• metabolic acidosis, arrhythmias, myocardial ischemia or infarction, and noncardiogenic pulmonary edema, although any organ system might be involved. (cdc.gov)
  • contemporary approach towards diagnosing acute myocardial ischemia. (medline.ru)
  • It is necessary to search for new forensic medical criteria proceeding from the practical experience of forensic medical examination when it is sometimes quite difficult to establish that death occurred as the result of the acute myocardial ischemia and to make a differential diagnostics. (medline.ru)
  • We have researched a possibility to apply the Enzyme Multiplied Immunoassay Technique (EMIT-test) for Troponin T to diagnose death resulting from the acute myocardial ischemia in the biological laboratory of the Leningrad Regional Bureau of Forensic Medical Examination. (medline.ru)
  • It means that Troponin T lends itself most widely for a diagnosis uniting the advantages of the quick and slow markers with the acute myocardial ischemia. (medline.ru)
  • Here we demonstrate the activation of cell survival PI3kinase/Akt and VEGF pathway as the mechanism behind the protection induced by intermittent fasting in a rat model of established chronic myocardial ischemia (MI). (nih.gov)
  • In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
  • I focus my attention on ischemic/reperfusion injury to the brain. (benbest.com)
  • The neuroprotective effects of remifentanil preconditioning against cerebral ischemia/reperfusion injury have been recently reported. (springer.com)
  • Here we investigated whether remifentanil postconditioning exerts neuroprotective effects against global cerebral ischemia/reperfusion injury in rats and its potential mechanisms. (springer.com)
  • We found remifentanil postconditioning markedly improved the spatial learning and memory as well as attenuated neuronal apoptosis in hippocampus caused by cerebral ischemia/reperfusion injury. (springer.com)
  • The results suggest that remifentanil postconditioning exhibits neuroprotective effects against global cerebral ischemia/reperfusion injury in rats, and its mechanisms might involve inhibition of neuronal apoptosis through the PI3K pathway. (springer.com)
  • Yuan Y, Guo Q, Ye Z et al (2011) Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. (springer.com)
  • This suggests that hepatic ischemia-reperfusion injury may play a critical role in the pathogenesis of AKI after liver transplantation. (birmingham.ac.uk)
  • The aim of this single-center study was to determine if hepatic ischemia-reperfusion injury, estimated by peak peri-operative serum amino-transferase (AST), is associated with AKI following donation after brain death (DBD) liver transplantation. (birmingham.ac.uk)
  • In conclusion, hepatic ischemia-reperfusion injury demonstrates a strong relationship with peri-operative AKI in DBD liver transplant recipients. (birmingham.ac.uk)
  • Molecular oxygen: friend and foe: the role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. (jamanetwork.com)
  • Other effects that may result from brain ischemia are stroke, cardiorespiratory arrest, and irreversible brain damage. (wikipedia.org)
  • An interruption of blood flow to the brain for more than 10 seconds causes unconsciousness, and an interruption in flow for more than a few minutes generally results in irreversible brain damage. (wikipedia.org)
  • citation needed] Other pathological events that may result in brain ischemia include cardiorespiratory arrest, stroke, and severe irreversible brain damage. (wikipedia.org)
  • He never regained consciousness, and neurological assessment indicated irreversible brain damage. (cdc.gov)
  • Neuroprotective mechanisms, mainly the blood-brain barrier, reduce neuronal firing in response to ischemia (a common physiological cause of unresponsiveness at the end of life), which could protect the brain from irreversible brain damage under these conditions 14 . (nature.com)
  • This increased temperature in the brain has been linked to cause irreversible brain damage due to ischemia or a lack of oxygen to tissues. (jacksoncountygov.com)
  • Experimental stroke (transient focal cerebral ischemia) was induced by a 2-hour middle cerebral artery occlusion (MCAO) with the use of a suture inserting into the lumen of the internal carotid artery (ICA) in male Wistar rats. (banglajol.info)
  • Wang JY, Shen J, Gao Q et al (2008) Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. (springer.com)
  • Ren C, Yan Z, Wei D et al (2009) Limb remote ischemic postconditioning protects against focal ischemia in rats. (springer.com)
  • Ding ZM, Wu B, Zhang WQ et al (2012) Neuroprotective Effects of Ischemic Preconditioning and Postconditioning on Global Brain Ischemia in Rats through the same effect on inhibition of apoptosis. (springer.com)
  • Jeong S, Kim SJ, Jeong C et al (2012) Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats. (springer.com)
  • Title : Thalamocortical Dysfunction and Thalamic Injury after Asphyxial Cardiac Arrest in Developing Rats Personal Author(s) : Shoykhet, Michael;Simons, Daniel J.;Alexander, Henry;Hosler, Christina;Kochanek, Patrick M.;Clark, Robert S. B. (cdc.gov)
  • Hang P, Sun C, Guo J, Zhao J, Du Z. BDNF-mediates Down-regulation of MicroRNA-195 Inhibits Ischemic Cardiac Apoptosis in Rats. (ijbs.com)
  • Cardiac function and apoptosis were detected in MI rats intravenously injected with antagomiR-195. (ijbs.com)
  • Moreover, inhibition of miR-195 significantly improved cardiac function of MI rats. (ijbs.com)
  • In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
  • The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. (hindawi.com)
  • Cardiac adaptation to hypertension in adult female Dahl salt-sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation. (uib.no)
  • Normoxic ventilation during resuscitation and outcome from asphyxial cardiac arrest in rats. (jamanetwork.com)
  • This leads to poor oxygen supply or cerebral hypoxia and thus leads to the death of brain tissue or cerebral infarction/ischemic stroke. (wikipedia.org)
  • Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
  • Excessive glutamate release resulting in excessive Ca +2 entry into cells is the excitotoxicity which initiates the brain ischemic damage seen in stroke and cardiac arrest. (benbest.com)
  • The brain, therefore, may be somewhat resistant to the effects of ischemic damage while the rest of the body shuts down just before death. (nature.com)
  • Zhou Y, Fathali N, Lekic T et al (2012) Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway. (springer.com)
  • In arterial ischemic stroke, children present with a focal neurologic deficit that corresponds to a region of ischemia in the brain. (logicalimages.com)
  • Brief periods of ischemia can protect a tissue from subsequent, prolonged ischemia, a phenomenon known as ischemic preconditioning, or IPC. (warf.org)
  • They demonstrated that, in cultured mouse cortical neurons, addition of zinc at a focus similar compared to that within ischemic human brain tissues created significant neuronal damage. (ole2011.org)
  • Thus, Zn2+ entry through TRPM7 stations plays a significant role in ischemic brain injury most likely. (ole2011.org)
  • Autopsy findings indicated acute brain and spinal cord damage due to hypoxia/ischemia (lack of oxygen), apparently a result of the cardiac arrest. (cdc.gov)
  • He has found that extremely low doses of THC - the psychoactive component of marijuana - protects the brain from long-term cognitive damage in the wake of injury from hypoxia (lack of oxygen), seizures, or toxic drugs. (science20.com)
  • SUR2 may help protect the heart during ischemia, which occurs when tissues such as heart or brain experience a lack of oxygen due to an obstruction of blood flow. (warf.org)
  • The death certificate, completed by the coroner of the deceased fire fighter's county, listed "Hypoxia / Ischemia, Acute [of the brain and spinal cord]" as the immediate cause of death, various autopsy findings as intermediate causes, and "Overexertion from responding to a fire call with Fire Dept" as the underlying cause. (cdc.gov)
  • Neuroprotection of brain and spinal cord from peri-anesthetic ischemia. (mayo.edu)
  • The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. (lookformedical.com)
  • VF is the most common initial state encountered, and, because of insufficient perfusion of vital cardiac tissues, it degenerates to asystole if left untreated. (medscape.com)
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • Taken together, these findings suggest that leptin deficiency affects cytokine gene expression differently in the brain compared to peripheral tissues with minimal interaction from acute SF. (peerj.com)
  • The effect of moderate whole body hypothermia (300 C) on transient focal cerebral ischemia induced inflammatory injury was investigated. (banglajol.info)
  • Our results indicate that moderate hypothermia has a significant protective effect on the inflammatory injury induced by transient focal cerebral ischemia. (banglajol.info)
  • In case of ongoing CPR, we recommend surgical groin incision, open puncture of the pulseless common femoral artery, and aortic balloon inflation in REBOA zone I. Hereby, fast access and CPR optimization for heart and brain perfusion are maintained. (frontiersin.org)
  • Because of this arrangement of collateral vessels, even when one of the main arteries is occluded, adequate perfusion of the brain still may be possible. (medscape.com)
  • Retrospective review of clinical, imaging, and electroencephalography data of 33 adult comatose survivors of cardiac arrest following therapeutic hypothermia was performed. (ajnr.org)
  • 6 , 7 However, brain imaging and malignant EEG patterns following therapeutic hypothermia have not been comprehensively described, to our knowledge. (ajnr.org)
  • In 2009, following the recommendations of the American Heart Association and after recognizing the success of other programs being used nationwide, EMTs and Paramedics with Jackson County initiated a hypothermia guideline that would be used to potentially benefit certain patients suffering from cardiac arrest. (jacksoncountygov.com)
  • Hypothermia After Cardiac Arrest Study Group. (jamanetwork.com)
  • Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. (jamanetwork.com)
  • Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. (jamanetwork.com)
  • I did my PhD on induced hypothermia after cardiac arrest with a clinical focus organizing the international Hypothermia Network Registry, now renamed the International Cardiac Arrest Registry (INTCAR). (lu.se)
  • This is particularly important for stroke and cardiac arrest, where treatment within a few hours is critical. (neurosciencenews.com)
  • Either can lead to a condition called cerebral hypoxia, which is insufficient oxygen supply to the brain regardless of the cause. (healthline.com)
  • Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
  • Oximetry-guided reoxygenation improves neurological outcome after experimental cardiac arrest. (jamanetwork.com)
  • In the first minute after stoppage of blood flow to the brain, ATP in neurons is primarily regenerated from ADP by phosphate from PhosphoCreatine ( PCr ). (benbest.com)
  • Global cerebral ischemia followed by reperfusion, which leads to extensive neuronal damage, particularly the neurons in the hippocampal CA1 region. (springer.com)
  • Lipofuscin is a toxic metabolic byproduct that accumulates in aging and damaged neurons, and is used as a marker of aging, poorly-functioning brains. (theguyerinstitute.com)
  • The PET scans show that piracetam specifically targets the language areas of the brain in these patients and only improved blood flow in those regions (the regions damaged by the strokes in these patients).4 This evidence suggests that piracetam specifically increases blood flow to damaged areas, allowing improved nutrient and oxygen uptake as well as toxin removal to damaged neurons. (theguyerinstitute.com)
  • In '09 2009, Sunlight and colleagues supplied proof that TRPM7 knockdown secured the hippocampal CA1 neurons within a cardiac arrest style of human brain ischemia [15]. (ole2011.org)
  • REBOA procedures carrying life-threatening risks such as arterial access complications, organ ischemia, vascular trauma, and time loss ( 2 ) should be critically evaluated in addition to resuscitative laparotomy, thoracotomy with aortic cross-clamping, or manual aortic compression. (frontiersin.org)
  • Cardiac and vascular surgery. (mayo.edu)
  • Keivan Javanshiri's Ph.D. project explores cardiac and vascular pathologies in Lewy body dementia and Alzheimer's disease. (lu.se)
  • Significance of arterial hypotension after resuscitation from cardiac arrest. (jamanetwork.com)
  • The symptoms of brain ischemia range from mild to severe. (wikipedia.org)
  • We hypothesized that malignant patterns on electroencephalography are associated with evidence of more severe brain injury on MR imaging. (ajnr.org)
  • Malignant electroencephalography patterns were generally more frequent in subjects with less severe brain injury by MR imaging. (ajnr.org)
  • One explanation for this effect is pre- and post-conditioning, whereby the drug causes minute damage to the brain to build resistance and trigger protective measures in the face of much more severe injury, explains Prof. Sarne. (science20.com)
  • The development of heart failure is seen by progressively higher cardiac output on fetal echocardiogram, finally with the development of hydrops (abnormal fluid collections in the chest and abdomen) and swelling of the skin, indicating severe heart failure. (connecticutchildrens.org)
  • Patients with VS/UWS and MCS have severe brain damage who survive initial periods of coma (usually 1 to 3 weeks), can maintain brainstem functions, do not require mechanical respiratory support, and redevelop sleep-wake cycles, including prolonged periods of eye-opening, but have no (vegetative state) or intermittent but definite clinical evidence of consciousness (MCS). (medlink.com)
  • Hypoxaemic reperfusion ameliorates the histopathological changes in the pig brain after a severe global cerebral ischaemic insult. (jamanetwork.com)
  • With mesenteric artery ischemia , the symptoms can include severe pain after meals, weight loss, and diarrhea . (medlineplus.gov)
  • Malignant electroencephalography patterns are considered predictive of poor outcome in comatose survivors of cardiac arrest. (ajnr.org)
  • Prognostication of survival and functional outcome in comatose survivors of cardiac arrest is challenging. (ajnr.org)
  • In 1974, Hossmann and Zimmermann demonstrated that ischemia induced in mammalian brains for up to an hour can be at least partially recovered. (wikipedia.org)
  • Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison to the average population. (wikipedia.org)
  • citation needed] Large blood clots can also cause ischemia by blocking blood flow. (wikipedia.org)
  • The carbon monoxide tolerance level for any person is altered by several factors, including genetics (hemoglobin mutations), behavior such as activity level, rate of ventilation, a pre-existing cerebral or cardiovascular disease, cardiac output, anemia, sickle cell disease and other hematological disorders, geography and barometric pressure, and metabolic rate. (wikipedia.org)
  • Agonal breathing commonly occurs with cardiac arrest or a stroke . (healthline.com)
  • If cardiac arrest occurs, the person usually drops or slumps to the ground. (healthline.com)
  • Numerous studies have documented that cardiomyocyte apoptosis occurs in border zone of infarct scars and in the remote zone of non-infarcted myocardium [ 2 - 4 ], which exacerbates the post-MI remodeling and aggravates cardiac dysfunction [ 5 ]. (ijbs.com)
  • Untreated heart attacks may slow blood flow enough that blood may start to clot and prevent the flow of blood to the brain or other major organs. (wikipedia.org)
  • Blood continues to flow briefly in the brain and other organs, which can cause gasps for a few minutes after the heart stops. (healthline.com)
  • Its effects are caused not only by impaired oxygen delivery but also by disrupting oxygen utilization and respiration at the cellular level, particularly in high-oxygen demand organs (i.e., heart and brain). (cdc.gov)
  • The ultrastructure of the brain can now be excellently preserved by vitrification, and solutions needed for vitrification can now be distributed through organs with retention of organ viability after transplantation. (supercentenarian.com)
  • If we were able to restore certain cellular functions in the dead brain, an organ known to be most susceptible to ischemia [inadequate blood supply], we hypothesized that something similar could also be achieved in other vital transplantable organs," Sestan said. (yale.edu)
  • It might also be able to help treat organs or tissue damaged by ischemia during heart attacks or strokes. (yale.edu)
  • It has been speculated whether they die from an unexplained sudden cardiac death or if the typical pathology seen in the brain in these individuals also appear in other organs, including the heart. (lu.se)
  • In the studies conducted in humans, it was not possible to determine whether G-CSF was successfully expressed in the brains of the patients, which could explain the discrepancy in results in humans versus mice. (neurosciencenews.com)
  • The dramatic reduction in brain atrophy in mice, if verified in humans, could lead to highly effective emergency treatments for stroke and other diseases that often cause brain damage such as heart attack. (neurosciencenews.com)
  • The researchers used MRI to confirm that G-CSF was expressed in treated mouse brains and to visualize the differences in brain tissue damage in both control and treated mice. (neurosciencenews.com)
  • For control mice, which did not receive G-CSF in eye drops, the MRI technique identified brain areas with reduced metabolic activity and eventual cerebral atrophy as the result of ischemia. (neurosciencenews.com)
  • On average, following ischemia, mouse brain striatum size was reduced more than 3-fold, from 15 square millimeters in normal mice to less than 5 square millimeters. (neurosciencenews.com)
  • In the lab, the researchers injected mice with a single low dose of THC either before or after exposing them to brain trauma. (science20.com)
  • A control group of mice sustained brain injury but did not receive the THC treatment. (science20.com)
  • the inventors found that mice in which SUR2 is disrupted suffered less damage following ischemia than wild-type mice without IPC. (warf.org)
  • Ob/ob mice exhibited elevated cytokine gene expression in liver (TNF-α, TGF-β1), heart (TGF-β1), fat (TNF-α), and brain (hippocampus, hypothalamus, prefrontal cortex: IL-1β, TNF-α) compared with wild-type mice. (peerj.com)
  • Apoptosis is one of the major mechanisms that lead to neuronal death after cerebral ischemia and reperfusion. (springer.com)
  • Thus, successfully reversal of cardiomyocyte apoptosis during early stage of MI is crucial for repairing the injured heart and ameliorating cardiac function [ 8 ]. (ijbs.com)
  • Imaging studies were visually scored for severity of brain injury. (ajnr.org)
  • Subjects with anatomic evidence of diffuse brain injury were less likely to have malignant electroencephalography patterns. (ajnr.org)
  • We found discordant evidence of brain injury by MR imaging and electroencephalography, refuting our initial hypothesis. (ajnr.org)
  • We hypothesize that malignant EEG patterns are associated with greater extent of brain injury evident on MR imaging, which would explain the typically poor outcomes within this subset of patients. (ajnr.org)
  • The chief aim in this study was to investigate whether changing temperature during and after ischemia could minimize this damage by reducing the inflammatory injury. (banglajol.info)
  • Furthermore, it was estimated that Troponin levels were significantly higher in COVID-19 patients who died or were critically ill due to which cardiac injury biomarkers were elevated in most of the complicated cases of COVID-19. (alliedmarketresearch.com)
  • The system also offers the intriguing possibility that acute brain injury may someday be treated by emergency medical workers through the simple delivery of eye drops carrying a therapeutic gene. (neurosciencenews.com)
  • Sarne's papers in Behavioural Brain Research and Experimental Brain Research say that even extremely low doses of THC - around 1,000 to 10,000 times less than that in a conventional marijuana cigarette - administered over a wide window of 1 to 7 days before or 1 to 3 days after injury can jump-start biochemical processes which protect brain cells and preserve cognitive function over time. (science20.com)
  • This treatment, especially in light of the long time frame for administration and the low dosage, could be applicable to many cases of brain injury and be safer over time, Sarne says. (science20.com)
  • The use of THC can prevent long-term cognitive damage that results from brain injury, the researchers conclude. (science20.com)
  • In addition, the low dosage makes it safe for regular use in patients at constant risk of brain injury, such as epileptics or people at a high risk of heart attack. (science20.com)
  • Donation after cardiac death liver transplant recipients have an increased frequency of acute kidney injury (AKI). (birmingham.ac.uk)
  • Partial kidney ischemia-reperfusion (IR) injury is the principal cause of acute kidney injury. (hindawi.com)
  • Kidney partial ischemia-reperfusion (IR) injury is defined as a reduction of the renal blood flow (RBF) followed by the recovery of RBF and reoxygenation [ 1 ]. (hindawi.com)
  • Even more relevant to human brain ischemia, Zn2+-mediated neuronal injury in OGD conditions was reduced by TRPM7 knockdown [50] also. (ole2011.org)
  • The second goal was to devise a non-invasive method to demonstrate that G-CSF was delivered to the brain and expressed at therapeutic levels. (neurosciencenews.com)
  • Brain ischemia has been linked to a variety of diseases or abnormalities. (wikipedia.org)
  • Cardiac biomarker tests allow the doctor to determine the risk of a patient associated with such diseases. (alliedmarketresearch.com)
  • 2. Department of Cardiology, the First Affiliated Hospital (Key Laboratory of Cardiac Diseases and Heart Failure), Harbin Medical University, Harbin 150001, Heilongjiang Province, P. R. China. (ijbs.com)
  • Mesenteric artery ischemia is plaque buildup in the arteries that supply your intestines with blood. (medlineplus.gov)
  • The common cardiac biomarkers that are tested for CVD include troponin, creatine kinase-muscle/brain (CK-MB), B-type natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP), and others. (alliedmarketresearch.com)
  • Brain ischemia is a condition in which there is insufficient bloodflow to the brain to meet metabolic demand. (wikipedia.org)
  • Preliminary results indicate that they will find the same protective phenomenon in relation to cardiac ischemia, in which the heart muscle receives insufficient blood flow. (science20.com)
  • Trunk blood and tissue samples from the periphery (liver, spleen, fat, and heart) and brain (hypothalamus, prefrontal cortex, and hippocampus) were collected. (peerj.com)
  • This list includes some preventive measures that have been recommended by other agencies to reduce the risk of on-the- job heart attacks and sudden cardiac arrest among fire fighters. (cdc.gov)
  • Here, he shares the most important findings and why sudden cardiac arrest is a common cause of death in patients with Lewy body disease. (lu.se)
  • The American Heart Association, in collaboration with seven other medical societies, has issued interim guidance to help rescuers treat adult and pediatric patients with cardiac arrest with suspected or confirmed COVID-19. (medscape.com)
  • These cooled fluids are administered to certain cardiac arrest patients en route to the hospital in an effort to lower their core body temperature. (jacksoncountygov.com)
  • This has led to increase in the demand of cardiac biomarker testing for the patients suffering from COVID-19. (alliedmarketresearch.com)
  • There has been increasing interest in the use of extracorporeal cardiopulmonary resuscitation (ECPR) to improve outcomes in out-of-hospital cardiac arrest (OHCA) patients. (biomedcentral.com)
  • Current law requires a few minutes of cardiac arrest before cryopreservation of terminal patients, but dogs and cats have recovered excellent brain function after 16-60 min of complete cerebral ischemia. (supercentenarian.com)
  • I have used post-mortem brain tissue from patients with different subtypes of dementia to address three critical challenges that we encounter in the clinic. (lu.se)
  • Brain tissue from deceased patients is extremely valuable since it allowed me to learn more about the underlying pathology. (lu.se)
  • Yes, their hearts were full of aggregated a-synuclein, a protein known to aggregate in the brain in patients with Lewy body dementia and Parkinson's disease. (lu.se)
  • And my examinations revealed that a majority of these patients displaying aggregated a-synuclein in their hearts died from what we think is sudden cardiac death. (lu.se)
  • BACKGROUND: Nicardipine is commonly used in the management of hypertensive crises, except those involving cardiac contractility defects despite its ability to reduce afterload and pulmonary congestion. (bvsalud.org)