• suggests
  • The shallow hypoallometry of organelle volumes during post-pouch growth suggests a decrease in relative cardiac requirements as body mass increases in free-roaming kangaroos, which is possibly because the energy required for hopping is independent of speed, and the capacity for energy storage during hopping could increase as the kangaroo grows. (biologists.org)
  • Abstract
  • Abstract- We have shown that exposure of pregnant ewes to dexamethasone (11.5 mg/d for 2 days) at 27 days of gestation (term, 150 days) led to increased blood pressure and cardiac output in adult offspring. (ahajournals.org)
  • structural
  • The cardiac extracellular matrix is a dynamic structural support network that is both influenced by, and a regulator of, pathological remodeling and hypertrophic growth. (ahajournals.org)
  • blood pressure
  • The wedge pressure was held constant during an infusion of dobutamine at incremental doses (0.4 to 12 μg/kg/min) while blood pressure and cardiac output were measured. (ahajournals.org)
  • contractile
  • In muscle from hearts without failure but with ventricular hypertrophy, there were qualitatively similar depressions of contractile function, although of lesser magnitude. (ahajournals.org)
  • The steep hyperallometry of organelle volumes and volume-densities across in-pouch growth is consistent with the improved contractile performance of isolated cardiac muscle during fetal development in placental mammals, and is probably critical in augmenting cardiac output to levels necessary for endothermy and independent locomotion in the young kangaroo as it prepares for pouch exit. (biologists.org)
  • Role
  • As a key regulator of inflammation, toll-like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. (frontiersin.org)
  • The excess production of reactive oxygen species (ROS) played critical role in the development of cardiac hypertrophy. (osti.gov)
  • body
  • In very severe anemia, the body may compensate for the lack of oxygen-carrying capability of the blood by increasing cardiac output. (wikipedia.org)
  • risk factor
  • Cardiac hypertrophy is a key pathophysiological component to biomechanical stress, which has been considered to be an independent and predictive risk factor for adverse cardiovascular events. (osti.gov)
  • changes
  • This is associated with characteristic changes in right ventricular β-adrenoceptors (β-AR), neuronal noradrenaline transporter (NAT) density and activity (uptake 1 ), and G protein-coupled receptor kinase (GRK) activity. (ahajournals.org)
  • high
  • By operating two cardiac circuits at vastly different pressures, and by preventing oxygenated and deoxygenated blood from mixing, mammals are equipped with an efficient, high-output, oxygen delivery system. (biologists.org)