• rheumatoid arthritis
  • Background Bone loss in inflammatory diseases like periodontitis, rheumatoid arthritis, septic arthritis and loosened joint prosthesis or tooth implants is being considered a consequence of cytokine induced RANKL and subsequent enhanced osteoclast formation. (bmj.com)
  • adult
  • Hunziker EB, Kapfinger E, Geiss J (2007) The structural architecture of adult mammalian articular cartilage evolves by a synchronized process of tissue resorption and neoformation during postnatal development. (springer.com)
  • Adult cells have had limited success in cartilage repair, but juvenile chondrocytes (from donors younger than 13 years of age) have been identified to generate superior cartilage. (biomedcentral.com)
  • However, the cultured amniotic fluid-derived MSCs have a similar phenotype to both adult bone-marrow-derived MSCs and MSCs originating from second trimester fetal tissue. (wikipedia.org)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • meniscus
  • He has published hundreds of scientific articles detailing structure-function relationships and tissue engineering approaches for articular cartilage, the knee meniscus, and the temporomandibular joint. (wikipedia.org)
  • A meniscus transplant or meniscal transplant is a transplant of the meniscus of the knee, which separates the thigh bone (femur) from the lower leg bone (tibia). (wikipedia.org)
  • Recognizing from experiments performed by R.J. Webber, PhD that meniscus cells have the ability to grow in tissue culture, K.R. Stone, M.D. developed the first meniscus reconstruction device called a collagen regeneration template in 1986. (wikipedia.org)
  • chondrocytes
  • Yang L, Tsang KY, Tang HC et al (2014) Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. (springer.com)
  • All rabbits were sacrificed at 4, 8, and 12 weeks postoperatively, the cartilage defect areas were examined macroscopically and microscopically, and the morphology of the chondrocytes and collagen fibers were examined by scanning electron microscopy. (duhnnae.com)
  • However, a major challenge to the widespread clinical use of juvenile cartilage or chondrocytes is the limited donor availability. (biomedcentral.com)
  • vivo
  • Using a battery of in vitro and in vivo bioassays for bone formation, a systematic study was undertaken in his laboratory to isolate and purify putative bone morphogenetic proteins. (wikipedia.org)
  • http://www.ucdmc.ucdavis.edu/publish/facultybio/orthopaedics/faculty/54 http://www.jhu.edu/gazette/aprjun96/apr1596/chairs.html Scientists Succeed In Growing Bone, The New York Times, Oct. 22, 1996 Hopkins grows its own bone orchard, The Baltimore Sun, Jan. 24, 1992 Khouri R, Koudsi B, Reddi H. Tissue Transformation Into Bone In Vivo: A Potential Practical Application. (wikipedia.org)
  • Synthesis and localization of fibronectin during collagenous matrix- mesenchymal cell interaction and differentiation of cartilage and bone in vivo. (wikipedia.org)
  • joints
  • Although regeneration of the damaged joints is considered very rare, accumulating evidence shows that it actually occurs in routine clinical practice as a result of strong inhibition of synovitis using highly potent medications. (springer.com)
  • Newer, smaller sensing devices that more accurately measure stress loads on joints are giving researchers testing newly grown engineered cartilage within a joint a better understanding of the healing process. (medindia.net)
  • Healthy cartilage is essential to the proper functioning of joints within the body. (wikipedia.org)
  • however, it is not an ideal replacement for the smooth, glassy articular cartilage that normally covers the surface of joints. (wikipedia.org)
  • The human body's own cartilage is still the best material for lining knee joints. (wikipedia.org)
  • Joint
  • Oral and intravenous medications affect the whole body, but to promote joint regeneration in a particular joint, two potent options are intra-articular steroid injection and synovectomy. (springer.com)
  • The loss of the articular cartilage in RA is evident on X-ray as joint-space narrowing, but in most cases, erosion and joint-space narrowing progress coordinately. (springer.com)
  • The sensors also transmit their measurements wirelessly, enabling patients undergoing cartilage growth therapy to monitor their own joint stress loads in real time. (medindia.net)
  • The 3-D images produced by CT scans are now being used to create patient-specific implantable scaffold systems that support joint cartilage while the tissue grows and gains strength. (medindia.net)
  • Using a 3-D scan of a patient''s joint to custom build an implantable scaffold to support new cartilage growth -- as well as an implanted sensor that provides real-time activity monitoring for the rehabilitated patient -- represent major milestones in cartilage tissue engineering. (medindia.net)
  • Nicolas Andry Prize award from the Association of Bone and Joint Surgeons in 1999. (wikipedia.org)
  • Articular cartilage is a connective tissue overlying the ends of bones that provides smooth joint surfaces. (wikipedia.org)
  • The Journal of Bone and Joint Surgery. (wikipedia.org)
  • Articular cartilage, most notably that which is found in the knee joint, is generally characterized by very low friction, high wear resistance, and poor regenerative qualities. (wikipedia.org)
  • Once cartilage damage is assessed there are two methods to access the joint to proceed with the AMIC surgery. (wikipedia.org)
  • The Kolling Institute's research interests fall under the following categories: Growth Research Cancer Genetics Perinatal Research Renal Medicine Research Neurogenetics Research Pain management Research Cardiac Technology Hypertension and Stroke Research Bone and Joint Research Laboratory and Community Genetics Cancer Diagnosis and Pathology Research Group Over the decades the Kolling Institute grew substantially and extended into a number of other buildings across the Royal North Shore Hospital campus. (wikipedia.org)
  • First, the damaged section of bone and cartilage is removed from the joint. (wikipedia.org)
  • Then a new healthy dowel of bone with its cartilage covering is punched out of the same joint and replanted into the hole left from removing the old damaged bone and cartilage. (wikipedia.org)
  • The healthy bone and cartilage are taken from areas of low stress in the joint so as to prevent weakening the joint. (wikipedia.org)
  • mechanism
  • Hayes AJ, MacPherson S, Morrison H et al (2001) The development of articular cartilage: evidence for an appositional growth mechanism. (springer.com)
  • Conclusion These data show that stimulation of TLR2 results in bone resorption mediated by increased RANKL in osteoblasts and may be one mechanism for developing inflammatory bone loss. (bmj.com)
  • cells
  • This study was performed to examine the capacity of a resorbable implant made from polylactide-co-glycolide acid (PGLA)-fleece combined with autologous bone marrow cells fixed with a fibrin/thrombin-clot in the weight-bearing area of the femoral condyle of mature sheep. (gulfcoaststemcell.com)
  • These results may indicate that FLS could be the candidate target cells of regeneration therapy. (nii.ac.jp)
  • In addition to tissue-level work, Athanasiou has established a highly innovative program to understand how single cartilage cells behave under direct and controlled biomechanical loads, not only in terms of deformation but also in terms of changes in gene expression. (wikipedia.org)
  • This drives efforts to develop ways of using a person's own cells to grow, or re-grow cartilage tissue to replace missing or damaged cartilage. (wikipedia.org)
  • The template or scaffold was composed of glycosaminoglycan (sugar/proteins that make up cartilage tissue) and was designed to have pores into which cells could grow. (wikipedia.org)
  • The cells also have potential medical applications, especially in organ regeneration. (wikipedia.org)
  • It is common in epithelial cells of the epidermis and intestine, liver hepatocytes, bone marrow cells, and fibroblasts. (wikipedia.org)
  • It occurs to a lesser extent in bone, cartilage, and smooth muscle cells. (wikipedia.org)
  • MSCs
  • Comparison of amniotic fluid-derived MSCs to bone-marrow-derived ones showed that the former has a higher expansion potential in culture. (wikipedia.org)
  • functional
  • Their group also demonstrated that hydrostatic pressure in conjunction with growth factors can have synergistic effects on the functional properties of engineered cartilage. (wikipedia.org)
  • biomedical
  • He studies the development of biomaterials from natural origin polymers and their possible biomedical applications, including bone replacement and fixation, drug delivery carriers, partially degradable bone cements and tissue engineering scaffolding. (wikipedia.org)
  • mechanisms
  • Some additional examples of cartilage failure mechanisms include cellular matrix linkage rupture, chondrocyte protein synthesis inhibition, and chondrocyte apoptosis. (wikipedia.org)