• Development of novel therapeutic approaches to bolster kinin activity in the vascular wall and in specific compartments in the kidney might be a highly effective strategy for the treatment of hypertension and its complications, including cardiac hypertrophy and renal failure. (nature.com)
  • BACKGROUND: Therapies are urgently required to ameliorate pathological cardiac hypertrophy and enhance cardiac function in heart failure. (bvsalud.org)
  • This study aims to investigate the positive inotropic effects of NADPH in pathological cardiac hypertrophy and heart failure, as well as the underlying mechanisms involved. (bvsalud.org)
  • The effects of NADPH were investigated in isoproterenol (ISO)-induced cardiac hypertrophy or transverse aortic constriction (TAC)-induced heart failure. (bvsalud.org)
  • During the pathological development of cardiovascular diseases, cardiac hypertrophy plays a critical role. (karger.com)
  • Although the cardiac hypertrophy is an adaptive response of the heart that responds to a variety of extrinsic and intrinsic stimuli, prolonged hypertrophy typically culminates in chronic heart failure or sudden cardiac death. (karger.com)
  • Compared to the deoxycorticosterone acetate group, the L-citrulline and spironolactone combination therapy dose-dependently ameliorated the elevated levels of different blood pressure parameters, improved cardiac hypertrophy, vascular reactivity, aorta relaxant responses and attenuated oxidative stress. (ijpsonline.com)
  • The pattern of hypertrophy is distinct from other forms of cardiac disease and begins to appear before hypertension or diabetes. (qmul.ac.uk)
  • Mutations in AMPK cause arrhythmias and cardiac hypertrophy. (qmul.ac.uk)
  • IOPD is caused by severe GAA deficiency and presents at birth with cardiac hypertrophy, muscle hypotonia, and severe respiratory impairment, leading to premature death, if not treated. (nih.gov)
  • Cs-Lpin1 -/- mice had normal systolic cardiac function but mild cardiac hypertrophy. (bioblast.at)
  • After transverse aortic constriction-induced pressure overload, loss of lipin 1 did not exacerbate cardiac hypertrophy or dysfunction. (bioblast.at)
  • The pathological consequences associated with normal cardiovascular aging include hypertrophy, altered left ventricular (LV) diastolic and systolic function, heart failure, enhanced arterial stiffness, and endothelial dysfunction, all of which can alter the structure and function of the heart and arterial system [ 5 , 6 ] . (oaepublish.com)
  • Targeted knockout of Kmt2d in precursors cells of brown adipocytes and myocytes results in decreases in brown adipose tissue and muscle mass in mice, indicating that KMT2D is required for adipose and muscle tissue development. (wikipedia.org)
  • These studies will employ multiple innovative reagents including mouse models of inducible, cardiomyocyte-specific L2A deletion and overexpression, a recently developed small molecule activator of CMA, and a new CMA reporter mouse. (elsevierpure.com)
  • In mice, KMT2D is coded by the Kmt2d gene located on chromosome 15F1. (wikipedia.org)
  • In the hearts of mice, a single copy of the Kmt2d gene is sufficient for normal heart development. (wikipedia.org)
  • Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site. (figshare.com)
  • In this study, we purified the 30-kDa protein from heart extract and identified it as cardiac troponin I (cTnI), encoded by a gene in which mutations can cause familial hypertrophic cardiomyopathy (HCM). (nih.gov)
  • Of these, we validated the functional importance of ten interactors on cardiac electrophysiology through genetic knockouts in zebrafish, gene silencing in mice, super-resolution microscopy and patch clamp experiments. (ku.dk)
  • This line was used to generate connecting tube/collecting duct (CNT/CD)-specific or mice [29] which drive Cre recombinase expression under the control of regulatory elements of the mouse gene. (bioskinrevive.com)
  • We generated mice that possess a heterozygous deletion of the PTG gene. (jci.org)
  • We further investigated the role of the RRBP1 gene using a transgenic mouse model and a human cell model. (biomedcentral.com)
  • In this study, we created a conditional CM-specific HP1 gamma (HP1γ) knockout (KO) mouse model and tested whether HP1γ is required for cell cycle gene silencing and cardiac growth. (altmetric.com)
  • HP1γ KO mice were generated by crossing HP1γ floxed mice (fl) with mice expressing Cre recombinase driven by the Nkx2.5 (cardiac progenitor gene) promoter (Cre). (altmetric.com)
  • Recently, a mouse model for Refsum disease (Phyh knockout mouse by targeted disruption of the PHYH gene). (medscape.com)
  • Complete loss of Kmt2d in cardiac precursors and myocardium leads to severe cardiac defects and early embryonic lethality. (wikipedia.org)
  • The current presence of GFP+ epicardial cells within the surface from the myocardium in mice demonstrated the integrity of this structure in mutant mice (Supplementary Fig. 4b). (hiv-proteases.com)
  • We generated mice with cardiac-specific lipin 1 KO (cs-Lpin1 -/- ) to examine the intrinsic effects of lipin 1 in the myocardium. (bioblast.at)
  • Endothelial-to-mesenchymal transition (EndMT) is an important mechanism underlying cardiac fibrosis. (dovepress.com)
  • Cardiac fibroblasts are generally the primary effector cells of fibrosis and have been reported to be partly derived from cardiac endothelial cells through the endothelial to mesenchymal transition (EndMT) process. (dovepress.com)
  • Epicardial epithelial-mesenchymal transition (EMT) is normally hypothesized to create cardiovascular progenitor cells that differentiate into several cell types including coronary even muscle and endothelial cells perivascular and cardiac interstitial fibroblasts and cardiomyocytes. (hiv-proteases.com)
  • Optical projection tomography (OPT) demonstrated how the coronary arteries didn't type in Wt1 mutant mice (Fig. 1e f and Supplementary films 1 2 This result was verified by staining for platelet/endothelial cell adhesion molecule-1 (PECAM-1) and α-soft muscle tissue actin (α-SMA) markers for endothelial and soft muscle tissue cells respectively (Fig. 1g h). (hiv-proteases.com)
  • During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac development by undergoing endothelial-to-mesenchymal transition (EndoMT). (surrey.ac.uk)
  • Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)
  • Cs-Lpin1 -/- mice exhibited diminished cardiac cardiolipin content and impaired mitochondrial respiration rates when provided with pyruvate or succinate as metabolic substrates. (bioblast.at)
  • We propose a new paradigm in which CMA, activated in response to cardiac stress, mediates cardiac dysfunction by depleting cardiomyocytes of proteins that would normally promote mitochondrial quality control through mitophagy. (elsevierpure.com)
  • Administration of monoclonal antibodies to cTnI induced dilatation and dysfunction of hearts in wild-type mice. (nih.gov)
  • TMZ treatment mitigated cardiac fibrosis, ameliorated left ventricular dysfunction, and reduced NOX activity. (dovepress.com)
  • Human lipin 1 mutations lead to episodic rhabdomyolysis, and some affected patients exhibit cardiac abnormalities, including exercise-induced cardiac dysfunction and cardiac triglyceride accumulation. (bioblast.at)
  • 1 Department of Regenerative Medicine and Advanced Cardiac Therapeutics, 2 Cardiology Division, Department of Internal Medicine, 3 Department of Cardiovascular Surgery, 4 Division of Diagnostic Pathology, 5 Department of Pathology, Keio University School of Medicine, Tokyo, Japan. (jci.org)
  • He did not have any cardiovascular risk factors, and his cardiac function and morphology were normal prior to sorafenib treatment. (biomedcentral.com)
  • Recently, EndMT has been increasingly recognized as a vital process that contributes to various cardiovascular pathologies in adults, which include atherosclerosis, valvular heart disease, cardiac fibrosis, and myocardial infarction. (dovepress.com)
  • We identified spleen as an important source of these cardiovascular complications in Hmox1 −/− mice. (springer.com)
  • Recently we have reported generation of a conditional knockout line using the LoxP-Cre system (function including the methyltransferase activity upon Cre-mediated recombination [23]. (bioskinrevive.com)
  • Quickly we utilized a conditional knockout range (range [29] to inactivate and therefore abolish histone H3 K79 methylation in Aqp2-expressing cells which can be found in the CNT/Compact disc [30]. (bioskinrevive.com)
  • Because Drosophila lack most of these redundant genes, we examined heart tubes of parkin knockout flies and observed accumulation of enlarged hollow donut mitochondria with dilated cardiomyopathy, which could be rescued by cardiomyocyte-specific Parkin expression. (wustl.edu)
  • An immunohistochemical study revealed renin accumulation in the juxtaglomerular cells of Rrbp1 -KO mice. (biomedcentral.com)
  • Rats injected with ISO exhibited severe interstitial cardiac fibrosis and perivascular fibrosis, decreased left ventricular ejection fraction, and increased NOX activity. (dovepress.com)
  • Patients with acromegaly demonstrated increased left ventricular mass index (LVMi), end diastolic volume index, stroke volume index and cardiac index, which persisted at one year, despite treatment of underlying disease. (qmul.ac.uk)
  • Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
  • The myocardial perfusion of healthy mice obtained by the SI-method , 5.6 ± 0.5 ml/g/min, (mean ± standard deviation) was similar (p=0.38) to that obtained by the conventional method, 5.6 ± 0.3 ml/g/min. (biomedcentral.com)
  • Myocardial fibrosis, characterized as interstitial fibroblast proliferation and excessive collagen deposition, is the structural basis of myocardial stiffness and the key process of cardiac function transformation from the compensatory phase to heart failure. (dovepress.com)
  • Cardiac-specific knockout of these genes in mouse hearts led to increased oxidative stress, which stimulated the secretion of the lysosomal peptidase cathepsin D that in turn cleaved the circulating nursing hormone prolactin. (groningencardiology.com)
  • No significant difference in expression of cell cycle genes or cardiac-specific genes was observed. (altmetric.com)
  • These data indicate that HP1γ is dispensable for cell cycle exit and normal cardiac growth but has a significant role in maintaining H4K20me3 and regulating a limited number of genes in CMs. (altmetric.com)
  • In addition, mutation of Y5477 in mouse KMT2D, which corresponds to Y5426 in human KMT2D, resulted in the inactivation of KMT2D's enzymatic activity in embryonic stem cells. (wikipedia.org)
  • Whole-body knockout of Kmt2d in mice results in early embryonic lethality. (wikipedia.org)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
  • When mice are infected with T. gondii , they show lethargy, severe weight loss and intestinal inflammation during the acute stage, Carter said. (deniseblough.com)
  • Rrbp1 - knockout (KO) mice had lower blood pressure and were more likely to die suddenly from severe hyperkalemia caused by phenotypically hyporeninemic hypoaldosteronism than wild-type controls. (biomedcentral.com)
  • RRBP1 deficiency in mice caused hyporeninemic hypoaldosteronism, resulting in lower blood pressure, severe hyperkalemia, and sudden cardiac death. (biomedcentral.com)
  • Consistently, we found that Rrbp1 - knockout (KO) mice had lower blood pressure and hyporeninemic hypoaldosteronism, which cause severe hyperkalemic cardiac arrhythmia-induced sudden death. (biomedcentral.com)
  • However, there has been no means to assess the functional significance of CMA in healthy or diseased hearts until recently, when we generated mice with an inducible, cardiomyocyte-specific knockout of LAMP2A (iCS- L2AKO). (elsevierpure.com)
  • Mice with an inducible knockout of ACSL1 ( Acsl1 T-/- ) have impaired cardiac fatty acid oxidation and rely on glucose for ATP production. (oroboros.at)
  • CONCLUSION: Long-term Cr deficiency in GAMT-/- mice reduces mitochondrial volume without affecting respiratory function, most likely due to impaired biogenesis. (ox.ac.uk)
  • Objective: We used germline mutants and cardiac-specific RNA interference to interrogate Parkin regulation of cardiomyocyte mitochondria and examine functional crosstalk between mitophagy and mitochondrial dynamics in Drosophila heart tubes. (wustl.edu)
  • Conclusions: Parkin deficiency and resulting mitophagic disruption produces cardiomyopathy in part by contamination of the cardiomyocyte mitochondrial pool through fusion between improperly retained dysfunctional/ senescent and normal mitochondria. (wustl.edu)
  • These data suggest that loss of lipin 1 impairs cardiac functional reserve, likely due to effects on glycerolipid homeostasis, mitochondrial function, and protein kinase A signaling. (bioblast.at)
  • Short-term Cr deficiency is metabolically well tolerated as GAMT-/- mice exhibit normal exercise capacity and response to ischemic heart failure. (ox.ac.uk)
  • This study used primary cardiomyocytes and mouse and rat models of GH excess and deficiency to study the effects of GH on cardiac AMPK. (qmul.ac.uk)
  • Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin and mitophagic quality control in maintaining normal cardiac homeostasis is poorly understood. (wustl.edu)
  • The mechanisms by which GH influences cardiac tissue are poorly understood. (qmul.ac.uk)
  • Here we report the experimental identification of the ensemble of protein interactors for 13 types of ion channels in murine cardiac tissue. (ku.dk)
  • These mice have reduced glycogen stores in adipose tissue, liver, heart, and skeletal muscle, corresponding with decreased glycogen synthase activity and glycogen synthesis rate. (jci.org)
  • The underlying mechanisms of NADPH were studied using SIRT3 knockout mice, echocardiography, Western blotting, transmission electron microscopy, and immunoprecipitation. (bvsalud.org)
  • The defects suggest Adprhl1 participation from the earliest stage of cardiac myofibrillogenesis and are consistent with previous MO results and Adprhl1 protein localization to actin filament Z-disc boundaries. (figshare.com)
  • In the amphibian Xenopus laevis, knockdown of the two cardiac Adprhl1 protein species (40 and 23 kDa) causes failure of chamber outgrowth but this has only been demonstrated using antisense morpholinos that interfere with RNA-splicing. (figshare.com)
  • Mice lacking Adprhl1 exons 3-4 are normal but production of the smaller ADPRHL1 species is unaffected, providing further evidence that cardiac activity is concentrated at the C-terminal protein portion. (figshare.com)
  • We recently reported that mice deficient in the programmed cell death-1 (PD-1) immunoinhibitory coreceptor develop autoimmune dilated cardiomyopathy (DCM), with production of high-titer autoantibodies against a heart-specific, 30-kDa protein. (nih.gov)
  • Protein-protein interactions are essential for normal cellular processes and signaling events. (ku.dk)
  • This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)
  • However, loss of lipin 1 dampened the cardiac ionotropic response to dobutamine and exercise endurance in association with reduced protein kinase A signaling. (bioblast.at)
  • This study aimed to investigate the possible effect of TMZ on cardiac fibrosis exerted via the inhibition of NOX2-mediated EndMT. (dovepress.com)
  • A cardiac fibrosis model was established in Sprague-Dawley rats through a subcutaneous injection of isoproterenol (ISO, 5 mg/kg/d). (dovepress.com)
  • TMZ may ameliorate EndMT and ISO-induced cardiac fibrosis through the NOX2/NF-κB/Snail pathway. (dovepress.com)
  • The findings of the study may provide new insights into the potential role of TMZ in the pathophysiology of cardiac fibrosis. (dovepress.com)
  • Cardiac magnetic resonance imaging (CMR) is the gold standard for assessment of cardiac mass and provides data on cardiac function, fibrosis, valve function and ischaemia. (qmul.ac.uk)
  • Finally the SI-method was used in comparison to a Late Gadolinium Enhanced (LGE) method to qualitatively and quantitatively assess perfusion deficits in an ischemia-reperfusion mouse model (n=4). (biomedcentral.com)
  • Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice. (ox.ac.uk)
  • Cardiac function was investigated, including coronary angiography and transthoracic and transesophageal echocardiography. (biomedcentral.com)
  • These studies documented normal cardiac function and normal morphology of the coronary arteries. (biomedcentral.com)
  • Although ACSL1 determines the acyl-chain composition of heart CL, a high tetralinoleoyl-CL content may not be required for normal function. (oroboros.at)
  • Then, starting from 7th until 21st day post-MI a more potent deterioration of LV function was observed in Hmox1 −/− than in the surviving Hmox1 +/+ mice. (springer.com)
  • Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
  • Analysis of cardiac size and function by echo revealed no significant differences between HP1γ KO and control (WT, Cre, fl/fl) mice. (altmetric.com)
  • The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
  • Methods and Results: Transcriptional profiling of Parkin knockout mouse hearts revealed compensatory upregulation of multiple related E3 ubiquitin ligases. (wustl.edu)
  • Afterwards, however, the hearts of Hmox1-deficient mice undergo adverse late LV remodeling due to overactive and prolonged post-ischemic inflammatory response. (springer.com)
  • 1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)
  • Insulin resistance in older PTG heterozygous mice correlates with a significant increase in muscle triglyceride content, with a corresponding attenuation of insulin receptor signaling. (jci.org)
  • Compared with littermate control mice, PA content was higher in cs-Lpin1 -/- hearts, which also had an unexpected increase in diacylglycerol and triglyceride content. (bioblast.at)
  • Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and sometimes MLL2 in humans and Mll4 in mice, is a major mammalian histone H3 lysine 4 (H3K4) mono-methyltransferase. (wikipedia.org)
  • Mice develop tumors resembling those seen in humans, including expression of high levels of miR-21. (genengnews.com)
  • Most humans and other intermediate hosts (such as mice) are presumed to acquire it through exposure to infected cat feces or poorly cooked food. (deniseblough.com)
  • There are 13 mammalian TLRs with TLRs 1 to 9 being conserved between humans and mice. (biomedcentral.com)
  • B ) Skeletal muscle sections prepared from 8-month-old Ptpmt1 +/+ /Ckm-Cre + and Ptpmt1 fl/fl /Ckm-Cre + mice were processed for Hematoxylin and Eosin (H&E) staining and Masson's Trichrome staining. (elifesciences.org)
  • PD can present with cardiac, skeletal muscle, and central nervous system manifestations, as a continuum of phenotypes among two main forms: classical infantile-onset PD (IOPD) and late-onset PD (LOPD). (nih.gov)
  • This is associated with hemodynamic changes without evidence of heart failure, which may represent an acceptable functional compromise in return for reduced energy demand in aging mice. (ox.ac.uk)
  • Altogether, we define interactomes of 13 major cardiac ion channels, contextualize their relevance to human electrophysiology and validate functional roles of ten interactors, including two regulators of the sodium current (epsin-2 and gelsolin). (ku.dk)
  • In 2 and 8 month old bovine GH-overexpressing (bGH) and GH receptor knock out (GHRKO) mice, functional AMPK assay did not demonstrate any difference in cardiac AMPK activity between transgenics and controls. (qmul.ac.uk)
  • D, E ) Seven- to eight-month-old Ptpmt1 +/+ /Ckm-Cre + ( n = 5 males and 5 females) and Ptpmt1 fl/fl /Ckm-Cre + ( n = 3 males and 5 females) mice were assessed by treadmill exercise tests as described in Materials and methods. (elifesciences.org)
  • Adherens junctions are a ubiquitous type of intercellular junction and are present in both epithelial and non-epithelial cells [ 3 , 6 ], whereas desmosomes are adhesive junctions that confer tensile strength and resilience on cells and are present not only in epithelial cells but also in non-epithelial cells that endure mechanical stress, such as cardiac muscle and meninges [ 7 . (oncotarget.com)
  • LOPD is characterized by levels of residual GAA activity up to ∼20% of normal and presents both in children and adults with a varied severity of muscle weakness and motor and respiratory deficit. (nih.gov)
  • It acts on the smooth muscle and, therefore, raises the resistance posed by these arteries to the heart, and so for the same cardiac output, the blood pressure will rise. (wikipedia.org)
  • RESULTS: In vivo LV catheterization revealed lower heart rate and developed pressure in aging GAMT-/- but normal lung weight and survival versus age-matched controls. (ox.ac.uk)
  • These mouse models revealed significant vascular damage in late pregnancy and consequent heart failure. (groningencardiology.com)
  • Thus, ACSL1 is required for the normal composition of several phospholipid species in heart. (oroboros.at)
  • Extensor Digitorum Longus (EDL) and Soleus ( n = 8 mice/genotype), and heart ( n = 4 mice/genotype) weights were measured. (elifesciences.org)
  • Ptpmt1 mRNA levels in EDL, Soleus, and heart tissues were determined by quantitative reverse transcription PCR (qRT-PCR) ( n = 4 mice/genotype). (elifesciences.org)
  • BrS is associated with an increased risk of syncope, palpitations, chest pain, convulsions, difficulty in breathing (nocturnal agonal breathing) and/or Sudden Cardiac Death (SCD) secondary to PVT/VF, unexplained cardiac arrest or documented PVT/VF or Paroxysmal atrial fibrillation (AF) in the absence of apparent macroscopic or structural heart disease, electrolyte disturbance, use of certain medications or coronary heart disease and fever. (bvsalud.org)
  • We worked on a mouse model that overexpresses the well-known oncogene RAS in hepatocytes. (genengnews.com)
  • The aim of this study was to determine the role of Hmox1 in the monocyte/macrophage-mediated cardiac remodeling in a mouse model of MI. (springer.com)
  • The normal concentration of renin in adult human plasma is 1.98-24.6 ng/L in the upright position. (wikipedia.org)
  • The polyuria phenotype in mice and in patients with DN may be partially due to upregulated Aqp5. (bioskinrevive.com)
  • Outcomes mice and explanation of their polyuria phenotype on a standard pellet Na+ diet plan are detailed inside our related manuscript [30]. (bioskinrevive.com)
  • Aqp1- 4 are important for maintenance of normal urinary concentration and implicated in the renal water disorders [4]-[7]. (bioskinrevive.com)
  • Acromegaly and GHD patients have increased cardiac mortality. (qmul.ac.uk)
  • We found that all the control mice died while the majority of treated mice survived. (genengnews.com)
  • Although young PTG heterozygous mice initially demonstrate normal glucose tolerance, progressive glucose intolerance, hyperinsulinemia, and insulin resistance develop with aging. (jci.org)
  • Hmox1 knockout (Hmox1 −/− ) and wild-type (WT, Hmox1 +/+ ) mice were subjected to a permanent ligation of the left anterior descending coronary artery. (springer.com)
  • A ) Representative 8-month-old of Ptpmt1 fl/fl /Ckm-Cre + and Ptpmt1 +/+ /Ckm-Cre + mice, and hind limbs and hearts dissected from these mice were photographed. (elifesciences.org)
  • Overall, our data provide a roadmap for our understanding of the molecular machinery that regulates cardiac electrophysiology. (ku.dk)
  • Mary Carter, second-year student at Ohio State's College of Veterinary Medicine, spent her summer at Stanford University studying the molecular underpinning of the parasite and its infectious processes in mice. (deniseblough.com)
  • Carter and her research team at Stanford (shown on right) want to understand how T. gondii causes weight loss in mice by examining its molecular processes throughout infection. (deniseblough.com)
  • Plasma levels of glucose and lipids are comparable in Ptpmt1 fl/fl /Ckm-Cre + mice and Ptpmt1 +/+ /Ckm-Cre + littermates. (elifesciences.org)
  • A ) Blood glucose and free fatty acid (FFA) levels were measured in 6- to 7-month-old male Ptpmt1 fl/fl /Ckm-Cre + and Ptpmt1 +/+ /Ckm-Cre + mice ( n = 4/genotype). (elifesciences.org)
  • Long-chain acyl-CoA synthetase 1 (ACSL1) contributes more than 90% of total cardiac ACSL activity, but its role in phospholipid synthesis has not been determined. (oroboros.at)
  • Efficient deletion of in epicardial cells was verified using immunohistochemistry on center sections and genuine time-PCR evaluation on FACS-sorted GFP+ epicardial cells isolated from (embryos can be normal. (hiv-proteases.com)