• Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. (wakehealth.edu)
  • Serotonin stimulates fibroblast growth and fibrogenesis, which can lead to cardiac valvular fibrosis. (karger.com)
  • Ma S, Ma J, Guo L, Bai J, Mao S, Zhang M ( 2019 ) Tongguan capsule-derived herb reduces susceptibility to atrial fibrillation by inhibiting left atrial fibrosis via modulating cardiac fibroblasts. (multichannelsystems.com)
  • The proliferation of cardiac fibroblasts (CFs) and excessive extracellular matrix protein accumulation are the basic pathological processes of myocardial fibrosis. (thieme-connect.com)
  • These results suggest that visfatin promote CFs proliferation and collagen synthesis via p38MAPK, PI3K, and ERK 1/2 pathways rather than JNK pathways, which also indicate that visfatin might play a role in myocardial fibrosis. (thieme-connect.com)
  • Renin-angiotensin system and myocardial fibrosis in hypertension: regulation of the myocardial collagen matrix. (thieme-connect.com)
  • Pathological hypertrophy and cardiac interstitium: fibrosis and renin-angiotensin-aldosterone system. (thieme-connect.com)
  • CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. (hindawi.com)
  • Amphiregulin (AREG) is a ligand of epidermal growth factor receptor and participates in the fibrosis of multiple organs. (beds.ac.uk)
  • In summary, this present study would probe the influences of AREG on cardiac hypertrophy and fibrosis, and quest whether AREG regulates cardiac hypertrophy through affecting oxidative stress and apoptosis. (beds.ac.uk)
  • Atherosclerotic plaque rupture is the leading cause of cardiovascular death resulting from acute coronary syndrome (ACS) and leads to cardiac remodeling and fibrosis following ACS. (archivesofmedicalscience.com)
  • Non-ischemic cardiomyopathy (NICM) can cause left ventricular dysfunction through interstitial fibrosis, which corresponds to the failure of cardiac tissue remodeling. (nature.com)
  • Recent evidence implicates monocytes/macrophages in the etiopathology of cardiac fibrosis, but giving their heterogeneity and the antagonizing roles of macrophage subtypes in fibrosis, targeting these cells has been challenging. (nature.com)
  • Here we focus on WWP2, an E3 ubiquitin ligase that acts as a positive genetic regulator of human and murine cardiac fibrosis, and show that myeloid specific deletion of WWP2 reduces cardiac fibrosis in hypertension-induced NICM. (nature.com)
  • Fibrosis account for a significant proportion of the annual death rate worldwide and include myocardial fibrosis, a global health issue related to nearly all forms of heart disease 2 . (nature.com)
  • Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. (wakehealth.edu)
  • These effects were diminished by SB203580, wortmannin, and PD98059, but not by JNK inhibitor II. (thieme-connect.com)
  • The combined neprilysin inhibitor/angiotensin II receptor blockers sacubitril-valsartan led to a significant reduction in event rate versus valsartan in women, which was not observed in men. (genderopen.de)
  • In the Prospective Comparison of angiotensin receptor neprilysin inhibitor (ARNI) With ACEi to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) study, treatment with sacubitril/valsartan reduced the primary outcome of cardiovascular (CV) death and heart failure (HF) hospitalization compared with enalapril in patients with chronic HF and reduced ejection fraction (HFrEF). (go.jp)
  • SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. (eurekaselect.com)
  • Ang II binds to AT 1 R, which can induce vasoconstriction, increase blood pressure, and further induce cardiac hypertrophy and proliferation of fibroblasts [15]. (researchsquare.com)
  • Under physiological conditions, the activation of EGFR in the heart induces major intracellular signal cascades and control fibroblast proliferation, migration and collagen synthesis. (beds.ac.uk)
  • However, under the chronic stress state characterized by the continuous increase of AREG, the long-term activation of EGFR can enhance the activation, proliferation, myofibroblast differentiation, migration and collagen synthesis of cardiac fibroblasts [ 9 ]. (beds.ac.uk)
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. (medecinesciences.org)
  • Characterization of the brain penetrant neuropeptide Y Y 2 receptor antagonist SF-11. (rndsystems.com)
  • Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats. (wakehealth.edu)
  • Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. (wakehealth.edu)
  • Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research. (wakehealth.edu)
  • Figure 2: Molecular basis for atrial ionic remodelling and therapeutic opportunities. (nature.com)
  • Additionally, targeting the SARS-CoV-2 viral receptors is considered a therapeutic option in this regard. (eurekaselect.com)
  • An upregulation of TRPC1, TRPC3, and TRPC6 genes are seen in heart disease states including fibroblast formation and cardiovascular disease. (wikipedia.org)
  • Upon stimulation of these channels in cardiovascular disease, there is an increase in hypertension and cardiac hypertrophy. (wikipedia.org)
  • Cardiac hypertrophy is related to the adverse consequences of various states of cardiovascular disease. (beds.ac.uk)
  • Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. (wakehealth.edu)
  • In selected patients affected by HF and severe dysfunction of left ventricle ejection fraction (LVEF), with left bundle brunch block, the cardiac resynchronization therapy with a defibrillator (CRT) is the treatment of choice to improve symptoms, NYHA class, and quality of life. (hindawi.com)
  • ii) increased lactate dehydrogenase LDH and iii) coagulation dysfunction (D-dimer). (spandidos-publications.com)
  • Among cardiac macrophage subtypes, WWP2 dysfunction primarily affects Ly6c high monocytes via modulating Ccl5, and consequentially macrophage infiltration and activation, which contributes to reduced myofibroblast trans -differentiation. (nature.com)
  • Cardiorenal Syndrome is a specific condition which is characterized by a rapid or chronic worsening of cardiac function leading to acute or chronic kidney injury (A/CKI) and the reciprocal organ dysfunction sequence can be possible. (cardiologyresearchjournal.com)
  • Acute or chronic systemic disorders can cause both cardiac and renal dysfunction. (cardiologyresearchjournal.com)
  • However, whether AREG participated in the regulation of cardiac hypertrophy is still unclear. (beds.ac.uk)
  • Pathological stress or hypertrophic agonists will trigger G-protein coupled receptors (GPCRs) and activates PLC to form DAG and inositol triphosphate (IP3). (wikipedia.org)
  • Pathological cardiac hypertrophy begins with an adaptive response to increased workload. (beds.ac.uk)
  • Different pathological and physiological stimuli are responsible for cardiac remodeling. (biomedcentral.com)
  • Ischemic injury due to coronary artery disease is the most common pathological cause of cardiac remodeling [ 6 ]. (biomedcentral.com)
  • Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats. (wakehealth.edu)
  • Angiotensin II induces p67phox mRNA expression and NADPH oxidase superoxide generation in rabbit aortic adventitial fibroblasts. (medecinesciences.org)
  • decrease the expression of β-MHC, ANF, Ang II, AT 1 R, c-fos and c-myc mRNA and the protein levels of PLC, IP 3 , AngII and AT 1 R in left ventricular myocardium, in addition, the content of Ca 2+ also decrease. (researchsquare.com)
  • AREG mRNA level raised in the mice heart treated with Ang II (Fig. 1 a). (beds.ac.uk)
  • Regulation of ACE2 in cardiac myocytes and fibroblasts. (wakehealth.edu)
  • Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. (wakehealth.edu)
  • SARS‑CoV‑2 infection is initiated when the virus interacts with angiotensin‑converting enzyme 2 (ACE2) receptors on host cells. (spandidos-publications.com)
  • In this review of literature, we summarized five potential host cell receptors, as host-cell surface bindings, including angiotensin-converting enzyme 2 (ACE2), neuropilin 1 (NRP-1), dipeptidyl peptidase 4 (DPP4), glucose regulated protein-78 (GRP78), and cluster of differentiation 147 (CD147) related to the SARS-CoV-2 infection. (eurekaselect.com)
  • Among these targets, ACE2 was recognized as the main SARS-CoV-2 receptor, expressed at a low/moderate level in the human respiratory system, which is also involved in SARS-CoV-2 entrance, so the virus may utilize other secondary receptors. (eurekaselect.com)
  • Besides ACE2, CD147 was discovered as a novel SARS-CoV-2 receptor, CD147 appears to be an alternate receptor for SARSCoV- 2 infection. (eurekaselect.com)
  • DPP4, which was discovered as the first gene clustered with ACE2, may serve as a potential SARS-CoV-2 spike protein binding target. (eurekaselect.com)
  • GRP78 could be recognized as a secondary receptor for SARS-CoV-2 because it is widely expressed at substantially greater levels, rather than ACE2, in bronchial epithelial cells and the respiratory mucosa. (eurekaselect.com)
  • Amend N, Thiermann H, Worek F, Wille T ( 2019 ) The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). Toxicol Lett 308:1-6. (multichannelsystems.com)
  • Kussauer S, David R, Lemcke H ( 2019 ) hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us. (multichannelsystems.com)
  • Oleaga C, Jalilvand G, Legters G, Martin C, Ekman G, McAleer CW, Long CJ, Hickman JJ ( 2019 ) A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia. (multichannelsystems.com)
  • The new coronavirus (SARS-CoV-2) that causes a severe acute respiratory syndrome emerges in Wuhan, China, in December 2019. (analesdepediatria.org)
  • El nuevo coronavirus (SARS-CoV-2) productor de síndrome respiratorio agudo severo surge en Wuhan, China, en diciembre de 2019. (analesdepediatria.org)
  • Recently, severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS‑CoV‑2)‑causing CoV disease 2019 (COVID‑19) emerged in China and has become a global pandemic. (spandidos-publications.com)
  • The virus was first officially named the 2019 novel coronavirus (nCoV) by the World Health Organization (WHO) and subsequently termed 'severe acute respiratory syndrome CoV 2 (SARS-CoV-2)' by The International Committee on Nomenclature of Viruses. (spandidos-publications.com)
  • Collectively, all the associated diseases caused by SARS-CoV-2 are termed Coronavirus Disease of 2019 (COVID-19). (spandidos-publications.com)
  • The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a major public health threat to all countries worldwide. (eurekaselect.com)
  • The factors affecting cardiac output include sodium intake, renal function, and mineralocorticoids. (medscape.com)
  • Fibroblast growth factor 23 (FGF23) is a peptide hormone mainly synthetized in the bone, regulating phosphate balance by blocking renal tubular phosphate reabsorption and inhibiting the synthesis of 1,25-dihydroxyvitamin D [ 1 ]. (biomedcentral.com)
  • Cardiorenal syndrome (CRS) is the term used to describe clinical conditions in which cardiac and renal dysfunctions coexist. (cardiologyresearchjournal.com)
  • Pluripotent cardiac progenitor cells resident in myocardium offer a potentially promising role in promoting recovery from injury. (stanford.edu)
  • we all hypothesized which silibinin would certainly attenuate cardiac hypertrophy by means of interfering with EGFR signaling Within this research, all of us analyzed this speculation utilizing neonatal cardiovascular myocytes as well as fibroblasts activated by simply angiotensin 2 (Ang 2) with an design by simply aortic banding (AB) mice. (ikksignal.com)
  • If we allow this to continue, the results may lead to ventricular remodeling, decompensation of cardiac function and dilated cardiomyopathy, heart failure and even sudden cardiac death[7] Therefore, preventing the occurrence and development of cardiac hypertrophy is very important. (researchsquare.com)
  • Sudden cardiac arrest affects more men than women, but women are less adequately treated. (genderopen.de)
  • Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death. (rupress.org)
  • They regulate the excitability of cells and contribute to their resting membrane potential [ 1 , 2 ]. (ersjournals.com)
  • It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes [ 1 , 2 ]. (archivesofmedicalscience.com)
  • Of the known genes, candidates include potential regulators of cardiac growth, a sodium channel and calcium channel as well as the fibroblast growth factor 2 gene. (mcw.edu)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
  • AT 1 R is a member of the 7-fold transmembrane G-protein-coupled receptor (GPCR) family[12,13], mainly exists in the myocardial membrane and can mediate cardiac hypertrophy induced by pressure overload and mechanical stimulation after activation [14]. (researchsquare.com)
  • Angiotensin II induces human TGF-beta 1 promoter activation : similarity to hyperglycaemia. (medecinesciences.org)
  • Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis. (thieme-connect.com)
  • ACE inhibition versus angiotensin type 1 receptor antagonism : differential effects on PAI-1 over time. (medecinesciences.org)
  • The enhancement of oxidative stress in mice heart with Ang II treatment was alleviated by AREG knockdown. (beds.ac.uk)
  • It is well known that oxidative stress promotes protein oxidation, lipid peroxidation, protease activation, DNA fragmentation and gene expression changes, resulting in cardiomyocyte damage and cardiomyocyte loss in patients with different types of heart disease [ 10 ]. (beds.ac.uk)
  • Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. (wakehealth.edu)
  • Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes. (wakehealth.edu)
  • Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation. (wakehealth.edu)
  • Down-regulation of AREG could inhibit Ang II induced the increases of atrial natriuretic peptide, brain natriuretic peptide, beta-myosin heavy chain in the heart of mice, and NRCMs and HL-1 cells. (beds.ac.uk)
  • The deletion of the TRPC1 gene in these mice resulted in reduced hypertrophy upon stimulation with hypertrophic stimuli, inferring that TRPC1 has a role in the progression of cardiac hypertrophy. (wikipedia.org)
  • These findings indicate that CS exposure worsens the progression of cardiac remodeling post-MI in male sex in a significant manner compared to female sex at least at early stages. (biomedcentral.com)
  • Given the evidence that the ligand for the angiotensin Type 1B receptor-angiotensin II-is a potent cardiotroph, we also consider this gene a potential candidate. (mcw.edu)
  • After AREG downregulation, the increases of Ang II induced cardiac weight and cardiomyocytes area were inhibited. (beds.ac.uk)
  • The raises of Ang II induced Bax and cleaved caspase3 in mice heart were inhibited by AREG downregulation. (beds.ac.uk)
  • Rare causes of specific inflammatory cardiomyopathies include cardiac sarcoidosis, giant cell myocarditis and eosinophilic myocarditis. (intechopen.com)
  • The mechanism of how TRPC channels promote cardiac hypertrophy is through activation of the calcineurin pathway and the downstream transcription factor nuclear factor of activated T-cells (NFAT). (wikipedia.org)
  • The expression of Type III transforming growth factor ß receptor (TGFBR3) is upregulated in colon, breast, and prostate cancer cells, and plays an important role in the occurrence and development of these cancers, so TGFBR3 may be developed as a novel target for tumor therapy, but so far there is no report on this research. (bvsalud.org)
  • Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells. (medecinesciences.org)
  • One of the most promising mechanisms addresses our mitochondria, 2,3 the powerhouses found in all human cells that control the energy we need to stay alive. (lifeextension.com)
  • Angiotensin (Ang) II induced cardiac hypertrophy in mice and neonatal rat cardiomyocytes (NRCMs) or HL-1 cells in vitro. (beds.ac.uk)
  • The coronavirus spike protein (S) is crucial in binding to receptors on host cells. (eurekaselect.com)
  • Multi-system Inflammatory Syndrome in Children (MIS-C) is a major complication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in pediatric patients. (bvsalud.org)
  • Multisystem inflammatory syndrome in children (MIS-C) manifests as a severe and uncontrolled inflammatory response with multiorgan involvement, occurring weeks after SARS-CoV-2 infection. (bvsalud.org)
  • This may to a certain degree explain why this type of CoV triggers severe inflammatory responses and immune damage and its associated complications. (spandidos-publications.com)
  • The term inflammatory cardiomyopathy (ICM) refers to a group of disorders for which an acute or chronic myocardial inflammation is the central cause of abnormal cardiac structure or impaired cardiac function. (intechopen.com)
  • Cardiac function, histology, and infarct size were assessed, and inflammatory markers quantified by RT-PCR. (biomedcentral.com)
  • Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia : enhancement by angiotensin II. (medecinesciences.org)
  • Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma. (medecinesciences.org)
  • The aim of this study was to investigate the effect and mechanism of Leonurine (Leo) against pressure-overload cardiac hypertrophy induced by abdominal aortic constriction (AAC) in rats. (researchsquare.com)
  • Previous studies have shown that its development is closely related to cardiac overload[6], so abdominal aortic constriction(AAC) can use this principle to establish model of myocardial hypertrophy. (researchsquare.com)
  • Aortic valve (AV) disease presents critical situations requiring surgery in over 2% of the US population and is increasingly the reason for cardiac surgery. (stanford.edu)
  • Reduced circulating levels of angiotensin-(1--7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control. (wakehealth.edu)
  • Increased expression of angiotensin converting enzyme 2 in conjunction with reduction of neointima by angiotensin II type 1 receptor blockade. (wakehealth.edu)
  • Weeks after an often mild or asymptomatic initial infection with SARS-CoV-2 children may present with a severe shock-like picture and marked inflammation. (bvsalud.org)
  • Two other proteins, stromal interaction molecules (STIMs) and Orais, however, have more recently been implicated in this process. (wikipedia.org)
  • Here we perform a comprehensive analysis of the plasma proteome of more than 1400 proteins in children with SARS-CoV-2. (bvsalud.org)
  • Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia. (wakehealth.edu)
  • Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. (thieme-connect.com)
  • and it may be related to the activation of PLC-IP3, PKC, JAK-STAT, MAPK, Ca/CaMK/CaN signaling pathways after Ang II binds to AT 1 R on the myocardium membrane. (researchsquare.com)
  • Angiotensin-converting enzyme 2 is an essential regulator of heart function. (wakehealth.edu)
  • Figure 6: Drugs targeting ryanodine receptor function through improved FKBP12.6 binding and domain zipping. (nature.com)
  • As a critical function of the system, Angiotensin II (Ang II) plays a key role in heart disease[9]. (researchsquare.com)
  • In patients under optimal medical therapy with moderate to severe HF and cardiac dyssynchrony, cardiac resynchronization therapy (CRT) with a defibrillator improves contractile function and reverse ventricular remodeling, ameliorating symptoms, quality of life (QoL), and clinical outcomes [ 7 , 8 ]. (hindawi.com)
  • IFPA meeting 2016 workshop report II: Placental imaging, placenta and development of other organs, sexual dimorphism in placental function and trophoblast cell lines Placenta , vol. 60 , nº Suppl. (inrs.ca)
  • theβ-myosin heavy chain(β-MHC)and atrial natriuretic factor (ANF), which are recognized as a marker of cardiac hypertrophy, were determined by Real-time quantitative PCR (qRT-PCR), then another gene phospholipase C (PLC), inositol triphosphate (IP 3 ), which associated with RAS were determined by Western blot(WB). (researchsquare.com)
  • Atrial fibrillation (AF) is the most common form of cardiac arrhythmia. (nature.com)
  • Atrial fibrillation is the most common type of cardiac arrhythmia, and is responsible for substantial morbidity and mortality in the general population. (nature.com)
  • New insights into the mechanisms underlying AF have identified promising new approaches, including the modulation of atrium-specific ion channels, connexins and the ryanodine receptor, the prevention of remodelling processes that lead to the arrhythmia as well as specific molecular events involved in arrhythmia generation. (nature.com)
  • Heart failure (HF) and type 2 diabetes mellitus (T2DM) are two growing and related diseases in general population and particularly in elderly people. (hindawi.com)
  • Heart failure (HF) and type 2 diabetes mellitus (T2DM) are two related and growing health care problems [ 1 , 2 ], with an increasing trend in elderly people [ 3 ]. (hindawi.com)
  • Globally, about one in eleven adults have diabetes, and 90% of whom are diagnosed as type 2 diabetes mellitus (T2DM). (frontiersin.org)
  • TGF-béta1 production is correlated with genetically determined angiotensin-converting enzyme expression in congenic rats. (medecinesciences.org)
  • Cardioprotective role for angiotensin-(1-7) and angiotensin converting enzyme 2 in the heart. (wakehealth.edu)
  • This creates a positive feedback loop, leading to a state of hypertrophic gene expression and thus, cardiac growth and remodelling of the heart. (wikipedia.org)
  • Localization of angiotensin converting enzyme in rat heart. (medecinesciences.org)
  • AREG protein level also increased in the mice heart with Ang II treatment detected by western blotting (Fig. 1 b) or immunofluorescence staining (Fig. 1 c). (beds.ac.uk)
  • Cardiac output is the product of stroke volume and heart rate. (medscape.com)
  • These types of schedules suggested the divergence of RHDV around Two decades prior to initial record involving haemorrhagic disease within bunnies.Heart failure hypertrophy can be a major element involving coronary heart failure The skin development factor receptor (EGFR) has a crucial role throughout cardiac hypertrophy. (ikksignal.com)
  • For 2 hours we heard from all parts of our health system, network, clinical practice, research infrastructure and most importantly numerous faculty and staff as to the affect he has had on our Heart Center. (duke.edu)
  • Despite significant improvements in the treatment of virtually all cardiac disorders, heart failure (HF) is an exception, its prevalence is increasing, and only small extensions occur in survival. (cardiologyresearchjournal.com)