• rats
  • LVH was induced by 6 weeks abdominal aortic banding and cardiac structure and function were determined with echocardiography and catheterization in sham-operated and LVH rats ( n = 10 for each group). (frontiersin.org)
  • myocardium
  • 2 3 4 It is still controversial whether cardiac structural changes in the clinical setting are due to long-term elevations in blood pressure or are a manifestation of nonhemodynamic factors acting on the myocardium. (ahajournals.org)
  • In animal models, both cardiac load and high circulating aldosterone levels regulate cardiac fibroblasts and result in excessive fibrous tissue accumulation in the myocardium that leads to pathological LVH. (ahajournals.org)
  • myocytes
  • Indeed, fibroblasts isolated from Pn −/− hearts were less effective in adherence to cardiac myocytes and were characterized by a dramatic alteration in global gene expression (7% of all genes). (ahajournals.org)
  • Abstract
  • Abstract- We have shown that exposure of pregnant ewes to dexamethasone (11.5 mg/d for 2 days) at 27 days of gestation (term, 150 days) led to increased blood pressure and cardiac output in adult offspring. (ahajournals.org)
  • Wall Stress
  • According to the principle of Laplace, as volume loads and pressure loads on the heart increase with body mass, so too must the thickness of the ventricular wall, ensuring that wall stress (N m −2 ) is conserved and the load is spread ( Grande and Taylor, 1965 ). (biologists.org)
  • differences
  • We aimed to investigate differences in characteristics and health care management of such patients treated as inpatients or outpatients by cardiac specialists. (biomedcentral.com)
  • suggests
  • The shallow hypoallometry of organelle volumes during post-pouch growth suggests a decrease in relative cardiac requirements as body mass increases in free-roaming kangaroos, which is possibly because the energy required for hopping is independent of speed, and the capacity for energy storage during hopping could increase as the kangaroo grows. (biologists.org)
  • pressure
  • The wedge pressure was held constant during an infusion of dobutamine at incremental doses (0.4 to 12 μg/kg/min) while blood pressure and cardiac output were measured. (ahajournals.org)
  • Role
  • As a key regulator of inflammation, toll-like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. (frontiersin.org)
  • The excess production of reactive oxygen species (ROS) played critical role in the development of cardiac hypertrophy. (osti.gov)
  • structural
  • The cardiac extracellular matrix is a dynamic structural support network that is both influenced by, and a regulator of, pathological remodeling and hypertrophic growth. (ahajournals.org)
  • contractile
  • In muscle from hearts without failure but with ventricular hypertrophy, there were qualitatively similar depressions of contractile function, although of lesser magnitude. (ahajournals.org)
  • The steep hyperallometry of organelle volumes and volume-densities across in-pouch growth is consistent with the improved contractile performance of isolated cardiac muscle during fetal development in placental mammals, and is probably critical in augmenting cardiac output to levels necessary for endothermy and independent locomotion in the young kangaroo as it prepares for pouch exit. (biologists.org)
  • high
  • Primary care physicians may refer patients with high CV risk - independent of a previous CV event - to a cardiac specialist in an outpatient setting for diagnostic and therapeutic support and risk stratification. (biomedcentral.com)
  • By operating two cardiac circuits at vastly different pressures, and by preventing oxygenated and deoxygenated blood from mixing, mammals are equipped with an efficient, high-output, oxygen delivery system. (biologists.org)
  • body
  • In very severe anemia, the body may compensate for the lack of oxygen-carrying capability of the blood by increasing cardiac output. (wikipedia.org)