• reperfusion
  • Variable degrees and durations of low-flow ischemia were followed by 30 minutes of reperfusion in an open-chest porcine model of regional myocardial stunning (n=27). (ahajournals.org)
  • 6 7 Although the etiology of stunning is not fully understood, considerable evidence suggests that the formation of oxygen-derived free radicals and elevated cytosolic Ca 2+ during ischemia and early reperfusion contributes to the development of stunning. (ahajournals.org)
  • 14 A subsequent study using the same model showed that Ca 2+ sensitivity of tension is unchanged during ischemia and that the decrease in Ca 2+ sensitivity occurs during reperfusion. (ahajournals.org)
  • 15 Taken together, these results demonstrate that Ca 2+ sensitivity of myocardial tension is reduced after reperfusion, and this may account for the depressed contractile function associated with stunning. (ahajournals.org)
  • occurs
  • Individuals with cocaine overdose should be transported immediately to the nearest emergency department, preferably by ambulance in case cardiac arrest occurs en route. (wikipedia.org)
  • Myocardial stunning is a form of reversible contractile dysfunction that occurs after brief periods of ischemia. (ahajournals.org)
  • demonstrate
  • We demonstrate our algorithm's ability in an example programming case that targets the subthalamic nucleus (STN) for the treatment of Parkinson's disease for three lead designs: the Medtronic 3389 (four cylindrical contacts), the direct STNAcute (two cylindrical contacts, six directional contacts), and the Medtronic-Sapiens lead (40 directional contacts). (utah.edu)
  • percutaneous
  • Following a surgical consultation, her LAD myocardial bridge was deemed not amenable to surgical or percutaneous revascularization, and resumption of medical management with calcium channel blockers was recommended. (massgeneral.org)
  • sensitivity
  • For early detection of myocardial necrosis , sensitivity of this laboratory test is superior to that of the creatine kinase-MB (CK-MB). (factbites.com)
  • We conclude that the basis of stunning involves decreased cycling rates of myofibrillar cross-bridges and, after more severe ischemia, a reduction in myofilament Ca 2+ sensitivity. (ahajournals.org)
  • Ca 2+ sensitivity of isometric tension and the rate of cross-bridge cycling were assessed, since a reduction in either of these properties would likely decrease both tension and the amount of muscle shortening during an individual heartbeat. (ahajournals.org)
  • severe
  • We present two cases of Marines with severe traumatic blast injuries secondary to improvised explosive device attacks whose hospital courses included amputation, massive blood transfusions, and multiple surgeries. (biomedsearch.com)
  • diagnosis
  • Although very unusual we feel this case highlights an important differential in the diagnosis of anterolateral MI and images similar to those presented here are previously unreported in the literature. (biomedsearch.com)
  • Myocardial bridges: Overview of diagnosis and management. (stanford.edu)
  • reduction
  • It is now known that hydrogen sulfide has cardioprotective effects in cases of ischemia related to its effects as an endogenous messenger molecule, primarily via its reduction of the rate of cellular metabolism. (wikipedia.org)
  • common
  • Deep MB ≥2mm was present in 25 out of 120 hearts (21%), and significantly more common in SD (21/82, 26%) than non-SD cases (4/38, 10%) (p=0.03). (ahajournals.org)
  • injury
  • Now, the markers most widely used in detection of MI are MB subtype of the enzyme creatine kinase and cardiac troponins T and I as they are more specific for myocardial injury. (wikipedia.org)