• tissue
  • Ablation, or cardiac ablation, is a therapeutic method used to destroy a small section of heart tissue causing abnormal electrical activity or irregular heartbeat. (heart.org)
  • Aminophylline causes bronchodilation, diuresis†, central nervous system and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis, and induces release of epinephrine from adrenal medulla cells. (wikipedia.org)
  • It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue. (wikipedia.org)
  • The cause of JET is felt to be due to manipulation of the tissue surrounding the AV node during surgery, however debate exists regarding the exact cause, as it is seen after procedures even without significant manipulation of this area. (wikipedia.org)
  • Treatment of non-post-operative JET is typically with antiarrhythmic medications or a cardiac catheterization with ablation (removal of affected tissue). (wikipedia.org)
  • citation needed] The use of radiofrequency energy is infrequently associated with damage to the normal conduction due to the close proximity to the AV node, the normal conduction tissue. (wikipedia.org)
  • Transthyretin cardiac amyloidosis diagnosed by analyzing a prostatic tissue sample: a case report. (wikipedia.org)
  • Cardiac muscle tissue has autorhythmicity, the unique ability to initiate a cardiac action potential at a fixed rate - spreading the impulse rapidly from cell to cell to trigger the contraction of the entire heart. (wikipedia.org)
  • SCN5A is mainly expressed in the heart, where expression is abundant in working myocardium and conduction tissue. (wikipedia.org)
  • Heart failure characteristically involves increased catecholamine activity on the heart, which is responsible for a number of deleterious effects, including increased oxygen demand, propagation of inflammatory mediators, and abnormal cardiac tissue remodeling, all of which decrease the efficiency of cardiac contraction and contribute to the low ejection fraction. (wikipedia.org)
  • arrhythmias
  • Also called an implantable cardioverter defibrillator, an automated internal defibrillator is a small battery-powered device that treats life-threatening irregular heartbeats (arrhythmias), including those that cause sudden cardiac arrest. (heart.org)
  • amyloidosis
  • Cardiac amyloidosis is any of several forms of amyloidosis (the accumulation of inappropriately folded proteins) in or affecting the heart. (wikipedia.org)
  • Types of cardiac amyloidosis include cardiac manifestations of AL amyloidosis and amyloidosis, cardiac manifestations of transthyretin-related hereditary amyloidosis, and isolated atrial amyloidosis, a form of amyloidosis affecting the atria of the heart. (wikipedia.org)
  • Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis that occurs in black Americans. (wikipedia.org)
  • Cardiac amyloidosis: a treatable disease, often overlooked. (wikipedia.org)
  • electrical
  • The AV node serves as a sort of electrical relay station that slows the current before the signal passes to the lower chambers. (heart.org)
  • adenosine
  • Transient cardiac arrest was induced by intravenous adenosine injection enabling accurate valve implantation. (hindawi.com)
  • however, this dose was not adequate, and thereafter cardiac arrest was induced with bolus injection of 18 mg of adenosine through a peripheral vein access. (hindawi.com)
  • Aminophylline competitively antagonizes the cardiac actions of adenosine at the cell surface receptors. (wikipedia.org)
  • stimulation
  • The AV node's normal intrinsic firing rate without stimulation (such as that from the SA node) is 40-60 times/minute. (wikipedia.org)
  • Normally, vagal stimulation predominates as, left unregulated, the SA node would initiate a sinus rhythm of approximately 100 bpm. (wikipedia.org)
  • Sympathetic stimulation causes the release of the neurotransmitter norepinephrine (also known as noradrenaline) at the neuromuscular junction of the cardiac nerves. (wikipedia.org)
  • sudden
  • Changes in the sinoatrial node represent the major mechanism of sudden death in humans, and because of the sparse knowledge about the effects of aging on this structure, light microscopic and quantitative studies of the sinoatrial node were undertaken. (ebscohost.com)
  • It can help save the life of someone who has suffered sudden cardiac arrest, the abrupt loss of heart function. (heart.org)
  • normal
  • Individuals with JET have a "short-circuit" in their heart, where the electricity bypasses the AV node, causing the heart to beat faster than normal. (wikipedia.org)
  • action potential
  • Upon a stimulus (through conduction by a neighboring cell), the membrane depolarizes and NaV1.5 channels open through the outward movement of the S4 segments, leading to the initiation of the action potential. (wikipedia.org)
  • blood
  • In the presence of high mean arterial pressure, the baroreceptor reflex produces a reflex bradycardia as a method of decreasing blood pressure by decreasing cardiac output. (wikipedia.org)
  • Blood pressure (BP) is determined by cardiac output (CO) and total peripheral resistance (TPR), as represented by the formula BP = CO x TPR. (wikipedia.org)