• contractility
  • This results in a spectrum of hemodynamic responses: On one end of the spectrum is the cardioinhibitory response, characterized by a drop in heart rate (negative chronotropic effect) and in contractility (negative inotropic effect) leading to a decrease in cardiac output that is significant enough to result in a loss of consciousness. (wikipedia.org)
  • The principal actions of cocaine on the cardiovascular system are from alpha- and beta-1-adrenoceptor stimulation resulting in increased heart rate, systemic arterial pressure, and myocardial contractility, which are major determinants of myocardial oxygen demand. (wikipedia.org)
  • diseases
  • In summary, linear and non-linear analysis of HRV are reliable approaches to assess changes of autonomic cardiac modulation during sleep both in health and diseases. (frontiersin.org)
  • This provides important information not only for the diagnosis and treatment planning of different cardiovascular diseases but also for the design of cardiovascular devices. (wisc.edu)
  • The phenomenon shared by these degenerative diseases is the deposition of amyloid proteins to normal functional cells, where they are hard to degrade under physiological conditions [ 9 , 10 ]. (hindawi.com)
  • To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. (mdpi.com)
  • sudden
  • 15 . The method of claim 13 , wherein determining the patient's susceptibility to heart disease comprises determining the patient's susceptibility to sudden cardiac death based on the autonomic tone. (google.com)
  • Thought to affect as many as one in ten thousand people, it is estimated to cause 15% of all unexplained sudden cardiac deaths in young people. (wikipedia.org)
  • Mutations of this gene may be associated with mild or absent hypertrophy and predominant restrictive disease, with a high risk of sudden cardiac death. (wikipedia.org)
  • occurs
  • The increased luminal calcium activation occurs because of a phenomenon termed store-overload induced calcium release (SOICR). (wikipedia.org)
  • The autonomic nervous system's physiological state (see below) leading to loss of consciousness may persist for several minutes, so If sufferers try to sit or stand when they wake up, they may pass out again The person may be nauseated, pale, and sweaty for several minutes or hours Reflex syncope occurs in response to a trigger due to dysfunction of the heart rate and blood pressure regulating mechanism. (wikipedia.org)
  • This phenomenon occurs due to dilation of the blood vessels, probably as a result of withdrawal of sympathetic nervous system tone. (wikipedia.org)
  • Individuals with cocaine overdose should be transported immediately to the nearest emergency department, preferably by ambulance in case cardiac arrest occurs en route. (wikipedia.org)
  • stroke
  • At fetal surgery, heart rate increased acutely, and combined cardiac output diminished at the time of fetal incision for all groups including those with MMC, which suggests diminished stroke volume. (ahajournals.org)
  • Based on previous studies indicating the presence of ACE2 and Mas in the brain as well as a protective role for ACE2/Ang-(1-7)/Mas axis during cardiovascular disease, we have developed the general hypothesis that activation of the brain ACE2/Ang-(1-7)/Mas axis will have cerebroprotective action during ischemic stroke. (ufl.edu)
  • Further, the mathematical analysis of CNAP pulse waves enables the noninvasive estimation of stroke volume and cardiac output. (wikipedia.org)
  • For the treatment of primary hypertension, meta-analyses of studies which mostly used atenolol have shown although beta blockers are more effective than placebo in preventing stroke and total cardiovascular events, they are not as effective as diuretics, medications inhibiting the renin-angiotensin system (e.g. (wikipedia.org)
  • platelet
  • cAMP goes on to inhibit any undue platelet activation (in order to promote circulation) and also counteracts any increase in cytosolic calcium levels that would result from thromboxane A2 (TXA2) binding (leading to platelet activation and subsequent coagulation). (wikipedia.org)
  • No evidence of platelet dysfunction or an increase in surgical bleeding after administration of inhaled epoprostenol has been found. (wikipedia.org)
  • Cocaine-induced platelet activation and thrombus formation is another deleterious effect, caused by alpha-adrenergic- and adenosine diphosphate-mediated increase in platelet aggregation. (wikipedia.org)
  • IP(-/-) mice) exhibit increased tendency to thrombosis in response to experimentally-induced Endothelium, a result which appears to reflect, at least in part, the loss of IP's anti-platelet activity. (wikipedia.org)
  • The PGI2-IP axis along with the production of nitric oxide, acting together additively and potentially synergistically, are powerful and physiological negative regulators of platelet function and thereby blood clotting in humans. (wikipedia.org)
  • Raynaud's
  • The most common indications for thoracic sympathectomy are focal hyperhidrosis (that specifically affects the hands and underarms), Raynaud's phenomenon, and facial blushing when accompanied by focal hyperhidrosis. (wikipedia.org)
  • tissue
  • Stem cells are administered to MI areas to encourage regeneration of cardiac tissue in the damaged area. (google.com)
  • 4. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 1 , wherein a compromised area of cardiac tissue has stem cells deposited thereon. (google.com)
  • 5. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 4 , wherein the LV and RV electrodes are located so as to electrically stimulate the compromised area of cardiac tissue on which stem cells have been deposited. (google.com)
  • Advances in the field of targeted drug delivery to cardiac tissue will be an integral component to regenerate cardiac tissue. (wikipedia.org)
  • congestive
  • A range of other outcomes/conditions may also be associated with modified (usually lower) HRV, including congestive heart failure, diabetic neuropathy, depression, post-cardiac transplant, susceptibility to SIDS and poor survival in premature babies. (wikipedia.org)
  • modulation
  • Much of the modulation of intestinal function can be explained by the 5-fold increase in microvillus length and apical surface area with feeding, and the subsequent shortening of the microvilli after digestion has finished. (biologists.org)
  • insight
  • 2-9 Therefore, recent advances in studies of Ang II receptors could prove the existence of a variety of new players and targets in addition to the traditional "Ang II world" and provide a new insight into cardiovascular biology. (ahajournals.org)
  • fetal
  • In this scenario, fetal cardiomyocytes undergo hypertrophy, likely due to increased cardiomyocyte loss resulting from increased apoptosis [ 8 ]. (hindawi.com)
  • The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system. (ahajournals.org)
  • Fetuses with MMC all had normal cardiovascular systems entering into fetal surgery, whereas those with ITM, CDH, and SCT all exhibited secondary cardiovascular sequelae of the anomaly present. (ahajournals.org)
  • Conclusions- Acute cardiovascular changes take place during fetal surgery that are likely a consequence of the physiology of the anomaly and the general effects of surgical stress, tocolytic agents, and anesthesia. (ahajournals.org)
  • 10,11 Although MMC is not a life-threatening anomaly, fetal MMC repair may reduce the need for ventriculoperitoneal shunt placement to treat hydrocephalus and potentially improve long-term neurological function. (ahajournals.org)
  • Little is known about the acute consequences of these interventions on the fetal cardiovascular system. (ahajournals.org)
  • In the present study, we report on the cardiovascular sequelae of fetal surgery and anesthesia for congenital anomalies in the human fetus. (ahajournals.org)
  • apoptosis
  • Polyphenols like epigallocatechin gallate (EGCG) can reduce apoptosis of cardiomyocytes, resulting in better health outcomes in animal models of cardiac disorders. (hindawi.com)
  • disorders
  • Further, sustained volume and pressure overload, seen in hypertension and other cardiac disorders, ultimately lead to cardiac hypertrophy and result in cell death. (hindawi.com)
  • The drug Prajmaline has been used to treat a number of cardiac disorders. (wikipedia.org)
  • nervous
  • These are cell atrophy, impaired metabolism (increased catabolism), reduction of the defense capacity of the organism, reducing healing processes and regeneration, degeneration of the nervous system. (erank.tv)
  • However, the activity of the sympathetic nervous system may not entirely reflect the cardiovascular actions of coffee in physiological conditions. (ahajournals.org)
  • potentially
  • This intronless gene is deleted in AMME contiguous gene syndrome and is potentially involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. (wikipedia.org)
  • proteins
  • Here, we have summarized these emerging concepts concerning Ang II receptor interacting proteins and discuss new potent therapeutic targets in cardiovascular disease. (ahajournals.org)
  • These amyloid proteins are generated from misfolded and denatured amyloid monomers under physiological conditions. (hindawi.com)
  • Moreover, transthyretin (TTR) amyloid proteins can contribute to cardiovascular disease by narrowing cardiac vasculature [ 7 , 8 ]. (hindawi.com)
  • rhythms
  • A further advantage of CNAP is hemodynamic optimization using continuous blood pressure and its parameters derived from physiological rhythms and pulse wave analysis. (wikipedia.org)
  • homeostasis
  • Prostacyclin's interactions in contrast to thromboxane (TXA2), another eicosanoid, strongly suggest a mechanism of cardiovascular homeostasis between the two hormones in relation to vascular damage. (wikipedia.org)
  • Systemic
  • This phenomenon indicates that alternative splicing of TNNT2 pre-mRNA is under the control of a genetically built- in systemic biological clock. (wikipedia.org)
  • function
  • Comprehensive characterization and quantification of blood flow is essential for understanding the function of the cardiovascular system under normal and diseased conditions. (wisc.edu)
  • An integrated phenomenon, digestion is also characterized by increases in the mass, and presumably the function, of the heart, pancreas, liver and kidneys. (biologists.org)
  • Therefore
  • Therefore, an interest on the evaluation of autonomic cardiovascular control in health and disease is growing by means of linear and non-linear heart rate variability (HRV) analyses. (frontiersin.org)
  • Therefore, it was the aim of the present study to assess the effects of coffee on the cardiovascular response to MS and CPT in humans. (ahajournals.org)
  • Therefore, small molecule ACE2 activators are promising compounds for ACE2/Ang-(1-7)/Mas axis activation and treatment of cardiovascular disease. (ufl.edu)
  • A Ryr2 mutation may increase sensitivity to luminal calcium activation, therefore increasing calcium release from the SR under store-overload conditions and thus triggered arrhythmias. (wikipedia.org)
  • electrically
  • All cardiac muscle cells are electrically linked to one another, by structures known as gap junctions (see below) which allow the action potential to pass from one cell to the next. (wikipedia.org)
  • output
  • however, venodilatation is an important component of the pathophysiology of septic shock and could contribute to the changes in cardiac filling pressure and cardiac output. (ahajournals.org)
  • apparatus
  • 2. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 1 , wherein the pulse is excitatory. (google.com)
  • changes
  • The biological changes that occur with increasing age play a key role in the quality of physical - motor performance. (erank.tv)
  • however, physiological changes caused by cocaine withdrawal include vivid and unpleasant dreams, insomnia or hypersomnia, anger, increased appetite and psychomotor retardation or agitation. (wikipedia.org)
  • efficiency
  • From the onset of reproductive maturity, throughout the organism's life, the efficiency of various physiological processes progressively declines [ 3 , 4 ]. (mdpi.com)
  • vessel
  • 22 Some studies have shown increased production of the vasodilator mediator NO in the vessel wall due to expression of an inducible isoform of NO synthase, 23 and enhanced production of vasodilator prostanoid may occur after induction of COX-II. (ahajournals.org)
  • system
  • Angiotensin II (Ang II) is the principal vasoactive substance of the renin-angiotensin system (RAS), having a variety of physiological actions including vasoconstriction, aldosterone release, and cell growth. (ahajournals.org)
  • Caffeine alone does not exert any potentiating effect, confirming that ingredients other than caffeine are partially responsible for the stimulating effect of coffee on the cardiovascular system. (ahajournals.org)
  • A system and method for managing and inhibiting cardiac remodeling in MI patients. (google.com)
  • During systole, when blood volume increases in the finger, the control system increases cuff pressure, too, until the excess blood volume is squeezed out. (wikipedia.org)
  • disease
  • Polyphenol intake has been associated with reduced incidences of cardiovascular disease and better overall health. (hindawi.com)
  • In the present study, we investigated the mechanical characteristics of transthyretin amyloid protein (TTR), which have been implicated in cardiovascular disease, and specifically considered the contribution of end-terminal capping effects. (hindawi.com)
  • Furthermore, ACE2 can form endogenous Ang-(1-7) from Ang II and has recently been a target for cardiovascular disease therapy. (ufl.edu)
  • anesthesia
  • Thus, the incidence is 0.2% in general surgery, about 0.4% during caesarean section, between 1 and 2% during cardiac surgery and between 10% and 40% for anesthesia of the traumatized. (wikipedia.org)
  • adult
  • Embryonic cTnT with more negative charge at the N-terminal region exerts higher calcium sensitivity of actomyosin ATPase activity and myofilament force production, compared with the adult cardiac TnT, as well as a higher tolerance to acidosis. (wikipedia.org)
  • cytosolic calcium
  • Under normal physiological conditions, RYR2 mutation has no discernable effect on calcium induced-calcium release from the sarcoplasmic reticulum (SR). Ryr2 is normally activated by increased cytosolic calcium, but under stressful conditions such as increased beta adrenergic activation, RYR2 is activated by luminal calcium in association with increased SR calcium loading. (wikipedia.org)
  • reflects
  • The apparently scrambled linkage between ssTnI-cTnT and cTnI-ssTnT genes actually reflects original functional linkages as that TNNT2 gene is expressed together with ssTnI gene in embryonic cardiac muscle. (wikipedia.org)
  • activity
  • In fact, several small molecule ACE2 activators have been identified that selectively increase ACE2 activity without having an effect on ACE activity. (ufl.edu)
  • Decreased PSNS activity or increased SNS activity will result in reduced HRV. (wikipedia.org)
  • Less is known about the physiological inputs of the low frequency (LF) activity (0.04 to 0.15 Hz). (wikipedia.org)
  • This co-assembly induces a +140 mV shift in voltage dependence of activation (when co-expressed in CHO cells) which would inhibit KCNQ1 activity across the normal physiological voltage range in most tissues. (wikipedia.org)
  • thus
  • The low pKa of taurine's sulfonic acid group ensures this moiety is negatively charged in the pH ranges normally found in the intestinal tract, thus it improves the surfactant properties of the cholic acid conjugate. (wikipedia.org)
  • effects
  • The present study was designed to evaluate the effects of coffee on cardiovascular response to mental stress. (ahajournals.org)
  • Despite the ubiquitous consumption of coffee and caffeine beverages and their circumstantial intake during stressful situations, little is known about its cardiovascular effects under such conditions. (ahajournals.org)
  • The ACE2/Ang-(1-7)/Mas axis has been shown to counteract many of the physiological effects of the Angiotensin II (Ang II) Type 1 Receptor (AT1R), including vasoconstrictor and proliferative actions. (ufl.edu)
  • Increasing developments to novel treatments requires a controlled microenvironment that is accomplished only through the implementation of therapeutic agents whose side-effects can be avoided with targeted drug delivery. (wikipedia.org)
  • muscular
  • With age, the amount of people with Down syndrome is reduced, hypotonia is improving, muscular body mass is reduced and there is increased fat storage. (erank.tv)