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  • arrhythmias
  • Also called an implantable cardioverter defibrillator, an automated internal defibrillator is a small battery-powered device that treats life-threatening irregular heartbeats (arrhythmias), including those that cause sudden cardiac arrest. (heart.org)
  • depolarization
  • NaV1.5 is found primarily in cardiac muscle, where it mediates the fast influx of Na+-ions (INa) across the cell membrane, resulting in the fast depolarization phase of the cardiac action potential. (wikipedia.org)
  • Mutations
  • Due to changes in amino acids and binding domains, mutations may also affect the ability of these channels to respond to physiological changes in cardiac demand. (wikipedia.org)
  • Mutations resulting in loss of function of K+ channels can result in delayed repolarization of the cardiac muscle cells. (wikipedia.org)
  • Pressure-volume relationships in patients with transthyretin (ATTR) cardiac amyloidosis secondary to V122I mutations and wild-type transthyretin. (wikipedia.org)
  • A vast number of cardiac diseases is associated with mutations in NaV1.5 (see paragraph genetics). (wikipedia.org)
  • Mutations in SCN5A, which could result in a loss and/or a gain-of-function of the channel, are associated with a spectrum of cardiac diseases. (wikipedia.org)
  • amyloidosis
  • Cardiac amyloidosis is any of several forms of amyloidosis (the accumulation of inappropriately folded proteins) in or affecting the heart. (wikipedia.org)
  • Types of cardiac amyloidosis include cardiac manifestations of AL amyloidosis and amyloidosis, cardiac manifestations of transthyretin-related hereditary amyloidosis, and isolated atrial amyloidosis, a form of amyloidosis affecting the atria of the heart. (wikipedia.org)
  • Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis that occurs in black Americans. (wikipedia.org)
  • Cardiac amyloidosis: a treatable disease, often overlooked. (wikipedia.org)
  • electrical
  • The AV node serves as a sort of electrical relay station that slows the current before the signal passes to the lower chambers. (heart.org)
  • muscle
  • Cardiac muscle (like skeletal muscle) is characterized by striations - the stripes of dark and light bands resulting from the organised arrangement of myofilaments and myofibrils in the sarcomere along the length of the cell. (wikipedia.org)
  • In cardiac muscle the T-tubules are only found at the Z-lines. (wikipedia.org)
  • SCN5A is part of a family of 10 genes that encode different types of sodium channels, i.e. brain-type (NaV1.1, NaV1.2, NaV1.3, NaV1.6), neuronal channels (NaV1.7, NaV1.8 and NaV1.9), skeletal muscle channels (NaV1.4) and the cardiac sodium channel NaV1.5. (wikipedia.org)
  • adenosine
  • Transient cardiac arrest was induced by intravenous adenosine injection enabling accurate valve implantation. (hindawi.com)
  • however, this dose was not adequate, and thereafter cardiac arrest was induced with bolus injection of 18 mg of adenosine through a peripheral vein access. (hindawi.com)
  • Aminophylline competitively antagonizes the cardiac actions of adenosine at the cell surface receptors. (wikipedia.org)
  • interval
  • In a randomized, observer-blind study, the effect of incremental doses of pindolol 0.001, 0.002, 0.003, and 0.004 mg/kg IV and propranolol 0.01, 0.02, 0.03, and 0.04 mg/kg IV on SA nodal recovery time (SNRT) and atrioventricular conduction interval (AH) was assessed in 20 patients (15 men and 5 women age range thirty to seventy-two, mean age fifty-three). (ebscohost.com)
  • pacemakers
  • The present invention generally relates to implantable cardiac pacemakers. (google.com)
  • The left and right branches of this bundle, and the Purkinje fibres, will also produce a spontaneous action potential at a rate of 30-40 beats per minute, so if the SA and AV node both fail to function, these cells can become pacemakers. (wikipedia.org)
  • Since the heart contains multiple pacemakers, this interruption of the cardiac cycle generally lasts only a few seconds before another part of the heart, such as the atrio-ventricular junction or the ventricles, begins pacing and restores the heart action. (wikipedia.org)
  • left atrium
  • In the heart's conduction system, Bachmann's bundle (also called the Bachmann bundle or the interatrial tract) is a branch of the anterior internodal tract that resides on the inner wall of the left atrium. (wikipedia.org)
  • congestive
  • But note that although the ECG is a valuable part of the cardiac evaluation, it cannot determine if congestive heart failure is present, or (in itself) predict whether an animal will survive procedures requiring anesthesia, nor can it provide much information on the strength (or even presence) of cardiac contractions. (vin.com)
  • 427.8) Other specified cardiac dysrhythmias (427.81) Sick sinus syndrome (427.89) Sinus bradycardia, NOS (427.9) Cardiac dysrhythmia unspecified Gallop rhythm (428) Heart failure (428.0) Congestive heart failure unspecified (428.1) Left heart failure Pulmonary edema, acute (428.2) Systolic heart failure (428.3) Diastolic heart failure (428.4) Heart failure, combined, unspec. (wikipedia.org)
  • ventricle
  • This is the property of the AV node that prevents rapid conduction to the ventricle in cases of rapid atrial rhythms, such as atrial fibrillation or atrial flutter. (wikipedia.org)
  • Cardiac output (CO) is affected by two factors, the heart rate (HR) and the stroke volume (SV), the volume of blood pumped from one ventricle of the heart with each beat (CO = HR x SV, therefore BP = HR x SV x TPR). (wikipedia.org)
  • fibers
  • alpha f's motor and proprioceptive fibers of the A type having conduction velocities of 70 to 120 meters per second and ranging from 13 to 22 micrometers in diameter. (thefreedictionary.com)
  • mechanisms
  • Various cardiac adaptation mechanisms develop during regular exercise that are affected by many factors, and these are reflected on a surface electrocardiogram. (biomedsearch.com)
  • secondary
  • Pressure-volume relationships in patients with transthyretin (ATTR) cardiac amyloidosis secondary to V122I mutations and wild-type transthyretin. (wikipedia.org)
  • syndrome
  • In general, the symptoms of the syndrome are a combination of decreased cardiac output, loss of atrial contribution to ventricular filling, loss of total peripheral resistance response, and nonphysiologic pressure waves. (wikipedia.org)
  • myocardial
  • In selected patients, Cardiac PET offers certain advantages over standard of care Single Photon Emission Computed Tomography Myocardial Perfusion Imaging (SPECT MPI). (radiologybillingcoding.com)
  • Cardiac PET is a useful technique that allows a noninvasive evaluation of myocardial blood flow, function, and metabolism, using physiological substrates prepared with positron-emitting radionuclides, such as oxygen, nitrogen, fluorine, and rubidium. (radiologybillingcoding.com)
  • occurs
  • Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis that occurs in black Americans. (wikipedia.org)