• pulmonary
  • The usefulness of the subject can also be understood by seeing the use of Biofluid Dynamics in the areas of physiology in order to explain how living things work and about their motions, in developing an understanding of the origins and development of various diseases related to human body and diagnosing them, in finding the cure for the diseases related to cardiovascular and pulmonary systems. (wikipedia.org)
  • hemorrhagic
  • The risk of thrombotic and hemorrhagic strokes is given as 0.72 and 1.45 per 1,000 women, while that of deep vein thrombosis is estimated to be 1.45 per 1,000 women. (wikipedia.org)
  • Leducq network investigators have contributed to the understanding of vascular malformations and hemorrhagic stroke, identified Calcium Calmodulin Kinase II as a critical node in signaling pathways in atrial fibrillation and heart failure, assessed the pathophysiological role and therapeutic potential of microRNAs in heart disease, provided new models of mitral valve disease, and implicated pericytes in the persistence of diminished in blood flow following a stroke. (wikipedia.org)
  • Cardiology
  • From the Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Tex (D.L.M.), and Division of Cardiology and Cardiovascular Institute, University of Colorado Health Science Center, Denver (M.R.B. (ahajournals.org)
  • He currently serves as Section Editor for Global Health for the Journal of the American College of Cardiology and Deputy Editor of the Journal of the American College of Cardiology-Cardiovascular Imaging. (wikipedia.org)
  • It includes national and international doctors and researchers in cardiology, imaging and signal processing and modeling, who have overlapping interests and skills in cardiac bio-electricity. (wikipedia.org)
  • It will house a platform for medical research and innovation, combining facilities and competencies in electrophysiology (optical mapping), interventional cardiology, cardiac imaging (high resolution MRI 9.4 Tesla), modeling and signal processing. (wikipedia.org)
  • vascular disease
  • In 2002, the World Health Organisation Annual Report outlined the substantial potential public health impact and cost-effectiveness of scaling up access to combination cardiovascular treatment and an editorial in The Lancet noted that a four component combination pill would reduce cardiovascular risk by about 75% among people with vascular disease. (wikipedia.org)
  • In lipoprotein metabolism, the interaction between LRP1 and APOE stimulates a signaling pathway that leads to elevated intracellular cAMP levels, increased protein kinase A activity, inhibited SMC migration, and ultimately, protection against vascular disease. (wikipedia.org)
  • treatment
  • Many of the risk factors predisposing people to CVD are known, and there are a number of survival models to identify those who could benefit from preventive treatment. (uea.ac.uk)
  • In 2008, the trust of the Leducq Foundation created a new company, Broadview Ventures, Inc., with an aim to accelerate the development of early-stage technology for the diagnosis and treatment of cardiovascular and neurovascular disease through targeted investment. (wikipedia.org)
  • The formula is: NEPP=N*Pd*Pe*ru*RRR where: N = population size, Pd = prevalence of the disease, Pe = proportion eligible for treatment, ru = risk of the event of interest in the untreated group or baseline risk over appropriate time period (can be multiplied by life expectancy to produce life-years), RRR = relative risk reduction associated with treatment. (wikipedia.org)
  • LIRYC is a basic research, clinical and teaching centre focusing on the understanding, care and treatment of cardiac electrical diseases that lead to heart failure and sudden death. (wikipedia.org)
  • The significance of this penetration is unknown, but it may account for the fact that it performs exceptionally well in treatment of arthritis in animal models. (wikipedia.org)
  • context
  • 3-5 ⇓ ⇓ To provide the proper framework for this discussion, we will review current and emerging therapies within the context of the extant conceptual biological models that clinician scientists have used for envisioning the syndrome of systolic heart failure. (ahajournals.org)
  • The benefits of antidepressants in this context and their effects on stroke recovery other than effects on mood are not clearly defined, with some studies suggesting efficacy in improving functional outcome in both depressed and nondepressed stroke patients. (ahajournals.org)
  • murine
  • The present study examines its usefulness for assessing the morphological/functional phenotype of the left ventricle (LV) in several transgenic and surgical murine models of cardiac disease. (ahajournals.org)
  • Accordingly, the present study was designed to further examine the reliability of transthoracic echocardiography in mice and, in particular, to assess its utility for detecting abnormalities of LV chamber size, LV WTh, and LV mass and function in transgenic and surgical murine models of cardiac disease and its application for transgenic colony screening. (ahajournals.org)
  • 20 , - , 23 To explore the effect of intracellular triglyceride on cardiac structure and function, we generated a murine model of cardiac steatosis by overexpressing DGAT1 selectively in the cardiac myocyte. (ahajournals.org)
  • reduction
  • The reduction in the Windkessel effect results in increased pulse pressure and elevated systolic pressure for a given stroke volume. (wikipedia.org)
  • A 2014 Cochrane review found evidence that salt reduction prevented cardiovascular disease, but that the magnitude of the effect was uncertain and "larger than would be predicted from the small blood pressure reductions achieved. (wikipedia.org)
  • Health
  • Biofluid dynamics may be considered as the discipline of biological engineering or biomedical engineering in which the fundamental principles of fluid dynamics are used to explain the mechanisms of biological flows and their interrelationships with physiological processes, in health and in diseases/disorder. (wikipedia.org)
  • An advocate of holistic medicine, his practice integrates the medical and biopsychosocial models of health care. (wikipedia.org)
  • Its mission is to improve human health through international efforts to combat cardiovascular and neurovascular disease. (wikipedia.org)
  • animal
  • The use of physiologically regulated, reproducible animal models is crucial to the study of ischemic brain injury--both the mechanisms governing its occurrence and potential therapeutic strategies. (ahajournals.org)
  • This technique has proved helpful in identifying acutely ischemic and contused myocardium in animal models. (ahajournals.org)
  • Conclusions- In line with current clinical data and despite some limitations, antidepressant treatments seem to improve infarct volume and neurobehavioral outcome in animal models of ischemic stroke. (ahajournals.org)
  • Since these rodents are used as animal models to define the functions of genes and their products, their failure to have two TP isoforms has limited understanding of the individual and different functions of each TP receptor isoform. (wikipedia.org)
  • In animal models and human tissues, they act through TP to promote platelet responses and stimulate blood vessel contraction. (wikipedia.org)
  • An article in The Scientist notes, "The difficulties associated with using animal models for human disease result from the metabolic, anatomic, and cellular differences between humans and other creatures, but the problems go even deeper than that" including issues with the design and execution of the tests themselves. (wikipedia.org)
  • citation needed] Animal models of ischemic stroke Pinto YM, Paul M, Ganten D (July 1998). (wikipedia.org)
  • scientists
  • Originally limited to investigators from Europe and North America, the Transatlantic Networks Program is, as of 2011, open to cardiovascular and neurovascular scientists worldwide. (wikipedia.org)
  • events
  • Therefore, this echocardiographic tool might help to identify those hypertensive individuals with abnormal interstitial collagen deposition, a condition that may promote and/or aggravate morbidity in this group of people who are at high risk for cardiovascular events. (ahajournals.org)
  • Models of Optimistic and Pessimistic attributions show that attributions themselves are a cognitive style - individuals who tend to focus on the global explanations do so for all types of events, and the styles correlate among each other. (wikipedia.org)
  • Like other NSAIDs, its use is associated with an increased risk of cardiovascular events such as heart attack and stroke. (wikipedia.org)
  • ischemic
  • We explore the utility of individual models and emphasize the necessity for meticulous experimental control of those variables that modulate the severity of ischemic brain injury. (ahajournals.org)
  • renal
  • Whereas clinicians initially viewed heart failure as a problem of excessive salt and water retention that was caused by abnormalities of renal blood flow (the "cardiorenal model" 1 ), as physicians began to perform careful hemodynamic measurements, it also became apparent that heart failure was associated with a reduced cardiac output and excessive peripheral vasoconstriction. (ahajournals.org)
  • citation
  • His citation into the Order called him "a positive role model and mentor to hundreds of medical residents, family physicians and nurse practitioners. (wikipedia.org)
  • citation needed] Even though SHR is usually considered to be a purely pathological model, the strain exhibit interesting compensatory abilities. (wikipedia.org)
  • citation needed] The Spontaneously Hypertensive Rat (SHR) is also used as a model of attention-deficit hyperactivity disorder. (wikipedia.org)
  • citation needed] The Spontaneous Hypertensive Rat is also a model for anxiety. (wikipedia.org)
  • study
  • The study involved the application of current CVD risk models to the THIN dataset. (uea.ac.uk)
  • The study of Biofluid Dynamics is also directed towards finding solutions to some of the human body related diseases and disorders. (wikipedia.org)
  • However, to properly study the effects of sodium intake levels on risk of development of cardiovascular disease, long-term studies of large groups using both dietary and biochemical measures are necessary. (wikipedia.org)
  • However
  • However, although both the cardiorenal and cardiocirculatory models for heart failure explained the excessive salt and water retention that heart failure patients experience, neither of these models explained the relentless "disease progression" that occurs in this syndrome. (ahajournals.org)
  • However, as discussed at the conclusion of this review, our current working models for heart failure are insufficient for explaining several of the new and emerging therapies for treating systolic heart failure. (ahajournals.org)
  • Research
  • The foundation's principal grant program, the Transatlantic Networks of Excellence for Cardiovascular and Neurovascular Research, promotes internationally collaborative basic and translational research. (wikipedia.org)
  • As of 2015, the Fondation Leducq has distributed or committed more than $300 million to support cardiovascular and neurovascular research. (wikipedia.org)
  • Her work helped to assure that, following her death in 2013, the foundation would continue to remain true to its mission in cardiovascular and neurovascular research. (wikipedia.org)
  • Pessac The Electrophysiology and Heart Modeling Institute (French: L'Institut de RYthmologie et Modélisation Cardiaque), is one of six French university hospital institutions created in 2011 as part of the investments in the future program ("Investissements d'avenir") to boost medical research and innovation. (wikipedia.org)
  • Research by Terje Sagvolden suggested that rats sourced from Charles River Laboratories perform as the best model. (wikipedia.org)
  • Cardiovascular Research. (wikipedia.org)
  • therapeutic
  • Thus, although the cardiorenal models provided the rational basis for the use of diuretics to control the volume status of patients with heart failure, and the cardiocirculatory model provided the rational basis for the use of inotropes and intravenous vasodilators to augment cardiac output, these therapeutic strategies have not prevented heart failure from progressing, nor have they led to prolonged life for patients with moderate to severe heart failure. (ahajournals.org)
  • Polypills are a useful therapeutic tool for those afflicted with various diseases/conditions, by consolidating multiple medications into a single product and thereby simplifying medication administration for healthcare personnel as well as alleviating pill-burden for patients. (wikipedia.org)
  • development
  • This latter realization led to the development of the "cardiocirculatory" or "hemodynamic" model for heart failure, 1 wherein heart failure was thought to arise largely as a result of abnormalities of the pumping capacity of the heart and excessive peripheral vasoconstriction. (ahajournals.org)
  • Stroke prone SHR (SHR-SP) is a further development of SHR that has even higher blood pressure than SHR and a strong tendency to die from stroke. (wikipedia.org)
  • blood pressure
  • Modeling blood pressure profiles. (ahajournals.org)
  • Windkessel effect is a term used in medicine to account for the shape of the arterial blood pressure waveform in terms of the interaction between the stroke volume and the compliance of the aorta and large elastic arteries (Windkessel vessels). (wikipedia.org)
  • Several of these studies show that groups with sodium-reduced diets have lower incidences of cardiovascular disease in all demographics, and in particular lower blood pressure. (wikipedia.org)
  • although
  • Although associated with the Leducq Foundation, with which it shares an overlap of mission and philosophy, Broadview Ventures is constituted as an independent, for-profit corporation on a venture philanthropy model. (wikipedia.org)
  • Medicine
  • and Departments of Medicine (Cardiovascular Division) and Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass. (ahajournals.org)
  • Combinatorial drug products were proposed for treating diagnosed conditions long before they were proposed for preventive medicine, including "aspolol" (a combination of aspirin and atenolol) for those diagnosed with cardiovascular disease. (wikipedia.org)
  • AIDS
  • Fixed-dose combination (FDC) products today are also common for treating other diseases, such as tuberculosis and HIV/AIDS. (wikipedia.org)