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  • extent
  • In contrast to popular perception, pain is not a good indicator for determining the extent of articular cartilage damage. (wikipedia.org)
  • Immunologically privileged sites were thought to include: the brain, but this is now known to be incorrect and indeed immune cells of the CNS contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood the eyes the placenta and the fetus the testicles Immune privilege is also believed to occur to some extent or able to be induced in articular cartilage. (wikipedia.org)
  • mechanisms
  • Some additional examples of cartilage failure mechanisms include cellular matrix linkage rupture, chondrocyte protein synthesis inhibition, and chondrocyte apoptosis. (wikipedia.org)
  • tissue
  • At some point, a signal is introduced (either in culture or after transplant to the damaged tissue) for the cells to differentiate into the end tissue (in this discussion, cartilage). (wikipedia.org)
  • This drives efforts to develop ways of using a person's own cells to grow, or re-grow cartilage tissue to replace missing or damaged cartilage. (wikipedia.org)
  • injury
  • The microfractures are treated as an injury by the body, which is why the surgery results in new, replacement cartilage. (wikipedia.org)