Cases autoimmune panniculitis lupus erythematosus. Medical search. Frequent questions

The aim of this study is to determine systemic uncommon non-classical manifestations of FMF and reveal the possible association with autoimmune diseases. (biomedcentral.com)
Skin involvement also was observed during the observation: 4(8%) of them developed erythema similar "butterfly" rash, livedo reticularis and photosensitivity with high titer of circulating immune complexes, ANA and anti-dsDNA antibodies like systemic lupus erythematosus, 1 patient had hemorrhagic rash on legs with developing of hemorrhagic vasculitis. (biomedcentral.com)
FMF may have systemic manifestations of autoimmune diseases. (biomedcentral.com)
The most common form of lupus is known as systemic lupus erythematosus (SLE). (healthline.com)
Overview of Systemic Lupus. (merckmanuals.com)
Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (merckmanuals.com)
Systemic lupus erythematosus (SLE) is more common and severe among Black and Asian patients than among White patients. (merckmanuals.com)
Rheumatoid Arthritis (RA) Rheumatoid arthritis is a chronic systemic autoimmune disease that primarily involves the joints. (merckmanuals.com)
Cutaneous lupus erythematosus (CLE) is an interferon (IFN)-driven autoimmune disease that may be limited to the skin or can be associated with systemic lupus erythematosus (SLE). (frontiersin.org)
Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune skin disease that can occur isolated to the skin or with additional systemic manifestation in several organs [systemic lupus erythematosus (SLE)] ( 1 ). (frontiersin.org)
What is Systemic Erythematosus? (famousskincarefordogs.com)
Systemic lupus erythematosus commonly known as SLE is a rare autoimmune mediated disease which is seen in dogs. (famousskincarefordogs.com)
Mild cases of RP are usually treated with non-steroidal anti-inflammatory drugs (NSAIDs) or low doses of systemic corticosteroids. (medscape.com)
Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
Discoid rash is one of the 11 diagnostic criteria for systemic lupus erythematosus (SLE), and 20% of patients with SLE will manifest discoid lesions. (logicalimages.com)
Systemic lupus erythematosus (SLE) is a complex connective tissue disorder that involves multiple organs. (bmj.com)
The center focuses on rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus and Sjögren's syndrome, and has researched and developed more than 20 new specific markers and immune techniques in diagnosis, such as antibodies to the citrullinated HPVP, antibodies to citrullinated fibrinogen peptide, anti-mDNA, anti-nucleosome, anti- M3 receptor and anti-α-fodrin antibodies. (bdfs.org.cn)
Recently, we have implemented and successfully applied a method based on genotype imputation of rare variation, on a set of genes detected by exome sequencing as possible candidates for association to systemic lupus erythematosus (SLE) by mutation in members of Icelandic SLE-multicase families ( 15 ). (frontiersin.org)
Effective and safe treatment of anti-CD38 therapy in systemic lupus erythematosus-associated refractory cerebral vasculitis induces immune tolerance. (uk-erlangen.de)
Treatment of refractory hypocomplementaemic urticarial vasculitis syndrome progressing to systemic lupus erythematosus with belimumab. (uk-erlangen.de)
Effects of casirivimab/imdevimab on systemic and mucosal immunity against SARS-CoV-2 in B-cell depleted patients with autoimmune rheumatic diseases refractory to vaccination. (uk-erlangen.de)
Neutralizing monoclonal antibodies against SARS-CoV-2 for COVID-19 pneumonia in a rituximab treated patient with systemic sclerosis-A case report and literature review. (uk-erlangen.de)
Lupus erythematosus, discoid LE, systemic LE. (cyberderm.net)
F:M = 3:1, in systemic lupus erythematosus 8:1. (cyberderm.net)
Depends on systemic involvement (CNS lupus, lupus nephritis). (cyberderm.net)
The diagnosis can be difficult, particularly in the early stages, because many of the symptoms are very common and require differentiation with other diseases, especially connective tissue, such as systemic lupus erythematosus. (epainassist.com)
Cutaneous lupus erythematosus (CLE) comprises multiple dermatological disorders, which may be skin-limited or found in association with underlying systemic lupus erythematosus (SLE). (cdc.gov)
This post discusses Systemic lupus erythematosus (SLE) and Social Security Disability . (disabilitylawfirmnc.com)
The Social Security Administration evaluates Lupus under Listing 14.02 Systemic lupus erythematosus . (disabilitylawfirmnc.com)

CLE can be classified based on clinical and histopathologic findings: typical morphological subsets are acute cutaneous (ACLE), subacute cutaneous (SCLE), intermittent cutaneous [ICLE, also termed lupus erythematosus tumidus (LET)], and chronic cutaneous (CCLE) lupus erythematosus ( 2 , 3 ). (frontiersin.org)
Discoid lupus erythematosus (DLE) is a disfiguring autoimmune skin disease and the most common form of chronic cutaneous lupus erythematosus. (logicalimages.com)
This syndrome has been described in patients with DLE, subacute cutaneous lupus erythematosus (SCLE), and SLE. (logicalimages.com)
Treatment of underlying disease - Suppression of activity of the associated autoimmune disease is suggested based upon the theory that autoimmune disease-related tissue injury contributes to risk for cutaneous calcification ( algorithm 1 ) [ 2 ]. (medilib.ir)
Relative to SLE, epidemiologic studies on chronic cutaneous lupus erythematosus (CCLE) are rare and limited to populations without racial diversity. (cdc.gov)

However, B cells are increasingly considered to have additional functions, supported by studies finding them to occur in highest numbers in chronic discoid lupus erythematosus (CDLE), a subtype in which autoantibodies are often absent. (frontiersin.org)
CCLE can be further subdivided into chronic discoid lupus erythematosus (CDLE), lupus erythematosus profundus (LEP) and chilblain lupus erythematosus (ChLE), of which CDLE represents the most frequent CCLE subtype ( 4 ). (frontiersin.org)
In discoid lupus erythematosus persistent several mm to cm sharply bordered, sometimes confluent, and painful lesions with triad of erythema, follicular keratotic plugs, and atrophy (each of which can dominate clinical picture). (cyberderm.net)
Age-standardized incidence rates stratified by sex and race were calculated for discoid lupus erythematosus (DLE) in particular and for CCLE in general. (cdc.gov)
CCLE comprises discoid lupus erythematosus (DLE), lupus erythematosus profundus (LEP), lupus erythematous tumidus (LET) and chilblain lupus erythematosus (CHLE). (cdc.gov)

The most common conditions associated with facial lipoatrophy are antiretroviral therapy for HIV infection and connective tissue disorders that are associated with panniculitis such as lupus lupus erythematosus profundus and localized scleroderma also known as morphea [ 4 ]. (biomedcentral.com)
CCLE: Epidermal atrophy, hyperkeratosis (primarily follicular), vacuolar degeneration of basal keratinocytes, thickened basement membrane zone (PAS stain), edema, dense lymphocytic perivascular and periadnexal infiltrate at all levels, and, including subcutaneous fat in lupus profundus. (cyberderm.net)

It includes lipophagic granulomatous panniculitis and other types of panniculitis, primarily associated with connective-tissue disease. (medscape.com)
Individuals of African and Hispanic descent are at increased risk, and there may be a positive family history of lupus or connective tissue disease. (logicalimages.com)
Treatment principles - The treatment of dystrophic calcinosis cutis associated with autoimmune connective tissue disease is often difficult. (medilib.ir)
Is the underlying autoimmune connective tissue disease adequately treated? (medilib.ir)

CONCLUSION: The presence of ghost adipocytes is a rather unique histopathological feature consistent with pancreatic panniculitis and should be considered in combination with the overall clinical picture to determine the underlying etiology. (bvsalud.org)
The present study aimed to report all the cases of children admitted to our tertiary pediatric hospital with the diagnosis of EN to evaluate the epidemiology, clinical manifestations, etiology, treatment, and the course of this disease in the pediatric age. (bvsalud.org)
The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)

In 2011, however, all cases of both disorders were found to be caused by inactivating mutations in the GATA2 gene. (wikipedia.org)
Subsequently, some but not all cases of an expanding list of other well-defined disorders have been attributed to inactivating GATA2 mutations. (wikipedia.org)
Importantly, however, its treatment differs critically from that used to treat cases of these disorders which are not due to GATA2 deficiency. (wikipedia.org)
There are many possible causes including :* Post-injection * Trauma* Local impairment of blood supply (ischaemia)* Immune disorders* Bacterial or fungal infections - may be secondary invaders* Idiopathic - sterile panniculitis What Breeds does it commonly affect? (famousskincarefordogs.com)
SLE has a variety of signs of most often cases are presented because of lameness or skin disorders. (famousskincarefordogs.com)
Medical care must include assessment for and treatment of other confounding or concurrent autoimmune disorders. (medscape.com)
Wierzbicka et al reported good airway patency for more than 24 months in eight of 12 patients with relapsing polychondritis or other autoimmune disorders treated with this approach. (medscape.com)

In most cases, the age of onset and initial signs and symptoms are variable with each presentation often being accompanied by signs or symptoms more typical of other presentations. (wikipedia.org)
Nonetheless, most cases of the deficiency exhibit a combination of signs and symptoms that fit the following presentations. (wikipedia.org)
Many people living with lupus experience periods of time when symptoms are worse than usual, known as flares. (healthline.com)
Lupus can affect nearly any part of your body, so symptoms can be extremely varied from person to person - and even from flare to flare. (healthline.com)
Lupus is a chronic condition, but you may not experience symptoms constantly. (healthline.com)
When the disease is active and there are new or worsening symptoms, it's called a lupus flare. (healthline.com)
When lupus is active, it means that you're experiencing symptoms. (healthline.com)
Lupus symptoms can mimic the symptoms of other conditions and can be subtle enough that they're only detected on lab tests. (healthline.com)
If you have been in a period of remission and you notice your lupus symptoms returning, you may be experiencing the start of a flare. (healthline.com)
Symptoms you may experience as part of a lupus flare are the result of this damage and inflammation. (healthline.com)
Lupus is a very individualized condition, so your symptoms during flares may be very different from other people living with lupus. (healthline.com)
What can I do to manage my lupus symptoms? (healthline.com)
When lupus symptoms appear, your healthcare team is your first line of defense. (healthline.com)
This listing requires involvement of two or more body systems with at least one being involved to a moderate degree AND at least two of the common symptoms of lupus OR repeated manifestations of lupus in the form of symptoms AND marked restriction in a domain of your life. (disabilitylawfirmnc.com)
If your lupus is affecting your major organs or you are experiencing severe symptoms from your lupus that affect your ability to function from day-to-day, you may meet this listing. (disabilitylawfirmnc.com)

The autoimmune disease lupus erythematosus, which can attack various cells, organs, and tissues in the body, can also lead to koilonychia. (news-medical.net)
Chronic inflammatory autoimmune disease with marked immunogenetic component which involves the skin and/or other organs. (cyberderm.net)

Studies have shown that people with certain antibodies indicating active lupus, increased protein in the urine, and arthritis are more likely to have severe lupus flares. (healthline.com)
Polyclonal B-cell activation with autoantibody formation: direct pathogenic antibodies (autoimmune haemolytic anaemia), circulating immune complexes (vasculitis, nephritis), antibody-mediated cytotoxicity (skin lesions). (cyberderm.net)
Goodpasture syndrome is an autoimmune disorder characterized by pulmonary hemorrhage and rapidly progressive glomerulonephritis in association with antibodies to alveolar and glomerular basement membrane (GBM). (rheumaknowledgy.com)

ACLE is most commonly associated with SLE-in approximately 80% of cases-whereas localized CDLE only presents with SLE in about 5% of cases ( 5 , 6 ). (frontiersin.org)
In my clients with lupus, I have seen fatigue with simple activity, fevers, rashes or lesions (panniculitis) and commonly the body has attacked a major organ, such as the kidneys. (disabilitylawfirmnc.com)

The third type represents a sequela from various types of panniculitis and is associated with preceding inflammation. (medscape.com)
Panniculitis is inflammation of fat under the skin. (famousskincarefordogs.com)
Inflammation in lupus is caused by the formation of autoantibodies and immune complexes and can cause inflammatory responses and activate the complement system. (bmj.com)
Panniculitis is an aggravation of the fatty layer underneath the skin which occurs due to Crohn's disease (inflammation of the digestive system) or ulcerative colitis (inflammation of the colon and rectum). (news-medical.net)

Germline HAVCR2 mutations are frequently detected in subcutaneous panniculitis-like T-cell lymphoma (SPTCL) patients with/without hemophagocytic lymphohistiocytosis (HLH) but factors associated with variable manifestations remain undetermined. (bvsalud.org)
Common manifestations may include arthralgias and arthritis, Raynaud syndrome, malar and other rashes, pleuritis or pericarditis, renal or central nervous system involvement, and autoimmune cytopenias. (merckmanuals.com)
15 The key role of aberrant B cell autoreactivity in SLE was revealed in a landmark murine study using a knockout gene mutation to prevent lupus mice from developing B cells, which resulted in a lack of autoantibody formation and clinical manifestations (nephritis or vasculitis). (bmj.com)

Treatment of calcinosis - Treatment of calcinosis cutis associated with autoimmune connective tissue diseases involves careful consideration of the need for treatment and the selection of an appropriate treatment regimen. (medilib.ir)
Li Z, He J, Miao M. Low-dose interleukin-2 therapy in autoimmune and inflammatory diseases: facts and hopes. (bdfs.org.cn)

It may be due to vascular involvement especially in accompaning amyloidosis cases. (biomedcentral.com)

Six cases with HAVCR2Y82C mutation manifested with HLH without panniculitis. (bvsalud.org)

INTRODUCTION: Pancreatic panniculitis is a rare skin manifestation of pancreatic disease. (bvsalud.org)
Pancreatic panniculitis can be a primary presenting feature and possible complication of pancreatic disease. (bvsalud.org)
The etiologic diagnosis of EN was made in 38 children (55.9%): 29 (42.6%) had infection-related EN (in particular EBV and ß-hemolytic streptococcus), 6 (8.8%) had Crohn's disease, 1 celiac disease, 1 Sjogren syndrome, and 1 Hodgkin lymphoma. (bvsalud.org)
Since granulomatous mastitis (GM) was first described as a benign disease entity in 1972 by Kessler and Wolloch [ 1 ], hundreds of cases have been reported from all over the world. (karger.com)
type 1 autoimmune pancreatitis , interstitial nephritis , Riedel's thyroiditis , Mikulicz's disease , Küttner's tumor , inflammatory pseudotumors (in various sites of the body), mediastinal fibrosis and some cases of retroperitoneal fibrosis . (mdwiki.org)
Lupus is an autoimmune disease. (disabilitylawfirmnc.com)
Psoriatic arthritis is an autoimmune disease that attacks the joints. (100arthritis.com)

CASE REPORT: The authors present a case of a 68-year-old man who developed painful, erythematous wounds on his lower extremities that progressed to purple, edematous lesions with purulent drainage. (bvsalud.org)
In these cases, lesions appear before age 3 years, they stop spreading by age 8 years, and they tend to resolve by age 13 years. (medscape.com)
Lupus erythematosus (LE) skin lesions typically feature a histopathologic pattern termed interface dermatitis, defined by the presence of necroptotic keratinocytes and an epitheliotropic cytotoxic lymphocytic infiltrate at the dermo-epidermal junction ( 7 , 8 ). (frontiersin.org)
The presence of erythema multiforme -like lesions in a patient with lupus, along with a speckled pattern of antinuclear antibody (ANA), positive anti-Ro/SSA or anti-La/SSB, and positive rheumatoid factor (RF) is known as Rowell syndrome. (logicalimages.com)

Cases with a clinical or clinical-histological diagnosis of CCLE were classified as definite. (cdc.gov)

A number of cases are idiopathic. (medscape.com)
Lipophagic lobular panniculitis, an entity of unknown origin, may lead to circumferential fat atrophy of the ankles and may represent an end-stage manifestation of an idiopathic lobular panniculitis of children localized to the lower part of the lower limbs. (medscape.com)
In many cases, involutional lipodystrophy is idiopathic. (medscape.com)
In 30 patients (45%), no definitive diagnosis was reached, and they were defined as having idiopathic EN. (bvsalud.org)
Idiopathic facial lipoatrophy has only been previously identified in three case reports, among which, the patient demographics vary considerably. (biomedcentral.com)
The aim of the current report is to present a rare case of idiopathic facial lipoatrophy, and to assess the use of autologous fat transfer as a treatment modality. (biomedcentral.com)
We present a case of a 40-year old woman from Nova Scotia, Canada who presented with asymptomatic idiopathic facial lipoatrophy. (biomedcentral.com)

Lupus is an autoimmune condition that causes your body's immune system to attack its own tissues. (healthline.com)
The specificity of autoimmune injury to cartilaginous tissues has led investigators to test the hypothesis that a cartilage-specific autoantibody is central to the pathogenesis of relapsing polychondritis. (medscape.com)

There are steps you can take to prevent lupus flares and feel better once they hit. (healthline.com)

[ 3 ] In cases linked to injections of insulin, an immune response mediated by tumor necrosis factor-alpha has been hypothesized. (medscape.com)
Autoimmune conditions like lupus cause your body's immune system to start recognizing healthy cells as invaders, like bacteria or viruses. (healthline.com)

FDG uptake in the panniculitis lesion is rarely reported in the literature. (bvsalud.org)
Rarely squamous cell carcinoma (lupus carcinoma) develops in old DLE scars. (cyberderm.net)

Investigations, including a full autoimmune workup, were unremarkable. (biomedcentral.com)

Pseudoacrocyanosis: a case for telemedicine in rheumatology. (uk-erlangen.de)
The Georgia Lupus Registry used multiple sources for case finding, including dermatology and rheumatology practices, multispecialty healthcare facilities, and dermatopathology reports. (cdc.gov)

Lipoatrophy secondary to panniculitis is more frequent. (medscape.com)
This case differs from those in the literature in patient demographics and severity of the facial lipoatrophy. (biomedcentral.com)

1 The first report of lupus in the eye was in 1929, and Semon and Wolff, in 1933, described the histopathological characteristics of choroiditis and subretinal exudation. (bmj.com)

This form of lupus affects many parts of the body and can be difficult to diagnose. (healthline.com)
Lupus affects everyone differently. (disabilitylawfirmnc.com)

Erythema nodosum (EN), although relatively uncommon in the pediatric population, is the most frequent type of panniculitis in children. (bvsalud.org)

Also panniculitis (1 patient), aphthae (2 patients), angiorethinopathy(2 patients), mononeyropathy and polyneyropathy ( 2 patients respectively), pneumonitis (4 patients), xerophthalmia (1 patient) like Sjogren's syndrome were observed. (biomedcentral.com)
Some drugs (eg, hydralazine , procainamide , isoniazid , anti-tumor necrosis factor [TNF] drugs) cause a reversible lupus-like syndrome. (merckmanuals.com)

Connective-tissue disorder-associated lipoatrophic panniculitis may be observed at any age, but it occurs most frequently in adults aged 20-60 years. (medscape.com)

The fact that the majority of cases in the US are predominantly in non-white patients suggests that the incidence in Europe (and specifically Germany) is even less [ 3 ]. (karger.com)

A female predominance is also observed in connective-tissue disorder-associated lipoatrophic panniculitis. (medscape.com)
Clinical Images: Tissue remodeling in autoimmune statin-induced necrotizing autoimmune myopathy. (uk-erlangen.de)

In the case of autoimmune conditions, the healthy cells are recognized as invaders. (healthline.com)

Skin excisional biopsy was performed, and the results suggested panniculitis. (bvsalud.org)
in SLE also in sun-exposed normal skin (lupus band test). (cyberderm.net)

however, intermittent administration of high doses during only flares of the condition is successful in rare cases. (medscape.com)

How severe is your lupus? (disabilitylawfirmnc.com)

Lupus often cycles between periods of activity and periods of remission. (healthline.com)
However, in many cases, the process goes into remission after some years of activity. (epainassist.com)

Inclusion body myositis represents 15% to 30% of IIM cases, which have a prevalence of five to 10 per million population. (rheumaknowledgy.com)

The things that trigger your lupus flares may also be different. (healthline.com)

Sixty-eight patients with EN were included. (bvsalud.org)
40(80%) patients developed spondyloarthrtitis, in 11 cases (22%) unilateral sacroiliitis and in 29(58%) bilateral sacroiliitis was observed. (biomedcentral.com)
In recent years, new guideline recommendations (including limiting GBCAs and delaying the use of these agents in patients with acute renal failure) have helped to vastly reduce the number of cases of NSF. (medscape.com)

The length of a lupus flare varies, but they typically last between a few days and a few weeks, depending on their severity. (healthline.com)

In some cases, a doctor will perform surgery on the affected joints. (100arthritis.com)

Anatomy10

Organisms3

Diseases52

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes14

Information Science1

Named Groups3

Health Care10

Systemic29

Cutaneous5

Discoid5

Profundus2

Connective-tissue4

Etiology3

Disorders7

Symptoms15

Organs2

Antibodies3

Commonly2

Inflammation4

Manifestations3

Diseases2

Involvement1

Mutation1

Disease7

Lesions4

CCLE1

Idiopathic7

Tissues2

Prevent lupus1

Immune2

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Workup1

Rheumatology2

Lipoatrophy2

Histopathological1

Affects2

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Syndrome2

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Tissue2

Invaders1

Skin2

Rare1

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Patients3

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Joints1