The Nucleobase cation symporter-2 (NCS2) family, also called the Nucleobase ascorbate transporter (NAT) family, consists of over 1000 sequenced proteins derived from gram-negative and gram-positive bacteria, archaea, fungi, plants and animals. (wikipedia.org)
The nucleobase/ascorbate transporter (NAT) proteins, also known as nucleobase/cation symporter 2 (NCS2) proteins, are responsible for the uptake of nucleobases in all kingdoms of life and for the transport of vitamin C in mammals. (rhea-db.org)
In particular, human organic cation transporter 2 (hOCT2) and multidrug and toxin extrusion proteins 1 and 2-K (hMATE1/2-K) likely mediate renal secretion of mIBG, whereas hOCT1 and hOCT3 may contribute to mIBG uptake into normal tissues such as the liver, salivary glands, and heart. (aspetjournals.org)
Norepinephrine transporter, organic cation transporters, and multidrug and toxin extrusion proteins play differential roles in tumor targeting, systemic elimination, and accumulation in normal tissues. (aspetjournals.org)
Proteins4
Cation Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane. (wakehealth.edu)
This graph shows the total number of publications written about "Cation Transport Proteins" by people in this website by year, and whether "Cation Transport Proteins" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "Cation Transport Proteins" by people in Profiles. (wakehealth.edu)
ORGANIC CATION2
Emerging evidences suggest that the polyspecific organic cation transporters play important roles in systemic disposition and tissue-specific uptake of mIBG. (aspetjournals.org)
Emerging evidences suggest that the polyspecific organic cation transporters are the major transporters driving the systemic elimination and tissue-specific disposition of mIBG in normal organs. (aspetjournals.org)
Solute1
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). (yeastrc.org)
Anion4
Specific point mutations in human anion exchanger 1 (AE1) convert this electroneutral anion exchanger into a monovalent cation conductance. (tcdb.org)
The iodide ions are transported into the follicular cells of the thyroid gland by the sodium/iodide symporter (NIS) and for each iodide anion (I-), NIS transports two sodiumcations (Na+) into the cell. (mugesh-iisc.in)
To maintain charge neutrality on the outside of cells every sodium cation is followed by a chloride anion. (hawaii.edu)
In water, perchlorates will rapidly dissolve and completely dissociate into the perchlorate anion and the corresponding cation. (cdc.gov)
Antiporters2
Since carriers are much more closely related, at least mechanistically, to symporters and antiporters than to channels, they are the type of uniporter emphasized in this volume. (biologists.com)
Nelson and Lill, 1994 ) the decision as to whether they are symporters or antiporters depends upon the direction of translocation, relative to that of the primary driving ion, of the substrate of greatest physiological importance. (biologists.com)
Amino1
Transport of Na+ and K+ coupled to active reabsorption of glucose, amino acids, other organic anions and PO3 4 ¯ through specific symporters. (pharmacy180.com)
Transporters3
The manuscript represents an important contribution to an ongoing discussion about the substrate binding site and mechanism of the Bile Acid Sodium Symporter (BASS) family of transporters. (elifesciences.org)
Once in periplasmic space, glucose is transported into the cytoplasm by several systems, including the phosphoenolpyruvate-dependent phosphotransferase system (PTS), the ATP-dependent cassette (ABC) transporters, and the major facilitator (MFS) superfamily proton symporters. (encyclopedia.pub)
Both reentrant loops of the sodium-coupled glutamate transporters contain molecular determinants of cation selectivity. (libguides.com)
Selectivity1
These studies provide initial insights into substrate selectivity in AgcS symporters. (rcsb.org)
Glucose1
The transport protein, called the glucose symporter, uses the sodium gradient to power glucose movement into the cell. (hawaii.edu)
Family1
The bile acid sodium symporter (BASS) family transports a wide array of molecules across membranes, including bile acids in humans, and small metabolites in plants. (elifesciences.org)
Escherichia1
Here we report the crystal structure of a representative NAT protein, the Escherichia coli uracil/H(+) symporter UraA, in complex with uracil at a resolution of 2.8 Å. (rhea-db.org)
Transport1
Primary active transport involves conversion of energy stored in readily oxidized, reduced or hydrolyzed chemical bonds into electrochemical gradients of solutes, usually protons ( Nelson, 1994 ) or other cations, across membranes. (biologists.com)
Cells2
For instance, the use of 131 I radiotherapy to treat thyroid cancer is highly dependent on the selective expression of the sodium/iodine symporter on these cells ( Kogai and Brent, 2012 ). (aspetjournals.org)
May, 2007: Our paper entitled "Participation of an Endomembrane Cation/H+ Exchanger AtCHX20 in Osmoregulation of Guard Cells" was accepted by Plant Physiology for publication. (umd.edu)
Cell1
The dissociated HCO 3 ¯ in the cell is transported to cortical e.c.f. by basolateral membrane Na+HCO¯ symporter resulting in net reabsorption of NaHCO 3 . (pharmacy180.com)
Addition1
In addition, a Na+Cl¯ symporter moves Cl¯ down its electrochemical gradient into e.c.f. and carries Na+ along. (pharmacy180.com)
Proteins1
Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane. (bvsalud.org)
[ 15 , 16 ] These chemical and electrical potentials provide the driving forces for the electrogenic sodium-dependent uptake of conjugated bile salts [ 17 ] and for proton extrusion by sodium-hydrogen exchangers and for bicarbonate entry by sodium-bicarbonate symporters. (medscape.com)
Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals. (nih.gov)
ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition. (wvu.edu)
Protein1
Within this microbial community, we identify Turicibacter sanguinis as a gut bacterium that expresses a neurotransmitter sodium symporter-related protein with sequence and structural homology to mammalian SERT. (nature.com)
HCO32
In addition, the basolateral membrane also contains a Na +-H +exchanger and a Na +-HCO3 symporter to maintain pH and ion homeostasis. (medscape.com)
Mouse Slc39a8 and Slc39a14 genes encode ZIP8 and ZIP14, respectively, which are ubiquitous divalent cation/(HCO3-)2 symporters responsible for uptake of Zn2+, Fe2+, and Mn2+ into cells. (nih.gov)
The bile acid sodium symporter (BASS) family transports a wide array of molecules across membranes, including bile acids in humans, and small metabolites in plants. (feedspot.com)
A symporter carries two different ions or molecules, both in the same direction. (edu.vn)
In that case, such 'antiporters' (as we now call them) were considered to be essential if mitochondria were to express a membrane potential, negative inside the organelle, for over the long term cytosolic Na + and K + would inevitably accumulate, driven inwards by the electrical potential and, unless some mechanism were available for cation extrusion, swelling and lysis would be just as inevitable. (biologists.com)
The drugs transported are generally cationic, and a simple cation antiport mechanism involving the conserved Glu-14 has been proposed ( Yerushalmi and Schuldiner, 2000 ). (tcdb.org)
Biological1
9. Synthesis and biological evaluation of aza-crown ether-squaramide conjugates as anion/cation symporters. (nih.gov)
Channel1
The TPC1/SV channel functions as a depolarization-stimulated, non-selective cation channel that is inhibited by luminal Ca2+. (feedspot.com)
Sugar2
Function Trumps Form in Two Sugar Symporters, LacY and vSGLT. (ucla.edu)
Fingerprints of hSGLT5 sugar and cation selectivity. (ucla.edu)
Table1
The cations of the solid perchlorate salts listed in Table 4-1 are naturally occurring and ubiquitous in the environment. (cdc.gov)