• When these T lymphocytes were pretreated with caspase inhibitors, DNA fragmentation (an indicator of apoptosis) was prevented. (wikipedia.org)
  • This suggests that apoptosis that is triggered by zinc deficiency is dependent on caspase proteins. (wikipedia.org)
  • One study examined the requirement for p53, a tumor suppressor protein, as an upstream transcription factor in TPEN-induced neuronal apoptosis, and found that depletion of intracellular zinc with TPEN induces apoptosis. (wikipedia.org)
  • These results suggest that the p53 tumor suppressor protein may play a role in regulating TPEN-induced neuronal apoptosis. (wikipedia.org)
  • The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. (thermofisher.com)
  • Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. (thermofisher.com)
  • Noxa and PUMA may represent direct mediators of p53-induced apoptosis. (thermofisher.com)
  • During cryopreservation apoptosis is induced by activation of both caspase-8 through the extrinsic pathway and caspase-9 through the intrinsic pathway. (ox.ac.uk)
  • In addition, cell cycle distribution analysis revealed that G0/G1 phase arrest was induced following pristimerin treatment in CAL‑27 and SCC‑25 cells, which was strongly associated with upregulation of p21 and p27, coupled with downregulation of cyclin D1 and cyclin E. Meanwhile, pristimerin induced significant apoptosis of CAL‑27 and SCC‑25 cells, alongside decreased levels of caspase‑3 and specific cleavage of poly (ADP‑ribose) polymerase. (spandidos-publications.com)
  • Caspase-9 is an enzyme whose function ultimately leads to cell degradation and apoptosis. (papersowl.com)
  • Diminution of p53 by RNA interference induced necrosis instead of apoptosis in A549 cells following terpinen-4-ol treatment, indicating that terpinen-4-ol-elicited apoptosis is p53-dependent. (hindawi.com)
  • Recent reports have indicated that terpinen-4-ol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanoma cell lines without affecting normal cells [ 14 , 15 ]. (hindawi.com)
  • Our results indicated that terpinen-4-ol induced apoptosis through a mitochondria-mediated pathway in NSCLC cells and that the apoptosis elicited by terpinen-4-ol was p53 dependent. (hindawi.com)
  • Chloroquine treatment enhanced markers of both macroautophagy and apoptosis in MEFs but ultimately impaired lysosomal protein degradation. (jci.org)
  • Interestingly, chloroquine-induced cell death was not dependent on caspase-mediated apoptosis, as neither overexpression of the antiapoptotic protein Bcl-2 nor deletion of the proapoptotic Bax and Bak affected chloroquine-induced MEF death. (jci.org)
  • Thus chloroquine induces lysosomal stress and provokes a p53-dependent cell death that does not require caspase-mediated apoptosis. (jci.org)
  • Kevetrin induces transcription-independent p53 mediated apoptosis. (shu.edu)
  • Stable monoubiquitinated form of wild type p53, accumulates in the cytoplasm and interacts with BAK or BAX proteins in mitochondria to induce apoptosis Thus Kevetrin activates both transcription dependent and transcription independent pathways to promote apoptosis. (shu.edu)
  • Mechanism of action studies showed that Kevetrin strongly induced apoptosis by activation of Caspase 3 and cleavage of PARP. (shu.edu)
  • Stabilized wild type p53 induced apoptosis by inducing the expression of PUMA. (shu.edu)
  • Forkhead box protein O1 (FoXO1) is a transcription factor involved in the regulation of a wide variety of physiological process including glucose metabolism, lipogenesis, bone mass, apoptosis, and autophagy. (scienceopen.com)
  • Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9. (scienceopen.com)
  • By restraining mammalian forkhead proteins, SIRT1 also reduces forkhead-dependent apoptosis. (scienceopen.com)
  • The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
  • The purpose of the current study was to determine if inhibition of protein synthesis caused by silvestrol triggers autophagy and apoptosis in cultured human cancer cells derived from solid tumors. (biomedcentral.com)
  • Silvestrol potently inhibits cell growth and induces cell death in human melanoma cells through induction of early autophagy and caspase-mediated apoptosis. (biomedcentral.com)
  • During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. (novusbio.com)
  • The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. (elabscience.com)
  • Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. (mdpi.com)
  • Apoptosis regulatory proteins are delicately balanced. (bmj.com)
  • The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
  • 13. Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells. (whocc.org.cn)
  • Evasion from apoptosis can occur from your dysregulation of particular tumor suppressors and success signals, adding to a reduction in level of sensitivity to chemotherapeutic brokers (7, 8). (bioskinrevive.com)
  • Like a grasp regulator of cell routine progression, DNA restoration, and apoptosis, the tumor suppressor p53 takes Cilomilast (SB-207499) manufacture on a central part in this technique (9C11). (bioskinrevive.com)
  • The next launch Cilomilast (SB-207499) manufacture of pro-apoptotic elements including SMAC (second mitochondria-derived activator of caspases) and cytochrome takes on a major part in caspase-dependent apoptosis (13, 14). (bioskinrevive.com)
  • XIAP (X-linked inhibitor of Cilomilast (SB-207499) manufacture apoptosis proteins), another determinant of chemoresistance in OVCA (7), blocks apoptosis signaling in its last levels by inhibiting caspases that could otherwise be turned on through the activities of pro-apoptotic mediators like NOXA. (bioskinrevive.com)
  • Additionally, the same study found that TPEN increased the expression of pro-apoptotic genes and led to the activation of caspase-11, a mammalian protease. (wikipedia.org)
  • MDM2 is one of the genes regulated by transcription which p53 regulates. (papersowl.com)
  • Our data show that the stable knockdown of HIPK2 led to wtp53 misfolding, as detected by p53 immunoprecipitation with conformation-specific antibodies, and that p53 protein misfolding impaired p53 DNA binding and transcription of target genes. (aacrjournals.org)
  • We present evidence that zinc supplementation to HIPK2i cells increased p53 reactivity to conformation-sensitive PAb1620 (wild-type conformation) antibody and restored p53 sequence-specific DNA binding in vivo and transcription of target genes in response to Adriamycin treatment. (aacrjournals.org)
  • In addition, Kevetrin increased expression of p53 target genes such as p21 (Waf1), an inhibitor of cell cycle progression. (shu.edu)
  • Discoveries have shown that melanoma frequently harbors mutations that attenuate tumor suppressor genes such as p53 and PTEN, leading to cell cycle dysregulation. (biomedcentral.com)
  • After irradiation, the expression of DDR-related genes and proteins in ΔNp63α-expressing and control cells was analysed by RT-qPCR, Western blotting, and flow cytometry. (researchsquare.com)
  • In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
  • Wild-type ES cells and ES cells deficient for the tumor suppressor p53 were exposed to pulse modulated EMF at 1.71 GHz, lower end of the uplink band of GSM 1800, under standardized and controlled conditions, and transcripts of regulatory genes were analyzed during in vitro differentiation. (drchrisbarnes.co.uk)
  • Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. (thermofisher.com)
  • Proliferating cell nuclear antigen and anti-apoptotic Bcl-2 were markedly increased in mammary carcinoma-induced rats, whereas the SM treatment significantly decreased the expression of these proteins. (greenmedinfo.com)
  • Increased sub-G1 population and annexin-V binding, activation of caspases 9 and 3, cleavage of poly(ADPribose) polymerase (PARP), and a decrease of mitochondrial membrane potential (MMP) indicated involvement of the mitochondrial apoptotic pathway in terpinen-4-ol-treated A549 and CL1-0 cells. (hindawi.com)
  • Next, the therapeutic efficiencies of Dox and/or chi-p53 in microsphere formulations were compared to free drug(s) and evaluated in terms of growth inhibition, and cellular expression of tumor suppressor p53 and apoptotic caspase 3 proteins. (uky.edu)
  • Silvestrol induced caspase-3 activation and apoptotic cell death in a time- and dose-dependent manner. (biomedcentral.com)
  • Low ATP concentrations in hypoxic tumour cells disable the apoptotic cascade and induce cell death by necrosis. (bmj.com)
  • Caspases, a class of cysteine proteases, are central players in the apoptotic process that trigger a cascade of proteolytic cleavage events [ 14 ]. (biomedcentral.com)
  • After nuclear activation, p53 up-regulates multiple pro-apoptotic elements including NOXA, which localizes towards the mitochondria and interacts with anti-apoptotic Bcl-2 family (12). (bioskinrevive.com)
  • Our results reveal that piceatannol enhances the apoptotic actions of CDDP in OVCA through nuclear activation and stabilization of p53, proteasome-dependent XIAP down-regulation, as well as the improvement of Drp1-reliant mitochondrial fission. (bioskinrevive.com)
  • A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. (thermofisher.com)
  • Increased levels of p53 and its target gene Noxa was found in the impaired tumor development. (thermofisher.com)
  • About half of cancers sustain mutations in the TP53 gene, whereas the other half maintain a wild-type p53 (wtp53) but may compromise the p53 response because of other alterations. (aacrjournals.org)
  • Here, double-walled microspheres were used to deliver doxorubicin (Dox) and/or chitosan-DNA nanoparticles containing the gene encoding the p53 tumor suppressor protein (chi-p53), loaded in the core and shell phases, respectively. (uky.edu)
  • Expression of p63 is almost exclusively restricted to epithelial cells, mutations in this gene are infrequent, and its expression is increased in a variety of solid tumors, particularly those of the head and neck area 12,13 . (bvsalud.org)
  • The retinoblastoma gene product (Rb) is a tumor suppressor protein and acts as cell cycle regulator. (novusbio.com)
  • TP63 is a member of the tumour suppressor TP53 gene family, and ΔNp63α, a TP63 splicing variant, is constitutively expressed in the stem cell-containing basal layer of stratified epithelial tissues, including the mammary gland, where it plays a critical role in stemness and tissue development. (researchsquare.com)
  • p53, a tumor suppressor gene, helps regulate the cell cycle. (biomedcentral.com)
  • This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • By considering RF interactions with the p53 system and mutations of the system for specific cancers, the conclusion is reached that Radio frequency exposure may cause serious problems for a subset of the community with genetic deficiencies in the p53 tumour suppressor gene. (drchrisbarnes.co.uk)
  • Thus of particular interest is p53, the tumour suppression gene. (drchrisbarnes.co.uk)
  • Additional analysis on piceatannol provides revealed its excellent and powerful bioactive properties, including inhibitory results on platelet-derived development factor-BB (22), changed gene expression leading to the hold off of adipogenesis, and cell routine inhibition in colorectal tumor cells (23, 24). (bioskinrevive.com)
  • These effects were associated with inhibition of the mitogen‑activated protein kinase/extracellular signal‑regulated kinase 1/2 and protein kinase B signaling pathways. (spandidos-publications.com)
  • The underlying mechanisms of these effects were primarily mediated by G 1 phase cell cycle arrest and inhibition of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulate kinase 1/2 (Erk 1/2) and protein kinase B (Akt) signaling pathways. (spandidos-publications.com)
  • Homeodomain-interacting protein kinase-2 (HIPK2) is a positive regulator of p53 oncosuppressor function. (aacrjournals.org)
  • Compaction, via activation of Rho-associated kinase (ROCK) and the stress kinase p38, leads to further p53 elevation, causing cell death. (nature.com)
  • Specifically, we show that scrib KD cells' compaction causes activation of the Rho-associated kinase (ROCK), which in turn activates p38 leading to further p53 elevation and cell death. (nature.com)
  • The morphological transition requires the RhoA-ROCK (Rho-associated coil-containing protein kinase) pathway and is prevented by RhoE. (rupress.org)
  • PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
  • Increased p53 levels result also increased of MDM2 transcription rate, followed by this, it results the degradation of the p53 protein, forming an autoregulatory circuit in cells. (papersowl.com)
  • The elevated expression of p53 leads to greater stability, which also induces the regulatory protein Mdm2. (shu.edu)
  • Mdm2 is a proto-oncogene that is amplified in approximately 7% of cancers and is frequently seen in soft tissue tumors. (shu.edu)
  • The combination of a p53 mutation with overexpression of Mdm2 results in a worse prognosis for a patient, as compared to a patient with only the mutation or the overexpression. (shu.edu)
  • Mdm2 protein has the activity of an ubiquitin ligase, which allows for the targeted degradation of its substrates, including p53. (shu.edu)
  • In addition to marking p53 for degradation, Mdm2 also binds to p53 and transports it out of the nucleus into the cytoplasm for degradation. (shu.edu)
  • When stress or DNA damage occurs in the body and the phosphorylation of p53 occurs on multiple sites, Mdm2 does not associate with p53. (shu.edu)
  • Researchers have recently discovered Mdm2 in human tumors and these scientists hypothesize that Mdm2 plays a role in tumorigenesis, with or without p53. (shu.edu)
  • The relationship between p53 and Mdm2 has been shown to be vital to the normal functioning of the human cell, and also has other implications in cancer. (shu.edu)
  • The complexity of the p53-Mdm2 link illustrates the importance of this signaling pathway and indicates it is a viable therapeutic target. (shu.edu)
  • Kevetrin induced phosphorylation of p53 at Ser15 leading to a reduced interaction between p53 and MDM2, an ubiquitin ligase for p53 that plays a central role in p53 stability. (shu.edu)
  • Mouse monoclonal p53 antibodies (Perform-1), MDM2, and PARP had been from Santa Cruz Biotechnology (Santa Cruz, CA). Rabbit monoclonal anti-Ser(P)15-p53, anti-poly(ADP-ribose) polymerase (PARP) antibodies and siRNA constructs had been from Cell Signaling Technology (Beverly, CA). Rabbit polyclonal anti-NOXA and anti-XIAP antibodies, aswell as mouse monoclonal anti-GAPDH and anti-caspase-3 antibodies had been from Abcam (Cambridge, MA). (bioskinrevive.com)
  • Rather, p53 accumulation by either knockdown of Mdm2 or addition of an Mdm2 inhibitor, Nutlin-3, before irradiation strongly attenuated the UV-induced DDR and increased cell survival. (rupress.org)
  • The mechanism underlying ASS1-mediated tumor suppression was investigated in HCC spheroids. (biomedcentral.com)
  • ΔNp63α has been reported to transcriptionally inhibit the tumour suppression protein p53. (researchsquare.com)
  • X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. (thermofisher.com)
  • Our study shows that SM-treated mammary carcinoma rats showed regression in tumor volume with concomitant increase in p(53), Bax, caspase-3, and caspase-9 mRNA and protein levels compared with mammary carcinoma-induced rats. (greenmedinfo.com)
  • The mRNA/protein expression levels of BAX and p21 were significantly increased in p63-siRNA-treated HMECs (sip63) after X-ray irradiation (4 Gy, 0.7 Gy/min) but not in scramble-siRNA treated HMECs (scr). (researchsquare.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
  • The inhibition of forkhead activity by SIRT1 parallels the effect of this deacetylase on the tumor suppressor p53. (scienceopen.com)
  • We studied whether cellular senescence induced by HDAC inhibitor sodium butyrate in E1a+cHa-Ras -transformed rat embryo fibroblasts (ERas) and A549 human Ki-Ras mutated lung adenocarcinoma cells would enhance the tumor suppressor effect of MEK/ERK inhibition. (aging-us.com)
  • The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)
  • PARP-1 cleavage by various suicidal proteases like caspases, calpain, cathepsins and granzymes liberates fragments with specific molecular weights and are shown in this schematic representation. (shu.edu)
  • Importantly, 21-kD and 55-kD PARP-1 fragments generated by caspase 3/7 and Gra-A respectively function as an inhibitor of PARP-1 activity and might also play important roles in reducing necrosis and/or parthanatos. (shu.edu)
  • Other markers, such as retinoblastoma and p53, may be related with early steps of carcinogenesis in oral cavity squamous cell carcinoma. (bvsalud.org)
  • Immunohistochemistry: cleaved Retinoblastoma 1 Antibody (172C1094) [NB100-56598] - Analysis in sections of primary human breast tumors. (novusbio.com)
  • Here we show that chloroquine, a drug that activates the stress-responsive Atm-p53 tumor-suppressor pathway, preferentially enhances the death of Myc oncogene-overexpressing primary mouse B cells and mouse embryonic fibroblasts (MEFs) and impairs Myc-induced lymphomagenesis in a transgenic mouse model of human Burkitt lymphoma. (jci.org)
  • In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
  • Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
  • Here, we found that bidirectional interactions between ASS1 ER stress responses in HCC-derived multicellular tumor spheroids can limit HCC progression. (biomedcentral.com)
  • In addition to its role in controlling cell cycle progression, the tumor suppressor protein p53 can also affect other cellular functions such as cell migration. (rupress.org)
  • Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
  • Furthermore, treatment of s.c xenografts derived from A549 cells with intratumor injections of terpinen-4-ol significantly inhibited tumor growth compared with the control group. (hindawi.com)
  • ASS1 overexpression effectively inhibited tumor growth and enhanced the efficacy of in vitro and in vivo anti-HCC combination chemotherapy via activation of the PERK/eIF2α/ATF4/CHOP axis, but was not dependent on the status of p53 and arginine metabolism. (biomedcentral.com)
  • Although reactive oxygen species are needed for some functions (such as secondary signaling), they are unstable and are commonly known to cause damage to DNA, lipids, and proteins when at high levels. (wikipedia.org)
  • The level of reactive oxygen species (ROS) is significantly increased, F-actin content and distribution is altered, and caspase-8 and caspase-9 are activated after cryopreservation. (ox.ac.uk)
  • Many cellular proteins are reversibly modified by O-linked N-acetylglucosamine (O-GlcNAc) moieties on Ser and Thr residues. (scienceopen.com)
  • Tight control of protein synthesis is essential for normal cellular function and survival, but unrestrained protein synthesis can promote tumorigenesis. (biomedcentral.com)
  • The tumor microenvironment (TME) has important physiological roles in cellular differentiation, tumorigenesis, metastasis, and therapeutic efficacy. (biomedcentral.com)
  • ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
  • In addition, numerous monoterpenes have been proposed to exert potent antitumor action, and some have shown promising results in the prevention and treatment of a variety of cancers in tumor model systems [ 5 , 6 ]. (hindawi.com)
  • Therefore, silvestrol's ability to block protein synthesis is of significant interest in potentially treating cancers. (biomedcentral.com)
  • Many tumors, including HCC, malignant melanoma, malignant pleural mesothelioma, and prostate and renal cancers, are arginine auxotrophic due to their variable loss of argininosuccinate synthase 1 (ASS1), which is severely reduced or absent in numerous types of aggressive and chemoresistant cancers. (biomedcentral.com)
  • Silvestrol-mediated cell death was attenuated in ATG7-null mouse embryonic fibroblasts (MEFs) lacking a functional autophagy protein. (biomedcentral.com)
  • In this study, we show that p53 deficiency in mouse embryonic fibroblasts cultured in three-dimensional matrices induces a switch from an elongated spindle morphology to a markedly spherical and flexible one associated with highly dynamic membrane blebs. (rupress.org)
  • Design Glutathione peroxidase 4 (GPx4), which is considered the master regulator of ferroptosis, was genetically altered in murine models for hepatocellular carcinoma (HCC) and colorectal cancer (CRC) to analyse the effect of ferroptosis on tumour cells and the immune tumour microenvironment. (bmj.com)
  • The eyes are highly susceptible to UV light, making them a prime target for free radical oxidation of both lipids and proteins, causing cell damage and eventually, cell death. (papersowl.com)
  • Chloroquine-induced cell death in primary MEFs and human colorectal cancer cells was dependent upon p53, but not upon the p53 modulators Atm or Arf. (jci.org)
  • Instead, GPx4-associated ferroptotic hepatocyte death causes a tumour suppressive immune response characterised by a CXCL10-dependent infiltration of cytotoxic CD8 + T cells that is counterbalanced by PD-L1 upregulation on tumour cells as well as by a marked HMGB1-mediated myeloid derived suppressor cell (MDSC) infiltration. (bmj.com)
  • Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)
  • An essay on protein might delve into its structure, types, and functions in cells, or discuss its importance in various biological processes like muscle contraction, immune responses, and enzymatic reactions. (papersowl.com)
  • Notably, terpinen-4-ol was able to increase p53 levels in A549 and CL1-0 cells. (hindawi.com)
  • This can provide Ras-expressing tumor cells additional selective advantages under stress or damage. (aging-us.com)
  • Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
  • These results demonstrate the critical functional roles for the arginine metabolism-independent tumor suppressor activity of ASS1 in HCC and suggest that upregulating ASS1 in these tumors is a potential strategy in HCC cells with low ASS1 expression. (biomedcentral.com)
  • This p53-repressive activity may cause genomic instability in epithelial stem cells exposed to radiation. (researchsquare.com)
  • To elucidate the role of the p53-repressive effect of ΔNp63α in radiation response, we performed a p63-siRNA knockdown experiment using human mammary epithelial cells (HMECs) expressing ΔNp63α and then performed ectopic and entopic expression experiments using human induced pluripotent stem cells (hiPSCs). (researchsquare.com)
  • Taken together, these results indicate that ΔNp63α represses p53-related radiation-induced DDR, thereby potentially causing genomic instability in epithelial stem cells. (researchsquare.com)
  • The DNA guardian protein p53 plays the most important role in DDR: it promotes DNA repair and the elimination of cells that are unable to repair the damage caused by oxidative stresses, including radiation. (researchsquare.com)
  • Given the involvement of p53, compaction hypersensitivity may be widespread among damaged cells and offers an additional route to eliminate unfit cells. (nature.com)
  • We find that scrib KD cells are hypersensitive to compaction and that this is due to elevation of baseline p53 levels, which is both necessary and sufficient to induce hypersensitivity to crowding and confer a mechanical loser status. (nature.com)
  • Overall, this work demonstrates that mechanical forces can be responsible for the elimination of cells during cell competition and that p53 levels play a key role both in instructing the mechanical loser status and in the execution of mechanical cell competition. (nature.com)
  • Possible mechanisms for overcoming the resistance of HPV-infected tumor cells to anticancer drugs will be discussed. (mdpi.com)
  • A similar p53-mediated transition is observed in melanoma A375P cancer cells. (rupress.org)
  • Moreover, tumor cells show an increased capacity to migrate. (rupress.org)
  • Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
  • Though it has been proven to inhibit ovarian tumor development in mouse xenograft versions also to sensitize tumor cells to CDDP and doxorubicin (19), latest studies have got shed doubts for the scientific electricity of resveratrol for the avoidance and treatment of individual malignancies (20). (bioskinrevive.com)
  • Nevertheless, the consequences of piceatannol kanadaptin on CDDP awareness in tumor cells hasn't previously been looked into. (bioskinrevive.com)
  • A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen. (novusbio.com)
  • Autophagy represents a caspase-independent process characterized by accumulation of autophagosomes in the cytoplasm and their subsequent fusion with lysosomes for degradation of unused or misfolded proteins or damaged structures such as ribosomes (ribophagy) and mitochondria (mitophagy). (aging-us.com)
  • This leads to the activation of caspases-3, -8, and -9. (wikipedia.org)
  • Moreover, increased activation of caspase 3 was observed, and was likely to have been facilitated by high levels of p53 expression. (uky.edu)
  • Melanoma also frequently exhibits enhanced activation of receptor tyrosine kinases like epidermal growth factor receptor (EGFR) and MET, as well as BRAF and small G proteins such as Ras [ 2 ]. (biomedcentral.com)
  • This protective effect of preaccumulated p53 was mediated, at least in part, by the increased expression of CDKN1A/p21, subsequent down-regulation of BRCA1, and impaired JNK activation accompanied by decreased association of replication protein A with chromatin. (rupress.org)
  • We conclude that Tip60 enables UV-induced DDR signaling even in the absence of p53, whereas preaccumulated p53 suppresses UV-induced DDR by reducing the levels of BRCA1. (rupress.org)
  • Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. (bmj.com)
  • High levels of inflammatory mediators, particularly interleukin IL-1, IL-6, IL-18, IL-12, and tumor necrosis factor alpha leads to a cytokine storm in the body. (bvsalud.org)
  • Studies of tumor tissue from Korean HCC patients showed that, although ASS1 expression was low in most samples, high levels of ASS1 were associated with favorable overall survival of patients. (biomedcentral.com)
  • Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample. (rndsystems.com)
  • Level of resistance to cisplatin (CDDP) in ovarian tumor (OVCA) comes from the dysregulation of tumor suppressors and success signals. (bioskinrevive.com)
  • Analysis of ischemic wound tissue extracts demonstrated significantly reduced expression of HIF-1alpha, p53, and BNip3. (nih.gov)
  • Several types of tumors have aberrant arginine-metabolic enzymes and rely completely on extracellular arginine to support necessary biological processes, a requirement known as arginine auxotrophy. (biomedcentral.com)
  • A previously suggested mechanism for this regulation consists of the ability of Tip60 to coactivate transcription by the tumor suppressor p53. (rupress.org)
  • Elevation of the Bax/Bcl-2 ratio and a decrease in IAP family proteins XIAP and survivin were also observed following terpinen-4-ol treatment. (hindawi.com)
  • these results demonstrate the program of piceatannol to improve CDDP awareness in OVCA, and it works on p53, XIAP, and mitochondrial fission. (bioskinrevive.com)
  • Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. (elabscience.com)
  • By two-dimensional gel electrophoretic analysis of synaptosomal fractions from transgenic mouse brains we detected additional isoforms of septin 6, a downstream target of Cdc42 effector proteins. (proteasomesignaling.com)
  • Accordingly, chloroquine impaired spontaneous lymphoma development in Atm-deficient mice, a mouse model of ataxia telangiectasia, but not in p53-deficient mice. (jci.org)
  • DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005). (novusbio.com)
  • Unintelligent simple chemicals can't self-organize into instructions for building solar farms (photosystems 1 and 2), hydroelectric dams (ATP synthase), propulsion (motor proteins), self-repair (p53 tumor suppressor proteins) or self-destruct (caspases) in the event that these instructions become too damaged by the way the universe USUALLY operates. (catsboard.com)
  • A critical event during tumorigenesis is the conversion from a static primary tumor to an invasive, disseminating metastasis. (rupress.org)
  • The p63 protein, a homologue of p53, may be associated with tumor formation in the epithelial tissue, acting as an oncogene 11,12 . (bvsalud.org)
  • Therefore, autophagy is currently considered as a promising target for anticancer therapy that can also be successful in mutant Ras-expressing tumors characterized by chemotherapy resistance due to the protective autophagy. (aging-us.com)
  • p53 is also activated and translocated into nucleus. (ox.ac.uk)
  • AIM: To evaluate and compare the effect of combined transarterial chemoembolization (TACE) and arterial administration of Bletilla striata (a Chinese traditional medicine against liver tumor) versus TACE alone for the treatment of hepatocellular carcinoma (HCC) in ACI rats. (uni-frankfurt.de)
  • Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
  • Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
  • FoXO1 dysfunction is involved in the pathophysiology of various diseases including metabolic diseases, atherosclerosis, and tumors. (scienceopen.com)