• angioplasty
  • Abstract The temporal relationship of matrix metalloproteinases (MMPs) and a specific tissue inhibitor (TIMP-1) has been examined by reverse transcription-polymerase chain reaction and substrate zymography, after balloon catheter angioplasty of the rat carotid artery. (ahajournals.org)
  • Smooth muscle cells have been shown to express mRNA for urokinase plasminogen activator and tissue-type plasminogen activator after balloon injury in the rat model of angioplasty. (ahajournals.org)
  • The role of carotid angioplasty and stenting in carotid revascularization. (naver.com)
  • Determinants of in-stent restenosis after carotid angioplasty: a case-control study. (naver.com)
  • The primary event in the development of atherosclerosis and restenosis after percutaneous transluminal coronary angioplasty is thought to involve injury to the endothelium, leading to a response that may be similar to wound healing requiring migration of vascular smooth muscle cells (VSMCs) from the media to the intima and subsequent proliferation. (ahajournals.org)
  • In the present study, the time course changes and cellular distribution of miR-221 and miR-222 expression were identified in rat carotid arteries after angioplasty, in which their expression was upregulated and localized in VSMCs in the injured vascular walls. (ahajournals.org)
  • Finally, knockdown of miR-221 and miR-222 in rat carotid arteries suppressed VSMC proliferation in vivo and neointimal lesion formation after angioplasty. (ahajournals.org)
  • A newer procedure, endovascular angioplasty and stenting, threads a catheter up from the groin, around the aortic arch, and up the carotid artery. (wikipedia.org)
  • stroke
  • A beneficial effect of anticoagulation therapy with unfractionated heparin has been demonstrated, with a reduction of the ischaemic stroke rate from 29.8% to 3.9% in grade I - IV injuries. (scielo.org.za)
  • The earliest known stroke treatments start to happen, when surgeons begin performing surgery on the carotid arteries. (wikipedia.org)
  • The vertebral artery supplies the part of the brain that lies in the posterior fossa of the skull, and this type of stroke is therefore called a posterior circulation infarct. (wikipedia.org)
  • However, when blood clots form and break off from the site of the tear, they form emboli, which can travel through the arteries to the brain and block the blood supply to the brain, resulting in an ischaemic stroke, otherwise known as a cerebral infarction. (wikipedia.org)
  • Pieces of plaque can break off and block the small arteries above in the brain, which causes a stroke. (wikipedia.org)
  • Each imaging modality has its advantages and disadvantages - Magnetic resonance angiography and CT angiography with contrast is contraindicated in patients with renal insufficiency, catheter angiography has a 0.5% to 1.0% risk of stroke, MI, arterial injury or retroperitoneal bleeding. (wikipedia.org)
  • A piece of the formed blood clot often breaks off and travels (embolizes) up through the internal carotid artery into the brain, where it blocks circulation, and can cause death of the brain tissue, a condition referred to as ischemic stroke. (wikipedia.org)
  • vascular
  • A penetrating trauma occurring in the neck can cause severe complications such as hemorrhage as the result of vascular injury, spinal cord injury, respiratory obstruction, and sepsis from esophageal injury. (biomedsearch.com)
  • Vinculin, a paxillin-binding protein, was not altered by vascular injury or by eNOS gene transfer. (ahajournals.org)
  • Growth factors, such as platelet-derived growth factor (PDGF) and fibroblast growth factor, released during vascular injury plays a pivotal role in regulating these events. (ahajournals.org)
  • Conclusions- These data suggest that curcumin is a potent inhibitor of key PDGF-stimulated VSMC functions and may play a critical role in regulating these events after vascular injury. (ahajournals.org)
  • 1,2 Although the mechanisms responsible for migration and proliferation of VSMCs are not fully understood, several factors produced in response to vascular injury have been implicated in this process. (ahajournals.org)
  • They are almost exclusively observed when the carotid canal is fractured, although only a minority of carotid canal fractures result in vascular injury. (wikipedia.org)
  • neointima formation
  • Methods and Results -We prepared diet-induced hyperhomocysteinemic rats in which neointima formation after balloon injury to the common carotid artery was assessed. (ahajournals.org)
  • Conclusions -Diet-induced hyperhomocysteinemia, even mild to moderate, exacerbates neointima formation after denuding injury, making hyperhomocysteinemia a likely risk factor for postangioplasty restenosis. (ahajournals.org)
  • The objective of this study was to investigate the ability of curcumin to inhibit PDGF-stimulated migration, proliferation, and collagen synthesis in cultured VSMCs and neointima formation after carotid artery injury in rats. (ahajournals.org)
  • Carotid artery neointima formation was significantly attenuated by perivascular curcumin compared with vehicle controls 14 days after injury, characterized by reduced DNA synthesis, collagen synthesis, and PDGF receptor phosphorylation. (ahajournals.org)
  • laceration
  • Suicide attempters who survive, because the cord or ligature point breaks, or because they are discovered and cut down can face a range of serious injuries, including cerebral anoxia (which can lead to permanent brain damage), laryngeal fracture, cervical spine fracture, tracheal fracture, pharyngeal laceration, and carotid artery injury. (wikipedia.org)
  • vivo
  • Trivedi RA, Mallawarachi C, King-Im JM et al (2006) Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages. (springer.com)
  • A catheter balloon-denuded rat carotid artery was transfected in vivo with the replication-deficient adenovirus Ad5/RSVeNOS or with Ad5/RSVLacZ as the control. (ahajournals.org)
  • The objective of the present study is to establish the roles miR-221 and miR-222 in VSMC growth and neointimal formation and their molecular mechanisms using both cultured VSMCs in vitro and balloon-injured rat carotid arteries in vivo. (ahajournals.org)
  • catheter
  • These results demonstrate that the process of extracellular matrix breakdown by MMPs after balloon catheter-induced injury is controlled by a tightly regulated temporal response by the genes responsible for the production of these enzymes and their inhibitor and by post-translational activation of the proenzymes. (ahajournals.org)
  • gelatinase B) was induced after balloon catheter injury during the period of migration of smooth muscle cells from the media to the intima. (ahajournals.org)
  • The catheter uses a balloon to expand the artery, and inserts a stent to hold the artery open. (wikipedia.org)
  • acute
  • This study investigated whether edema in the carotid artery wall induced by acute balloon injury could be detected by cardiovascular magnetic resonance (CMR) using a T2-weighted short-tau inversion recovery sequence (T2-STIR). (springer.com)
  • stents
  • However, the European International Carotid Stenting Study (ICSS) found that stents had almost double the rate of complications. (wikipedia.org)
  • anticoagulation
  • There are no definitive management guidelines regarding this type of injury, and our report emphasises the role of conservative anticoagulation therapy in the management of this rare condition. (scielo.org.za)
  • cranial nerves
  • Due to the proximity of the cranial nerves, injury to those nerves may occur. (wikipedia.org)
  • The compartments of each guttural pouch contain many important structures including several cranial nerves and arteries that lie directly against the pouch as they pass into and out of foramina in the caudal aspect of the skull. (wikipedia.org)
  • proliferation
  • Medial smooth muscle cell proliferation begins immediately after injury and peaks early, reaching a maximum at 2 days. (ahajournals.org)
  • Abstract -Injury-caused dedifferentiation accompanied by proliferation and migration of smooth muscle cells (SMCs) is an important process in the development of the neointima. (ahajournals.org)
  • intimal
  • These results suggest that NO inhibition of intimal hyperplasia may be mediated by enhancing the recovery of injury-caused downregulation of paxillin. (ahajournals.org)
  • External
  • 1 , 4 In cases of penetrating neck injury, however, the neck zone cannot be accurately differentiated by means of the external wound only. (biomedsearch.com)
  • The airgun pellet caused a defect in the anterior wall of the external carotid artery, which required rapid access and surgical repair. (biomedsearch.com)
  • Upon evacuation of the haematoma extensive haemorrhage developed from a defect in the anterior wall of the external carotid artery, which required rapid access and surgical repair. (biomedsearch.com)
  • Branches of the external carotid supply the face, scalp, and most of the neck and throat tissues. (thefreedictionary.com)
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. (icd10data.com)
  • In order to gain control of the bleeding, the surgeon may need to extend the original incision laterally to ligate the artery at its origin at the external carotid artery. (wikipedia.org)
  • The external carotid artery passes ventral to the medial compartment before crossing to the lateral wall of the lateral compartment. (wikipedia.org)
  • walls
  • Its delivery was controlled via the affinity between SLX and E-selectin proteins, which are expressed on vessel walls with injury. (naver.com)