• emerin
  • In cardiac muscle, emerin localizes to adherens junctions within intercalated discs where it appears to function in mechanotransduction of cellular strain and in beta-catenin signaling. (wikipedia.org)
  • expression of emerin is highest in skeletal and cardiac muscle. (wikipedia.org)
  • In cardiac muscle specifically, emerin also resides at adherens junctions within intercalated discs. (wikipedia.org)
  • In cardiac muscle, emerin is also found complexed to beta-catenin at adherens junctions of intercalated discs, and cardiomyocytes from hearts lacking emerin showed beta-catenin redistribution as well as perturbed intercalated disc architecture and myocyte shape. (wikipedia.org)
  • beta-catenin
  • In cardiac muscle, beta-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. (wikipedia.org)
  • contraction
  • Actin therefore contributes to processes such as the intracellular transport of vesicles and organelles as well as muscular contraction and cellular migration. (wikipedia.org)
  • arrhythmia
  • In addition, each affected individual exhibited either cardiac arrhythmia, which was evident as sinus tachycardia, atrial flutter or complete atrioventricular inhibition. (nih.gov)
  • clinical
  • Because myocardial fibrosis preceded the clinical and echocardiographic signs, we consider the disease to be a hereditary form of cardiac fibrosis. (onlinejacc.org)
  • actin
  • Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated. (deepdyve.com)
  • In vivo expression of cofilin-1, phosphorylated on Thr25 by endogenous ERK1/2 signaling, leads to alterations in left ventricular function and cardiac actin. (deepdyve.com)