• Surgical castration is bilateral orchiectomy (excision of both testicles), while chemical castration uses pharmaceutical drugs to deactivate the testes. (wikipedia.org)
  • Either surgical removal of both testicles or chemical castration may be carried out in the case of prostate cancer. (wikipedia.org)
  • Testosterone-depletion treatment (either surgical removal of both testicles or chemical castration) is used to slow down the cancer, greatly reduce sex drive or interest in those with sexual drives, obsessions, or behaviors, or any combination of those that may be considered deviant. (wikipedia.org)
  • Mississippi banned genital mutilation surgeries and chemical castration drugs for children claiming to be "transgender. (breitbart.com)
  • BIRMINGHAM, Ala. (WBRC) - There's a bill on Governor Kay Ivey's desk that would require convicted sex offenders on parole to undergo chemical castration. (wsfa.com)
  • The bill says a person convicted of a sex offense involving a child under 13, who is eligible for parole, will be required to undergo chemical castration. (wsfa.com)
  • A person required to undergo the chemical castration must begin the treatment no less than one month prior to their release from custody, and must continue treatment until the court determine it's no longer necessary. (wsfa.com)
  • Two months after President Dmitry Medvedev called for the voluntary chemical castration of child molesters, a Just Russia deputy introduced a bill demanding mandatory chemical castration to the State Duma on Monday. (themoscowtimes.com)
  • He said 97 percent of convicts return to child molestation after serving their prison time, but only 3 percent commit new crimes in countries where chemical castration is used. (themoscowtimes.com)
  • Countries that implement chemical castration include Britain, France and the United States, where nine states, among them Florida and California, employ the procedure as punishment for serious sex offenses. (themoscowtimes.com)
  • Among the more famous victims of such treatment was computer scientist Alan Turing, who agreed to chemical castration in 1952 to avoid being jailed for being gay. (themoscowtimes.com)
  • The issue was addressed by Medvedev in May, when he also called for chemical castration of child molesters, but only as a voluntary measure. (themoscowtimes.com)
  • Chemical Castration==== Chemical castration is a form of temporary castration caused by hormonal medication. (wikidoc.org)
  • In the case of chemical castration, ongoing regular injections of [[anti-androgen]]s are administered. (wikidoc.org)
  • Chemical castration seems to have a greater effect on bone density than physical castration. (wikidoc.org)
  • The opposition Jobbik party on Tuesday called for harsher punishments for paedophiles and people who commit sex crimes, including the introduction of chemical castration. (budapesttimes.hu)
  • Chemical castration is a pharmaceutical treatment that could significantly reduce the high recidivist rate, she added. (budapesttimes.hu)
  • Jobbik proposes chemical castration as optional for first-time sexual offenders but mandatory for recidivists, she said. (budapesttimes.hu)
  • Aim 1: To assess preferences and barriers for de-implementation of chemical castration in prostate cancer. (biomedcentral.com)
  • Although some patients with prostate cancer benefit from ADT in terms of survival and symptom improvement, chemical castration is also commonly performed when there is no high level evidence for use and little to no health benefits to patients raising questions of low value care. (biomedcentral.com)
  • This clinical trial is studying a potential treatment for men with metastatic castration resistant prostate cancer. (facingourrisk.org)
  • First-line options for treating metastatic castration-resistant prostate cancer (mCRPC) were debated throughout the annual meeting of the American Urological Association (AUA). (medpagetoday.com)
  • Metastatic Castration-Sensitive Prostate Cancer (mCSPC) requires systematic treatments. (physiciansweekly.com)
  • The Food and Drug Administration (FDA) has approved Lynparza ® (olaparib) in combination with abiraterone and prednisone or prednisolone for the treatment of adults with deleterious or suspected deleterious BRCA -mutated metastatic castration-resistant prostate cancer (mCRPC). (empr.com)
  • FDA approves olaparib with abiraterone and prednisone (or prednisolone) for BRCA -mutated metastatic castration-resistant prostate cancer. (empr.com)
  • Lynparza plus abiraterone approved in the US for the treatment of BRCA -mutated metastatic castration-resistant prostate cancer. (empr.com)
  • NEW YORK, November 13, 2023 - Pfizer Inc. (NYSE: PFE) announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a positive opinion for TALZENNA® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI® (enzalutamide), for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) in whom chemotherapy is not clinically indicated. (pfizer.com)
  • Despite recent approval of some novel drugs, metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease and additional treatment options are still needed. (snmjournals.org)
  • In a single-institution phase I dose-expansion trial reported in The Lancet Oncology , Aggarwal et al found that a single dose of lutetium-177-PSMA-617 (LuPSMA) followed by pembrolizumab maintenance was associated with activity in patients with metastatic castration-resistant prostate cancer. (ascopost.com)
  • The investigators concluded, "A single priming dose of [LuPSMA] followed by pembrolizumab maintenance was safe and had encouraging preliminary activity in patients with metastatic castration-resistant prostate cancer. (ascopost.com)
  • Efficacy and safety of abiraterone acetate in elderly (75 years or older) chemotherapy naïve patients with metastatic castration resistant prostate cancer. (springer.com)
  • Potential drug-drug interactions with abiraterone in metastatic castration-resistant prostate cancer patients: a prevalence study in France. (springer.com)
  • Belinostat is under clinical development by Acrotech Biopharma and currently in Phase I for Metastatic Castration-Resistant Prostate Cancer (mCRPC). (pharmaceutical-technology.com)
  • According to GlobalData, Phase I drugs for Metastatic Castration-Resistant Prostate Cancer (mCRPC) have an 88% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. (pharmaceutical-technology.com)
  • The study will enroll participants with metastatic castration-resistant prostate cancer (mCRPC) previously treated with one prior androgen receptor axis-targeted therapy (ARAT). (uclahealth.org)
  • Received 1 prior ARAT for metastatic or non-metastatic, castration-sensitive or castration-resistant prostate cancer. (uclahealth.org)
  • New nomograms can predict survival outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC) treated with lutetium-177 prostate-specific membrane antigen ( 177- Lu-PSMA), according to a study published in The Lancet Oncology . (renalandurologynews.com)
  • JANX-007 is under development for the treatment of metastatic castration resistant prostate cancer (mCRPC). (globaldata.com)
  • Metastatic castration-resistant prostate cancer (mCRPC) is a type of cancer that is resistant to conventional prostate cancer treatments, such as androgen deprivation therapies (ADTs) and other chemotherapies. (oncologynurseadvisor.com)
  • On August 11, the U.S. Food and Drug Administration (FDA) approved the fixed-dose combination of niraparib and abiraterone acetate (Akeega), with prednisone, for adult patients with deleterious or suspected deleterious BRCA -mutated metastatic castration-resistant prostate cancer, as determined by an FDA-approved test. (ascopost.com)
  • Efficacy was evaluated in cohort 1 of MAGNITUDE (ClinicalTrials.gov identifier NCT03748641 ), a randomized, double-blind, placebo-controlled trial that enrolled 423 patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer. (ascopost.com)
  • Patients with metastatic castration-resistant prostate cancer were eligible if they had not received prior systemic therapy in the metastatic castration-resistant prostate cancer setting except for a short duration of prior abiraterone acetate plus prednisone (up to 4 months) and ongoing androgen-deprivation therapy. (ascopost.com)
  • No benefit was observed in patients with metastatic castration-resistant prostate cancer without an HRR gene mutation (cohort 2 of MAGNITUDE) as the criterion for futility was met. (ascopost.com)
  • Among all patients with metastatic castration-resistant prostate cancer treated with niraparib and abiraterone acetate plus prednisone in cohort 1 of MAGNITUDE (n = 423), 27% required a blood transfusion, including 11% who required multiple transfusions. (ascopost.com)
  • Re: Niraparib and Abiraterone Acetate for Metastatic Castration-resistant Prostate Cancer. (bvsalud.org)
  • The US Food and Drug Administration (FDA) has approved niraparib and abiraterone acetate (Akeega, Janssen Pharmaceuticals) to treat BRCA -positive, metastatic castration-resistant prostate cancer in adult patients with deleterious or suspected deleterious disease, as determined by an FDA-approved test. (medscape.com)
  • About 10% - 15% of patients who develop metastatic castration-resistant prostate cancer have BRCA gene alterations, and those patients are more likely to have aggressive disease, poor outcomes, and shorter survival. (medscape.com)
  • Phase I/II study with the HER1 therapeutic vaccine in patients with asymptomatic or minimally symptomatic hormonal castration-resistant prostate cancer or metastatic colon cancer. (who.int)
  • Biomarker-Directed Therapy in Black and White Men With Metastatic Castration-Resistant Prostate Cancer. (cdc.gov)
  • In this cohort study of 962 men with metastatic castration-resistant prostate cancer, mismatch repair deficiency or microsatellite instability-high was significantly more frequent in Black men than White men. (cdc.gov)
  • Genomic alterations in DNA damage response (DDR) genes are common in metastatic castration-resistant prostate cancer (mCRPC). (cdc.gov)
  • Castration is any action, surgical, chemical, or otherwise, by which a male loses use of the testicles: the male gonad. (wikipedia.org)
  • The term castration may also be sometimes used to refer to emasculation where both the testicles and the penis are removed together. (wikipedia.org)
  • Surgical castration entails the removing of the testicles. (thelocal.se)
  • In castration, the testicles are removed in order to address problems relating to prostate enlargement. (liu.se)
  • Students perform both a castration and sham-control surgery on male rats and test the effects of reduced testosterone due to castration on the weight and histology of seminal vesicles. (ed.gov)
  • Demonstrating the effects of testosterone through castration surgery bridges concepts learned in a traditional physiology class setting with data gleaned from research in a laboratory. (ed.gov)
  • Prostate-specific membrane antigen (PSMA) is an excellent target for radionuclide therapy of metastasized castration-resistant prostate cancer (mCRPC). (snmjournals.org)
  • Castration eliminates the risk of testicular cancer. (wikidoc.org)
  • Must have been administered ARAT (abiraterone, enzalutamide, darolutamide, or apalutamide) in the castration-sensitive or castration-resistant setting. (orlandohealth.com)
  • Skip forward a few thousand years and castration fantasies are not just Freudian references and psychoanalytical complexes, but full aspects of some people's sexual desires. (cvltnation.com)
  • However, Sweden Democrat spokesperson Martin Kinnunen told Expo that surgical castration of under aged sex offenders is not an issue the party is currently pursuing. (thelocal.se)
  • Prior chemotherapy treatment for castration-sensitive or castration-resistant prostate cancer (docetaxel or cabazitaxel). (orlandohealth.com)
  • Castration resistant prostate cancer has historically been considered chemotherapy insensitive. (urotoday.com)
  • Docetaxel is a primary chemotherapy agent used for the treatment of Castration-Resistant Prostate Cancer (CRPC) ( 1 , 2 ). (iiarjournals.org)
  • Background: Osteodex (ODX) is a cytotoxic bone-targeting polybisphosphonate, intended for treatment of bone metastasis from castration-resistant prostate cancer (CRPC). (lu.se)
  • PURPOSE: To review the current literature and discuss potential future roles of the novel positron emission tomography (PET) tracers targeting the prostate-specific membrane antigen (PSMA) in patients with castration-resistant prostate cancer (CRPC). (uzh.ch)
  • Various molecular mechanisms have been implicated in the progression from hormone-sensitive to castration-resistant prostate cancer (CRPC). (escholarship.org)
  • In study B, 23 patients with castration-resistant prostate cancer received probes for CYP3A4 (midazolam), CYP2C9 (warfarin), CYP2C19 (omeprazole), and CYP2C8 (pioglitazone), and transporter substrates for P-glycoprotein (P-gp) (fexofenadine) and breast cancer resistance protein (BCRP)/organic anion transporting polypeptide (OATP) 1B1 (rosuvastatin) at baseline and after repeat once-daily administration of apalutamide 240 mg to steady state. (springer.com)
  • An open-label, multicenter, phase Ib study investigating the effect of apalutamide on ventricular repolarization in men with castration-resistant prostate cancer. (springer.com)
  • Despite these advances, until recently, only docetaxel had been shown to improve survival in patients with castration-resistant disease, and there has been no standard treatment options available for men with disease progression on docetaxel. (urotoday.com)
  • In this review, we examine the clinical development of cabazitaxel for the treatment of castration-resistant prostate cancer, as well as rationale and direction of future therapeutic investigation. (urotoday.com)
  • For men with prostate problems, castration was a treatment method for many years. (liu.se)
  • In her thesis, Elin Björk investigates the treatment method that was prevalent from the late 19th century to the early 20th century: castration. (liu.se)
  • But by studying castration as a treatment for benign prostate enlargement, Elin Björk discovered that the prevalent notion in medicine of the man as norm is not always accurate. (liu.se)
  • Castration as a treatment method for prostate hypertrophy 1893-1910. (liu.se)
  • Expansion of the castration-sensitive prostate cancer market in the upcoming years will be influenced by a number of variables, including increased R&D initiatives and surge in research into prostate cancer treatment options. (reportsanddata.com)
  • Patients' resistance to expensive treatments, clinical trial failure rates, high proportion of treatment-related side effects, prolonged treatment duration, and lack of awareness in developing nations are all factors that are predicted to restrain growth of the castration-resistant prostate cancer market. (reportsanddata.com)
  • Guided by the theoretical domains framework (TDF), urologists and patients from facilities with the highest and lowest castration rates across the VA will be interviewed to identify key preferences and de-implementation barriers for reducing castration as prostate cancer treatment. (biomedcentral.com)
  • The investigators will conduct national surveys of urologists to prioritize key barriers identified in Aim 1 for stopping incident castration as localized prostate cancer treatment using a DCE experiment design. (biomedcentral.com)
  • Aim 3: To pilot two tailored de-implementation strategies to reduce castration as localized prostate cancer treatment. (biomedcentral.com)
  • Today's topic is a new antiandrogen for the treatment of men with nonmetastatic, castration-resistant prostate cancer . (medscape.com)
  • Castration has been considered one of the most severe punishments a man can receive throughout the history of human beings, but for some people that is not exactly the case. (cvltnation.com)
  • Rubber banding may be, if done appropriately less stressful and safer for young calves particularly because surgical castration is often associated with severe complications such as infections and hemorrhages. (thecattlesite.com)
  • Those who are treated with medical castration for more severe forms of prostate cancer often develop the disease again within a few years. (lu.se)
  • Castration also figured in a number of religious castration cults. (wikipedia.org)
  • Researchers say the childhood castration and subsequent opera career of 19th-century singer Gaspare Pacchierotti left permanent marks on his skeleton. (mentalfloss.com)
  • Our research is helping the sheep sector manage the health and welfare of lambs at tail docking and castration time, known as 'marking', as well as other livestock management practices. (www.csiro.au)
  • With our supporting research, pain relief options for lambs undergoing castration and/or tail docking are now available to producers in Australia and New Zealand. (www.csiro.au)
  • Also use these castration loops and bander for docking lambs' tails. (valleyvet.com)
  • Despite that average daily gain was not affected by the technique of castration employed, rubber banding is not advisable to use for post pubertal cattle because their developed genital organs may affect its precise application and result on some wounds. (thecattlesite.com)
  • Castration has also been used in the United States for sex offenders as a way of avoiding incarceration. (wikipedia.org)
  • Castration reduces aggressive behaviour by male sheep, injuries when handling male sheep and unplanned breeding, allowing for improved health and welfare. (www.csiro.au)
  • Castration at birth or close to birth reduces drastically the weight loss and associated stress. (thecattlesite.com)
  • After castration, calves start loosing weight and their average daily gain drops for a period. (thecattlesite.com)
  • The head of a Sweden Democrat party district and member of the party's election committee used the party's website to call for the castration of four young boys suspected of sexual crimes. (thelocal.se)
  • Growing focus on "patient-centric" care is anticipated to foster innovation regarding efficient drugs and therapies, rise in pharmaceutical spending by emerging markets, and technological breakthroughs creating a plethora of opportunities, revolutionize technological advancements in research & development, and increase in clinical studies contribute to growth of the global castration-resistant prostate cancer market over the forecast period. (reportsanddata.com)
  • In ancient times, castration often involved emasculation or the total removal of all the male genitalia. (wikipedia.org)
  • In male dogs it's called castration . (bluecross.org.uk)
  • however, castration will not restore hair growth after hair has already been lost due to male pattern baldness. (wikidoc.org)
  • Thus, knowledge of how the female body functioned was transferred to the male body, and by extension, knowledge of women's bodies was used as an argument for the castration of men. (liu.se)
  • Previous research has found that there was a very restrictive stance on male castration, although there were few alternatives. (liu.se)
  • Overall, the male castration surgery provides students with hands-on skills and an understanding of the work done by scientific researchers and health care professionals. (ed.gov)
  • Castration in humans has been proposed, and sometimes used, as a method of birth control in certain poorer regions. (wikidoc.org)
  • But Belyakov said mandatory castration was the only measure short of a life sentence guaranteed to stop molesters. (themoscowtimes.com)
  • Till date, few studies have explored if compared to dry kibbles, canned diet can have advantages in promoting recovery from castration surgery and maintaining normal body condition after castration in cats. (asas.org)
  • In our study, dry and canned diets were fed to cats experiencing castration surgery with a free-feeding method. (asas.org)
  • Collectively, canned food with high palatability and low energy density promoted the recovery of cats from the castration surgery and reduced their weight gain after castration. (asas.org)
  • Patients and Methods: Twenty-eight patients with castration-resistant prostate cancer and confirmed bone metastasis were assigned to seven infusions of ODX every third week, divided in seven ascending dose cohorts. (lu.se)
  • Medical consequences === A subject of castration who is castrated before the onset of [[puberty]] will retain a high voice, non-muscular build, and small genitals. (wikidoc.org)
  • Castrations after the onset of puberty will typically reduce the sex drive considerably or eliminate it altogether. (wikidoc.org)
  • Additionally, the market for castration-sensitive prostate cancer will be directly driven by medication innovation, advances in genetics and proteomics , label extension within prostate cancer, and other factors. (reportsanddata.com)
  • The punishment must be surgical castration and deportation. (thelocal.se)
  • They found that the star's early castration and later musical success had indeed left traces on his body. (mentalfloss.com)
  • My thesis shows that when it comes to the castration of men, the female body has been the norm. (liu.se)
  • The equivalent of castration for female animals is spaying. (wikipedia.org)
  • Actually, we don't have spaying for now because we have no anesthetics to perform ligation for female dogs so we're now relying on castration," she said. (mindanaotimes.com.ph)
  • Castration banding is an easy and safe method of bloodless castration that cuts off the blood flow to the scrotum, allowing it to drop away after a matter of days or weeks. (valleyvet.com)
  • Why is it so important to evaluate the effects of age and method of castration? (thecattlesite.com)
  • However, the age and method of castration have an important impact on growth performance and stress response of beef cattle. (thecattlesite.com)
  • What about the method of castration? (thecattlesite.com)
  • Effect of castration in adolescent and young adult males upon further changes in the proportion of bare and hairy scalp. (wikidoc.org)
  • Effect of castration on performance is independent of the breed and feeding systems. (thecattlesite.com)
  • Therefore, it's suggested that an earlier castration may reduce the stress, improve the animal welfare by reducing the castration-associated trauma and also the weaning associated stress. (thecattlesite.com)
  • On March 13 - 14, they will conduct free castration for dogs and cats in Barangay Matina Crossing to control population. (mindanaotimes.com.ph)
  • Even after castration, dogs may still serve as a source of infection because the bacteria can persist in the prostate and lymphoid tissues ( 13 , 14 ). (cdc.gov)
  • The global castration-resistant Prostate Cancer market is expected to register a robust revenue CAGR over the forecasted period due to increased burden of prostate cancer. (reportsanddata.com)
  • castration was indeed considered a solution by the medical profession. (liu.se)
  • Castration of animals is intended to favor a desired development of the animal or of its habits, as an anaphrodisiac or to prevent overpopulation. (wikipedia.org)