• occur
  • Falls in CO that occur as a consequence of hypoxia would lead to closure of this potassium channel and this would lead to membrane depolarisation and consequence activation of the carotid body. (wikipedia.org)
  • Tumors of the paraganglionic tissues are known as paragangliomas, though this term tends to imply the nonchromaffin type, and can occur at a number of sites throughout the body. (wikipedia.org)
  • In the highly metabolically active tissues of the heart and brain, irreversible damage to tissues can occur in as little as 3-4 minutes at body temperature. (wikipedia.org)
  • cells
  • Individual tumor cells are polygonal to oval and are arranged in distinctive cell balls, called Zellballen. (wikipedia.org)
  • The carotid body functions as a sensor: it responds to a stimulus, primarily O2 partial pressure, which is detected by the type I (glomus) cells, and triggers an action potential through the afferent fibers of the glossopharyngeal nerve, which relays the information to the central nervous system. (wikipedia.org)
  • Nonchromaffin paragangliomas are issued from glomus cells, also known as glomus tumors. (wikipedia.org)
  • blood
  • Thromboembolism (blood clots) Embolism (foreign bodies in the circulation, e.g. amniotic fluid embolism) Traumatic injury to an extremity may produce partial or total occlusion of a vessel from compression, shearing or laceration. (wikipedia.org)
  • tissue
  • The carotid body contains the most vascularized tissue in the human body[citation needed]. (wikipedia.org)
  • The glomus body consists of an arteriovenous shunt surrounded by a capsule of connective tissue. (wikipedia.org)
  • Unconsciousness, such as due to the ingestion of excessive doses of central depressants like alcohol or opioids, can result in ischemia of the extremities due to unusual body positions that prevent normal circulation Ischemia results in tissue damage in a process known as ischemic cascade. (wikipedia.org)
  • role
  • Haem reversibly binds O2 with an affinity similar to that of the carotid body, suggesting that haem containing proteins may have a role in O2, potentially this could be one of the complexes involved in oxidative-phosphorylation. (wikipedia.org)
  • Although
  • The adult human brain weighs on average about 1.2-1.4 kg (2.6-3.1 lb) which is about 2% of the total body weight, with a volume of around 1260 cm3 in men and 1130 cm3 in women, although there is substantial individual variation. (wikipedia.org)
  • given
  • It also means local anemia in a given part of a body sometimes resulting from congestion (such as vasoconstriction, thrombosis or embolism). (wikipedia.org)
  • leads
  • AMPK has a number of targets and it appears that, in the carotid body, when AMPK is activated by hypoxia, it leads to downstream potassium channel closure of both O2-sentive TASK-like and BK channels An increased PCO2 is detected because the CO2 diffuses into the cell, where it increases the concentration of carbonic acid and thus protons. (wikipedia.org)