• I believe understanding nutritional interventions to attenuate loss of lean body mass at altitude may have future application to muscle wasting associated with subcaloric diets and disease states such as chronic obstructive pulmonary disease and cancer cachexia. (utah.edu)
  • Combivent (ipratropium bromide and albuterol sulfate ) is an inhaler that is a combination of an anticholinergic bronchodilator and a selective beta2-adrenergic bronchodilator used to treat and prevent symptoms ( wheezing and shortness of breath) caused by ongoing lung disease ( chronic obstructive pulmonary disease - COPD which includes bronchitis and emphysema ). (rxlist.com)
  • COMBIVENT Inhalation Aerosol is indicated for use in patients with chronic obstructive pulmonary disease (COPD) on a regular aerosol bronchodilator who continue to have evidence of bronchospasm and who require a second bronchodilator. (rxlist.com)
  • [ 7 ] Hypertensive disorders in pregnancy may cause maternal and fetal morbidity, and they remain a leading source of maternal mortality. (medscape.com)
  • The levels of angiogenic and anti-angiogenic molecule concentrations in pregnancy based disorders in the maternal and fetal circulation. (bham.ac.uk)
  • The abnormal spiral arteries lead decreased level of oxygen diffusion through the placental villus, which cause chronic hypoxia. (wikipedia.org)
  • Studies of the effects of chronic hypoxemia can be performed in the laboratory by decreasing either the concentration of inspired oxygen or the barometric pressure in a hypobaric chamber. (medscape.com)
  • Exposure times to oxygen at different depths of water (and, hence, different levels of pressure) were quantified and tested based on time to convulsions. (medscape.com)
  • Hypoxia (low oxygen availability) can occur in physiologica. (uc.edu)
  • Severe or complicated illness is characterized by signs of lower respiratory tract disease (e.g., hypoxia requiring supplemental oxygen, abnormal chest radiograph, mechanical ventilation), CNS findings (encephalitis, encephalopathy), complications of low blood pressure (shock, organ failure), myocarditis or rhabdomyolisis, or invasive secondary bacterial infection based on laboratory testing or clinical signs (e.g. persistent high fever and other symptoms beyond three days). (cdc.gov)
  • Also, exposure to sudden trauma can increase the risk of placental abruption which coincides with placental disease. (wikipedia.org)
  • These can be loosely defined as peripartum in nature, such as placental abruption, vasa praevia (a condition where fetal blood vessels cross the external orifice of the uterus and often rupture), or a hypoxic-ischemic event at birth ( 2 , 3 ). (frontiersin.org)
  • Although effects are poorly understood, fetal vasoconstriction and hypoxia are likely, and there is a risk of stillbirth, placental abruption, and possibly congenital malformations. (msdmanuals.com)
  • Chronic fetal hypoxaemia is a common pregnancy complication that increases the risk of infants experiencing respiratory complications at birth. (researchgate.net)
  • In turn, chronic fetal hypoxaemia promotes oxidative stress, and maternal antioxidant therapy in animal models of hypoxic pregnancy has proven to be protective with regards to fetal growth and cardiovascula. (researchgate.net)
  • Gestational hypertension (transient hypertension of pregnancy or chronic hypertension identified in the latter half of pregnancy). (medscape.com)
  • Chronic hypertension is defined as blood pressure exceeding 140/90 mm Hg before pregnancy or before 20 weeks' gestation. (medscape.com)
  • When hypertension is first identified during a woman's pregnancy and she is at less than 20 weeks' gestation, blood pressure elevations usually represent chronic hypertension. (medscape.com)
  • Hypertensive disorders of pregnancy: observations on cardiovascular pathophysiology. (bham.ac.uk)
  • or methamphetamine have indirect fetal risks (eg, maternal stroke or death during pregnancy). (msdmanuals.com)
  • DRUG INTERACTIONS CNS depressants, including alcohol: Possible adverse additive CNS-depressant effects (5.1, 7.1) Imipramine: Decreased alertness observed (7.1) Chlorpromazine: Impaired alertness and psychomotor performance observed (7.1) Rifampin: Combination use may decrease effect (7.2) Ketoconazole: Combination use may increase effect (7.2) USE IN SPECIFIC POPULATIONS Pregnancy: Based on animal data, zolpidem may cause fetal harm (8.1) Pediatric use: Safety and effectiveness not established. (drugs-library.com)
  • However, it is now recognized that a range of other in utero adverse exposures including chronic fetal hypoxia, maternal over-nutrition and maternal stress can also lead to increased risk of cardio-metabolic and renal diseases in later life. (cambridge.org)
  • Fetal Alcohol Syndrome Alcohol exposure in utero increases the risk of spontaneous abortion, decreases birth weight, and can cause fetal alcohol syndrome, a constellation of variable physical and cognitive abnormalities. (msdmanuals.com)
  • It is now over thirty years since epidemiological studies revealed a relationship between low birth weight and subsequent risk of developing traditionally adult-onset diseases, such as type 2 diabetes, cardiovascular and renal disease. (cambridge.org)
  • This report describes the role of neuroprotection in acute disorders such as stroke and injuries of the nervous system as well as in chronic diseases such as neurodegenerative disorders because many of the underlying mechanisms of damage to neural tissues are similar in all these conditions and several products are used in more than one disorder. (researchandmarkets.com)
  • Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. (jci.org)
  • The low endogenous regenerative capacity of the heart,added tothe prevalence of cardiovascular diseases, triggered the advent ofcardiac tissue engineering in the last decades. (ibecbarcelona.eu)
  • Asthma is one of the most common chronic diseases of childhood, affecting about 6 million children in the US. (msdmanuals.com)
  • Diabetes mellitus Maternal age less than 20 years or over the age of 35 Multiple pregnancies Chronic high blood pressure Being underweight or obese Also, chronic renal disease, collagen vascular disease, thrombophilia, and cardiovascular disease increase the risk of developing placental disease. (wikipedia.org)
  • Gestational hypoxia is a major contributor to fetal growth restriction (FGR) and perinatal morbidity and mortality and has been closely linked to the activation of the unfolded protein response (UPR) in the placenta. (researchgate.net)
  • Abruptio placentae Placenta accreta Placenta increta Placenta percreta Placentitis Villitis of unknown etiology TORCH infections Circumvallate placenta Placental villous immaturity Placenta previa Vasa previa Fetal thrombotic vasculopathy Hypertrophic decidual vasculopathy Chorangiosis Chorangioma Placental infarction Trophoblastic neoplasms derive from trophoblastic tissue. (wikipedia.org)
  • Antenatal glucocorticoids accelerate fetal lung maturation and reduce mortality in preterm babies but can trigger adverse effects on the cardiovascular system. (researchgate.net)
  • BACKGROUND: It has been suggested that antenatal exposure to environmental endocrine disruptors is responsible for adverse trends in male reproductive health, including male infertility, impaired semen quality, cryptorchidism and testicular cancer. (diagenode.com)
  • Anecdotal clinical reports appeared claiming efficacy in various metabolic and cardiovascular disorders from pharmaceutical mixtures of pangamic acid and DIPA. (srcinhibitors.com)
  • The aetiology of the ND disability is multiple, and the most frequent causes are different in the foetus -intrauterine growth restriction (IUGR), exposure to drugs and environmental toxic substances, malformations. (redsamid.net)
  • 1077) introduced the concept of early programming induced by altered intrauterine environment related to the maternal or fetal protein restrictions, and induces epigenetic gene regulation, in the context of the developmental origins (foetal) of health and cardiovascular disease (Gluckman PD et al 2004;15;183). (redsamid.net)
  • Developmental hypoxia has profound and persistent effects on the vertebrate cardiovascular system, but the nature, magnitude and long-term outcome of the hypoxic consequences are species-specific. (researchgate.net)
  • Our understanding of fetal cardiovascular physiology has markedly increased in the last 50 years, with the introduction of suitable animal models. (researchgate.net)
  • This treatment may be unnecessary, but it is given to mimic sea-level oxygenation and to promote the transition from fetal to adult physiology. (medscape.com)
  • Nature has provided a third option, high altitude, which allows examination of the effects of chronic hypoxemia in individuals under varying conditions. (medscape.com)
  • The cardiovascular changes at high altitude are influenced by factors such as population ancestry and sociocultural determinants, as well as adaptation, nutrition, intercurrent infection, exposure to pollutants and toxins, socioeconomic status, and access to medical care. (medscape.com)
  • Although cold, low humidity, increased solar radiation, and poor economic conditions limit the ability to survive at high altitude, hypoxia is the most important factor. (medscape.com)
  • Aniline has a characteristic aromatic or fishy odor which provides adequate warning of acute exposure. (cdc.gov)
  • T he 1986 National Research Council (NRC) report on commercial airliner cabin air quality notes that information regarding the environmental characteristics (e.g., relative humidity and air pressure) and contaminants identified in surveys of airline cabin air "suggests a diverse set of adverse health effects that could arise from exposure to the cabin environment-from acute effects…to long-term effects. (nationalacademies.org)
  • Animal and human data demonstrate independent relationships between fetal growth, hypothalamic-pituitary-adrenal axis function (HPA-A) and adult cardiometabolic outcomes. (cambridge.org)
  • While the association between fetal growth and adult cardiometabolic outcomes is well-established, the role of the HPA-A in these relationships is unclear. (cambridge.org)
  • This change probably reflects a variable adaptive response to the transition from a fetal circulation to an adult circulation. (medscape.com)
  • Adult patients with Chronic Lymphocytic Leukemia (CLL) ( 1.2 ). (drugs.com)
  • In adult patients with newly diagnosed or imatinib-resistant or -intolerant chronic phase CML, grade 3/4 fluid retention occurred in 6% of patients treated with SPRYCEL at the recommended dose (n=548). (sprycel-hcp.com)
  • Those insults to the brain occurred during the foetal, neonatal or early post-neonatal periods, and although the specific mechanisms are complex and vary, all are related to cerebral hypoxia and ischemia, and reperfusion (Hilario E. Current Pediatr Review 2006;2:131). (redsamid.net)
  • in patients with chronic cardiopulmonary disease, changes may occur at modest elevations. (medscape.com)
  • In pediatric patients with chronic phase CML, cases of Grade 1 or 2 fluid retention were reported in 10.3% of patients. (sprycel-hcp.com)
  • can cross the placenta, recreational use of marijuana use does not consistently appear to increase risk of congenital malformations or fetal growth restriction. (msdmanuals.com)
  • Those who survive often suffer from a range of health issues including brain damage-manifesting as cerebral palsy (CP)-respiratory insufficiency, cardiovascular collapse, and renal dysfunction, to name a few. (frontiersin.org)
  • Knowledge gained on mountain peaks may give insight into the pathophysiology of patients with cyanotic heart disease or chronic lung disease. (medscape.com)
  • BACKGROUND: The association between chronic anterior cruciate ligament (ACL) injury and inferior postoperative outcomes following ACL reconstruction (ACLR) has been highlighted in the literature. (bvsalud.org)
  • The association between fetal position at the onset of labour and birth outcomes. (bham.ac.uk)
  • Treatment with SPRYCEL is associated with severe (NCI CTCAE Grade 3/4) thrombocytopenia, neutropenia, and anemia, which occur earlier and more frequently in patients with advanced phase CML or Ph+ ALL than in patients with chronic phase CML. (sprycel-hcp.com)
  • Obesity plays a key role on insulin resistance and the metabolic syndrome (MS) with severe cardiovascular -hypertension- and metabolic risk factors (abdominal obesity, hyperglycemia due to type-2 diabetes, dyslipidemia) (Simmons R. Pediatr Clin N Amer 2009;56:449). (redsamid.net)
  • Digital Fetal Scalp Stimulation (dFSS) versus Fetal Blood Sampling (FBS) to assess fetal wellbeing in labour- a multi-centre randomised controlled trial. (hrb.ie)
  • 2013) Effect of leucine supplementation on fat free mass with prolonged hypoxic exposure during a 13-day trek to Everest Base Camp: A double-blind randomized study. (utah.edu)
  • Effects can result from all routes of exposure. (cdc.gov)
  • Any consideration of health effects in the context of airline cabin air must distinguish between effects of exposures that result from the ambient environment encountered during boarding, waiting at the gate with the aircraft door open, and normal operation of the aircraft and effects of exposures that result from incidents during flight. (nationalacademies.org)
  • As a product of water chlorination and a metabolite of certain industrial chemicals, DCA is ubiquitous in our biosphere at low μg/kg body weight daily exposure levels without obvious adverse effects in humans. (srcinhibitors.com)
  • it includes fetal growth restriction, facial and cardiovascular defects, and neurologic dysfunction. (msdmanuals.com)
  • This effect is possible during the organogenesis or fetal stage, but not during the pre- implantation stage [url=https://sritalent.com/reports/buy-kamagra-soft/] erectile dysfunction kolkata order kamagra soft with american express[/url]. (ehd.org)
  • Risk factors such as diabetes, chronic blood pressure and multiple pregnancies can increase the risk of developing placental disease. (wikipedia.org)
  • Idiopathic central nervous system stimulant acne, boils, indigestion, abortifacient improve health, lengthen life span, chronic bladder disease, paraquat poisoning result from local injury to the brain, and elsewhere with resultant airwaypromise is a specific sexual difficulty or demonstrated an inability to practice values that include nausea, vomiting, and ushing can occur at 28-minute intervals. (reflectionsbodysolutions.com)
  • Mild or uncomplicated illness is characterized by typical symptoms like fever (although not everyone with influenza will have a fever), cough, sore throat, rhinorrhea, muscle pain, headache, chills, malaise, sometimes diarrhea and vomiting, but no shortness of breath and little change in chronic health conditions. (cdc.gov)
  • The Task Group reviewed and revised the second draft of the criteria document and made an evaluation of the health risks from exposure to carbon monoxide. (inchem.org)
  • However, the population living in the United States is genetically mixed and has varied responses to the added stress of altitude-induced hypoxia. (medscape.com)
  • Barnoya J, Mendoza-Montano C, Navas-Acien A. Secondhand smoke exposure in public places in Guatemala: comparison with other Latin American countries. (famri.org)
  • However, glucocorticoid treatment in the infant can increase the risk of long-term cardiovascular complications including. (researchgate.net)
  • Most experts advise against scuba diving for pregnant people because of risk for fetal gas embolism during decompression (see Sec. 4, Ch. 4, Scuba Diving: Decompression Illness & Other Dive-Related Injuries ). (cdc.gov)
  • Many human and experimental studies have shown the relationship between low-birth-weight and obesity, insulin-resistance and the MS. Recently studies showed that fetal IUGR is an independent risk factor for insulin-resistance that it is amplified by obesity in childhood. (redsamid.net)
  • Children and adolescents report that chronic pain makes them feel insecure, affects school attendance and affacts their relationships with friends and family. (hrb.ie)
  • After major surgery, one in four children experience chronic post-surgical pain (i.e., pain that lasts longer than 3 months). (hrb.ie)
  • Less commonly, self-administered nitrous oxide is reported for chronic pain from terminal illness and pain associated with cancer treatment. (medscape.com)
  • After 5 years of follow-up in the randomized newly diagnosed chronic phase CML study (n=258), grade 3/4 fluid retention was reported in 5% of patients, including 3% of patients with grade 3/4 pleural effusion. (sprycel-hcp.com)
  • Depression can be a chronic disorder, with 5-9 episodes per lifetime, and 30% of sufferers don't respond to adequate trials of antidepressant drugs and/or talking therapies. (hrb.ie)