AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Mycosis FungoidesSezary SyndromeSkin NeoplasmsLymphoma, T-Cell, CutaneousParapsoriasisPUVA TherapyMucinosis, FollicularUltraviolet TherapySkinAcitretinHypopigmentationAntigens, CD7Lymphomatoid PapulosisSkin DiseasesVitiligoMethoxsalenDermatitis, ExfoliativeGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorMechlorethamineRadiotherapy, High-EnergyLymphoma, T-CellGene Rearrangement, T-LymphocyteTelangiectasisAntigens, CD30Lymphatic DiseasesImmunophenotypingOcclusive DressingsBiopsyT-LymphocytesLymphoma
LymphomaStage of mycosis fungoidesCTCLCutaneous T-cell lyLesionsLymphocytesTumorAtopic dermatitisDiagnosisMelanomaLeukemicGranulomaPatientsDermatologyGenesAcneTopicalTumorsEruptionPoorlyStagesEczemaNonspecificOccurLupus erythematosusClinicopathologicSeverePrognosisReportClinicalAffectsChronic100,000SkinDisorderCommonInvolvementPatientCancerIncidenceCommonlyTypeCellStudyExposureDataTreatment
Lymphoma15
  • Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form of cutaneous T-cell lymphoma. (wikipedia.org)
  • Mycosis fungoides is the most common type of cutaneous T-cell lymphoma (CTCL), but there are many other types of CTCL that have nothing to do with mycosis fungoides and these disorders are treated differently. (wikipedia.org)
  • Mycosis fungoides is the most common form of a type of blood cancer called cutaneous T-cell lymphoma. (medlineplus.gov)
  • Background: Hypopigmented mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma, it is more frequent in dark-skinned or Asian patients, particularly children. (unipv.it)
  • As the nomenclature and description of the disease spectrum under the descriptive term parapsoriasis evolved, the primary focus has been on the distinction of whether the disorder progresses to mycosis fungoides (MF) or cutaneous T-cell lymphoma (CTCL). (medscape.com)
  • The most common form of T-cell skin lymphoma-accounting for almost half of all skin lymphoma cases-is mycosis fungoides (MF). (moffitt.org)
  • In most cases lymphomas of the skin have a T-cell origin, the most common of skin lymphoma is mycosis fungoides. (qigonginstitute.org)
  • The differential diagnosis includes other cutaneous lymphomas, particularly the cutaneous nasal type T/natural killer-cell lymphoma, mycosis fungoides, precursor T-cell lymphoblastic lymphoma, nonspecific peripheral T-cell lymphoma, cutaneous anaplastic large cell lymphoma, and subcutaneous panniculitic T-cell lymphoma. (nih.gov)
  • Las Vegas - The most common diagnosis of cutaneous T-cell lymphoma diagnosis in the practice of dermatology is mycosis fungoides (MF), according to Peter W. Heald, M.D., professor of dermatology, Yale School of Medicine, New Haven, Conn., who spoke here at the 27th Annual Fall Clinical Dermatology Conference. (dermatologytimes.com)
  • Efficacy and safety of topical hypericin photodynamic therapy for early-stage cutaneous T-cell lymphoma (mycosis fungoides): the FLASH phase 3 randomized clinical trial. (cancertherapyadvisor.com)
  • We recommend the term primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphoma as this more broad designation better describes this clinical-pathologic presentation, which allows the inclusion of cases with CD8 negative and/or αβ/γδ T-cell receptor chain double-positive or double-negative expression. (escholarship.org)
  • They comprise less than 5% of all lymphoma cases. (msdmanuals.com)
  • Mycosis fungoides (cutaneous T-cell lymphoma) can be difficult to distinguish from nonmalignant chronic dermatoses. (msdmanuals.com)
  • Cutaneous T-cell lymphoma is a general term from mycosis fungoides or occur spontane- to identify non-Hodgkin's T-cell lymphomas ously, although some authors now consider that primarily affect the skin. (bvsalud.org)
  • subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
Stage of mycosis fungoides4
CTCL2
Cutaneous T-cell ly1
  • Mycosis fungoides and Sézary syndrome are the 2 main types of cutaneous T-cell lymphomas. (msdmanuals.com)
Lesions2
  • Monoclonality of the T lymphocytes could be detected in hypopigmented lesions in all 7 cases with the use of a polymerase chain reaction technique. (unipv.it)
  • We have identified early skin signs of chronic patch/plaque lesions that are often misdiagnosed as eczema, psoriasis, or mycosis fungoides. (escholarship.org)
Lymphocytes5
  • The lymphocytes in the MF and spongiotic dermatitis cases lacked nuclear staining for TdT. (karger.com)
  • Mycosis fungoides (MF) and Sézary syndrome (SS) are related conditions, with the same type of cancer t-lymphocytes, that initially grow in different body compartments. (wikipedia.org)
  • Mycosis fungoides is caused by abnormal white blood cells (T-lymphocytes). (wikipedia.org)
  • The phenotype of neoplastic lymphocytes was T helper in 4 cases and T suppressor in 3 (2 of them children). (unipv.it)
  • However, this description includes several skin diseases that likely arise from a variable degree of lymphocytic inflammation, which may have nonspecific histopathology to histology, with abnormal lymphocytes seen in mycosis fungoides. (medscape.com)
Tumor1
  • Each week, our tumor board of cancer specialists meets to review complex cases and make any necessary treatment adjustments. (moffitt.org)
Atopic dermatitis1
Diagnosis2
  • Histologic examination confirmed the diagnosis in all cases. (unipv.it)
  • In all cases of chronic hand dermatitis, a full diagnostic examination should be undertaken and the etiology should be clarified and addressed in the treatment concept, instead of just moving directly from a morphological diagnosis to therapy. (medscape.com)
Melanoma3
  • Previously, Bell has been a traumatic brain injury clinical educator, a nurse case manager for the U.S. Army, a lead nurse case manager and supervisor for the Army National Guard, and a dermatology oncology nurse navigator for patients with melanoma and mycosis fungoides at Medstar Washington Hospital Center. (chamberlain.edu)
  • Exposure to the sun and sunbeds and the risk of knowledge relating to exposure and health cutaneous melanoma in the UK: a case-control risks], Report, Maisons-Alfort, France (in study. (who.int)
  • Malignant melanoma and exposure to fluores- tion: the case of sunbeds. (who.int)
Leukemic1
  • In some cases, a leukemic phase called Sézary syndrome is characterized by the appearance of malignant T cells with serpentine nuclei in the peripheral blood. (msdmanuals.com)
Granuloma1
Patients12
  • We evaluated the immunostaining profile of TdT in a cohort of 23 patients, including 13 cases of MF and 10 cases of spongiotic dermatitis. (karger.com)
  • Black and Hispanic patients had higher inpatient care utilization for mycosis fungoides (MF) - and were admitted at a younger age - compared with White patients, according to an analysis of the 2012-2017 National Inpatient Sample (NIS). (the-hospitalist.org)
  • Hypopigmented mycosis fungoides in Caucasian patients: a clinicopathologic study of 7 cases. (unipv.it)
  • Only 9 cases in Caucasian patients have been reported in the literature so far. (unipv.it)
  • Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of methotrexate administration. (nih.gov)
  • The problem of the treatment of primary malignant lymphomas of the skin is now becoming increasingly important due to the increase of cases among people of working age and disability of these patients. (qigonginstitute.org)
  • In rare cases the cancer will spread to the blood, and these patients are diagnosed with Sézary syndrome (SS). (damonrunyon.org)
  • Some cases of serious infections, including tuberculosis (TB) and sepsis have been reported in patients treated with infliximab. (mydr.com.au)
  • Covid-19 does not necessarily increase the risk of myxomatosis, but the excessive use of steroids for treatment may be the reason for this infection in patients with SARS-CoV-2," the official said in response to a question about cases of mycosis fungoides. (sundayvision.co.ug)
  • Ulcerations can sometimes develop in patients with mycosis fungoides. (msdmanuals.com)
  • Serum Vitamin D and Vitamin D Receptor Gene Polymorphism in Mycosis Fungoides Patients: A Case Control Study. (cdc.gov)
  • Pediatric mycosis fungoides: a study of the human leukocyte antigen system among Israeli Jewish patients. (cdc.gov)
Dermatology1
  • Topical synthetic hypericin ointment activated with visible light is a safe and effective photodynamic therapy (PDT) for mycosis fungoides (MF), according to a placebo-controlled, double-blind, phase 3 randomized trial published in JAMA Dermatology . (cancertherapyadvisor.com)
Genes1
Acne1
  • In 30% of the cases, combinations of acne vulgaris have been described. (e-ijd.org)
Topical2
  • 6 Treatment is identical to other cutaneous forms of LP. In localized cases, topical corticosteroids are considered first-line therapy, followed by narrowband ultraviolet B. There are numerous options for generalized or refractory cases, including systemic or intramuscular corticosteroids, plaquenil, dapsone, oral retinoids, or apremilast. (jcadonline.com)
  • Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
Tumors3
  • It was so named because Alibert described the skin tumors of a severe case as having a mushroom-like appearance. (wikipedia.org)
  • The tumors in mycosis fungoides, which are composed of cancerous T cells, are raised nodules that are thicker and deeper than plaques. (medlineplus.gov)
  • Mycosis fungoides was so named because the tumors can resemble mushrooms, a type of fungus. (medlineplus.gov)
Eruption1
  • The disease mimics many other dermatoses and can be confused with conditions, such as sarcoidosis, discoid lupus erythematosus, mycosis fungoides, and fixed drug eruption. (medscape.com)
Poorly1
  • Themorphology, however, is poorly related to the etiology in chronic cases. (medscape.com)
Stages4
Eczema2
  • 3,4 While the vast majority of eczema herpeticum cases are caused by HSV (HSV1 and HSV2), cocksackie virus A16 and vaccinia virus have also been implicated. (racgp.org.au)
  • Bork K, Brauninger W. Increasing incidence of eczema herpeticum: analysis of seventy-five cases. (racgp.org.au)
Nonspecific1
  • As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: psoriatic arthritis, rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy), ankylosing spondylitis, acute and subacute bursitis, acute nonspecific tenosynovitis, acute gouty arthritis, post-traumatic osteoarthritis, synovitis of osteoarthritis, epicondylitis. (nih.gov)
Occur1
  • Broad age range from infancy to late adult, although majority of cases occur in the fifth to eighth decades of life. (oncolink.org)
Lupus erythematosus2
  • During an exacerbation or as maintenance therapy in selected cases of: systemic lupus erythematosus, systemic dermatomyositis (polymyositis), acute rheumatic carditis. (nih.gov)
  • See Sarcoidosis , Discoid Lupus Erythematosus , Mycosis Fungoides , and Fixed Drug Eruptions for more information on these topics. (medscape.com)
Clinicopathologic1
  • Based on a series of 16 such cases referred to the Institute of Neoplastic Diseases, the objective of this report is not only to provide a better clinicopathologic understanding of this entity but also a reappraisal of it as a malignancy. (nih.gov)
Severe1
  • These include: bacteria (especially Propionibacterium acnes, but in severe cases, also Staphylococcus aureus ), Yeasts (Malassezia species) and mites (Demodex folliculorum). (e-ijd.org)
Prognosis4
  • These cases have a worse prognosis because of the dermal lymphatic invasion. (cancer.gov)
  • Our experience confirms the poor prognosis of this entity and highlights the inefficacy of our standard therapies with the exception of allogeneic stem cell transplantation in selected cases. (escholarship.org)
  • Immunogenetic factors in mycosis fungoides: can the HLA system influence the susceptibility and prognosis of the disease? (cdc.gov)
  • Mycosis fungoides: association of KIR ligands and HLA-DQB1*05 with bad prognosis of the disease. (cdc.gov)
Report1
  • I would like to thank the patient for his consent to publish this case report, including his photograph. (racgp.org.au)
Clinical3
  • Given the evidence presented, a case is made that itraconazole warrants further clinical investigation as an anti- cancer agent. (ecancer.org)
  • We identified cases with lack of CD8 or αβ T-cell receptor expression yet with similar clinical and pathological presentation. (escholarship.org)
  • Clinical Cases. (dermakuwait.com)
Affects2
Chronic1
  • Mycosis fungoides and Sézary syndrome are uncommon chronic T-cell non-Hodgkin lymphomas primarily affecting the skin and occasionally the lymph nodes. (msdmanuals.com)
100,0001
  • Mycosis fungoides occurs in about 1 in 100,000 to 350,000 individuals. (medlineplus.gov)
Skin4
  • The patient was a 35-year-old man with mycosis fungoides, cocaine addiction, diabetes mellitus, and a history of repetitive skin and soft tissue infections. (cdc.gov)
  • For mycosis fungoides: Use code 25 when skin involvement is present but only a general location/site is mentioned (i.e., face, legs, torso, arms). (cancer.gov)
  • In case of prolonged irritation and other skin reactions, it is advisable to consult your oncologist. (yashodahospitals.com)
  • patient suffers black mushroom Usually there is congestion and nosebleeds, but among the most dangerous are swelling and pain in the eyes, drooping eyelids, blurred vision, and in some cases, there may be spots on the skin. (sundayvision.co.ug)
Disorder2
  • El-Darouti et al reported on a 7-year study of a hypopigmented disorder that the researchers believe should be classified as a new variant of parapsoriasis en plaque. (medscape.com)
  • In February, when the US government conceded that vaccines had caused an autism-inducing reaction in little Hannah Poling, most experts declared that her underlying condition, a mitochondrial disorder, was exceedingly rare - so rare, in fact, that it had no bearing on other autism cases. (weeksmd.com)
Common1
  • Most cases are in people over 20 years of age, and it is more common in men than women. (wikipedia.org)
Involvement2
  • Mycosis fungoides with early central nervous system involvement. (medicaljournals.se)
  • The authors present a rare case of mycosis fungoides with early central nervous system involvement mimicking an intramedullary tumour in a 38- year-old white male. (medicaljournals.se)
Patient1
Cancer1
  • Comprehensive cancer-related gene analysis reveals that active KRAS mutation is a prognostic mutation in mycosis fungoides. (cdc.gov)
Incidence1
  • Incidence is 63,000 cases each year in the US [1], with a dramatic increase in Western countries in the last 40 years. (oncolink.org)
Commonly1
  • Itching (pruritus) is the most commonly reported symptom of people experiencing mycosis fungoides with up to 88% of people reporting varying intensities of pruritus that typically worsens as the disease progresses. (wikipedia.org)
Type1
  • T-cell receptor gamma (TCRgamma) displayed monoclonal-type rearrangement in four cases studied. (nih.gov)
Cell2
  • Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)
  • Analysis of differential ß variable region of T cell receptor expression and NAV3/TNFRSF1B gene mutation in mycosis fungoides. (cdc.gov)
Study2
  • STUDY DESIGN: We used a case-control study design to obtain data from parents of children with LCH (n = 459) who were members of the Histiocytosis Association of America and Canada. (thedoctorsdoctor.com)
  • cutánea maligna de células T. Luego se realizó el frotis de médula ósea, en el que se identificaron células «cerebriformes» study conception, manuscript que confirmaron el diagnóstico de síndrome de Sézary. (bvsalud.org)
Exposure1
  • It is possible that other factors, such as environmental exposure or certain bacterial or viral infections, are involved in the development of mycosis fungoides. (medlineplus.gov)
Data1
Treatment1