• Diabetes in humans accelerates cardiovascular disease caused by atherosclerosis. (jci.org)
  • The relative contributions of hyperglycemia and dyslipidemia to atherosclerosis in patients with diabetes are not clear, largely because there is a lack of suitable animal models. (jci.org)
  • We therefore have developed a transgenic mouse model that closely mimics atherosclerosis in humans with type 1 diabetes by breeding low-density lipoprotein receptor-deficient mice with transgenic mice in which type 1 diabetes can be induced at will. (jci.org)
  • Some strains of oral bacteria associated with periodontal disease have been shown to accelerate atherosclerosis and induce arterial lesions in animal models. (colgateprofessional.com)
  • Iron accumulation can affect older people through atherosclerosis that can lead to vascular disease and neurological disease such as Alzheimer's and Parkinson's. (northwestern.edu)
  • At that time there weren't any good animal models to study diabetes-accelerated atherosclerosis, the process that leads to cardiovascular disease. (asbmb.org)
  • we generated a new mouse model that we still use a lot to study mechanisms whereby diabetes promotes atherosclerosis. (asbmb.org)
  • Since this time, a number of papers have been published on the relationship between copper intake and cardiovascular disease in animals, including several showing that copper supplementation prevents atherosclerosis in one of the most commonly used animal models of cardiovascular disease ( 6 , 7 , 8 ). (blogspot.com)
  • A growing body of scientific evidence shows that berry polyphenols' antioxidant capacity powerfully targets numerous degenerative diseases, from cancer and atherosclerosis to impaired glucose control and blood lipid abnormalities. (lifeextension.com)
  • Ischemic cardiovascular diseases such as Peripheral Arterial Disease (PAD) are caused by atherosclerosis that results in impaired blood flow to the tissues. (jhu.edu)
  • His laboratory has developed small synthetic peptide mimetics of apoA-I, and like the full-length protein, these peptides mobilize excess cholesterol from cells and have been shown to reduce atherosclerosis and inflammation in animal models. (nih.gov)
  • W e 're hoping that our studies (with iron chelators and cardiovascular disease) in the preclinical phase , will guide us to translate those into clinical practice and treating patients with various chronic diseases. (northwestern.edu)
  • Preclinical animal studies from Dr. Remaley's laboratory have also demonstrated that a combination therapy of recombinant LCAT and HDL acts synergistically in the removal of cholesterol from cells. (nih.gov)
  • The use of porcine heart slices will determine reduction of the number of small animals involved these in preclinical studies by substantially replacing the in vivo whole heart approach. (ukri.org)
  • To date, PA imaging has mainly been developed for measuring oxygen saturation mainly in phantoms and numerous preclinical studies in animals have exploited the oxygenated and deoxygenated hemoglobin components to characterize tumour microenvironment. (lu.se)
  • Golden or Syrian hamsters (Mesocricetus auratus) are used to model the human medical conditions including various cancers, metabolic diseases, non-cancer respiratory diseases, cardiovascular diseases, infectious diseases, and general health concerns. (wikipedia.org)
  • As recent as the 1970s, infectious diseases were the number one killer globally. (northwestern.edu)
  • Laboratory and animal studies further reveal that fucoidans prevent certain infectious diseases, and block cancer cells from spreading and trigger their early death. (lifeextension.com)
  • The new 4-year PhD programme in One Health Models of Disease: Science, Ethics and Society will provide unique training in state-of-the-art techniques in the design and application of new One Health models of neurodegenerative, cardiovascular, developmental, and infectious diseases of humans and animals. (ed.ac.uk)
  • Genetic factors are important in the development of autoimmune disease, since such diseases develop in certain strains of mice (e.g., systemic lupus erythematosus or lupus in MRL mice) without any apparent infectious environmental trigger. (cdc.gov)
  • More often, many different microorganisms have been associated with a single autoimmune disease, which indicates that more than one infectious agent can induce the same disease through similar mechanisms ( Table ) ( 9 ). (cdc.gov)
  • The National Institute of Occupational Safety and Health (NIOSH) and the National Center for Emerging Zoonotic and Infectious Disease (NCEZID) contributed the most with 12 and 8 articles, respectively. (cdc.gov)
  • 1949: Black-Schaffer advanced the diagnosis, proved the systemic nature of this disease, and raised the suspicion of an infectious cause for Whipple disease. (medscape.com)
  • 1961: Electron microscopy (EM) studies by Yardley et al provided more evidence for an infectious cause of Whipple disease by finding bacillary bodies within membrane-bound vesicles in the cytoplasm of macrophages. (medscape.com)
  • These contain thousands of animal-free procedures from various disciplines such as neurodegenerative diseases, respiratory diseases, breast cancer, cardiovascular diseases, or autoimmune diseases. (aerzte-gegen-tierversuche.de)
  • Autoimmune diseases affect approximately 8% of the population, 78% of whom are women. (cdc.gov)
  • The reasons for the high prevalence in women are unknown, but circumstantial evidence links autoimmune diseases with preceding infections. (cdc.gov)
  • Animal models of autoimmune diseases have shown that infections can induce autoimmune disease. (cdc.gov)
  • Sex hormones may further amplify this hyperimmune response to infection in susceptible persons, which leads to an increased prevalence of autoimmune diseases in women. (cdc.gov)
  • Major autoimmune diseases, comparing the incidence of disease in women (white bar) to the incidence in men (black bar) by percentage. (cdc.gov)
  • An important unifying theme in autoimmune diseases is a high prevalence in women ( Figure 1 ) ( 4 , 5 ). (cdc.gov)
  • Conservative estimates indicate that 6.7 million or 78.8% of the persons with autoimmune diseases are women ( 4 ). (cdc.gov)
  • Soon after autoimmune diseases were first recognized more than a century ago, researchers began to associate them with viral and bacterial infections. (cdc.gov)
  • Autoimmune diseases tend to cluster in families and in individuals (a person with one autoimmune disease is more likely to get another), which indicates that common mechanisms are involved in disease susceptibility. (cdc.gov)
  • However, a body of circumstantial evidence links diabetes, multiple sclerosis, myocarditis, and many other autoimmune diseases with preceding infections ( Table ) ( 7 , 8 ). (cdc.gov)
  • This difficulty raises the question of whether autoimmune diseases really can be attributed to infections. (cdc.gov)
  • Are Autoimmune Diseases Caused by Infections? (cdc.gov)
  • To address the question of whether autoimmune diseases can be induced by infections, first autoimmunity needs to be defined. (cdc.gov)
  • Toxic substances such as heavy metals-for example, arsenic and nickel-are associated with epigenetic changes that may lead to cancer, cardiovascular diseases, autoimmune diseases, and neurological disorders. (medlineplus.gov)
  • Experimental rodent models play a central role in cardiovascular disease research by effectively simulating human cardiovascular diseases. (springer.com)
  • we're combining data that we get from large human cardiovascular outcome studies with the mechanistic mouse models that we have in the lab. (asbmb.org)
  • 11 of 33 died of coronary heart disease, the quintessential modern human cardiovascular disease. (blogspot.com)
  • Yet questions have been raised about the relevance of this method to human cardiovascular disease, because studies have shown that the amount of time it takes copper to oxidize LDL in a test tube doesn't predict how much oxidized LDL you'll actually find in the bloodstream of the person you took the LDL from ( 10 , 11 ). (blogspot.com)
  • They are widely considered to be the prime model of inherited human disease and share 99% of their genes with humans. (wikipedia.org)
  • Rodents such as rats are the most common model in researching effects of cardiovascular disease, as the effects on rodents mimic those in humans. (wikipedia.org)
  • Animal models have many facets that mimic various disease conditions in humans representing the importance for its tremendous use in biomedical research (Mukherjee et al. (springer.com)
  • These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo . (hindawi.com)
  • We're now basing our research on data from human studies to be sure that we're studying the most important drivers of cardiovascular disease risk in diabetes in humans. (asbmb.org)
  • In fact, 90 percent of drugs that are successful in animal tests do not work in humans. (wpi.edu)
  • This seems to be the case in animal models of obesity but has not been demonstrated to be operational in humans. (medscape.com)
  • Students will be supervised by world-leading life scientists addressing important diseases of humans and animals, and social scientists and bioethicists conducting cutting-edge research into the social and ethical dimensions of 21st century science. (ed.ac.uk)
  • Genetic changes in microbes, animal vectors, and humans were included. (cdc.gov)
  • Development of an inhalation reference concentration (RfC) typically involves extrapolation of an effect level observed in a laboratory animal exposure study to a level of exposure in humans that is not expected to result in an appreciable health risk. (cdc.gov)
  • Dosimetry models for the lower respiratory tract (LRT) of humans and rats are used to calculate deposition and retention using the principle of particle mass balance in the lower respiratory tract. (cdc.gov)
  • Realistic asymmetric lung geometries using detailed morphomet- ric measurements of the tracheobronchial (TB) airways in rats and humans are employed in model calculations. (cdc.gov)
  • In our studies, the feasibility of using PAI for estimating the spatial distribution of oxygen saturation is examined, in models of occlusion reperfusion and adrenalin-dependent vasoconstriction in humans. (lu.se)
  • Eight-week-old male and female C57Bl/6 mice were fed a high fat diet (40% kcal from fat) supplemented with one of 3 freeze-dried kefir preparations (whole kefir, cell-free kefir, or heat-treated kefir) for 8 weeks prior to analysis of plasma and liver lipid profiles, circulating cardiovascular disease (CVD) biomarkers, cecal microbiome composition, and cecal short-chain fatty acid levels. (frontiersin.org)
  • We will review several projects based on the use of panels of biomarkers for a better understanding of risk of disease and prognosis. (lu.se)
  • Furthermore, we are presenting not yet associated loss-of-function genes affecting both, metabolism and the cardiovascular system, such as the RING finger protein 10 ( Rfn10 ), F-box protein 38 ( Fbxo38 ), and Dipeptidyl peptidase 8 ( Dpp8 ). (springer.com)
  • In this study we investigated how different preparations of kefir impact cholesterol and lipid metabolism and circulating markers of cardiovascular disease risk and determine if freeze-drying impacts health benefits relative to past studies. (frontiersin.org)
  • The Lipoprotein Metabolism Laboratory, led by Dr. Alan T. Remaley, seeks to better understand lipoprotein metabolism and to translate new insights gained from basic biochemistry, cell biology, and transgenic animal models into much-needed clinical advances in the treatment and prevention of cardiovascular disease. (nih.gov)
  • The exposure to patients with rare diseases often leads to new insights into common disease processes that can be obtained in no other manner and inspires him and his co-workers to translate their basic science findings in cholesterol metabolism into new therapies for cardiovascular disease. (nih.gov)
  • The hallmark of the pathologic report was the marked infiltration by foamy macrophages of joints and aortic valves, and prominent deposits of fat within intestinal mucosa and mesenteric lymph nodes, which made Whipple consider this case an obscure disease of fat metabolism and propose the name intestinal lipodystrophy. (medscape.com)
  • Complete studies on how shielding gases, heat, and humidity impact neurologic disease risk in welders. (cdc.gov)
  • The Cancer, Reproductive, Cardiovascular, and Other Chronic Disease Prevention Program provides leadership in preventing work-related diseases related to many types of cancer, reproductive health, and cardiovascular diseases, as well as occupational neurologic and renal diseases. (cdc.gov)
  • Dr. Yee's previous research focused on neurologic prognostication in patients with critical brain disease. (osteopathic.org)
  • This article, besides being a general presentation of Whipple disease, focuses on both the neurologic manifestations and specifics of diagnosis and treatment of Whipple disease with symptomatic CNS involvement (CNS-WD). (medscape.com)
  • Autonomic dysfunction and sleep problems are closely associated with hypertension and predict cardiovascular morbidity and mortality. (nature.com)
  • Cholesterol has a bad reputation, associated with cardiovascular disease, the leading worldwide cause of morbidity and mortality. (nih.gov)
  • The purpose of the physiologic phenotyping core laboratory is to provide investigators at Stanford the resources to establish precise cardiovascular and metabolic phenotypes for their genetically altered animals. (stanford.edu)
  • The Stanford Murine Cardiovascular Phenotyping Core Facility was established in 1994 for two purposes: first, to develop new methods for studying in vivo cardiovascular and metabolic physiology in the mouse and second, to support Stanford investigators in performing physiologic studies in rodent models. (stanford.edu)
  • Given the substantial effects of anesthesia on cardiovascular and metabolic parameters, it was likely that anesthetic agents could mask important physiologic phenotypes in some cases and yield false positive results in others. (stanford.edu)
  • We have performed the necessary background studies by establishing baseline data for different murine strains, evaluated the cardiovascular and metabolic responses to anesthesia and restraint, determined normal murine pharmacokinetics, and established one of the nation's leading laboratories for evaluation of murine cardiovascular responses. (stanford.edu)
  • Hossein Ardehali, MD, PhD, is working to understand the role of iron and metabolic processes in cardiovascular disease and develop new therapies that target iron accumulation in people with CVD and many other chronic diseases. (northwestern.edu)
  • Today's guest, Dr. Hossein Ardehali, is focused on the role of metabolic processes and cardiovascular disease. (northwestern.edu)
  • These extensive high-throughput data from IMPC mice provide a promising opportunity to explore genetics causing metabolic heart disease with an important translational approach. (springer.com)
  • Nonalcoholic fatty liver disease (NAFLD) is a globally observed metabolic disease with high prevalence both in adults and children. (mdpi.com)
  • Metabolic syndrome is a pathophysiological state that brings about diabetes, hypertension and dyslipidemia, and is also a major risk factor for cardiovascular disease or ischemic heart disease. (nature.com)
  • It is widely accepted that early detection and early intervention are critical for preventing lifestyle-related diseases, including metabolic syndrome. (nature.com)
  • Although this was an animal model study, the authors believe their results have implications for human health as well: "Considering that hyperlipidemia is a well-known risk factor for cardiovascular diseases and that fatty liver disease… also increases cardiovascular disease risk, our finding clearly indicates a great potential for dietary insect meal to improve metabolic health. (nutrition.org)
  • With the growth of genetic engineering, mice have become increasingly common as models of human diseases, and this has stimulated the development of techniques to assess the murine cardiovascular system. (nih.gov)
  • CVD encompasses various types of atherosclerotic diseases, including coronary heart disease, cerebrovascular disease, and peripheral vascular disease. (colgateprofessional.com)
  • There is a strong positive association between periodontitis and coronary heart disease, cerebrovascular disease (e.g., stroke), heart failure, and atrial fibrillation. (colgateprofessional.com)
  • There is a positive association between periodontitis and higher cardiovascular mortality due to coronary heart disease and cerebrovascular disease. (colgateprofessional.com)
  • While mice, rats and other rodents are by far the most widely used animals in biomedical research, recent studies have highlighted their limitations. (wikipedia.org)
  • ECVAM is part of the European Commission and has published a total of seven reports on animal-free models in biomedical research in the past 2 years. (aerzte-gegen-tierversuche.de)
  • Doppler methods have been used to characterize and evaluate numerous cardiovascular phenotypes in mice and have been particularly useful in evaluating the cardiac and vascular remodeling that occur following transverse aortic constriction. (nih.gov)
  • Rodents are commonly used in animal testing, particularly mice and rats, but also guinea pigs, hamsters, gerbils and others. (wikipedia.org)
  • Regarding experiments on mice in particular, some researchers have complained that "years and billions of dollars have been wasted following false leads" as a result of a preoccupation with the use of these animals in studies. (wikipedia.org)
  • Furthermore, mice exhibit a very high degree of variability in cardiovascular parameters depending on their strain, sex, state of arousal and the manner in which the data is obtained. (stanford.edu)
  • Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene knockout models by a global network of mouse clinics. (springer.com)
  • Mice with pulmonary arterial hypertension had very high levels of Nogo in their lung arteries, but animal models that were genetically lacking Nogo were completely resistant to developing the disease," said Michelakis. (wun.ac.uk)
  • Extrapolating from our experimental design and the data reported by Dr. Smart, we assume that 20% of these mice and rats could be replaced by EpCardio-TS, totalling to 1,000 animals in the UK. (ukri.org)
  • The same disease can be induced by injecting mice with heart proteins mixed with adjuvant(s), which indicates that an active infection is not necessary for the development of autoimmune disease. (cdc.gov)
  • We have found that CB3 triggers autoimmune disease in susceptible mice by stimulating elevated levels of proinflammatory cytokines from mast cells during the innate immune response. (cdc.gov)
  • We are hoping that if we see positive results, we will extend it to other chronic diseases, including neurological diseases and maybe other chronic diseases like cancer. (northwestern.edu)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • To explore work on gene-environment interaction (GxE) at the Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ATSDR), we examined the CDC-Authored Genomics and Precision Health Publications Database (CDC-Authored GPHPD) , which includes articles published by CDC/ATSDR authors since 2011. (cdc.gov)
  • His work is currently in animal models, but he hopes to bring it into human clinical trials to investigate iron chelator therapies for many chronic diseases, including cancer. (northwestern.edu)
  • Available therapies may alleviate some symptoms but they cannot reverse the disease and prolong survival of the patients. (wun.ac.uk)
  • New therapies are planned in other diseases where Nogo is important, like spinal-cord injury. (wun.ac.uk)
  • We believe that by bringing along these [spinal cord and neurology] colleagues into the field of pulmonary hypertension, we'll contribute to accelerating knowledge and discovery of new therapies in this disease," said Michelakis. (wun.ac.uk)
  • Such models can transform our approach to understanding pathogenesis, facilitating the development of therapies or preventive measures. (ed.ac.uk)
  • Once our model is tested, it will be used to develop new therapies harnessing the reparative potential of the epicardium. (ukri.org)
  • This enabling model will contribute to further our understanding of the contribution of the epicardium to cardiac repair and improve the outcomes of therapies targeted to this tissue, reducing the burden to animals. (ukri.org)
  • Biopsychosocial Factors Associated with Pain and Pain-Related Outcomes in Adults and Children with Sickle Cell Disease: A Multivariable Analysis of the GRNDaD Multi-Center Registry. (iasp-pain.org)
  • Exposure to welding fumes may result in disorders of the pulmonary, cardiovascular, and reproductive systems. (cdc.gov)
  • In addition to work done in laboratory models, the research team found that the level of Nogo was also high in arteries of patients with pulmonary arterial hypertension. (wun.ac.uk)
  • Michelakis took samples from 41 patients at his pulmonary hypertension clinic and compared it to 26 patients who didn't have the disease. (wun.ac.uk)
  • Statins are known to improve pulmonary arterial hypertension (PAH) by their anti-inflammatory and anti-proliferative effects in animal models. (escardio.org)
  • Transgenic animal production consists of injecting each construct into 300-350 eggs, typically representing three days' work. (wikipedia.org)
  • The number of transgenic animals typically varies from two to eight. (wikipedia.org)
  • Published animal studies modeling Gulf War illness among veterans, including an evaluation of brain inflammation , an intervention strategy , and support of establishing a sample biorepository . (cdc.gov)
  • Research in these departments is mainly focused on different aspects of mechanisms of inflammation and cardiovascular pharmacology, with many projects overlapping these two areas. (bioethics.ac.uk)
  • Currently, she is testing the role of inflammation in this model. (portlandpress.com)
  • The supervisors contributing to the programme are mainly based in the University of Edinburgh's Roslin Institute, the Centres for Inflammation Research and Cardiovascular Research, and the Usher Institute. (ed.ac.uk)
  • Here we describe a novel experimental model of the peripheral neuro-cardiac axis to study the neuron's ability to drive a myocyte cAMP phenotype. (bvsalud.org)
  • In 2006-07, Syrian hamsters accounted for 19% of the total animal research participants in the United States. (wikipedia.org)
  • A major goal of his research is to find ways to reduce iron in chronic diseases and therefore reduce the oxidative stress that iron can cause. (northwestern.edu)
  • This trend to cardiovascular disease (CVD) claiming the most lives every year was one reason why Ardehali became interested in CVD research and finding new treatments for CVD. (northwestern.edu)
  • A multidisciplinary research team in the Faculty of Medicine & Dentistry at the University of Alberta has taken a big step towards understanding the cause and potential cure for a deadly cardiovascular disease. (wun.ac.uk)
  • She continues to probe the links between the two diseases as the deputy director of, and director of the diabetes complications research program at, the University of Washington's Diabetes Institute. (asbmb.org)
  • I thought better animal models would be needed in order to understand mechanisms and move the research area forward. (asbmb.org)
  • The Center for Experimental Therapeutics works with OHSU's Knight Cancer Institute, Vollum Institute, Knight Cardiovascular Institute, Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Brenden-Colson Center, Center for Regenerative Medicine, Brain Institute, and more. (ohsu.edu)
  • The goal of our research is to develop better treatments for the disease. (jhu.edu)
  • A research team at Worcester Polytechnic Institute (WPI) is engineering self-assembling human blood vessels that exhibit the symptoms of common cardiac and vascular conditions, like aneurisms and blockages, work that may provide a better way for scientists to test the effectiveness of new medications and, potentially, speed up the development of more effective treatments for life-threatening diseases. (wpi.edu)
  • The research could speed the process of discovering new drugs for cardiovascular disease, Rolle said, noting that it currently takes an average of 10 years to develop a new medication. (wpi.edu)
  • John Keaney Jr., MD, chief of cardiovascular medicine at UMass Memorial Health Care and professor of medicine at UMass Medical School, is collaborating with Rolle on her blood vessel research. (wpi.edu)
  • The impact of the osteopathic approach on chronic disease and elderly care: Proposals should explore the impact of the osteopathic approach on chronic disease and elderly care through clinical, translational or basic science research. (osteopathic.org)
  • Owen's research interests include immunology, cardiovascular health, and LGBTQ+ health disparities. (portlandpress.com)
  • On July 29th, 2020, our NAT database was launched with 250 entries describing animal-free research methods. (aerzte-gegen-tierversuche.de)
  • We proudly look back on a success story that makes a decisive contribution to avoiding animal testing and advancing animal-free research. (aerzte-gegen-tierversuche.de)
  • Nowadays, numerous modern animal-free research methods are readily available and the quantity of publications describing them is steadily increasing. (aerzte-gegen-tierversuche.de)
  • Conventional literature databases are still dominated by animal-consuming research, causing animal-free methods to become overshadowed by animal experimentation studies. (aerzte-gegen-tierversuche.de)
  • Consequently, the full potential of modern human-based research methods has not yet been exploited - countless animals continue to suffer and die in animal experiments, despite the existence of viable animal-free methods. (aerzte-gegen-tierversuche.de)
  • It is essential to promote the availability of the existing non-animal research methods to successfully abolish animal experiments. (aerzte-gegen-tierversuche.de)
  • This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research. (awionline.org)
  • As the use of zebrafish (Danio rerio) as a research model continues to rise, so too will the shipping and sharing of zebrafish strains across collaborating institutions. (awionline.org)
  • The development of treatments and vaccines (5 articles), methods and models for evaluating GxE (5 articles), and recommendations for future research (1 article) complete the remaining topics explored in these publications. (cdc.gov)
  • The research program focuses on environmental agents such as industrial chemicals, metals, pesticides and herbicides, air pollutants, and biologically derived toxins (hazardous substances made from plants, animals, and microorganisms). (medlineplus.gov)
  • In several instances, such as rheumatoid arthritis, multiple sclerosis, and myocarditis, the autoimmune disease can be induced experimentally by administering self-antigen in the presence of adjuvant (collagen, myelin basic protein, and cardiac myosin, respectively) ( 3 ). (cdc.gov)
  • It's been a rewarding progression in my career, going from studying single cells in culture to animal models to translational and clinical studies. (asbmb.org)
  • However, emerging clinical data highlights a dominant role in disease progression by the neurons themselves. (bvsalud.org)
  • The IVIS Spectrum CT enables longitudinal workflows to characterize disease progression and therapeutic effect in animals throughout the complete experimental time frame with both quantitative CT and optical reconstructions. (lu.se)
  • We are also learning more about the effects of inherited traits, such as blood type, on disease susceptibility and progression. (cdc.gov)
  • In cardiovascular disease and diabetes the measurement of abnormalities of the microcirculation can monitor the progression of the disease. (lu.se)
  • The National Institute for Occupational Safety and Health (NIOSH) Cancer, Reproductive, Cardiovascular, and Other Chronic Disease Prevention (CRC) Program works with partners in industry, labor, trade associations, professional organizations, and academia. (cdc.gov)
  • These findings could be important to many other conditions where Nogo is involved, including cancer or diseases of the nervous system. (wun.ac.uk)
  • The overarching goal of the Systems Biology Laboratory is to apply modern methods of biomedical engineering to better understand the mechanisms of cancer and to significantly advance treatments for this devastating disease. (jhu.edu)
  • Johns Hopkins Medicine researchers develop an image-based computer model of tumor behavior that captures more of the complexity of cancer growth. (jhu.edu)
  • Researchers with the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine received a $3 million grant to use computational modeling and software to understand biological data, in combination with unique in vitro and animal studies, to better treat liver cancer. (jhu.edu)
  • Fisetin, a flavonoid phytonutrient present in almost all kinds of fruits and vegetables, has recently emerged as a powerful antioxidant for health promotion [ 9 , 10 ] and exerts multiple protective effects in different oxidative stress-related conditions in human, such as degenerative diseases (e.g., vascular dementia), cancer, diabetes, and cardiovascular diseases [ 11 - 14 ]. (hindawi.com)
  • Cardiovascular diseases cause a high mortality rate worldwide and represent a major burden for health care systems. (springer.com)
  • Sex and Circadian Periodicity of Cardiovascular Diseases: Are Women Sufficiently Represented in Chronobiological Studies? (elsevier.ca)
  • The goal of these studies was to use an established model of welding particulate exposure to mimic the effects of welding fume inhalation on reproductive functions. (cdc.gov)
  • Animal studies and clinical observations have identified exercise as an important factor in preventing and treating hypertension. (nature.com)
  • Before my graduate studies, I had not heard of women having heart attacks in their 30s, and it made me realize that the connection between diabetes and early heart disease was something that we urgently needed to understand and find treatments for. (asbmb.org)
  • This project aims at developing an ex vivo model to study the epicardial cell behaviour in order to understand the observed in vivo reparative effect and provide a platform to enable future screening of arrays of gene/drug therapy candidates ex vivo, replacing animals in this type of studies. (ukri.org)
  • Studies of the prevalence of autoimmune disease in monozygotic twins show that genetic as well as environmental factors (such as infection) are necessary for the disease to develop ( 6 ). (cdc.gov)
  • More than half (23 of 39) of the articles represent epidemiologic studies including candidate gene and genome-wide association studies (GWAS) examining genetic effect modification on disease risk. (cdc.gov)
  • Findings were done using mouse models, which will be used to inform human studies. (medlineplus.gov)
  • How do you apply an insight from a large clinical trial to a mouse model? (asbmb.org)
  • Plasma free amino acid profiles may also be useful as markers for monitoring the risks of developing lifestyle-related diseases and measuring improvement in physiological states. (nature.com)
  • thus, treatment of ED in these patients must take cardiovascular risks into account. (medscape.com)
  • and stratify disease risks and differentiate interventions for different subgroups of the population. (cdc.gov)
  • The goals are to prevent disease and help individuals reduce their unique health risks from environmental exposures. (medlineplus.gov)
  • Tangier disease, a rare genetic disorder characterized decades ago by Dr. Donald S. Frederickson at the NIH, is defective in the ABCA1 transporter and provided an early clue to the importance of the reverse cholesterol transport pathway. (nih.gov)
  • Occupational exposures involving crystalline silica and multiwalled carbon nanotubes were also studied in relation to genetic damage and initiation of disease processes. (cdc.gov)
  • Researchers seek to use this information to understand the causes of diseases and the effects of environment, diet, lifestyle, and genetic factors on human health. (medlineplus.gov)
  • Researchers can use ENCODE data-which has been combined with other data, such as environmental information-to better understand diseases and drugs, how an individual's genetic makeup interacts with the environment, and how those affect their health. (medlineplus.gov)
  • Dr. Orosz has a diverse portfolio that overarches a broad range of alcohol induced pathologies including the cardiovascular system, proteostasis (protein homeostasis) pathways, alcoholic liver disease, epigenetics, mitochondrial dysfunction and apoptosis, and identification and validation of alcohol biomarker signatures. (nih.gov)
  • Importantly, CYP epoxygenase-derived EETs are involved in the maintenance of cardiovascular homeostasis. (frontiersin.org)
  • Designed to explore the role of selected cellular and physiological systems in the maintenance of homeostasis in animals under varying environmental conditions, as well as the molecular basis of hereditary and environmental variation. (trentu.ca)
  • The in vivo neointimal hyperplasia model was established 2 weeks after the carotid artery balloon injury in SHR rats. (hindawi.com)
  • We will base our model on the ex vivo culture of porcine superficial cardiac slices, comprising the epicardial layer and the underlying myocardial tissue (Epicardial/Cardiac-Tissue Slices, EpCardio-TS). (ukri.org)
  • Epicardial/Cardiac-Tissue Slice (EpCardio-TS) is an ex vivo model for the study of the epicardial cell reparative potential and the development of targeted therapeutic approaches. (ukri.org)
  • Welders are also at a greater risk of developing symptoms similar to those seen in individuals with idiopathic Parkinson's disease. (cdc.gov)
  • The rat thoracic aortic smooth muscle cells (A10 cells) stimulated by AngII were used as the in vitro neointimal hyperplasia model, where AngII significantly induced the proliferation and migration in A10 cells. (hindawi.com)
  • Current models are based on simplified in vitro systems (isolated epicardial cells) or on small animal models of cardiovascular diseases. (ukri.org)
  • Another NIH-funded study, Utilizing In Vitro Functional Genomics Advances for Gene-Environment (GxE) Discovery and Validation , aims to better understand the connection between environmental exposure and human disease. (medlineplus.gov)
  • The goal is to find new in vitro approaches to understand and treat human diseases caused by the environment. (medlineplus.gov)
  • That represents 45% of deaths from non-communicable diseases and a third of all total deaths, making CVD a burdensome global health condition. (colgateprofessional.com)
  • Cardiovascular disease (CVD) is a world-leading health problem and encompasses a broad spectrum of disorders, including diseases of the blood vessels, the heart muscle, the electrical conduction system, and congenital heart disease. (springer.com)
  • You will also gain insight into the specific health benefits of açaí and similarly potent fruits and vegetables-and their unrivalled power to combat free radical damage and the killer diseases of aging. (lifeextension.com)
  • This Wellcome programme combines training in experimental techniques, bioethics and social sciences for human and animal health. (ed.ac.uk)
  • Smoking, which has an adverse effect on periodontal health, also affects this overall disease condition. (medscape.com)
  • Direct calculation of delivered dose in the species of interest potentially affects the magnitude of an uncertainty factor needed to address extrapolation of laboratory animal data to equivalent human exposure scenarios, thereby improving the accuracy of human health risk estimates. (cdc.gov)
  • In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)
  • Precision Environmental Health is about understanding those differences and developing disease prevention efforts that are based on a person's specific needs. (medlineplus.gov)
  • Cardiovascular disease (CVD) is the number one cause of death globally, and nearly half of all U.S. adults are currently at risk for heart attack and stroke. (northwestern.edu)
  • Hereditary DNA sequence variants play a role in the transmission of disease risk in almost all of them (Basson et al. (springer.com)
  • Total cholesterol is an independent risk factor for cardiovascular disease. (ecopolitan.com)
  • A person with this level has twice the risk of heart disease compared with someone whose cholesterol is 200 mg/dL. (ecopolitan.com)
  • The higher the level of LDL, the greater your risk for heart disease. (ecopolitan.com)
  • We did manage to ban trans fats because they are more harmful than butter in terms of risk for cardiovascular disease (CVD), but I'm not sure that this ban amounted to less risk for CVD. (medscape.com)
  • Taking vitamin B6 supplements by mouth or eating large amounts of vitamin B6 in the diet doesn't seem to reduce the risk for Alzheimer disease. (medlineplus.gov)
  • Because time is an explicit parameter incorporated in species-specific constants such as mu- cociliary clearance rates used in the models, the impact of the application of optimal model structures to refine adjustments and assumptions used in default risk assessment approaches to address exposure duration are discussed. (cdc.gov)
  • A population-based study found significant increases in the risk of death from cardiovascular disease among residents 65 years of age and older living in communities with high levels of barium in the drinking water. (cdc.gov)
  • However, these data cannot be used to establish a causal relationship because the study did not control for other cardiovascular risk factors or the use of water softeners, which would decrease barium levels and increase sodium levels. (cdc.gov)
  • Investigate emerging diseases such as chronic kidney disease in agricultural workers. (cdc.gov)
  • The Phenotyping Core has pioneered the adaptation of chronic non-anesthetized physiologic monitoring techniques, previously established as a superior methodology in larger animals, to the murine model. (stanford.edu)
  • He has long been fascinated with the role of iron in chronic diseases such CVD. (northwestern.edu)
  • He has authored 20 original peer-reviewed papers relating to the use of osteopathic manipulation for pneumonia, chronic obstructive lung disease, influenza vaccine, improving immune function, applications of osteopathic philosophy, falls prevention, leg length discrepancies and, most recently, leg edema. (osteopathic.org)
  • This study will determine the efficacy of diuretics in patients with chronic kidney disease. (stanford.edu)
  • Using multivariate analysis, the factors significantly associated with acute kidney injury were age, diabetes, preoperative chronic kidney disease and emergent surgery. (who.int)
  • With support from the NIH, she is using her innovative methods to create diseased blood vessels, which could serve as better models for testing new medications and help speed the development of better treatments for cardiac and vascular conditions. (wpi.edu)
  • We ensure that different biomedical disciplines are represented (e.g., oncology or toxicology), as well as different models (e.g., 3-dimensional cell models or computer-based procedures). (aerzte-gegen-tierversuche.de)
  • 145 disease terms (MeSH) has been reported with DRD3 gene. (cdc.gov)
  • These specific conditions in the oral cavity may create foci of infection that can affect many other vital systems, such as the cardiovascular and renal systems. (medscape.com)
  • Given the well-established link to CVD, as well as other systemic diseases like diabetes, it is clear that the value of preventing periodontal disease goes far beyond the teeth. (colgateprofessional.com)
  • Increasing evidence indicates that oral microbiota participate in various systemic diseases. (medscape.com)
  • EpCardio-TS employs multicellular cardiac slices derived from pigs sacrificed for other projects, maximising the use of the sacrificed animal. (ukri.org)
  • Many therapeutic interventions in disease states of heightened cardiac sympathetic activity are targeted to the myocytes. (bvsalud.org)
  • That scientific knowledge will help to improve disease prevention efforts at the individual level. (medlineplus.gov)
  • Progress in our ability to manipulate the mammalian genome has led to the proliferation of genetically altered models of cardiovascular disease. (stanford.edu)
  • Scientists have discovered that fucoidans are a source of necessary components of cell-surface molecules that facilitate cell-to-cell signaling, the core regulatory process responsible for everything from immunity and cardiovascular function to healthy cellular proliferation. (lifeextension.com)
  • In this article, we discuss the growing body of evidence showing the link between cardiovascular disease (CVD) and periodontitis and how dental students can help to prevent and manage periodontitis in their patients. (colgateprofessional.com)
  • Specific diseases, such as histiocytosis, may result in necrotizing ulcerative periodontitis. (medscape.com)
  • Globally, cardio-cerebrovascular diseases (CCVDs) are the leading cause of death, and thus the development of novel strategies for preventing and treating such diseases is in urgent need. (nih.gov)
  • In this project we will develop a model based on leftover pig heart tissues to mimic in a dish the behaviour of the epicardium after stimulation. (ukri.org)
  • The problem, she added, is exacerbated by the fact that animal testing, which is the way most new drugs are tested, is not always an accurate indicator of how human blood vessels will respond to the same drugs. (wpi.edu)
  • However, the underlying molecular mechanisms of medicinal herbs in treating these diseases are still unclear. (nih.gov)
  • Rodrigues B, Feriani DJ, Gambassi BB, Irigoyen MC, Angelis KD, Hélio José Júnior C. Exercise training on cardiovascular diseases: role of animal models in the elucidation of the mechanisms. (nature.com)
  • Immunosuppressive drug therapy and any disease (eg, HIV infection) resulting in suppression of the normal inflammatory and immune mechanisms can cause or enhance severe periodontal diseases. (medscape.com)
  • They are having preliminary success in their laboratory models. (wun.ac.uk)
  • To aid in their development, there is a need for three-dimensional disease models that closely resemble functioning human organs to more accurately assess the effects of new drugs, something that cannot be accomplished as well with animal models or cells cultured in a dish. (wpi.edu)
  • There are many drugs which have favourable effects on cardiovascular disease, however, the use of some strong drugs is limited because of side effects or off-target effects. (escardio.org)
  • 2014 Chair , Symposium Biomarker-based modeling tools: safer drugs and faster development? (rug.nl)