Cardiovascular association of apolipoprotein apolipoprotein e2. Medical search. Frequent questions

Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans. (dovepress.com)
The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
Several major APOE isoforms can be distinguished: E2, E3, and E4. (dovepress.com)
3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
Apolipoprotein E (ApoE) is involved on cholesterol and triglycerides metabolism regulation. (biomedcentral.com)
Once ApoE polymorphism may influence lipid metabolism, it is possible that it brings on individual susceptibility consequences for the development of MetS and cardiovascular risk. (biomedcentral.com)
The objective of the study is to measure the discriminatory power of ApoE polymorphism in determining cardiovascular risk stratification based on the presence MetS in a cohort of hypertensive patients. (biomedcentral.com)
The results presented demonstrate that the association between ApoE gene and CVD may be modulated by the presence of MetS, with an increased CV burden observed among E4 allele carriers with the syndrome. (biomedcentral.com)
The characteristic components of the syndrome are mostly determined by apolipoprotein E (ApoE) modulation of atherogenic plasma Apo-B containing lipoproteins. (biomedcentral.com)
Corbo RM, Scacchi R. Apolipoprotein E (APOE) allele distribution in the world. (medscape.com)
Currently, it includes the three genes associated with autosomal-dominant AD ( APP , PSEN1 , PSEN2 ) plus four genes associated with AD through association studies or pathology ( APOE , MAPT , SORL1 , and TREM2 ). (alzforum.org)
APOE encodes a secreted apolipoprotein involved in lipid metabolism. (alzforum.org)
Every person has an APOE genotype determined by pairs of these alleles: APOE3/E3 (the most common), APOE3/E4, APOE3/E2, APOE2/E4, APOE4/E4, or APOE2/E2. (alzforum.org)
Apolipoprotein E (APOE) is a lipoprotein found primarily in chylomicrons and intermediate-density lipoprotein (IDL). (docsopinion.com)
Transcriptome analysis was performed using retinal pigment epithelium cells of apoE knockout and apolipoprotein E2 mice using microarray analysis. (geneticsmr.com)
The meta-analysis was performed according to the apolipoprotein E (APOE) ɛ4 allele status. (geneticsmr.com)
In the present study, the correlation of polymorphisms of the apolipoprotein E ( apoE ) gene with the susceptibility of essential hypertension (EH) was investigated. (geneticsmr.com)
We examined the prevalence of cardiovascular risk factors, including apolipoprotein E (ApoE) polymorphism, in elderly subjects who were born in Japan, migrated to South Brazil and have lived in that region for over 40 years, versus a group of elderly, locally born Brazilians living in the same region. (geneticsmr.com)
Independent associations of TOMM40 and APOE variants with body mass index. (sdu.dk)
C 2 N's PrecivityAD2 blood test joins the company's Precivity-ApoE blood test, which is indicated for use in adult patients for whom knowledge of apolipoprotein E2, E3, E4 allele status may be informative for medical management and treatment decisions. (biotech-365.com)
Apolipoprotein E (ApoE) is expressed as Molecular Biology of Neurodegenerative Diseases. (web.app)
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. (web.app)
Apolipoprotein E spielt im Katabolismus von Chylomikronen, IDL und VLDL-Remnants wie auch von ApoE-reichem HDL eine wichtige Rolle. (web.app)
Apolipoprotein E (APOE) plays an important role in cholesterol transport and genetic variants in APOE have been linked to the risk of Alzheimer's disease. (web.app)
2020-08-16 · The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (web.app)
APOE / Apolipoprotein E Protein LS-G39871 is a Recombinant Human APOE / Apolipoprotein E produced in Human Cells Lys19-His317 with 6His, C-terminus tag(s). (web.app)
Six possible apoE genotypes exist: e2/e2, e2/e3, e2/e4, e3/e3, e3/e4 and e4/e4. (news-medical.net)
Apolipoprotein Gene Polymorphisms (APOB, APOC111, APOE) in the Development of Coronary Heart Disease in Ethnic Groups of Kazakhstan. (cdc.gov)
Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease. (cdc.gov)
Everyone inherits a form of APOE from their parents (it may be type e2, e3 or e4). (bodychargenutrition.com)
Apolipoprotein E (ApoE) polymorphism influences lipid metabolism, but its association with arterial hypertension is controversial. (scite.ai)
The objective of this study was to examine the association between ApoE polymorphism and prevalent hypertension in a large unselected population of older adults. (scite.ai)
Apolipoprotein E (ApoE) is one of the most extensively studied genes in the context of aging, but there are few population-based studies on ApoE polymorphism in the elderly in developing countries. (scite.ai)
The objective of the present study was to assess ApoE allele and genotype distribution in a large elderly community-based sample and its association with age, sex and skin color. (scite.ai)
No association between number of ApoE4 alleles and age was found, suggesting the absence of association of ApoE genotype with mortality in this population. (scite.ai)
Common variants in the cholesteryl ester transfer protein (CETP-629C/A), lipoprotein lipase (LPL S447X), hepatic lipase (HL-480C/T) and apolipoprotein E (apoE e2/e3/e4) genes were studied in relation to LDL particle size distribution in 377 healthy, middle-aged men. (ox.ac.uk)

Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. (medscape.com)
The distribution of apolipoprotein E gene polymorphism in Chinese civil aircrews, and a possible risk factor to their overweight and dyslipidemia is cumulative flight time. (cdc.gov)
The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee. (web.app)
Association between apolipoprotein E gene polymorphism and myocardial infarction. (cdc.gov)
Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction. (cdc.gov)
Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction. (cdc.gov)
Association between Apolipoprotein E polymorphism and myocardial infarction risk: A systematic review and meta-analysis. (cdc.gov)

Apo E has three different alleles (E2, E3 and E4) determining different and complex associations with clinical phenotype expressions. (biomedcentral.com)
The major alleles are called e2, e3, and e4. (docsopinion.com)
Apolipoprotein E alleles, dyslipidemia, and coronary heart disease: the Framingham Off spring Study. (web.app)

Considering its association with lipoprotein levels, APOA5 is implicated in metabolic syndrome. (wikipedia.org)
The association between thyroid autoimmunity and lipoprotein (a) levels is controversial. (hormones.gr)
Apolipoprotein B (apoB ) is a major component of atherogenic lipoprotein particles such as LDL, VLDL and Lp(a). (docsopinion.com)
Intake of cooked tomato sauce preserves coronary endothelial function and improves apolipoprotein A-I and apolipoprotein J protein profile in high-density lipoprotein. (lycoprozen.com)
2012). Comparison of Apolipoprotein (apoB/apoA-I) and Lipoprotein (Total Cholesterol/HDL) Ratio Determinants. (gianlucatognon.com)
Reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia (Fredrickson type IIa, heterozygous familial and nonfamilial) or mixed dyslipidemia (Fredrickson type IIb). (globalrph.com)

Finding genes and variants for lipid levels after genome-wide association analysis. (medscape.com)
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. (medscape.com)
Association between Apolipoprotein E Variants and Obesity-Related Traits in Mexican School Children. (cdc.gov)
Genome-wide association study identifies variants screening. (who.int)

The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. (wikipedia.org)
Regarded as a clinicopathological clustering of metabolic disorders determining increased cardiovascular disease (CVD) risk, MetS has a polygenic inherence in which abdominal fat accumulation plays pivotal role for such epidemic morbidity [ 2 ]. (biomedcentral.com)
Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. (medscape.com)
Some have been tied to AD, to other neurological disorders, and/or to peripheral conditions, including alterations of lipid metabolism, cardiovascular or kidney disease. (alzforum.org)
Elevated LDL-cholesterol (LDL-C) levels are well-established to cause cardiovascular disease and several LDL-C-lowering therapies are clinically available to manage this vascular risk factor. (biomedcentral.com)
Cardiovascular disease (CVD) is the leading cause of death in India, accounting for 28% of mortality. (hindawi.com)
The association between lipid disorders and heart disease is well known. (docsopinion.com)
High levels of apo-C-III are associated with high triglyceride levels and increased risk of cardiovascular disease. (docsopinion.com)
The metabolic syndrome is associated with increased risk of cardiovascular disease ( 9 ). (docsopinion.com)
Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women. (cdc.gov)
According to international data compiled by the American Heart Association, the rate of death (per 100,000 people) from coronary heart disease (CHD) in 2011 in Japan was 47 and in the US, 132 [1]. (vitamindwiki.com)
A study from MESA [13] that also used plasma phospholipid omega-3 levels to predict risk for cardiovascular disease (CVD) endpoints reported FA levels by quartiles, just as Hamazaki et al. (vitamindwiki.com)
Prevalence of Cardiovascular Disease and Osteoporosis During Androgen Deprivation Therapy Prescription Discordant to EAU Guidelines: Results From a Multicenter, Cross-sectional Analysis From the CHOsIng Treatment for Prostate canCEr (CHOICE) Study Morgia G et al Urology 2016 Oct;96:165-170. (lycoprozen.com)
The inclusion of plasma analyte ratios using the company's proprietary mass spectrometry methods has been shown to improve test robustness and help mitigate the effects of confounding factors such as chronic kidney disease and cardiovascular disease. (biotech-365.com)
His recent research presented at the 2023 Alzheimer's Association International Conference outlined that this blood test had very high accuracy (AUC 0.95-0.97) for identifying Alzheimer's disease pathology, primarily using CSF biomarkers as the reference standard. (biotech-365.com)
Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. (web.app)
Maintaining normal levels of cholesterol is essential for the Apolipoprotein E has been found in amyloid plaques in the cerebral cortex of patients with Alzheimer's disease as well as in other types of amyloid. (web.app)
The Mediterranean diet in relation to mortality and cardiovascular disease: a Danish cohort study. (gianlucatognon.com)
Plasma levels of apolipoprotein E and risk of ischemic heart disease in the general population. (cdc.gov)
The gene thought to be most strongly associated with Alzheimer's disease is the apolipoprotein E4 (APoE4) gene. (bodychargenutrition.com)
Chronic inflammation is now believed to be a contributing factor in many cancers and cardiovascular disease. (healthyfellow.com)
Metabolically-obese, normal-weight (MONW) individuals are not obese in terms of weight and height but have a number of obesity-related features (e.g. greater visceral adiposity, insulin resistance, and increased risk of cardiovascular disease). (biomedcentral.com)
Cardiovascular disease ( CVD ) is any disease involving the heart or blood vessels . (wikipedia.org)
[3] Most cardiovascular disease affects older adults. (wikipedia.org)

Hypertension has a worldwide prevalence estimated in 1 billion of people, an attributable mortality of 7,1 million of deaths per year and a significant relevance as a cardiovascular risk factor. (biomedcentral.com)
Epidemiological studies have been conducted in India to determine the prevalence and age-specific trends in cardiovascular risk factors among adolescents and young Asian Indians. (hindawi.com)
It was observed that the prevalence of multiple cardiovascular risk factors was low in adolescents, but rapid escalation of these risk factors occurred by the age 30-39 years [ 6 ]. (hindawi.com)

Apolipoprotein E2 transgenic rabbits. (medscape.com)
However, there have been no reports on gene expression patterns in animal models of non-neovascular AMD with abnormal lipid metabolism such as apolipoprotein E knockout and human apolipoprotein E2 transgenic mice. (geneticsmr.com)

Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene on chromosome 11. (wikipedia.org)
The gene for apolipoprotein A5 (APOA5, gene ID 116519, OMIM accession number - 606368) was originally found by comparative sequencing of human and mice DNA as a last member of the gene cluster of apolipoproteins APOA1/APOC3/APOA4/APOA5, located on human chromosome 11 at position 11q23. (wikipedia.org)
A Dutch group simultaneously described an identical gene as apolipoprotein which it is associated with the early phase of liver regeneration, but failed to recognise its important role in the determination of plasma triglyceride levels. (wikipedia.org)
This gene uses alternate polyadenylation sites and is located proximal to the apolipoprotein gene cluster on chromosome 11q23. (wikipedia.org)
The observed associations were further modulated by gene-gene and gene-environment interactions. (ox.ac.uk)

Apolipoprotein E genotype and mortality in Southern European and Anglo-Celt patients with type 2 diabetes: the Fremantle Diabetes Study. (cdc.gov)
Effect of obesity, serum lipoproteins, and apolipoprotein E genotypes on mortality in hospitalized elderly patients. (cdc.gov)
Exploring the intersection: Cardiovascular mortality trends among Alzheimer's patients in the U.S. (news-medical.net)
The understanding of such factors is critical to the prevention of cardiovascular morbidities and mortality. (medscape.com)

We conducted a meta-analysis of the associations between the PPARγ Pro12Ala and His447His polymorphisms and AD in subjects. (geneticsmr.com)
In summary, the investigated polymorphisms were associated with diverse effects on the LDL particle size distribution, consistent with respect to protein function and proposed association with CHD risk. (ox.ac.uk)

Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. (web.app)
Apolipoprotein E Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases. (web.app)

A consistent increase on world's Metabolic Syndrome (MetS) incidence has been associated with an epidemic cardiovascular risk in different populations. (biomedcentral.com)
Apolipoprotein E4 association with metabolic syndrome depends on body fatness. (cdc.gov)

Lycopene and Its Antioxidant Role in the Prevention of Cardiovascular Diseases-A Critical Review. (lycoprozen.com)
Currently, results are available from two studies with TZD focusing on cardiovascular diseases, including stroke, and from 12 cardiovascular outcome trials focusing on major adverse cardiovascular events associated with new antidiabetic agents (four with dipeptidyl peptidase-4 inhibitors, three with sodium-glucose cotransporter-2 inhibitors, and five with glucagon-like peptide-1 analogues). (j-stroke.org)
Cardiovascular diseases are the leading cause of death worldwide except Africa. (wikipedia.org)
There are many cardiovascular diseases involving the blood vessels. (wikipedia.org)
There are also many cardiovascular diseases that involve the heart. (wikipedia.org)

Given the known cardioprotective effects of these FAs [8,9], many studies have examined the associations between the intake of omega-3 FAs and risk for CHD in Japan, but few have used circulating FA biomarkers as their exposure variable. (vitamindwiki.com)
The expanding list of nontraditional biomarkers is outweighed by the standard risk factors for predicting future cardiovascular events and adds only moderately to standard risk factors. (medscape.com)
The most informative biomarkers for predicting major cardiovascular events were BNP and the urinary albumin-to-creatinine ratio. (medscape.com)

The results also showed an association with the 'traditional' genetic culprit, APoE4, but the link was not as strong. (bodychargenutrition.com)

For instance, research presented at the 2014 Alzheimer's Association International Conference (AAIC) revealed Alzheimer's patients with TDP-43, an infectious protein, were 10 times more likely to have been cognitively impaired at death than those without. (bodychargenutrition.com)

In comparison with other apolipoproteins, plasma concentration of APOA5 is very low (less than 1 μg/mL). (wikipedia.org)
Recent studies show an association between elevated plasma LDL, a well-known cardiovascular risk factor, and a higher risk of AD, and considerable evidence suggests that high HDL levels are associated with reduced CAA and lower neuroinflammation. (biomedcentral.com)
1-3 Although individuals carrying the ε4 allele have higher and those carrying the Apolipoprotein (apo) E is a 299‐residue protein which functions as a key regulator of plasma lipid levels. (web.app)

Smelt AH, de Beer F. Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects. (medscape.com)
Genetic and pharmacological studies support the hypothesis that CETP inhibition reduces cardiovascular risk by lowering LDL, which, by extension, may also lower VCID. (biomedcentral.com)
[ 7 , 8 ] The recognition that DS is associated with trisomy 21 helped in understanding the genetic basis of this association. (medscape.com)

Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science . (medscape.com)

The breaking research is revealing a number of roles for vitamin K reaching well beyond coagulation to not only long term cardiovascular and skeletal health, but that of the brain and nervous system, and also for insulin production and sensitivity, and genomic stability / cancer prevention. (vitamindwiki.com)
These studies showed different results for primary cardiovascular outcomes and stroke prevention. (j-stroke.org)

Apolipoprotein C-III (apo C-III) is found on the surface of triglyceride-rich lipoproteins ( 6 ). (docsopinion.com)
Apolipoprotein E is the recognition site for receptors involved in the clearance of remnants of very low density lipoproteins and chylomicrons (summary by Blum, 2016). (web.app)

Apolipoprotein E2 Genotype Is Associated with a 2-Fold Increase in the Incidence of Type 2 Diabetes Mellitus: Results from a Long-Term Observational Study. (cdc.gov)

Obesity, Apolipoprotein E e4, and Difficulties in Activities of Daily Living Among Older Adults: a 6-Year Follow-up Study. (cdc.gov)
Body shape also influences the consequences of obesity, with a higher risk of metabolic and cardiovascular complications for large waist size but lower risk for large hip size 2 . (nature.com)
Furthermore, associations between obesity and impaired cognitive function have more recently been recognised [ 16 ]. (biomedcentral.com)

Using data from UK Biobank, we have previously described the associations of body shape phenotypes based on ABSI and HI with allometric body-composition indices, which similarly to ABSI and HI normalise body composition measurements for weight and height 11 . (nature.com)
In the current study, we have examined the association of body shape phenotypes based on allometric indices with serum levels of oestradiol and testosterone and their binding proteins (SHBG and albumin) and have explored heterogeneity by BMI, separately in men and women from the UK Biobank cohort, defining in men subgroups according to age and in women subgroups according to menopausal status and use of hormone replacement therapy (HRT). (nature.com)

Hypertension has a significant relevance as a cardiovascular risk factor. (biomedcentral.com)

1997) No association between apolipoprotein E epsilon4 allele and the age of onset in type I familial amyloid polyneuropathy. (web.app)

Association between vitamin A, vitamin E and apolipoprotein E status with mild cognitive impairment among elderly people in low-cost residential areas. (cdc.gov)

Survivin and NAIP in Human Benign Prostatic Hyperplasia: Protective Role of the Association of Serenoa repens, Lycopene and Selenium from the Randomized Clinical Study Morgia G et al Int J Mol Sci (2017) 18(3). (lycoprozen.com)

Associations of sex steroids and their binding proteins with body shape are unclear, because waist and hip circumference are correlated strongly with body size. (nature.com)

After issues with rosiglitazone in 2007, the U.S. Food and Drug Administration strongly recommended that trials investigating cardiovascular risk associated with new antidiabetic medications should be conducted before drug approval in the United States, to prove the safety of these new drugs and to determine their superiority to previous medications. (j-stroke.org)

Mahley RW, Rall SC Jr. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal metabolism. (medscape.com)

The association between DM and stroke involves the interplay of complex mechanisms, including various hemodynamic and metabolic pathways ( Figure 1 ). (j-stroke.org)

Associations between energy intake, daily food intake and energy density of foods and BMI z-score in 2-9-year-old European children. (gianlucatognon.com)

Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. (cdc.gov)

Prospective associations between dietary patterns and high sensitivity C-reactive protein in European children: the IDEFICS study. (gianlucatognon.com)

Anatomy23

Organisms7

Diseases37

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Psychiatry and Psychology8

Phenomena and Processes46

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Health Care8

APOE38

Polymorphism7

Alleles3

Lipoprotein6

Variants4

Disease24

Prevalence3

Transgenic2

Gene5

Mortality4

Polymorphisms2

Neurodegenerative diseases2

Metabolic syndrome2

Diseases5

Biomarkers3

APOE41

Alzheimer's Association International Conference1

Plasma3

Genetic3

Mice1

Prevention2

Lipoproteins2

Incidence1

Obesity3

Phenotypes2

Hypertension1

Amyloid1

Elderly1

Clinical1

Proteins1

Strongly1

Role1

Stroke1

Intake1

Patients1

Patterns1