AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
PancytopeniaBone MarrowBone Marrow CellsBone Marrow TransplantationBone and BonesBone ResorptionHematopoietic Stem CellsBone Marrow DiseasesAnemia, AplasticBone DensityBone Marrow ExaminationLymphohistiocytosis, HemophagocyticFemurHypersplenismOsteoclastsOsteoblastsHistiocytosis, Non-Langerhans-CellAnemia, MegaloblasticBone RemodelingMyelodysplastic SyndromesBone Marrow NeoplasmsFatal OutcomeHematopoiesisAnemia, MacrocyticBlood Cell CountLymphomatoid GranulomatosisHemoglobinuria, ParoxysmalTransplantation, HomologousTuberculosis, MiliarySplenomegalyColony-Forming Units AssayThrombocytopeniaPrimary MyelofibrosisBone Marrow PurgingFanconi AnemiaMice, Inbred C57BLTachycardia, SinusHistiocytic SarcomaHistiocytesHistiocytosis, Langerhans-CellLymphatic DiseasesHistiocytosisEncyclopedias as TopicLangerhans CellsCiprofloxacinTreatment OutcomeAnti-Infective AgentsFluoroquinolonesMicrobial Sensitivity TestsAnti-Bacterial AgentsQuinolones
AplasticThrombocytopeniaSuppressionPlateletsBiopsyDiagnosisAnemiaLymphadenopathyHypocellular bone marrowPeripheralSevereFeverToxic epidermalAspirationTransplantationBiopsiesSymptomsExaminationHematopoietic stemPatientsAbnormalProliferationFailureWeaknessLiverOccurCellsSpongySyndromeToxicitySuppressInvolvementDisruptionTransplantDiseaseTreatmentClinicalCytokines
Aplastic19
  • [ 1 ] The most common cause of acquired bone marrow failure is aplastic anemia . (medscape.com)
  • Her research on the effects of inflammatory signaling on bone marrow stem cells may lead to novel ways to interrupt the development of aplastic anemia. (bcm.edu)
  • Bone marrow suppression is a risk factor for increased mortality for patients with chronic infections and aplastic anemia. (bcm.edu)
  • and immune-mediated diseases such as aplastic anemia, in which the bone marrow loses its ability to produce red-blood cells. (petmd.com)
  • Megaloblastic anemia, hypersplenism and aplastic anemia are the common causes of pancytopenia in our study. (unboundmedicine.com)
  • decreased formation of blood cells (aplastic anemia) or decreased red or white blood cells and platelets (pancytopenia) leading to weakness, bleeding, and infections. (cdc.gov)
  • Aplastic anemia (AA) is a hematopoietic stem cell disorder characterized by pancytopenia and hypocellular bone marrow. (haematologica.org)
  • Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (merckmanuals.com)
  • The term aplastic anemia commonly implies a panhypoplasia of the bone marrow with cytopenias in at least two hematopoietic lineages. (merckmanuals.com)
  • Aplastic anemia is suspected in patients, particularly young patients, with pancytopenia. (merckmanuals.com)
  • Acquired aplastic anemia is a rare, serious blood disorder, due to failure of the bone marrow failure to produce blood cells. (rarediseases.org)
  • In acquired aplastic anemia, an almost complete absence of hematopoietic stem cells results in low levels of red and white blood cells and platelets (pancytopenia). (rarediseases.org)
  • Although bone marrow failure can occur secondary to other disorders, most aplastic anemia is due to the immune system mistakenly targeting the bone marrow (autoimmunity). (rarediseases.org)
  • The symptoms of acquired aplastic anemia occur as a consequence of the bone marrow failing to produce enough blood cells. (rarediseases.org)
  • It is believed that PNH arises in the setting of autoimmune acquired aplastic anemia and bone marrow failure. (rarediseases.org)
  • A rare constitutional aplastic anemia characterized by progressive trilineage bone marrow failure (with hypocellularity), developmental delay with learning disabilities, and microcephaly. (orpha.net)
  • Aplastic Anemia (AA) is a bone marrow failure (BMF) disorder, resulting in bone marrow hypocellularity and peripheral pancytopenia. (duke.edu)
  • Fundal height of the uterus marrow of patients with aplastic anaemia corresponded with the period of gestation. (who.int)
  • Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)
Thrombocytopenia3
Suppression14
Platelets6
  • These diseases are intrinsic disorders of the bone marrow involving disruption in the homeostasis and function of hematopoietic stem cells, resulting in inadequate production of either a single or multiple cell lines (erythroid for red cells, myeloid for white blood cells, megakaryocytic for platelets). (medscape.com)
  • Ataxia-pancytopenia syndrome also causes a shortage of one or more types of normal blood cells: red blood cells, white blood cells, and platelets. (medlineplus.gov)
  • In the bone marrow, the resulting reduction in cell proliferation leads to a shortage of red blood cells, white blood cells, and platelets. (medlineplus.gov)
  • Thrombopoietin helps control the number of circulating platelets by stimulating the bone marrow to produce megakaryocytes. (merckmanuals.com)
  • Red and white blood cells and platelets are formed in the bone marrow. (rarediseases.org)
  • With diffuse marrow involvement, granulocytes are affected first, followed by platelets. (merckvetmanual.com)
Biopsy10
  • Bone marrow aspiration and biopsy showed presence of hemophagocytes with large proerythrocytes and no myeloid cells or megakaryocytes. (pediatriconcall.com)
  • In this setting, immediately perform a bone marrow aspiration and obtain a biopsy from the posterior iliac crest. (medscape.com)
  • If bone marrow aspiration is found to be impossible, imprints from the biopsy specimen should be obtained. (bmj.com)
  • Ideally, reporting of trephine biopsy sections should be done by an individual who is competent in both histopathology and haematology, and who is able to make an appropriate assessment of both the bone marrow aspirate and the trephine biopsy sections. (bmj.com)
  • Clinical details and the results of relevant laboratory tests including the blood count and blood film features must be known before a bone marrow biopsy is performed. (bmj.com)
  • In general, patients who have a hypocellular bone marrow or bone marrow fibrosis are likely to need a trephine biopsy for adequate assessment. (bmj.com)
  • Similarly, only a trephine biopsy shows the architecture of the bone marrow and permits the detection of an abnormal distribution of cells, bone marrow granulomas, and focal lymphoid infiltrates. (bmj.com)
  • Unexplained pancytopenia and an unexplained leucoerythroblastic blood film are indications for a trephine biopsy because they are likely to indicate bone marrow infiltration or fibrosis. (bmj.com)
  • Diagnosis requires demonstration of peripheral pancytopenia and a bone marrow biopsy revealing a hypocellular marrow. (merckmanuals.com)
  • Bone marrow aspi- she delivered vaginally a healthy male baby rate and trephine biopsy were markedly weighing 2050 g with good Apgar scores. (who.int)
Diagnosis1
  • SCD patients with fever, severe anaemia or pancytopenia should be investigated for early diagnosis and prompt treatment of IAH, which is a life- threatening haematological emergency for which transfusion therapy alone may not suffice. (bvsalud.org)
Anemia4
Lymphadenopathy2
  • Leukemia should be suspected if persistent vague symptoms are accompanied by evidence of abnormal bleeding, bone pain, lymphadenopathy or hepatosplenomegaly. (aafp.org)
  • There was no lymphadenopathy or sia, which means that the damaged bone organomegaly. (who.int)
Hypocellular bone marrow1
Peripheral3
  • Hematopoietic stem cells (HSCs) are the precursors of all cells of the peripheral blood, and they usually reside in a quiescent state in the bone marrow. (bcm.edu)
  • It is defined as greater than or equal to 20% mast cells in bone marrow smears and by circulating mast cells, often greater than or equal to 10% in peripheral smears. (logicalimages.com)
  • Pancytopenia can occur and may explain instances in which peripheral mast cells comprise less than 10% of the differential. (logicalimages.com)
Severe3
  • We report a unique case of antibiotic-induced TEN developed in a patient who also suffered from prolonged severe methotrexate-induced pancytopenia. (spandidos-publications.com)
  • IAH in SCD manifests as febrile haemolytic crisis with clinical and laboratory features of severe anaemia or pancytopenia. (bvsalud.org)
  • While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)
Fever1
Toxic epidermal1
  • Paquet P, Jacob E, Pirson J and Pierard GE: Drug-induced toxic epidermal necrolysis and pancytopenia: A puzzling association. (spandidos-publications.com)
Aspiration1
Transplantation2
Biopsies2
  • Blood counts, bone marrow examinations and trephine biopsies were performed according to standard methods. (unboundmedicine.com)
  • Trephine biopsies of the bone marrow should be carried out, when clinically indicated, by trained individuals following a standard operating procedure. (bmj.com)
Symptoms3
  • The symptoms that develop in the patient depend largely on the underlying cause leading to pancytopenia. (petmd.com)
  • Symptoms and severity can vary greatly, ranging from neonatal onset with serious complications (such as bone marrow failure) to the incidental finding of osteopetrosis on X-ray. (nih.gov)
  • Depending on severity and age of onset, symptoms may include fractures, short stature, compressive neuropathies (pressure on the nerves), hypocalcemia with attendant tetanic seizures, and pancytopenia. (nih.gov)
Examination5
Hematopoietic stem1
  • Bone marrow failure can be either inherited or acquired and can involve a single hematopoietic stem cell line or all three cell lines. (medscape.com)
Patients6
  • This study was done to describe the etiology, presentation and outcome of patients with pancytopenia presenting in a general medical ward. (unboundmedicine.com)
  • Hundred patients with pancytopenia were included in the study from October 2001 to October 2002. (unboundmedicine.com)
  • The alpha-emitter radium-223 ((223)Ra) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
  • Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to four intravenous injections of (223)Ra (50 kBq/kg, 33 patients) or placebo (31 patients), given every 4 weeks. (researchgate.net)
  • patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
  • Il s'agit d'une étude transversale, monocentrique et descriptive, durant 12 mois, incluant les patients âgés d'au moins 18 ans admis en réanimation polyvalente pour un sepsis ou choc septique. (bvsalud.org)
Abnormal2
  • Acute myeloid leukemia (AML) is a malignant disorder of the hematopoietic stem cells characterized by abnormal proliferation of myeloid blast cells in the bone marrow and blood, preventing them from further differentiating into the specialized cells of the bone marrow and thus causing pancytopenia. (dovepress.com)
  • Osteopetrosis refers to a group of rare, inherited skeletal disorders characterized by increased bone density and abnormal bone growth. (nih.gov)
Proliferation2
  • The protein produced from this gene is involved in regulating the growth and division (proliferation) and maturation (differentiation) of cells, particularly cells in the bone marrow that give rise to blood cells . (medlineplus.gov)
  • They prevent an overactive SAMD9L protein from excessively restricting cell proliferation, which reduces the severity of pancytopenia in affected individuals. (medlineplus.gov)
Failure9
  • The bone marrow failure syndromes comprise a group of disorders than can be either inherited or acquired. (medscape.com)
  • Diseases that can present in a manner similar to acquired bone marrow failure include myelodysplastic syndromes , paroxysmal nocturnal hemoglobinuria , and large granular lymphocytic leukemia . (medscape.com)
  • Dr. King discusses the impact of receiving an AAMDSIF research grant on her career and her study of bone marrow failure. (bcm.edu)
  • This knowledge is a key to understanding the pathophysiology of bone marrow failure syndromes and will likely provide novel targets for drug development. (bcm.edu)
  • Myelophthisis is a form of bone marrow failure that results from the destruction of bone marrow precursor cells and their stroma, which nurture these cells to maturation and differentiation. (medscape.com)
  • [ 1 ] Bone marrow failure resulting from secondary infiltration is a possible cause of lack of blood cell production (as differentiated from a primary cause of failure). (medscape.com)
  • The expanding number and volume of pathologic cells and the release of suppressive cytokines can eventually lead to bone marrow failure without the characteristic morphologic features of myelophthisis. (medscape.com)
  • If you begin to experience myelosuppression from bone marrow failure, doctors may recommend a transplant or transfusion to replenish blood cells. (healthline.com)
  • It is rarer to get bone marrow failure secondary to microfilaria in bone marrow. (annexpublishers.co)
Weakness1
  • The etiology is uncertain, and the main complaint was of general weakness treatment of choice, bone marrow trans- and easy bruising. (who.int)
Liver2
  • Effete red cells are phagocytized and metabolized by the macrophages of spleen, bone marrow, and liver. (ivis.org)
  • Five unusual causes of brucellosis were identified: hepatic, epidural and thyroid abscesses, intrahepatic cholestatic liver disease and pancytopenia. (who.int)
Occur2
  • Leukemic cells, such as those occurring in chronic leukemias in which the expanding cells are mature and coexist peacefully with the normal bone marrow cells, show no evidence of myelophthisis, and marrow damage does not occur. (medscape.com)
  • When an implant fixture is displaced to the bone marrow defect site of the mandible, damage to the inferior alveolar nerve may occur. (koreamed.org)
Cells15
  • This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. (medscape.com)
  • It appears that certain cells in the bone marrow with an inherited gain-of-function SAMD9L gene mutation can develop additional genetic changes that are associated with milder pancytopenia but an increased cancer risk. (medlineplus.gov)
  • These additional changes compensate for the effects of the gain-of-function mutation in bone marrow cells. (medlineplus.gov)
  • Medications for the underlying cause may be necessary, in addition to various medications to stimulate the production of neutrophils (a type of white blood-cell that fights infection), and another medication to stimulate the production of red-blood cells by bone marrow. (petmd.com)
  • most of the neutrophils in the body are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
  • Bone marrow cells are completely replaced by large carcinoma cells with clear nucleoli. (medscape.com)
  • The bone marrow becomes infiltrated by collagen, reticulin, and other forms of fibrosis, which replace the normal, hematopoietic cells. (medscape.com)
  • BACKGROUND AND OBJECTIVES: Most studies in cardiac regeneration have explored bone marrow mesenchymal stem cells (BM-MSC) with variable therapeutic effects. (koreamed.org)
  • The bone marrow contains hematopoietic stem cells. (rarediseases.org)
  • A decrease in all three types of blood cells is referred to as pancytopenia. (healthline.com)
  • While this procedure is meant to destroy cancer cells, it can also affect your bone marrow and destroy your healthy blood cells. (healthline.com)
  • Red blood cells (RBC) are produced in the bone marrow. (ivis.org)
  • The presence of a great number of Factor XIIIa+ DD without any possible recent recruitment from bone marrow suggests that these cells differentiated from resident cells of the skin. (spandidos-publications.com)
  • Chemotherapy medicines make it harder for the bone marrow to make blood cells the way it normally does. (aultcare.com)
  • Your child may be given medicines to help the bone marrow make more blood cells. (aultcare.com)
Spongy2
  • Bone marrow is the spongy substance found in the center of the bones of the body, in adults mainly the spine, pelvis, and large bones of the legs. (rarediseases.org)
  • Bone marrow is spongy tissue inside some of the larger bones. (aultcare.com)
Syndrome6
  • People with ataxia-pancytopenia syndrome have neurological problems associated with a loss of tissue (atrophy) and other changes in the cerebellum. (medlineplus.gov)
  • Ataxia-pancytopenia syndrome is also associated with an increased risk of certain cancerous conditions of the blood, particularly myelodysplastic syndrome and acute myeloid leukemia . (medlineplus.gov)
  • Ataxia-pancytopenia syndrome appears to be very rare. (medlineplus.gov)
  • Ataxia-pancytopenia syndrome is caused by inherited mutations in the SAMD9L gene. (medlineplus.gov)
  • The mutations that cause ataxia-pancytopenia syndrome are described as "gain-of-function. (medlineplus.gov)
  • It is unclear how the effects of these mutations are related to ataxia and the other neurological problems associated with ataxia-pancytopenia syndrome. (medlineplus.gov)
Toxicity1
Suppress2
Involvement1
  • BACKGROUND: Waldenström macroglobulinemia (WM) is a subset of lymphoplasmacytic lymphoma (LPL) with bone marrow (BM) involvement and an IgM monoclonal gammopathy of any level. (koreamed.org)
Disruption1
Transplant1
Disease1
  • Treatment depends on the primary condition that led to pancytopenia, as it is essential that the primary disease be diagnosed and treated first. (petmd.com)
Treatment1
  • For cats with cancer, there is a danger of developing pancytopenia as a side effect of cancer treatment, and frequent CBC monitoring will need to be done. (petmd.com)
Clinical2
  • There has been little systematic study on the clinical spectrum of pancytopenia. (unboundmedicine.com)
  • AU - Ishtiaq,Osama, AU - Baqai,Haider Z, AU - Anwer,Faiz, AU - Hussain,Nisar, PY - 2004/5/6/pubmed PY - 2004/5/28/medline PY - 2004/5/6/entrez SP - 8 EP - 13 JF - Journal of Ayub Medical College, Abbottabad : JAMC JO - J Ayub Med Coll Abbottabad VL - 16 IS - 1 N2 - BACKGROUND: There has been little systematic study on the clinical spectrum of pancytopenia. (unboundmedicine.com)
Cytokines1
  • However, very little is known about the mechanisms by which inflammatory cytokines affect the hematopoietic progenitors that reside in bone marrow. (bcm.edu)