• stroke
  • A beneficial effect of anticoagulation therapy with unfractionated heparin has been demonstrated, with a reduction of the ischaemic stroke rate from 29.8% to 3.9% in grade I - IV injuries. (scielo.org.za)
  • The earliest known stroke treatments start to happen, when surgeons begin performing surgery on the carotid arteries. (wikipedia.org)
  • The vertebral artery supplies the part of the brain that lies in the posterior fossa of the skull, and this type of stroke is therefore called a posterior circulation infarct. (wikipedia.org)
  • However, when blood clots form and break off from the site of the tear, they form emboli, which can travel through the arteries to the brain and block the blood supply to the brain, resulting in an ischaemic stroke, otherwise known as a cerebral infarction. (wikipedia.org)
  • Pieces of plaque can break off and block the small arteries above in the brain, which causes a stroke. (wikipedia.org)
  • Each imaging modality has its advantages and disadvantages - Magnetic resonance angiography and CT angiography with contrast is contraindicated in patients with renal insufficiency, catheter angiography has a 0.5% to 1.0% risk of stroke, MI, arterial injury or retroperitoneal bleeding. (wikipedia.org)
  • A piece of the formed blood clot often breaks off and travels (embolizes) up through the internal carotid artery into the brain, where it blocks circulation, and can cause death of the brain tissue, a condition referred to as ischemic stroke. (wikipedia.org)
  • vascular
  • A penetrating trauma occurring in the neck can cause severe complications such as hemorrhage as the result of vascular injury, spinal cord injury, respiratory obstruction, and sepsis from esophageal injury. (biomedsearch.com)
  • Objectives- We have previously reported that vascular injury or treatment of cultured vascular smooth muscle cells with platelet-derived growth factor-BB (PDGF-BB) or fibroblast growth factor-2 (FGF2) increases the levels of protein tyrosine phosphatase (PTP)1B. (ahajournals.org)
  • Conclusions- PTP1B suppresses cell proliferation and motility in cultured smooth muscle cells treated with PDGF-BB or FGF2, and the phosphatase plays a counter-regulatory role in vascular injury-induced cell proliferation and neointima formation. (ahajournals.org)
  • Migration and proliferation of smooth muscle cells are of critical importance in neointima formation and remodeling occurring in response to vascular injury. (ahajournals.org)
  • 7,8 These studies indicate that PDGF and FGF are important mediators of neointima formation in models of vascular injury. (ahajournals.org)
  • Furthermore, balloon injury or treatment in vivo with PDGF also induces PDGF receptor tyrosyl phosphorylation in vascular smooth muscle, 6,9 a finding consistent with experiments in vitro. (ahajournals.org)
  • Antimitotic therapies used in cancer may also protect against vascular disorders 4 because abnormal growth of vascular smooth muscles (SMCs) contributes to vascular remodeling, such as neointima formation, atherosclerosis, and injury-induced restenosis. (ahajournals.org)
  • 1 Hence, 1 of the aims of the present study was to test the hypothesis that 2-ME can inhibit vascular injury-induced neointima formation. (ahajournals.org)
  • 2 More recent studies suggest an important role of circulating endothelial progenitor cells (EPCs) contributing to reendothelialization after vascular injury by homing to denuded parts of the artery after balloon injury. (ahajournals.org)
  • They are almost exclusively observed when the carotid canal is fractured, although only a minority of carotid canal fractures result in vascular injury. (wikipedia.org)
  • laceration
  • Suicide attempters who survive, because the cord or ligature point breaks, or because they are discovered and cut down can face a range of serious injuries, including cerebral anoxia (which can lead to permanent brain damage), laryngeal fracture, cervical spine fracture, tracheal fracture, pharyngeal laceration, and carotid artery injury. (wikipedia.org)
  • coronary
  • Cell adhesion molecules in coronary artery disease (1994) Jang Yangsoo et al. (naver.com)
  • In patients with coronary artery disease (CAD), caffeinated coffee increased caffeine serum concentration from 2 μmol/L to 23 μmol/L, coinciding with a significant increase in migratory activity of patient-derived EPCs. (ahajournals.org)
  • This most frequently results from atherosclerosis, which is the long-term accumulation of cholesterol-rich plaques in the coronary arteries. (wikipedia.org)
  • balloon
  • Methods and Results -We prepared diet-induced hyperhomocysteinemic rats in which neointima formation after balloon injury to the common carotid artery was assessed. (ahajournals.org)
  • Abstract The temporal relationship of matrix metalloproteinases (MMPs) and a specific tissue inhibitor (TIMP-1) has been examined by reverse transcription-polymerase chain reaction and substrate zymography, after balloon catheter angioplasty of the rat carotid artery. (ahajournals.org)
  • These results demonstrate that the process of extracellular matrix breakdown by MMPs after balloon catheter-induced injury is controlled by a tightly regulated temporal response by the genes responsible for the production of these enzymes and their inhibitor and by post-translational activation of the proenzymes. (ahajournals.org)
  • Smooth muscle cells have been shown to express mRNA for urokinase plasminogen activator and tissue-type plasminogen activator after balloon injury in the rat model of angioplasty. (ahajournals.org)
  • gelatinase B) was induced after balloon catheter injury during the period of migration of smooth muscle cells from the media to the intima. (ahajournals.org)
  • Methods and Results- Treatment of cultured cells with adenovirus expressing PTP1B decreased PDGF-BB- or FGF2-induced cell motility and blocked PDGF-BB- or FGF2-induced proliferation, whereas expression of dominant negative PTP1B (C215S-PTP1B) uncovered the motogenic effect of subthreshold levels of PDGF-BB or FGF2, increased neointimal and medial cell proliferation, and induced neointimal enlargement after balloon injury. (ahajournals.org)
  • This study investigated whether edema in the carotid artery wall induced by acute balloon injury could be detected by cardiovascular magnetic resonance (CMR) using a T2-weighted short-tau inversion recovery sequence (T2-STIR). (springer.com)
  • Edema was induced unilaterally by balloon injury in the carotid artery of six pigs. (springer.com)
  • The catheter uses a balloon to expand the artery, and inserts a stent to hold the artery open. (wikipedia.org)
  • Furthermore
  • Furthermore, the external laryngeal branch of the superior laryngeal nerve courses in close proximity to the superior thyroid artery, making it at risk for injury during surgery. (wikipedia.org)
  • restenosis
  • Conclusions -Diet-induced hyperhomocysteinemia, even mild to moderate, exacerbates neointima formation after denuding injury, making hyperhomocysteinemia a likely risk factor for postangioplasty restenosis. (ahajournals.org)
  • anticoagulation
  • There are no definitive management guidelines regarding this type of injury, and our report emphasises the role of conservative anticoagulation therapy in the management of this rare condition. (scielo.org.za)
  • walls
  • Its delivery was controlled via the affinity between SLX and E-selectin proteins, which are expressed on vessel walls with injury. (naver.com)
  • External
  • 1 , 4 In cases of penetrating neck injury, however, the neck zone cannot be accurately differentiated by means of the external wound only. (biomedsearch.com)
  • The airgun pellet caused a defect in the anterior wall of the external carotid artery, which required rapid access and surgical repair. (biomedsearch.com)
  • Upon evacuation of the haematoma extensive haemorrhage developed from a defect in the anterior wall of the external carotid artery, which required rapid access and surgical repair. (biomedsearch.com)
  • Branches of the external carotid supply the face, scalp, and most of the neck and throat tissues. (thefreedictionary.com)
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. (icd10data.com)
  • In order to gain control of the bleeding, the surgeon may need to extend the original incision laterally to ligate the artery at its origin at the external carotid artery. (wikipedia.org)
  • branch
  • A second branch descends on the posterior surface of the gland and anastomoses with the inferior thyroid artery. (wikipedia.org)
  • Besides the arteries distributed to the muscles and to the thyroid gland, the branches of the superior thyroid are: The infrahyoid branch (or hyoid artery): a small artery that runs along the lower border of the hyoid bone beneath the thyrohyoid muscle. (wikipedia.org)
  • This artery connects with the infrahyoid branch of the opposite side. (wikipedia.org)
  • plaques
  • Trivedi RA, Mallawarachi C, King-Im JM et al (2006) Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages. (springer.com)
  • neointima formation
  • The current study was designed to test the hypothesis that PTP1B attenuates PDGF- or FGF-induced motility and proliferation of cultured cells, as well as neointima formation in injured rat carotid arteries. (ahajournals.org)
  • Here we studied the intracellular mechanisms by which 2-ME inhibits SMC growth and whether 2-ME prevents injury-induced neointima formation. (ahajournals.org)
  • sensitivity
  • Despite having a sensitivity of 50 - 68%, it is a popular diagnostic screening modality because of fast scanning times, and has the added benefit of excluding multiple injuries in the polytrauma patient. (scielo.org.za)
  • None of the multi-contrast weighted sequences detected edema in the carotid artery with reasonable sensitivity or specificity. (springer.com)