Cathepsin neutrophils. Medical search. Frequent questions

Cathepsin G has a specificity similar to that of chymotrypsin C, but it is most closely related to other immune serine proteases, such as neutrophil elastase and the granzymes. (wikipedia.org)
It localizes to Neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases. (wikipedia.org)
Cathepsin C (CtsC) functions as a central coordinator for activation of many serine proteases in immune cells . (bvsalud.org)
Serine protease inhibitor (SERPIN)B1 is an inhibitor of neutrophil proteases, including neutrophil elastase (NE) and cathepsin G (cat G). Recent studies suggest that SERPINB1 could provide protection in the airways by regulating excess protease activity associated with inflammatory lung disorders. (elsevierpure.com)
Thus SERPINB1 upregulation in new BPD may be protective by contributing to the regulation of neutrophil proteases NE and cat G. (elsevierpure.com)
Brensocatib is an oral, selective, reversible inhibitor of dipeptidyl peptidase-1 (DPP-1), responsible for activating neutrophil serine proteases (NSPs) including neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG). (nih.gov)
2. Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases. (nih.gov)
9. NETosis occurs independently of neutrophil serine proteases. (nih.gov)
13. Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice. (nih.gov)
14. The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases. (nih.gov)
During inflammation, IL-33 is processed in the central activation domain by inflammatory proteases from mast cells and neutrophils, that generate mature forms of the protein with 10 to 30 fold higher biological activity 29 , 30 . (nature.com)
These proteases include neutrophil elastase, cathepsin G as well as proteases of the coagulation and fibrinolytic cascades. (oncotarget.com)
As a result, serum levels of alpha1-antitrypsin are decreased, leading to low alveolar concentrations, where the alpha1-antitrypsin molecule normally would serve as protection against proteases such as neutrophil elastase. (medscape.com)
The major biochemical activity of the alpha1-antitrypsin molecule is inhibition of several neutrophil-derived proteases (eg, trypsin, elastase, proteinase 3, cathepsin G). Therefore, the protein is more accurately termed alpha1-antiprotease. (medscape.com)
Brensocatib is a reversible inhibitor of dipeptidyl peptidase 1, the enzyme that activates neutrophil serine proteases. (touchrespiratory.com)
7 Over-exuberant neutrophil activity is a major driver of this cycle, and increased levels of neutrophil elastase (one of several neutrophil serine proteases) have been correlated with exacerbation risk, 8 particularly in patients with chronic Pseudomonas colonization. (touchrespiratory.com)
Brensocatib is a small-molecule, reversible inhibitor of the lysosomal cysteine proteinase dipeptidyl peptidase 1 (DPP1, also known as cathepsin C). DPP1 activates neutrophil serine proteases, and its inhibition within the bone marrow reduces the levels of what may be excessive neutrophil and airway serine proteases, including neutrophil elastase. (touchrespiratory.com)
Other serine proteases tested: bacterial glu-C endopeptidase and mammalian Pro-protein Convertase Subtilase-Kexin-3 (PCSK3, furin), urokinase plasminogen activator (uPA), cathepsin G or neutrophil elastase, did not induce IDO1, indicating that the reported effects are not a general property of all serine proteases. (ox.ac.uk)
The imbalance of the protease/antiprotease activity in favour of the neutrophil serine proteases can result in a self-perpetuating cycle of inflammation and respiratory tissue damage. (ersjournals.com)
Produced by cells of mucosal surfaces, SLPI is a potent inhibitor of human neutrophil elastase and cathepsin G, and it also inhibits other serine proteases, such as trypsin and chymotrypsin. (nih.gov)

Among them, eight glycoproteins showed greater than 2-fold elevations in cancer BAL, including Neutrophil elastase (NE), Integrin alpha-M, Cullin-4B, Napsin A, lysosome-associated membrane protein 2 (LAMP2), Cathepsin D, BPI fold-containing family B member 2, and Neutrophil gelatinase-associated lipocalin. (nih.gov)

6. Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis. (nih.gov)
Neutrophil extracellular traps (NETs) are meshworks of extracellular fibres of chromatin DNA, histones and bactericidal proteins such as neutrophil proteinase 3 (PR3) and neutrophil elastase. (touchrespiratory.com)
This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. (nih.gov)
Moreover, α 1 -AT also inhibits two other serine proteinases, namely cathepsin G and proteinase 3, which are produced by neutrophils and cause lung damage. (ersjournals.com)
This pattern results from binding of ANCA to antigen targets throughout the neutrophil cytoplasm, the most common protein target being proteinase 3 (PR3). (wikidoc.org)

1. Cathepsin C inhibition as a potential treatment strategy in cancer. (nih.gov)
7. Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS? (nih.gov)
Background Neutrophil elastase (NE) has been linked to lung neutrophil dysfunction in bronchiectasis and cystic fibrosis (CF), making NE inhibition a potential therapeutic target. (ersjournals.com)
The role of inhibition that α 1 -AT carries out towards neutrophil elastase is well known ( figure 1a ) [ 2 ]. (ersjournals.com)
Researchers at Synergen have shown by site-directed mutagenesis that residue Leu-72 within the COOH-terminal domain is the active site for inhibition of leukocyte elastase and cathepsin G, as well as of chymotrypsin and trypsin (11). (nih.gov)

SERPINB1 expression was detected in the conducting airway and glandular epithelial cells in addition to neutrophils, macrophages, and mast cells. (elsevierpure.com)
The exact mechanisms of phagosome formation in neutrophils are not known since neutrophils are rather resilient to the techniques that are often used to study this process in for example macrophages. (medscape.com)
In contrast to macrophages, neutrophils differ in the contents of these endosomes. (medscape.com)
Functionally this correlates with increased infiltrations of immune cells due to dendritic cells, macrophages, neutrophils and different subpopulations of T cells. (nature.com)
Histologically, the incidence and severity of pulmonary inflammation was confirmed to be dose-dependent, and inflammatory infiltrates were characterized by increased numbers of alveolar macrophages with small numbers of neutrophils. (cdc.gov)
Amongst the key players, macrophages, which originate from myeloblasts similar to neutrophils, have garnered significant attention. (biomedcentral.com)
The engulfment and digestion of microorganisms are assigned to two major cell types recognized by Elie Metchnikoff at the turn of the last century as microphages (now known as neutrophils) and macrophages. (pediagenosis.com)
Unlike neutrophils, macrophages are longlived cells with significant rough‐surfaced endoplasmic reticulum and mitochondria and, whereas neutrophils provide the major defense against pyogenic (pus‐forming) bacteria, as a rough generalization it may be said that macrophages are at their best in combating those bacteria, viruses, and protozoa that are capable of living within the cells of the host. (pediagenosis.com)

Similarities between human and rat leukocyte elastase and cathepsin G". European Journal of Biochemistry. (wikipedia.org)
The ability of human neutrophil elastase and cathepsin G to activate matrix metalloproteinase 3 (MMP-3 = stromelysin) and MMP-2 ('gelatinase') purified from human rheumatoid synovial fibroblasts in culture was examined. (elsevierpure.com)
The zymogen of MMP-3 (proMMP-3) was activated to full activity with elastase and cathepsin G by limited proteolysis of the molecule into two active forms of M r ∼ 45000 and M r ∼ 25000. (elsevierpure.com)
These data suggest that neutrophil elastase and cathepsin G may play an important role in the activation of proMMP-3 in vivo in various inflammatory conditions, but proMMP-2 may be activated in different ways. (elsevierpure.com)
Dive into the research topics of 'Activation of matrix metalloproteinase 3 (stromelysin) and matrix metalloproteinase 2 ('gelatinase') by human neutrophil elastase and cathepsin G'. Together they form a unique fingerprint. (elsevierpure.com)
Okada, Y & Nakanishi, I 1989, ' Activation of matrix metalloproteinase 3 (stromelysin) and matrix metalloproteinase 2 ('gelatinase') by human neutrophil elastase and cathepsin G ', FEBS Letters , vol. 249, no. 2, pp. 353-356. (elsevierpure.com)

In contrast, proMMP-2 was not activated at all by these neutrophil serine proteinases, although it was degraded into small fragments. (elsevierpure.com)
Sepper , R et al "Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. (ersjournals.com)
The principal pathophysiological pathway is associated with neutrophil recruitment and the release of serine proteinases, especially neutrophil elastase, which causes collateral tissue damage due to inadequate α 1 -AT protection. (ersjournals.com)

Cathepsin G is a protein that in humans is encoded by the CTSG gene. (wikipedia.org)
Cathepsin G is a 255-amino-acid-residue protein including an 18-residue signal peptide, a two-residue activation peptide at the N-terminus and a carboxy terminal extension. (wikipedia.org)
This protein is crucial in Fc-mediated phagocytosis, as neutrophils from Syk-deficient mice are unable to ingest IgG-opsonized particles. (medscape.com)
By far the most common p-ANCA target is myeloperoxidase (MPO), a neutrophil granule protein whose primary role in normal metabolic processes is generation of oxygen radicals . (wikidoc.org)

In chronic inflammatory lung diseases such as non-cystic fibrosis bronchiectasis (NCFBE), neutrophils accumulate in the airways resulting in excess active NSPs that cause damaging inflammation and lung destruction. (nih.gov)
5. BI 1291583: a novel selective inhibitor of cathepsin C with superior in vivo profile for the treatment of bronchiectasis. (nih.gov)
Neutrophil elastase (NE) has long been implicated in the pathophysiology of bronchiectasis [ 12 - 14 ]. (ersjournals.com)

The activity of cathepsin G depends on a catalytic triad composed of aspartate, histidine and serine residues which are widely separated in the primary sequence but close to each other at the active site of the enzyme in the tertiary structure. (wikipedia.org)
As a neutrophil serine protease, was first identified as degradative enzyme that acts intracellularly to degrade ingested host pathogens and extracellularly in the breakdown of ECM components at inflammatory sites. (wikipedia.org)
Its principal function in the lung is to inactivate neutrophil elastase, an enzyme that is released during normal phagocytosis of organisms or particles in the alveoli. (medscape.com)
Background: Serine protease inhibitor member 3 of clade A (SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G. The release of neutrophil cathepsin G (proteolytic enzyme) can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders. (elsevierpure.com)

In the presence of active CtsC, isolated human neutrophils activated via NF-κB pathway with augmented bactericidal capacity in vitro . (bvsalud.org)

Moreover, these effects can be enhanced when complement factors as C3bi, which is recognized by β 2 -integrin MAC-1, [ 22 ] or antibodies bind to receptors on the neutrophil membrane. (medscape.com)
[ 4 ] If bacteria are opsonized with antibodies, they will bind to Fc receptors on the neutrophil membrane. (medscape.com)
Chemotaxis was indicated by neutrophil migration through a membrane to the bottom chamber. (nih.gov)
Cathepsin G may attack laminin, proteoglycans, collagen I and insoluble fibronectin, to provoke proinflammatory events, to degrade the basement membrane, to destroy the tissue inhibitor of metalloproteinases and to increase the endothelial permeability. (biomedcentral.com)

8. Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C. (nih.gov)

Olfactomedin 4 contributes to hydrogen peroxide-induced NADPH oxidase activation and apoptosis in mouse neutrophils. (nih.gov)
Neutrophil apoptosis , or programmed cell death, is vital in controlling the duration of the early inflammatory response, thus restricting damage to tissues by the neutrophils. (wikidoc.org)

The vesicles and granules in neutrophils contain a highly specialized, heterogeneous and powerful mixture of microbicidal peptides and proteolytic enzymes. (medscape.com)
NE (Neutrophil elastase) is a serine protease mainly existed in neutrophils azurophilic granules [ 4 ], which is involved in a variety of physiological processes like formation of neutrophil extracellular trap and degradation of extracellular matrix and proteins [ 5 , 6 ]. (biomedcentral.com)
A serine protease found in the azurophil granules of NEUTROPHILS . (nih.gov)

Neutrophil elastase (NE) plays a causal role in inflammation and participates actively in cardiovascular diseases. (biomedcentral.com)
VGCFTM-H caused dose- and time-dependent increases in cathepsin activity and cytokines in the acellular lavage fluid, indicating activation of the NLRP3 inflammasome by VGCFTM-H may contribute to lung inflammation. (cdc.gov)
Neutrophils, the predominant common type of polymorphonuclear leukocytes [ 1 ], hold a prominent position in the realm of inflammation, particularly acute inflammation, serving as a fundamental part of the innate immune system [ 2 ]. (biomedcentral.com)
Hence, we considered the expression of cathepsin G as a potential marker indicating UVA1-induced reduction of cutaneous inflammation. (biomedcentral.com)
2015) The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation. (guidetoimmunopharmacology.org)
This article is based on the evidence that ANCA can directly activate neutrophils and monocytes and lead to inflammation of small and medium-sized arteries, capillaries, and venules, hence ANCA-associated vasculitis (AAV). (musculoskeletalkey.com)

Recent studies have demonstrated that neutrophil accumulation, which is generally considered to play a critical role in host defense during bacterial infections, can significantly contribute to lung injury and immune subversion, leading to pneumococcal invasion of the bloodstream. (frontiersin.org)
10. Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases. (nih.gov)
15. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. (nih.gov)
The presence of increased numbers of neutrophils in cigarette smokers' lungs has also been documented by extracting inflammatory cells from open lung biopsies of smokers and nonsmokers (Hunninghake and Crystal 1983). (nih.gov)

NETs are fibers of DNA and histones (chromatin) coated with antimicrobial proteins, such as MPO, cathepsin G and neutrophil elastase. (icthic.com)

Other functions of cathepsin G have been reported, including cleavage of receptors, conversion of angiotensin I to angiotensin II, platelet activation, and induction of airway submucosal gland secretion. (wikipedia.org)
Dahlgren C, Gabl M, Holdfeldt A, Winther M, Forsman H. (2016) Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and mitochondria. (guidetoimmunopharmacology.org)

We also found that neutrophils activated and cleared bacteria in active CtsC-injected mice and that there was no bactericidal capacity in mice that were simultaneously neutrophil -depleted by Ly6G antibody. (bvsalud.org)

Despite its name, AAT reacts with neutrophil elastase much more readily than with trypsin and represents a major defense mechanism against elastase produced by neutrophils in the lower respiratory tract. (clinlabnavigator.com)

Neutrophil Cathepsin G Proteolysis of Protease Activated Receptor 4 Generates a Novel, Functional Tethered Ligand. (utah.edu)

Cathepsin G, a serine protease, is often associated with the degradation of cells and participates in a cascade of other proteolytic proinflammatory pathways. (biomedcentral.com)

One year later a paper from Australia described a syndrome of febrile systemic illness with myalgias, arthralgias, microscopic hematuria, and a serum antibody reacting with neutrophil cytoplasm antigens. (musculoskeletalkey.com)
Anti-neutrophil cytoplasmic antibodies ( ANCAs ) are a group of mainly IgG antibodies against antigens in the cytoplasm of neutrophil granulocytes (the most common type of white blood cell ) and monocytes . (wikidoc.org)

Vi udviklede en høj-throughput assay at måle neutrofil ekstracellulære fælder, eller NETs. (jove.com)
NETs kan fælde og dræbe mikroorganismer og er derfor en vigtig anti-infektiøs mekanisme, men de spiller også en patogen rolle i autoimmune sygdomme. (jove.com)
4) They can also enhance thrombus formation through production of neutrophil extracellular traps (NETs). (icthic.com)
NETs can support neutrophils' pro-tumoral role as they are involved in tumor growth and dissemination and the awakening of dormant cancer cells. (icthic.com)

The adequate production and distribution of normally functioning neutrophils is vital to host defense. (medscape.com)
Evasion of Human Neutrophil-Mediated Host Defense during Toxoplasma gondii Infection. (immunochemistry.com)

The purpose of our study was to investigate to what extent UVA1 irradiation is able to modulate the status of protease activity by the use of a monoclonal antibody labeling cathepsin G. (biomedcentral.com)
Western Blot: At a dilution of 1:4000 the antibody reacts with 0.075, 0.15, and 0.3 ug human liver cathepsin D and does not react with cathepsins B, H or L. (athensresearch.com)
The Cathepsin D immunogen used to prepare this antibody was purified in the Athens Research & Technology laboratory. (athensresearch.com)

Cathepsin G plays an important role in eliminating intracellular pathogens and breaking down tissues at inflammatory sites, as well as in anti-inflammatory response. (wikipedia.org)

12. A rare CTSC mutation in Papillon-Lefèvre Syndrome results in abolished serine protease activity and reduced NET formation but otherwise normal neutrophil function. (nih.gov)
Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity. (immunochemistry.com)
Full text "To directly evaluate caspase-1 enzymatic activity under each condition, we used the FAM-FLICA (ImmunoChemistry Technologies) probe on neutrophils treated with LPS and/or infected with tdTomato-expressing T. gondii and analyzed the cells by ImageStream flow cytometry. (immunochemistry.com)
Neutrophils are the first immune cells recruited to inflammatory sites and resist circulating pathogens with their microbicidal activity. (icthic.com)

Tumor cells can secrete cytokines that induce the switch of neutrophils from N1 to N2 type. (icthic.com)
Moreover, N2 neutrophils secrete inflammatory cytokines that promote cancer cell migration and invasion [2]. (icthic.com)
Furthermore, α 1 -AT may have other anti-inflammatory and immunomodulatory effects, including reduction of Toll-like receptor expression, reduction of neutrophil adherence to the endothelium, and reduction of selected proinflammatory cytokines in the lungs [ 4 , 5 ]. (ersjournals.com)

3. Targeting Cathepsin C in PR3-ANCA Vasculitis. (nih.gov)
ANCA were originally shown to divide into two main classes, c-ANCA and p-ANCA , based on the pattern of staining on ethanol -fixed neutrophils and the main target antigen. (wikidoc.org)
and cathepsin G . p-ANCA is fairly sensitive, but not specific for ulcerative colitis , so not useful as a sole diagnostic test. (wikidoc.org)

Neutrophils not only constitute the preeminent population of circulating cells within the human bloodstream but also exhibit a remarkable propensity for infiltration into the intricate milieu of the tumor microenvironment (TME) in substantial quantities [ 4 , 5 ]. (biomedcentral.com)
These studies indicated a marked increase in neutrophil infiltration in the lungs of cigarette smokers compared with nonsmokers, and identified the site of the accumulation as the alveolar septa. (nih.gov)

Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. (nih.gov)

DNA, which are released from the contents monia AND neutrophil extracellular traps, of neutrophils as a defense mechanism to respiratory tract infection AND neutrophil trap and destroy microorganisms1. (bvsalud.org)

Neutrophils were found in the alveolar walls of smokers both with and without emphysema. (nih.gov)

Bile duct epithelial cells exposed to alpha-naphthylisothiocyanate produce a factor that causes neutrophil-dependent hepatocellular injury in vitro. (nih.gov)
The acute hepatotoxicity induced by alpha-naphthylisothiocyanate (ANIT) in rats is manifested as neutrophil-dependent necrosis of bile duct epithelial cells (BDECs) and hepatic parenchymal cells. (nih.gov)

In neutrophils, this occurs via sequential fusions with early and late endosomes and finally lysosomes, thus yielding a phagolysosome. (medscape.com)
No increase in immature (nonsegmented) neutrophils occurs, because no change occurs in the inflow of neutrophils from the marrow. (medscape.com)
The researchers con- cluded that a marked neutrophil accumulation occurs in the lungs of cigarette smokers, that it precedes the development of emphysema, and that it continues once emphysema is established. (nih.gov)

Our findings identified a mechanism that H. pylori abrogate CtsC to impair neutrophil activation and to ensure persistence in gastric mucosa . (bvsalud.org)
Efforts to enable and boost this neutrophil activation pathway by active CtsC may therefore become valuable strategies in treating H. pylori infection . (bvsalud.org)
Cathepsin C (CTSC) is a cysteine protease of the papain family (1). (rndsystems.com)

Role of neutrophil extracellular la NETosis en las enfermedades infecciosas pulmonares. (bvsalud.org)
Despite not having a standardized measurement parameter, the excess of neutrophil extracellular traps corresponds conception, manuscript to the severity of tissue damage observed in patients with respiratory tract infections, revealing the important prognostic role design, literature search, data of the neutrophil response and NETosis process in pulmonary infectious diseases. (bvsalud.org)

For example, neutrophils enhance the secretion of chemokines during cancer development, and cancer cells secrete chemokines that induce neutrophils to migrate to the primary tumor [2]. (icthic.com)

In addition, neutrophil-derived MVs may contain myeloperoxidase (MPO), which plays a role in thrombus propagation [5]. (icthic.com)

A chemokine gradient recruits circulating neutrophils to extra-vascular inflammatory sites [1]. (icthic.com)

Finally, they play a key role in forming metastases by secreting matrix metallopeptidase 9 (MMP9) and neutrophil elastase to favor the remodeling of the extracellular matrix necessary for tumor progression. (icthic.com)

Abrogation of cathepsin C by Helicobacter pylori impairs neutrophil activation to promote gastric infection. (bvsalud.org)
In resting neutrophils, these are mainly CD32A, CD32C (which trigger phagocytosis and activation of oxidative burst) and CD14. (medscape.com)
Activation of the neutrophil by interferon leads to high-affinity binding by CD64 as well. (medscape.com)
Neutrophil activation during cardiopulmonary bypass (CPB) surgery may occur because of the release of complement chemotactic products or the local release of interleukin (IL)-8. (medscape.com)

Denne protokol beskriver en meget følsom og høj overførselshastighed neutrofile ekstracellulære fælde (NET) assay for semi-automatiske kvantificering af ex vivo nettet formation ved immunfluorescens tredimensionale Konfokal mikroskopi. (jove.com)

1983) evaluated the relationship between cigarette smoking and the accumulation of neutrophils in the lungs of smoking and nonsmoking humans. (nih.gov)

An upregulation of cathepsin G was reported in studies of keratoconus. (wikipedia.org)

The first mechanism that neutrophils usually employ is that of phagocytosis. (medscape.com)
Though both will lead to phagocytosis, complement-opsonized particles will slowly 'sink in' to the cell, whereas binding of the antibodies to the Fcγ receptor will lead to extension of neutrophil pseudopods until they surround and eventually entrap the particle. (medscape.com)

4. Therapeutic targeting of cathepsin C: from pathophysiology to treatment. (nih.gov)

Neutrophils, the most prevalent innate immune cells in humans, have garnered significant attention in recent years due to their involvement in cancer progression. (biomedcentral.com)
The role of neutrophils in innate immunity is well known, but only recently they have been linked to other phenomena such as thrombosis and hemostasis. (icthic.com)

Cathepsin G has been reported to play an important role in a variety of diseases, including rheumatoid arthritis, coronary artery disease, periodontitis, ischemic reperfusion injury, and bone metastasis. (wikipedia.org)
Here, we review bacterial and host factors, focusing on the role of neutrophils and their elastase, which contribute to the progression of pneumococcal pneumonia. (frontiersin.org)
During an infection, chemotactic agents are generated that attract neutrophils to the site of infection, which in turn play a critical role in phagocytosing and killing microorganisms. (medscape.com)
Thus, researchers have recognized the pivotal role of tumor-associated neutrophils (TANs) within the TME, and substantial endeavors have been devoted to elucidating their potential as therapeutic targets [ 6 ]. (biomedcentral.com)
The role of neutrophils in cancer and thrombosis. (icthic.com)
Neutrophils and tumor cells influence each other, and neutrophils can play a role in cancer development. (icthic.com)
They further suggested that the neutrophils may play a role in the destruction of the alveolar septa of the lungs in cigarette smokers. (nih.gov)

Cathepsin G was also found to exert broad-spectrum antibacterial action against Gram-negative and -positive bacteria independent of the function mentioned above. (wikipedia.org)

Neutrophils have two specific characteristics: a short lifespan and an inability to proliferate, which distinguishes them from other immune cells. (biomedcentral.com)

Anatomy24

Organisms5

Diseases8

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes32

Disciplines and Occupations1

Information Science3

Proteases20

Including neutrophil elastase1

Proteinase5

Inhibition5

Macrophages8

Elastase and cathepsin6

Proteinases3

Protein4

Bronchiectasis3

Enzyme4

Human Neutrophils1

Membrane4

Inhibitor1

Apoptosis2

Granules3

Inflammation6

Lung4

Proteins1

Receptors2

Bactericidal1

Trypsin1

Proteolysis1

Proteolytic1

Cytoplasm2

NETs4

Host defense2

Antibody3

Tissues1

Activity4

Cytokines3

ANCA3

Infiltration2

Granulocytes1

Defense mechanism1

Alveolar walls1

Epithelial cells2

Occurs3

CtsC3

NETosis2

Secretion1

Myeloperoxidase1

Inflammatory sites1

Extracellular matrix1

Activation4

Vivo1

Accumulation1

Upregulation1

Phagocytosis2

Pathophysiology1

Innate2

Role7

Bacteria1

Immune1