin including acne, rosacea, and even eczema (12). (clearskinregime.com)
Phase3
  • Each Phase 3 trial will be randomized (2:1), double-blind, and placebo-controlled, enrolling approximately 550 acne patients ages 9 years and older in the United States and Latin America. (statenews.net)
  • Top-line results of US Phase 2b trial with SB204 in 200 subjects with acne are expected by the third quarter of this year. (plasticsurgerypractice.com)
  • There have been positive phase 3 results for acne, and positive phase 2 results for androgenic alopecia. (aadhighlights.com)
Dapsone1
  • Patients applied dapsone 7.5% gel once daily to the face and acne-affected areas on the upper chest, upper back, and shoulders for 12 weeks. (mssm.edu)
Populations1
  • Able to quantify patient populations in global Acne Vulgaris market to target the development of future products, pricing strategies and launch plans. (industrytoday.co.uk)
Skin8
  • According to the article published in the Adolescent Health, Medicine and Therapeutics journal, acne vulgaris is the most common skin condition diagnosed in adolescents worldwide. (medgadget.com)
  • P. acnes exists on every skin surface and it tends to proliferate and colonise the hair follicle leading to inflammation, which in itself causes the release of pro-inflammatory cytokines, such as CD4+ T-Lymphocytes, which causes the initial formation of papules and pustules. (positivehealth.com)
  • Acne vulgaris , probiotics and the gut-brain-skin axis : from anecdote to translational medicine, 5 (2), 185-199. (kivh.nl)
  • AE}} {{HQ}} {{TAM}} ==Overview== ==Historical Perspective== The historical backdrop of skin acne compasses back to the beginning of written history. (wikidoc.org)
  • Skin inflammation medicines are likewise of the significant relic: : * Ancient Rome: Taking a hot bath, and frequently sulfurous, mineral water was one of only a handful few accessible skin acne medicines. (wikidoc.org)
  • It has multiple mechanisms of action that include mechanical components and chemical compounds to help treat inflammatory skin diseases, like acne. (statenews.net)
  • There are studies that showed that patients with severe acne had a lower serum level of Vitamin E than patients without severe acne so supplementing with vitamin E could potentially help with annoying pimples or skin redness. (clearskinregime.com)
  • Acne vulgaris is the most common skin disorder affecting children and young adults in North America. (skintherapyletter.com)
Abstract1
  • abstract = "BACKGROUND: Acne vulgaris in patients aged younger than 12 years is increasingly common and primarily noninflammatory (i.e., comedonal). (mssm.edu)
Proven3
  • Scalptone is aproduct of SBL's Research & Development and is a combination of well proven drugs of homoeopathic therapeutics, for prevention of hairloss and premature greying. (madanapalas.com)
  • AF-200 is a product of SBL's Research and Development and is a combination of well proven drugs of homoeopathic therapeutics which bring quick and significant relief from signs and symptoms of flu and is highly effective in common cold. (madanapalas.com)
  • FP (Ointment and Tablets) is a product of SBL's Research and Development and is a combination of well proven drugs of homoeopathic therapeutics to have pain relieving, anticonstipatory and haemostatic properties which help in curing anal fissures and piles (Haemorrhoids) by reducing pain and venous congestion of the anus. (madanapalas.com)
Treat acne3
Follicle2
  • The blockage within the hair follicle allows for build up of sebum, which is an ideal environment for P. Acnes to proliferate. (positivehealth.com)
  • Clear acne and blemishes quickly by penetrating deep into the root of the follicle using a unique, solubilized form of prescription-strength benzoyl peroxide. (bendoralsurgery.com)
Young adults1
  • Acne is a common dermatological condition found in about 85% of adolescents and young adults. (skintherapyletter.com)
Study1
  • Effects of oral supplementation with fos and gos prebiotics in women with adult acne: The "s.o. sweet" study: A proof-of-concept pilot trial. (kivh.nl)