Cardiac and skeletal muscle muscle development. Medical search. Frequent questions

It is present in cardiac and skeletal muscle and may play an important role in development of these tissues. (nih.gov)
cardiac tissues (28). (bio-cavagnou.info)
Indeed, the scaffold modulated or mitigated the scarring reactions in subcutaneous, skeletal muscle, and cardiac tissues. (dst.gov.in)
The system has been used in various tissues and organs (in vitro or in vivo), including tumor tissues, kidney, cardiac, skeletal muscle, and vascular smooth muscle. (hindawi.com)
In this study, we assembled transcriptomes using RNA-seq data published in previous studies by our group and identified 11,408 known lncRNAs and 2269 potential lncRNAs in seven tissues, heart, longissimus dorsi, gastrocnemius muscle, liver, spleen, lung and kidney, of ZBED6 KO (lean mass model) and WT Bama pigs. (biomedcentral.com)
Weighted gene coexpression network analysis (WGCNA) of 1570 DE-lncRNAs between WT and ZBED6 KO pigs was used to define the following six lncRNA modules specific to different tissues: skeletal muscle, heart, lung, spleen, kidney and liver modules. (biomedcentral.com)
The expression level of the SFRP1 was highly varied across numerous pig tissues and it was down-regulated during porcine skeletal muscle development. (biomedcentral.com)

Titin is a giant scaffold protein with multiple functions in striated muscle physiology. (frontiersin.org)
King's graduate studies comprised research on cardiac and skeletal muscle physiology and mechanics. (c-path.org)
Trying to guess the examiners' minds from the way this syllabus item is positioned (in the "musculoskeletal" section), we can infer that the detailed anatomy and physiology of cardiac muscle is probably intended for the cardiovascular section , and what they wanted from us here is more of a comparison of the ultrastructural elements that distinguish the three muscle types. (derangedphysiology.com)
This certainly seems to be the spirit of Question 11 from the second paper of 2015, which asked for a comparison of the anatomy and physiology of skeletal and smooth muscle. (derangedphysiology.com)
The techniques that we use range from single molecule mechanics, (immuno) electron microscopy, exon microarray analysis, in vitro motility assays, low angle X-ray diffraction, cell physiology (including calcium imaging), muscle mechanics, and isolated heart physiology. (bio5.org)
As a highly competitive athlete I have always been interested in understanding skeletal muscle physiology. (uoguelph.ca)
However, when I was introduced to the research process and a larger understanding of skeletal muscle physiology during my masters training at the University of Waterloo, I immediately found a career I was interested in pursing. (uoguelph.ca)
My interest in understanding how muscle utilizes substrates (carbohydrates and fats) during exercise was further strengthened during my PhD at the University of Guelph, as I became aware of the ability to apply general physiology to the study of various diseases. (uoguelph.ca)

Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle. (uoguelph.ca)
Sex-Differences in Mitochondrial Respiratory Function in Human Skeletal Muscle. (uoguelph.ca)

Metabolic myopathies are heterogeneous conditions that have common abnormalities of muscle energy metabolism that result in skeletal muscle dysfunction. (medscape.com)
We are currently studying the effect of the ALPK3 mutations on the production of the protein in heart muscle, but also in skeletal muscle, as ALPK3 gene mutations may result in skeletal muscle problems too. (pharmacytimes.com)

The HRC gene encodes the histidine-rich calcium-binding protein, which is found in the lumen of the junctional sarcoplasmic reticulum (SR) of cardiac and skeletal muscle and within calciosomes of arterial smooth muscle. (ox.ac.uk)
This influx of calcium causes calcium-induced calcium release from the sarcoplasmic reticulum , and free Ca 2+ causes muscle contraction . (wikipedia.org)
Small Ankyrins (sAnk1) are muscle-specific isoforms generated by the Ank1 gene that participate in the organization of the sarcoplasmic reticulum (SR) of striated muscles. (mdpi.com)

We are excited to announce our work and collaborative efforts with CardioNXT and these highly respected physicians to develop a new and exciting modality for cardiac ablation and the treatment of arrhythmias," said Kevin Danahy, CEO and President of Pulse Biosciences. (businesswire.com)
Pulsed field ablation is an exciting new modality for ablating tissue and in particular cardiac tissue for the treatment of cardiac arrhythmias. (businesswire.com)
Unnecessary movement or agitation may induce cardiac arrhythmias and interstitial emphysema associated with these conditions (see below). (wildliferesearch.com)
One of the greatest dangers associated with hypothermia is cardiac arrhythmias, which can result in ventricular fibrillation and death, particularly at core temperatures below 28°C (82°F) (Knochel, 1985). (wildliferesearch.com)
The concomitant metabolic imbalance leads to cardiac arrhythmias (Bowen and Bellamy, 1988). (wildliferesearch.com)
Physical stimulation predisposes the animal to the development of these arrhythmias. (wildliferesearch.com)
It ated with cardiac arrhythmias, neurological functions as the first line of defence protec- damage and significant long and short-term ting against the invasion of foreign bodies morbidity. (who.int)

Differential splicing of the titin gene results in numerous species- and muscle-specific titin isoforms. (frontiersin.org)
Initially, her lab focused on regulation of the biosynthesis and assembly of sodium pump subunits and molecular mechanisms controlling sodium pump isoforms in kidney, cardiac and skeletal muscle by potassium, hormones, and other factors under normal conditions and during human heart failure. (usc.edu)

Within this conserved region is a consensus site for myocyte enhancer factor 2 (MEF2) proteins that we show is bound efficiently by MEF2 and is required for transgene expression in all three muscle lineages in vivo. (ox.ac.uk)
these proteins are found in muscles used for movement (skeletal muscles) and in heart (cardiac) muscle. (medlineplus.gov)
Myosin binding protein C interacts with other muscle proteins, including myosin, actin, and titin. (medlineplus.gov)
These proteins play essential roles in muscle cell structures called sarcomeres, which generate the mechanical force needed for muscles to contract. (medlineplus.gov)
Protein-interactions e.g., with muscle ankyrin repeat proteins or muscle LIM-protein link titin to hypertrophic signaling and via p62 and Muscle Ring Finger proteins to mechanisms that control protein quality control. (frontiersin.org)
At the most basic level we can separate muscle tissue into smooth and striated, where the striations originate from a repeating pattern of regularly arranged proteins, whereas "smoothness" is conferred by an irregular arrangement without a repeating pattern. (derangedphysiology.com)
Our research is focused on elucidating the structure and function of titin and nebulin, two large filamentous proteins found in muscle. (bio5.org)
I am especially interested in how contractile proteins of muscle sarcomeres regulate the force and speed of contraction in the heart. (bio5.org)
The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. (bio5.org)
Myosin binding protein-C (MyBP-C) is a muscle regulatory protein that speeds actomyosin cycling kinetics in response to adrenaline (b-adrenergic stimuli) and is one of the two most commonly affected proteins linked to HCM. (bio5.org)
To gain further insight into how impaired mitochondrial FAO affects skeletal muscle metabolism in a chronic setting we analyzed the activation from the energy sensor AMP-activated proteins kinase (AMPK) and mRNA appearance of genes mixed up in legislation of energy and lipid fat burning capacity mitochondrial biogenesis and function. (bio-cavagnou.info)
I use a variety of techniques to examine mitochondrial function (isolated mitochondria, permeabilized fibres, whole muscle incubations), use molecular biological approaches to up-and down-regulate mitochondrial proteins, as well exercise, altered nutrition and aerobic training to study novel regulation in mitochondrial bioenergetics. (uoguelph.ca)
The same disease can be induced by injecting mice with heart proteins mixed with adjuvant(s), which indicates that an active infection is not necessary for the development of autoimmune disease. (cdc.gov)

The slow isoform of myosin binding protein C is active during the development of skeletal muscles. (medlineplus.gov)
Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment. (medlineplus.gov)
reldesemtiv, a fast-skeletal muscle troponin activator (FSTA) and CK-3773274 (CK-274), a cardiac myosin inhibitor. (stash.com)
In several instances, such as rheumatoid arthritis, multiple sclerosis, and myocarditis, the autoimmune disease can be induced experimentally by administering self-antigen in the presence of adjuvant (collagen, myelin basic protein, and cardiac myosin, respectively) ( 3 ). (cdc.gov)

The cardiac conduction system (CCS) (also called the electrical conduction system of the heart ) [1] transmits the signals generated by the sinoatrial node - the heart 's pacemaker , to cause the heart muscle to contract , and pump blood through the body's circulatory system . (wikipedia.org)
The conduction system consists of specialized heart muscle cells , situated within the myocardium . (wikipedia.org)
Embryologic evidence of generation of the cardiac conduction system illuminates the respective roles of this specialized set of cells. (wikipedia.org)
Inherited cardiomyopathies may also be accompanied by cardiac conduction-system defects that affect the atrioventricular node, resulting in bradycardia. (duke.edu)

We investigate intracellular dynamics in photosynthetic systems, research contractility mechanisms in cardiac and skeletal muscle cells, and study structural organization of cancerous tissue. (utoronto.ca)
The research in my laboratory is focused on identifying the components and molecular mechanisms regulating actin architecture in cardiac and skeletal muscle during normal development and disease. (bio5.org)
The long-term goal of research in my lab is to understand the molecular mechanisms of muscle contraction. (bio5.org)
Laboratory work has centered on the mechanisms of how cells acquire specific fates during growth and development, providing insights into normal and abnormal mechanisms of growth control. (stanford.edu)
describe the risk factors for hypertension and the mechanisms underlying the development of primary and secondary hypertension. (manchester.ac.uk)
Building on these findings, the lab addressed the coordinated and concerted control of extracellular potassium by skeletal muscle, kidney and gut in response to altered metabolic and electrolyte demands and have begun to use these findings to address the mechanisms responsible for the cardiovascular benefit of raising dietary K/Na ratio. (usc.edu)

Thus, these studies identify the HRC enhancer as the first MEF2-dependent, CArG-independent transcriptional target in smooth muscle and represent the first analysis of the transcriptional regulation of an SR gene in vivo. (ox.ac.uk)
The version produced from the MYBPC1 gene, which is known as the slow skeletal isoform, is found primarily in skeletal muscles. (medlineplus.gov)
mice possess normal degrees of appearance in the heart but there is near-complete knockdown of both gene expression and Cpt activity in skeletal muscle (Fig. 1 and = 5-7). (bio-cavagnou.info)
With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. (hindawi.com)
Therefore, the development of novel visible ultrasonic responsive nanosized drug/gene carriers is necessary. (hindawi.com)
Furthermore, by conjoint analysis of longissimus dorsi data (tissue-specific expression, muscle module and DE-lncRNAs) and ChIP-PCR revealed NONSUSG002145.1 (adjusted p -values = 0.044), which is coexpressed with the IGF2 gene and binding with ZBED6, may play important roles in ZBED6 KO pig skeletal muscle development. (biomedcentral.com)
In a recent study, researchers discovered a novel disease gene implicated in the development of pediatric cardiomyopathies. (pharmacytimes.com)
However, several family members who carried only 1 mutated gene copy also developed cardiac disease, albeit at a later stage in life,' said Johanna Herkert, MD. 'The identification of these mutations enables us to provide genetic counselling, predictive testing of family members, and prenatal testing in future pregnancies. (pharmacytimes.com)
Better knowledge of the precise role of the gene in disease development, as well as the elucidation of the molecular pathways involved, should lead us towards improved clinical care from the point of view of screening and surveillance, and to targeted drug development. (pharmacytimes.com)
Several different chromosomal regions have been linked with the development of autosomal dominant FDC, but the gene defects in these disorders remain unknown. (duke.edu)
The miRNA-mRNA profiles and bioinformatics study suggested that the SFRP1 gene was potentially regulated by miRNA-1/206 during porcine skeletal muscle development. (biomedcentral.com)
Our results indicate that the SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development. (biomedcentral.com)
Submitter supplied) Desmin-related myofibrillar myopathy, a severe muscle disease, is caused by mutations in the desmin-encoding gene, leading to skeletal myopathies and/or cardiomyopathy. (nih.gov)

"It was expected answers would describe in detail the role of troponin, tropomyosin and calmodulin in mediating muscle contraction" , the examiners rejoined. (derangedphysiology.com)

Moreover, a large genome study has shown a possible link between ALPK3 and cardiac hypertrophy, or thickening of the heart muscle. (pharmacytimes.com)
Reduced levels of cardiac phosphofructokinase activity were found as well, which, combined with the other hematologic changes, led to the development of cardiac hypertrophy. (medscape.com)
Myotonia Congenita Myotonia congenita is an inherited disorder causing muscle stiffness and hypertrophy beginning during childhood. (msdmanuals.com)

These studies in the mdx mouse demonstrate that oral administration of SMT022357 leads to increased utrophin expression in skeletal, respiratory and cardiac muscles. (drugdiscoverynews.com)
This form is characterized by severe hypotonia (floppy infant), feeding and respiratory difficulties, skeletal deformities, facial weakness, and delayed psychomotor development. (msdmanuals.com)

describe neural, endothelial and pharmacological mediation of excitation-contraction coupling in vascular smooth muscle. (manchester.ac.uk)

Metabolic myopathies refer to a group of hereditary muscle disorders caused by specific enzymatic defects due to defective genes. (medscape.com)
Most recognized metabolic myopathies are considered primary inborn errors of metabolism and are associated with known or postulated enzymatic defects that affect the ability of muscle fibers to maintain adequate energy and adenosine triphosphate (ATP) concentrations. (medscape.com)
Metabolic myopathies are the most clearly defined and etiologically understood muscle disorders because their fundamental biochemical defects are known through recent molecular biology and biochemistry developments. (medscape.com)
Understanding energy metabolism in exercising muscles is a prerequisite to the study of metabolic myopathies. (medscape.com)
Ability to generate branchiomeric muscle could catalyse efforts in modelling myopathies that selectively involve head muscles. (ncbs.res.in)

Finally, understanding these muscle disorders enables a better understanding of the dynamics of muscle and body metabolism. (medscape.com)

We apply basic knowledge garnered from these studies to the study of human exercise performance as well as type 2 diabetes, heart failure, diabetic cardiomyopathy and various neuropathologies, conditions that have all been affiliated with alterations in mitochondria as a key event in the progression and/or development of the disease. (uoguelph.ca)
Cardiomyopathy is the deterioration of the heart muscles' ability to contract. (pharmacytimes.com)
Overview of Cardiomyopathies A cardiomyopathy is a primary disorder of the heart muscle. (msdmanuals.com)
Symptoms and signs of myotonic dystrophy begin during adolescence or young adulthood and include myotonia (delayed relaxation after muscle contraction, which may be asymptomatic or described as muscle stiffness), weakness and wasting of distal limb muscles (especially in the hand) and facial muscles (ptosis is especially common), and cardiomyopathy. (msdmanuals.com)

Researchers believe that this protein helps regulate the tensing of muscle fibers (muscle contraction). (medlineplus.gov)
However, researchers speculate that contractures may be related to problems with muscle contraction that limit the movement of joints before birth. (medlineplus.gov)
Muscle contraction depends on the chemical energy of ATP and several biochemical processes within the muscle cell maintain a supply of ATP to support muscle contraction. (medscape.com)
All these improvements combine to protect the mdx muscle from contraction-induced damage and enhance physiological function. (drugdiscoverynews.com)
This addressed the primary cause of fiber degeneration and increased muscle stability in hind-limb muscles of the mdx mouse, which resulted in reduced regeneration and necrosis, enhanced protection of the muscle against contraction-induced damage and improved muscle function. (drugdiscoverynews.com)
Myotonia refers to delayed relaxation after muscle contraction, which can cause muscle stiffness. (msdmanuals.com)

Upon modulation of utrophin protein with the second-generation utrophin modulator SMT022357, in-vivo models of DMD showed significantly improved muscle stability and a marked reduction of the muscle regeneration, necrosis and fibrosis that are at the core of DMD pathology. (drugdiscoverynews.com)
dystrophic changes (eg, muscle fiber necrosis and regeneration) are seen on biopsy specimens. (msdmanuals.com)

Here, we provide evidence that exposure of human skin fibroblasts to a Radio Electric Asymmetric Conveyer (REAC), an innovative device delivering radio electric conveyed fields at a radiofrequency of 2.4 GHz, afforded remarkable commitment toward cardiac, neuronal, and skeletal muscle lineages. (nih.gov)
The HRC enhancer contains a small, highly conserved sequence that is required for expression in all three muscle lineages. (ox.ac.uk)

Skeletal muscle-specific Cpt1b ablation alters local and systemic lipid homeostasis. (bio-cavagnou.info)

Dedicated muscle tissue in multicellular organisms tends to exhibit a comforting structural homology, to effect that one could recognise striated muscle in a jellyfish and feel a warm kind of brotherly Verbundenheit, but it evolved probably at least four separate times in separate clades rather than arising from some early eumetazoan ancestor. (derangedphysiology.com)
These findings indicate that the identified lncRNAs may play essential roles in tissue function and regulate the mechanism of ZBED6 action in skeletal muscle development in pigs. (biomedcentral.com)
Phosphofructokinase is found in muscle tissue and red blood cells. (medscape.com)
Garcia et al investigated the effects of phosphofructokinase deficiency in tissue other than skeletal muscle on the pathogenesis of GSD type VII. (medscape.com)

Accordingly, the volume of SR tubules localized around the myofibrils is strongly reduced in skeletal muscle fibers of 4- and 10-month-old sAnk1 knockout (KO) mice, while additional structural alterations only develop with aging. (mdpi.com)
To verify whether the lack of sAnk1 also alters intracellular Ca 2+ handling, cytosolic Ca 2+ levels were analyzed in stimulated skeletal muscle fibers from 4- and 10-month-old sAnk1 KO mice. (mdpi.com)

Both affect voluntary muscles and one also affects involuntary muscles. (msdmanuals.com)
Both types affect voluntary muscles, and DM1 also affects involuntary muscles (eg, of the gastrointestinal tract, uterus). (msdmanuals.com)

The Company is developing small molecule drug candidates, which are specifically engineered to enhance muscle function and contractility. (stash.com)

MicroRNA-1/206(miRNA-1/206) is specifically expressed in skeletal muscle and play a critical role in myogenesis. (biomedcentral.com)

Skeletal system: structural support and protection with bones, cartilage, ligaments and tendons. (wikipedia.org)
It is distinct from structural cardiac disorders such as coronary artery disease, valvular disorders, and congenital heart disorders. (msdmanuals.com)

Inherited cardiomyopathies may arise from mutations in genes that are normally expressed in both heart and skeletal muscle and therefore may be accompanied by skeletal muscle weakness. (duke.edu)
Most patients experience muscle symptoms, such as weakness and cramps, although certain GSDs manifest as specific syndromes, such as hypoglycemic seizures or cardiomegaly. (medscape.com)
Although at least 14 unique GSDs are discussed in the literature, the 4 that cause clinically significant muscle weakness are Pompe disease (GSD type II, acid maltase deficiency), Cori disease (GSD type III, debranching enzyme deficiency), McArdle disease (GSD type V, myophosphorylase deficiency), and Tarui disease (GSD type VII, phosphofructokinase deficiency), which is often misspelled as Tauri disease. (medscape.com)
Phosphofructokinase deficiency leads to muscle pain and exercise-induced fatigue and weakness. (medscape.com)
Symptoms begin at adolescence or early adulthood and include myotonia, weakness, and wasting of distal limb muscles and facial muscles. (msdmanuals.com)

Over the course of my career, I have been involved in many other biomedical research/development projects, including studying the electrical activity of the heart (ECG) and blood pressure in individuals who might be at risk for sudden cardiac death, studying the electrical activity of the brain (EEG) to help in the proper delivery of anesthesia during surgery, and studying hand muscles during work tasks (in the interest of reducing injuries). (wpi.edu)

muscles (Fig. 8or mRNA (Fig. 8and Desk S1). (bio-cavagnou.info)
A single nucleotide transition from G to A in intron 3 of IGF2 , a paternally expressed quantitative trait locus (QTL) in pigs, abrogates ZBED6-IGF2 binding and results in 3-fold greater postnatal expression of IGF2 mRNA in skeletal muscle, leading to increased muscle mass and heart size and reduced fat deposition in pigs. (biomedcentral.com)

My research is primarily focused on understanding the regulation of mitochondrial bioenergetics, with a particular interest in studying fatty acid oxidation (breakdown of fat yielding energy) in skeletal and cardiac muscle. (uoguelph.ca)
Controlling CPT-I M-CoA Sensitivity in Skeletal Muscle: The Importance of AMPK-Independent Regulation of Intermediate Filaments During Exercise. (uoguelph.ca)

Significantly, this is the first report of directed differentiation of pluripotent stem cells, without transgenes, into progenitors with muscle/heart dual potential. (ncbs.res.in)
The expression level of the SFRP1 was significantly higher in the embryonic skeletal compared with postnatal skeletal muscle, whereas miR-206 showed the inverse pattern of expression. (biomedcentral.com)
Among the findings of the research published in the Aug. 1, 2015, issue of Human Molecular Genetics was that utrophin was expressed across the entire length of the muscle fiber, likely contributing to its ability to significantly reduce disease progression in animal models. (drugdiscoverynews.com)
By pharmacologically modulating the expression of the dystrophin-related protein utrophin, we have previously demonstrated in dystrophin-deficient mdx studies, daily SMT C1100 treatment significantly reduced muscle degeneration, leading to improved muscle function. (drugdiscoverynews.com)
Significantly, utrophin expression is localized along the length of the muscle fiber, not just at the synapse, and is fiber-type independent, suggesting that drug treatment is modulating utrophin transcription in extra-synaptic myonuclei. (drugdiscoverynews.com)

Therefore, our findings provide compelling evidence that dual inhibition specifies head mesoderm and unravel the mechanism that diversifies head and trunk muscle programmes during early mesoderm fate commitment. (ncbs.res.in)
Researchers are hopeful that the findings from this study can lead to a drug development target for a treatment that could be administered after birth to prevent the disease from developing further, according to the study. (pharmacytimes.com)

Myotonic dystrophy is rare, autosomal dominant muscle disorder. (msdmanuals.com)

Although previous studies suggested that desmin mutations alter the cellular structure and mitochondria function in myocyte, the pathophysiological mechanism by which mutated desmin impairs cardiac function has been poorly explored in physiologically relevant human disease models. (nih.gov)

Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)

With the development of immune checkpoint inhibitors in cancer therapy, tumor microenvironments have attracted the attention of many researchers as a critical compartment of immune therapies. (bvsalud.org)

Taken together we can conclude that skeletal muscle-specific Cpt1b depletion successfully recapitulates a model of FAO impairment and lipid accumulation. (bio-cavagnou.info)

The heart is a functional syncytium as opposed to a skeletal muscle syncytium . (wikipedia.org)
This study aimed to determine whether SFN can prevent age-related loss of function in the heart and skeletal muscle. (usda.gov)
At the end of the study, skeletal muscle and heart function, mitochondrial function, and Nrf2 activity were measured. (usda.gov)
Therefore, the restoration of Nrf2 activity by SFN may be a safe and effective strategy to protect against muscle and heart dysfunction due to aging. (usda.gov)
This twin potential is the defining feature of cardiopharyngeal mesoderm: the head subtype giving rise to heart and branchiomeric head muscles. (ncbs.res.in)
6) Cardiac Muscle - heart wall, involuntary, striated muscle with intercalated discs connecting cells for synchronized contractions during heart beat. (exploringnature.org)
describe the ionic basis of the resting membrane and action potentials in the heart and the steps involved in coupling electrical activity to the development of active force. (manchester.ac.uk)
Reductions in heart rate, blood pressure, peripheral vascular resistance, cardiac output, and central venous pressure occur during severe hypothermia. (wildliferesearch.com)
A Cardiac Deep Learning Model (CDLM) to Predict and Identify the Risk Factor of Congenital Heart Disease. (cdc.gov)

muscles Metabolic Remodeling Network marketing leads to Choice Substrate Usage by Mitochondria. (bio-cavagnou.info)
It was observed an improvement in skeletal muscle mass, resting metabolic rate, as well as the consumption of fresh foods/g and processed food/kcal after the intervention period. (bvsalud.org)

In February 2023, Entrada announced the closing of its strategic collaboration and license agreement with Vertex for the discovery and development of intracellular EEV-therapeutic candidates for myotonic dystrophy type 1 (DM1). (biospace.com)

However, CPK also may increase from handling stress and from cardiac and skeletal muscle damage (capture myopathy syndrome) not associated with a hypothermic event (Bossart and Dierauf, 1990). (wildliferesearch.com)

The results showed that older had lower Nrf2 activity and mitochondrial function, together with a lower skeletal muscle mass and cardiac function compared to young mice. (usda.gov)
In the old mice, SFN restored Nrf2 activity, mitochondrial function, cardiac function, capacity to exercise, handling of sugar, and activation of skeletal muscle satellite cells (important for renewal of the muscle cells). (usda.gov)
Our studies revealed a significant drop in Nrf2 activity and mitochondrial functions, together with a loss of skeletal muscle and cardiac function in the old control mice compared to the younger age group. (usda.gov)
IGF2 mutation knock-in (IGF2 KI) and ZBED6 knockout (ZBED6 KO) lead to changes in IGF2 expression and increase muscle mass in mice and pigs. (biomedcentral.com)
Genetic factors are important in the development of autoimmune disease, since such diseases develop in certain strains of mice (e.g., systemic lupus erythematosus or lupus in MRL mice) without any apparent infectious environmental trigger. (cdc.gov)

This narrative review provides preliminary insights that will guide the development and future utilization of these biomarkers. (cdc.gov)

Immunoreceptor signaling during development, homeostasis, and effector function of T cells and NK cells. (upstate.edu)
Disruption of Drosophila larval muscle structure and function by UNC45 knockdown, BMC Mol. (utoronto.ca)
It is focused on the discovery and development of small molecule therapeutics that modulate muscle function for the treatment of serious diseases and medical conditions. (stash.com)

Class IIa histone deacetylases (HDACs) regulate a variety of cellular processes, including cardiac growth, bone development, and specification of skeletal muscle fiber type. (jci.org)
The SFRPs inhibit Wnt receptor binding to down-regulate pathway signaling during development [ 8 ]. (biomedcentral.com)

There are three primary types of muscles. (azumio.com)
The agonistic muscles are the primary movers in a motion and do the most work, synergist muscles aid the agonists in either assisting the movement or stabilizing it, and antagonists perform the opposite movements of the agonist muscles. (azumio.com)
The primary mover in a bicep curl is the biceps brachii, the outermost muscle on your upper arm. (azumio.com)
As it's doing this, the brachialis muscle will shorten to assist the primary mover, while the tricep muscle is stimulated to relax and lengthen so you can move your arm further. (azumio.com)

He is an expert in project management, with more than a decade of experience in managing several working group efforts for PSTC, including those for hepatotoxicity, pancreatic injury, skeletal muscle injury and vascular injury. (c-path.org)
However, the application of membrane forms of the scaffold for treating cardiac injury was cumbersome. (dst.gov.in)
Loss of the functional skin such as muscle, nerves, blood vessels and barrier after thermal injury results in in- bone despite the absence of a major cutane- creased susceptibility to infection, which is ous injury. (who.int)

Many theories regarding the causes of insulin resistance in skeletal muscle focus on the power of muscle to oxidize fats with evidence accommodating either reduced or improved fatty acidity oxidation (FAO) as causal to insulin ITGA10 resistance. (bio-cavagnou.info)
The mutation of insulin-like growth factor 2 (IGF2 mutation) that a single-nucleotide substitution (G→A) in the third intron of IGF2 abrogates the interaction with zinc finger BED-type containing 6 (ZBED6) and leads to increased muscle mass in pigs. (biomedcentral.com)
In terms of future research, he believes that one important focus needs to be the development of a way of preventing the deleterious effects of hyperglycemia without having to keep lowering glucose levels and thus risk triggering hypoglycemia and without "using a lot of insulin to do that. (medscape.com)

This haplotype analysis excludes a number of striated muscle-expressed genes present in this region, including laminin alpha2, laminin alpha4, triadin, and phospholamban. (duke.edu)

Explainable machine learning model for predicting skeletal muscle loss during surgery and adjuvant chemotherapy in ovarian cancer. (cdc.gov)

Our results suggest that the age-associated decline in Nrf2 signaling activity and the associated mitochondrial dysfunction might be related to the development of age-related disease processes. (usda.gov)
Impairment of Mitochondrial FAO in Muscle Kinetin Attenuates Development of Adiposity. (bio-cavagnou.info)
To probe further the implications of reduced mitochondrial FAO on fat burning capacity within the muscles we used muscles homogenates to look at oxidation of various other substrates. (bio-cavagnou.info)
Mitochondrial dysfunction is a common feature of normal aging and is closely associated with the development of age-related neurodegenerative disease [ 1 - 3 ]. (aging-us.com)

HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo. (ox.ac.uk)
The expression of HRC in cardiac, skeletal, and smooth muscle raises the possibility of a common transcriptional mechanism governing its expression in all three muscle cell types. (ox.ac.uk)
Includes skeletal muscles, smooth muscles and cardiac muscle. (wikipedia.org)
Of the freely available peer-reviewed resources appropriate for revision of this topic, none beat Sweeney & Hammers (2018) , as this review covers all possible examinable topics and has sections comparing skeletal muscle to smooth and cardiac muscle. (derangedphysiology.com)
They include cardiac muscle, smooth muscle, and skeletal muscle. (azumio.com)

Skeletal manifestations include a selective cortical bone loss. (medscape.com)

Divergent early mesoderm specification underlies distinct head and trunk muscle programmes in vertebrates. (ncbs.res.in)
Head and trunk muscles have discrete embryological origins and are governed by distinct regulatory programmes. (ncbs.res.in)

However, the role of the ZBED6-lncRNA axis in skeletal muscle development is poorly characterized. (biomedcentral.com)

uterine muscle abnormalities may cause problems for women during labor and delivery. (msdmanuals.com)

With new articles being added to these collections on a daily basis, the collections serve as an ideal tool to keep researchers updated with new developments in the respective fields. (eurekaselect.com)

Peripheral vasoconstriction and shivering are frequent physiological manifestations of mild hypothermia as core temperature declines to 32°C (90°F). At lower core temperatures, hyporeflexia, stupor, cessation of shivering, and muscle rigidity become evident (Knochel, 1985). (wildliferesearch.com)

In March 2023, Entrada presented additional preclinical data at the Muscular Dystrophy Association (MDA) Clinical & Scientific Conference supporting the development of ENTR-601-45 for the potential treatment of patients with Duchenne who are exon 45 skipping amenable, including data visualizing dystrophin restoration in skeletal and cardiac muscle cells. (biospace.com)
Entrada anticipates that its cash, cash equivalents and marketable securities as of March 31, 2023, together with ongoing research support and the anticipated achievement of certain milestones under the Vertex Agreement, will be sufficient to extend its cash runway into the second half of 2025, supporting the Company's expansion and continued development of EEV-therapeutic candidates targeting Duchenne as well as other indications beyond neuromuscular diseases. (biospace.com)

In keeping with AMPK/PGC1α activation EM in soleus muscles reveals large rings of mitochondria encircling enlarged lipid droplets in Cpt1bm? (bio-cavagnou.info)

There is tremendous therapeutic potential for utrophin modulation in this devastating disease because there is currently no approved disease-modifying therapy applicable to all patients with DMD, and many other candidates in clinical development are restricted to a single mutation. (drugdiscoverynews.com)

Remarkably, the progenitors derived from embryonic stem cells by dual inhibition efficiently differentiate into cardiac and skeletal muscle cells. (ncbs.res.in)

Anatomy58

Organisms23

Diseases25

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes59

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena4

Information Science3

Health Care2

Tissues7

Physiology8

Human skeletal muscle2

Result in skeletal muscle2

Sarcoplasmic reticulum3

Arrhythmias7

Isoforms2

Proteins13

Myosin4

Conduction system4

Mechanisms6

Gene13

Troponin1

Hypertrophy3

Respiratory2

Vascular smooth1

Myopathies5

Metabolism1

Cardiomyopathy4

Contraction6

Regeneration2

Lineages2

Ablation1

Tissue4

Fibers2

Affects2

Contractility1

Myogenesis1

Structural2

Weakness5

Sudden cardi1

MRNA2

Regulation2

Significantly5

Findings2

Autosomal dominant1

Mutations1

Coronary1

Tumor1

Accumulation1

Heart9

Metabolic2

Intracellular1

Myopathy1

Mice5

Biomarkers1

Function3

Regulate2

Primary4

Injury3

Insulin3

Genes1

Adjuvant1

Mitochondrial4

Smooth5

Bone1

Distinct2

Poorly1

Abnormalities1

Researchers1

Hypothermia1

20232

Mitochondria1

Candidates in clinical development1

Cells1