Carcinomas germ cell tumor sertoli leydig cell tumor. Medical search. Frequent questions

The last two subtypes -- endodermal sinus tumor, also known as "yolk sac tumor," and Choriocarcinoma -- grow and spread rapidly, but they are very rare. (webmd.com)
The 4 main types of non-seminoma tumors are embryonal carcinoma, yolk sac carcinoma, choriocarcinoma, and teratoma. (cancer.org)
These tumors appear to arise from a pluripotent germ cell capable of differentiating into embryonic structures (teratoma and embryonal carcinoma), placental structures (yolk-sac tumor and choriocarcinoma) or seminoma (the most primitive germ cell tumor). (health.am)

Benign tumors are divided into germ cell tumors such as dermoid cyst (mature cystic teratoma), mature solid teratoma, epithelial tumors, which include adenomas (serous, mucinous, endometrioid) and Brenner tumor, as well as benign sex cord-stromal tumors such as Sertoli-Leydig cell tumor, and fibromas. (12healthy.com)
In postpubertal males, teratoma is considered as a malignant tumor. (in4arts.com)

Many testicular cancers contain both seminoma and non-seminoma cells. (cancer.org)
Most tumors are a mix of different types (sometimes with seminoma cells too), but this doesn't change the treatment of most non-seminoma cancers. (cancer.org)
The cells can be seminoma, nonseminoma, or both. (medlineplus.gov)
While the rarer non-seminoma (15%) are testicular tumors, the most common testicular tumor after the age of 50 is lymphoma, and testicular involvement is present in about 35% of lymphoma patients. (neolife.com.tr)
A recently developed cell culture model consisting of human FS1 Sertoli cells and human TCam-2 seminoma-like cells offers new opportunities for research on seminoma. (biomedcentral.com)
Results were compared to human testicular biopsies at different stages of seminoma development via immunohistochemistry to confirm the cell lines' representativeness. (biomedcentral.com)
Concerning the expression of these junctional proteins, FS1 and TCam-2 cells are largely representative for Sertoli and seminoma cells, respectively. (biomedcentral.com)

Rarely, high MSAFP is due to endodermal sinus tumor (EST) or another germ cell tumor containing EST. (wikipedia.org)
Principal tumors that secrete AFP are endodermal sinus tumor (yolk sac carcinoma), hepatoblastoma, and hepatocellular carcinoma.In patients with AFP-secreting tumors, serum levels of AFP often correlate with tumor size. (wikipedia.org)
The aim of this study was to evaluate the conservative management and prognosis of primary vaginal endodermal sinus tumor and rhabdomyosarcoma in children. (oncotarget.com)
Medical records of children with vaginal endodermal sinus tumor and rhabdomyosarcoma between 1996 and 2015 were reviewed. (oncotarget.com)
range, 7-44 months) were included in this study, comprising 17 patients with endodermal sinus tumor and 7 patients with rhabdomyosarcoma. (oncotarget.com)
Among the 17 patients with endodermal sinus tumor, 15 were initially treated at our hospital with chemotherapy alone, and 2 were initially treated in other hospitals with conservative surgery and chemotherapy. (oncotarget.com)
1 with endodermal sinus tumor and 2 with rhabdomyosarcoma) developed recurrence. (oncotarget.com)
At the last follow-up, 22 patients (91.7%) were alive without evidence of disease, 1 patient with botryoid rhabdomyosarcoma died of disease progression, and 1 patient with endodermal sinus tumor died of respiratory and circulatory failure. (oncotarget.com)
To allow preservation of sexual and reproductive function, conservative therapeutic strategies should be considered for children with vaginal endodermal sinus tumor and botryoid rhabdomyosarcoma. (oncotarget.com)
endodermal sinus tumor (EST) is the most common histological subtype that occurs primarily in infants [ 10 ]. (oncotarget.com)

More than 90% of cancers of the testicle start in cells known as germ cells. (cancer.org)
These cancers grow from germ cells, the cells that make sperm. (medlineplus.gov)
The disease-free survival rate for Stage II and III cancers is slightly lower, depending on the size of the tumor and when treatment is begun. (medlineplus.gov)
Germ cell tumours make up three per cent (three in 100) of ovarian cancers. (ovacome.org.uk)
Not all germ cell tumours are cancers. (ovacome.org.uk)
Clear cell ovarian cancer (also known as clear-cell carcinoma) is a rare type of ovarian cancer, accounting for around 3-5% of epithelial ovarian cancers. (ovarian.org.uk)
Testicular cancers are the malignant tumors that occur in the testes. (in4arts.com)
Primary vaginal malignancies are rare tumors of the female genital system, accounting for approximately 0.3% of all invasive cancers among women, and 1%-2% of all gynecologic malignant neoplasms [ 1 ]. (oncotarget.com)
Testicular cancer accounts for 1% to 1.5% of male cancers and 5% of urological tumors. (neolife.com.tr)
Most testicular cancers start in the germ cells. (medicalnewstoday.com)
Germ cell cancers may express features of only one of these histopathologies or mixtures of two or more. (health.am)
HER2 mutations have been found in non-small-cell lung cancers (NSCLC) and can direct treatment. (iiab.me)

They are relatively rare tumors and are most common in the fifth to sixth decades of life. (medscape.com)
Other malignancies of the testis include lymphoma (the most common non-germ cell cause of testicular malignancy in elderly men), metastatic cancer or leukemia, tumors of the testicular stroma, and other rare tumors. (health.am)

However, based on lesions observed, we hypothesize that it is more likely that this testis-antler dysgenesis resulted from continuing exposure of pregnant females to an estrogenic environmental agent(s), thereby transforming testicular cells, affecting development of primordial antler pedicles, and blocking transabdominal descent of fetal testes. (nih.gov)
Germ cell tumors of the testis are the most common cancer in young men between the ages of 15 and 35 years. (health.am)
Germ cell tumors of the testis represent greater than 90% of all tumors of the testis. (health.am)
The diagnosis of germ cell tumor of the testis requires histopathologic examination of tissue obtained from an orchiectomy specimen. (health.am)
Ultrasonography of the testes should be performed in the event that there is doubt about which testis may harbor the tumor, that bilateral tumors are suspected, or that there is an extragonadal presentation of a germ cell tumor. (health.am)
Autophagy, an evolutionarily conserved cell reprograming machinery, had been shown to function as an important regulatory mechanism in spermatogenesis and steroid production in testis. (intechopen.com)
By showing autophagy in physiological and pathophysiological conditions, we try to elicit the regulatory role of autophagy in spermatogenic cells and somatic cells of testis. (intechopen.com)
Objective To explore the physiological function of gene for cell devision cycle associated 2 ( Cdca2 ), a highly expressed testis gene, in spermatogenesis and fertility in mice. (magtechjournal.com)
These in vitro culture methods might be a prospective application for regenerative therapy of infertility but could not lead germ cells to elongated spermatids in the reconstructed testis [5-7]. (cyberleninka.org)

One third of all ovarian tumors are serous, and two thirds of these serous tumors are benign. (medscape.com)
Of these tumors, 75% are benign and are found in women aged 30-50 years. (medscape.com)
Brenner tumors may be benign, intermediate, or malignant transitional cell tumors. (medscape.com)
These "benign" epithelial tumors include serous adenomas, mucinous adenomas and Brenner tumors. (webmd.com)
Most tumors that start in germ cells are benign. (webmd.com)
Out of all ovarian tumors, 80-90% are benign, and 20-25% are premalignant and malignant tumors. (12healthy.com)
The most common benign tumors are epithelial tumors, and the second in frequency are the germ cell tumors. (12healthy.com)
Borderline malignant tumors are intermediate in features between benign and malignant tumors of the ovary, and they are also known as semi-malignant. (12healthy.com)
Benign germ cell tumors are mostly found during an early age, while epithelial tumors are commonly seen in late reproductive ages. (12healthy.com)
When the benign tumors are symptomatic, they typically feature lower abdominal/pelvic pain, which on most occasions, is acute and may be due to rupture, bleeding, infection and/or torsion of the tumor mass. (12healthy.com)
The Urologic Tumor Program at Children's Hospital Colorado specializes in the diagnosis and surgical treatment and/or removal of benign (non-cancerous) and malignant (cancerous) tumors of the kidney, adrenal gland, bladder, pelvis and testicles in children, teens and young adults. (childrenscolorado.org)
This type of cancer begins in the ovarian cells that develop into eggs (germ cells) and is often non-cancerous (benign). (ovarian.org.uk)
Mature teratomas are a common type of usually non-cancerous (benign) ovarian germ cell tumour. (ovarian.org.uk)
A benign pituitary tumor that produces thyroid-stimulating hormone. (nih.gov)
C3268 Nervous System Neoplasm C90259 Pediatric Terminology A C3502 Thyroid Gland Follicular Adenoma Thyroid Adenoma A benign, encapsulated tumor, arising from the follicular cells of the thyroid gland. (nih.gov)

DICER1 tumor predisposition (DICER1) is characterized by an increased risk for pleuropulmonary blastoma (PPB), pulmonary cysts, thyroid gland neoplasia (multinodular goiter, adenomas, and/or thyroid cancer), ovarian tumors (Sertoli-Leydig cell tumor, gynandroblastoma, and sarcoma), and cystic nephroma. (nih.gov)
Ovarian carcinosarcoma are tumours that display a mix of epithelial (carcinoma) and stromal (sarcoma) characteristics. (ovarian.org.uk)
The neoplasms most frequently observed, in decreasing order of frequency, were: adenocarcinoma (9/50), squamous cell carcinoma (9/50), transmissible venereal tumor (5/50), osteosarcoma (5/50), chondrosarcoma (4/50), and undifferentiated sarcoma (4/50). (bvsalud.org)
Os neoplasmas mais frequentemente observados, em ordem decrescente de frequência, foram: adenocarcinoma (9/50), carcinoma de células escamosas (9/50), tumor venéreo transmissível (5/50), osteossarcoma (5/50), condrossarcoma (4/50) e sarcoma indiferenciado (4/50). (bvsalud.org)
Dr. Howitt is a gynecologic and sarcoma pathologist, with academic interests in gynecologic mesenchymal tumors and morphologic and clinical correlates of molecular alterations in gynecologic neoplasia. (stanford.edu)

Brenner tumors are usually found incidentally at pathologic evaluation, often in conjunction with a mucinous cystadenoma or dermoid cyst. (medscape.com)

Epithelial cystic tumors account for about 60% of all true ovarian neoplasms. (medscape.com)

Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
An enlarged ovary with a papillary serous carcinoma on the surface. (medscape.com)
These tumors are usually small, firm, and solid, and when confined to the ovary, they carry a good-to-excellent prognosis, depending on the malignancy status. (medscape.com)
Stromal cells, which hold the structure of your ovary together and make the hormones estrogen and progesterone . (webmd.com)
An extremely rare form of ovarian cancer is called small cell carcinoma of the ovary, or SCCO. (webmd.com)
You can get more information about them in our booklet Clear cell carcinoma of the ovary . (ovacome.org.uk)
Sex-cord tumours are made up of the cells that produce hormones and support cells in the ovary. (ovacome.org.uk)
Epithelial Malignant tumors peak at 50 to 70 years of age, and non-epithelial malignancies of ovary occur before 40 years of age. (12healthy.com)
Primary or metastatic carcinoma, germ cell tumours and all mesenchymal tumours of the ovary were excluded only sex cord stromal tumours were included in the study. (org.pk)
Cumulus oophorus refers to an appearance in the ovary in which multiple granulosa cells enlarge around a developing oocyte. (radiopaedia.org)
Tumors or cancer of the OVARY. (bvsalud.org)

Ovarian sex cord-stromal tumors are most often diagnosed before age 40 years. (nih.gov)

Lichtenberger JP, Biko DM, Carter BW et al (2018) Primary lung tumors in children: radiologic-pathologic correlation from the radiologic pathology archives. (springer.com)
Compared with other mouse strains, the observed incidences of tumors in FVB/N mice suggest a higher than usual rate of lung tumors and a lower than usual incidence of liver tumors and lymphomas. (jax.org)

Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
Approximately 80% of epithelial tumors are of the serous type, 10% are mucinous, and 10% are endometrioid, with rarer varieties including clear cell tumors, Brenner tumors, and undifferentiated ovarian carcinomas. (medscape.com)
Most epithelial tumors turn out not to be cancer . (webmd.com)
Malignant ovarian tumors are classified as epithelial tumors and non-epithelial ovarian malignant tumors. (12healthy.com)

The two main types of stromal tumors are Leydig cell tumors and Sertoli cell tumors. (medlineplus.gov)

Testicular Germ Cell Tumours (TGCT) are the most frequently occurring malignancy in males from 15-45 years of age. (nih.gov)
DICER1 mutations were found in 60% of Sertoli-Leydig cell tumours, clustering in four codons encoding metal-binding sites. (nih.gov)
We conclude therefore that hot-spot mutations, frequently seen in Sertoli-Leydig cell tumours, are not common in TGCTs. (nih.gov)
epithelial, germ cell and sex-cord stromal tumours, depending on the type of tissue the cancer cells have grown out of. (ovacome.org.uk)
Clear cell tumours make up three per cent to five per cent (three to five in 100) of epithelial ovarian cancer cases. (ovacome.org.uk)
Epithelial, germ cell and metastatic tumours were excluded from the study. (org.pk)
Age range for granulosa cell tumour was 15- 71 mean age 48 years, age range for sertoli leydig cell tumours 12- 67 mean age 39 years. (org.pk)
Thirty four out of 36 Granulosa cell tumours (32 out of 33 adult and 2 out 3 juvenile granulosa cell tumours), all cases of sertoli leydig cell tumours, three of fibroma/ thecoma cases and one case of microcystic stromal tumour. (org.pk)
Sertoli leydig cell tumours showed diffuse positivity of CK in all seven cases with co-expression of Inhibin. (org.pk)
Sertoli-Leydig cell tumours are more morphologically diverse than pure Sertoli cell tumours. (org.pk)
Undifferentiated or unclassified tumours are the types of ovarian cancer that do not fit neatly into any category as it is not possible to tell which type of cell the cancer started in. (ovarian.org.uk)
Germ cell tumours are rare and account for around 5% of ovarian cancer cases. (ovarian.org.uk)
HER2 is colocalised and most of the time, coamplified with the gene GRB7, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. (iiab.me)

Okay, now, for your exams, it's important to know that the main risk factors for developing testicular cancer , especially the germ cell variety, include cryptorchidism , which is when the testicles fail to descend to the scrotum or get stuck in the inguinal canal , as well as Klinefelter syndrome , where biological male individuals inherit more than one X chromosome leading to small, undeveloped testicles . (osmosis.org)
For symptoms, a testicular tumor most often comes up as a small, firm lump that is typically painless, but can sometimes cause a sharp or dull pain in the testicles and lower abdomen. (osmosis.org)
Testicular tumors are abnormal growths that can develop in one or both testicles . (osmosis.org)
Sperm cells are made in long, thread-like tubes inside the testicles called seminiferous tubules. (cancer.org)
The testicles are made up of many types of cells, each of which can develop into one or more types of cancer. (cancer.org)
The main types of germ cell tumors (GCTs) in the testicles are seminomas and non-seminomas . (cancer.org)
Children's Colorado is the only hospital in our region with a specialized team of experts dedicated to the care and treatment of urologic pediatric tumors of the kidney, adrenal gland, bladder, pelvis and testicles. (childrenscolorado.org)
Why choose Children's Colorado for tumors of the kidney, adrenal gland, bladder, pelvis and testicles? (childrenscolorado.org)
Every day, our surgeons are dedicated to the clinical care and research of tumors in the kidney, adrenal gland, bladder, pelvis and testicles in children, teens and young adults. (childrenscolorado.org)
These tumors grow aggressively and spread outside the testicles. (surgeonformen.com)
These tumors tend to develop in the stroma of the testicles. (surgeonformen.com)
These are the tumors that arise elsewhere in the body but spread to the testicles subsequently. (surgeonformen.com)
These are the cells in the testicles that produce immature sperm. (medicalnewstoday.com)
A surgeon will remove one or both testicles to prevent the tumor from spreading. (medicalnewstoday.com)

Brenneman M, Field A, Yang J et al (2015) Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in pleuropulmonary blastoma/DICER1 syndrome: a unique variant of the two-hit tumor suppression model. (springer.com)

germline and somatic DICER1 mutations were subsequently identified in several other familial associated tumors in several extrapulmonary sites (Table 1). (hypothes.is)
Individuals with germline DICER1 mutations also had non-neoplastic conditions including macrocephaly, renal structural anomalies, retinal abnormalities, dental perturbations, and the GLOW syndrome (global developmental delay, lung cysts, overgrowth and Wilms tumor). (hypothes.is)
These associations encircle the DICER1 tumor predisposition syndrome (Online Mendelian Inheritance in Man numbers 606241, 601200 and 138800), with the estimation that 90% of those affected by this syndrome inherited a germline mutation from one of their parents, with a pattern of autosomal dominant inheritance10. (hypothes.is)
DICER1 syndrome is a highly pleiotropic tumor predisposition syndrome that has been increasingly recognized in the last 10 years. (springer.com)
Slade I, Bacchelli C, Davies H et al (2011) DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome. (springer.com)
de Kock L, Geoffrion D, Rivera B et al (2018) Multiple DICER1-related tumors in a child with a large interstitial 14q32 deletion. (springer.com)
de Kock L, Sabbaghian N, Druker H et al (2014) Germ-line and somatic DICER1 mutations in pineoblastoma. (springer.com)

These tumors are so named because their cells look like the yolk sac of an early human embryo. (cancer.org)

7. Sertoli-Leydig cell tumor , thyroid follicular carcinoma and rhabdomyosarcoma of the uterine cervix in a prepubertal girl with pathogenic germ line variant in dicer 1 gene. (nih.gov)
14. Genetic analysis of a hereditary medullary thyroid carcinoma case with normal preoperative serum calcitonin levels. (nih.gov)
A C8054 Thyroid Gland Follicular Carcinoma Follicular Thyroid Carcinoma A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. (nih.gov)
The nuclear features which characterize the thyroid gland papillary carcinoma are absent. (nih.gov)
C3414 Thyroid Tumor C90259 Pediatric Terminology A C3879 Thyroid Gland Medullary Carcinoma Medullary Thyroid Carcinoma C Cell Carcinoma A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. (nih.gov)
Approximately 10% to 20% of medullary thyroid carcinomas are familial. (nih.gov)
Carcinoma arising from the C-cells of the thyroid gland. (nih.gov)
C3414 Thyroid Tumor C90259 Pediatric Terminology A C8011 TSH-Producing Pituitary Gland Adenoma Thyroid Stimulating Hormone-Producing Adenoma TSH-producing Adenoma A rare adenoma of the anterior lobe of the pituitary gland that produces thyrotropin. (nih.gov)
A non-malignant neoplasm of the thyroid gland arising from epithelial cells. (nih.gov)
C3414 Thyroid Tumor C90259 Pediatric Terminology A C9381 Childhood Acute Myeloid Leukemia with Maturation Childhood Acute Myeloid Leukemia with Maturation An acute myeloid leukemia with maturation occurring in children. (nih.gov)
C3250 Acute Myeloid Leukemia with Maturation C90259 Pediatric Terminology A C3878 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma Anaplastic Thyroid Carcinoma Undifferentiated Thyroid Tumor A primary carcinoma of the thyroid gland composed of undifferentiated cells. (nih.gov)
An aggressive carcinoma of the thyroid gland composed of undifferentiated cells. (nih.gov)
C3414 Thyroid Tumor C90259 Pediatric Terminology A C3342 Prolactin-Producing Pituitary Gland Adenoma Prolactinoma An adenoma of the anterior lobe of the pituitary gland that produces prolactin. (nih.gov)

Mucinous tumors are most common in the third to fifth decades of life and are only rarely bilateral. (medscape.com)

We understand that not knowing if your child's tumor is cancerous is very stressful. (childrenscolorado.org)
Our surgical team and the pediatric cancer specialists at the Center for Cancer and Blood Disorders treat cancerous tumors. (childrenscolorado.org)
Doctors do not know why testicular cells become cancerous, but some genetic factors may increase the risk. (medicalnewstoday.com)

Non- germ cell testicular tumors come from the Sertoli cells, which don't produce hormones, or the Leydig cells which can secrete excess male and female sex hormones . (osmosis.org)
As a result of sex steroid secretion, peripheral causes of PPP include ovarian cysts and ovarian tumors that increase circulating estradiol, such as granulosa cell tumors, which would cause isosexual PPP and Sertoli-Leydig cell tumors that secrete testosterone, which can result in contrasexual PPP. (medscape.com)

The epithelial neoplasms have occurred in older dogs compared to those of other histogenic origins (mesenchymal and other origins/round cells). (bvsalud.org)
The frequency was 48% of epithelial neoplasms, 32% of mesenchymal neoplasms, and 10% of neoplasms with other origins and round cells. (bvsalud.org)
All tumors in males and most in females at this time were alveolar-bronchiolar (AB) neoplasms of the lung. (jax.org)

The most common type is granulosa cell tumour and others include sertoli-leydig. (ovacome.org.uk)
Adult Granulosa cell tumour is the commonest tumour seen in our study. (org.pk)
Thirty fourcases of Granulosa cell tumour were stained for Inhibin, Calretinin and Cytokeratin. (org.pk)

There are several subtypes of germ cell carcinomas, and tumors can also be a mix of more than one subtype. (webmd.com)

By definition, serous tumors are characterized by a proliferation of epithelium resembling that lining the fallopian tubes. (medscape.com)
Serous adenocarcinoma is the most common malignant tumor of the ovaries. (12healthy.com)
High grade serous ovarian cancer (sometimes known as high-grade carcinoma) is the most common type of epithelial ovarian cancer, accounting for more than half the cases of this type. (ovarian.org.uk)
Low-grade serous ovarian cancer (sometimes known as low-grade serous carcinoma) is a rare, slow-growing type of epithelial cancer that usually affects younger women between the ages of 45 and 55. (ovarian.org.uk)

q They make sperm, the male cells needed to fertilize a female egg cell to start a pregnancy. (cancer.org)
During ejaculation, sperm cells are carried from the epididymis through the vas deferens to the seminal vesicles. (cancer.org)
These are the cells that make sperm. (cancer.org)
these tumors arise out of the Sertoli cells which are responsible for providing nourishment to the sperm making cells. (surgeonformen.com)
Sperm cells carry the fluid produced by the prostate gland through the sperm duct into the semen sac. (neolife.com.tr)
During ejaculation, sperm cells, sperm sac fluid and prostatic fluid enter the urinary tract. (neolife.com.tr)
CDCA2 deletion in mice had no statistically significant effect on spermatogenic cells, sperm motility parameters and male fertility at all stages of spermatogenesis. (magtechjournal.com)
found that in vitro organ culture with the gas-liquid interphase method can lead spermatogonia and germline stem cells to fertile sperm [3,4]. (cyberleninka.org)

These tumors can occur in the pregnant woman (often as an ovarian tumor) or in the fetus. (wikipedia.org)
The majority of tumors occur in individuals younger than age 40 years. (nih.gov)
These cells are found in about 40% of testicular tumors, but pure embryonal carcinomas occur only 3% to 4% of the time. (cancer.org)
Stromal tumors usually occur during childhood. (medlineplus.gov)
Leydig cell hyperplasia may also occur with aging. (medscape.com)

Throughout spermatogenesis multiplication, maturation and differentiation of germ cells results in the formation of the male gamete. (biomedcentral.com)
The understanding of spermatogenesis needs detailed informations about the organization of the germinal epithelium, the structure and function of different types of germ cells, endocrine and paracrine cells and mechanisms, intratesticular and extratesticular regulation of spermatogenesis. (biomedcentral.com)
The profound knowledge of the complicate process of spermatogenesis and all cells or cell systems involved with is the prerequisite to develop concepts for therapy of male infertility or to handle germ cells in the management of assisted reproduction. (biomedcentral.com)
The complete process of germ cell development is called spermatogenesis. (biomedcentral.com)
Spermatogenesis depends from intratesticular and extratesticular hormonal regulatory processes and functions of the intertubular microvasculature, the Leydig cells and other cellular components of the intertubular space. (biomedcentral.com)
Transcriptional regula-tion of P63 on the apoptosis of male germ cells and three stages of spermatogenesis in mice[J]. Cell Death Dis, 2018, 9: 76. (magtechjournal.com)
Abstract The regulation of Sertoli cells by some hormones and signaling factors is important for normal spermatogenesis. (cyberleninka.org)
Therefore, we inferred that Jagged1 in Sertoli cells contributes to the Notch signaling involved in spermatogenesis. (cyberleninka.org)
Homeostatic and stable spermatogenesis is supported by the strict regulation of precise proliferation, differentiation, and meiosis of germ cells [l,2]. (cyberleninka.org)
Notch signaling in Sertoli cells inactivated by deletion of the protein O-fucosyltransferasel showed normal spermatogen-esis [l2], whereas RBPj knockout in Sertoli cells led to abnormal spermatogenesis and an atrophic tubule [l5]. (cyberleninka.org)

Your ovaries have three main types of cells, and a tumor can develop in any of them. (webmd.com)
Most cases of ovarian cancer involve tumors that start in the layer of tissue that covers your ovaries. (webmd.com)
Epithelial ovarian cancer develops from cells that cover or line the ovaries. (ovacome.org.uk)
They originate from cells that produce the eggs in the ovaries and are more common in young people. (ovacome.org.uk)
It starts in the cells that lines or cover the ovaries and fallopian tubes (the epithelium). (ovarian.org.uk)
PPP is gonadotropin independent, caused by sex steroid secretion from any source - ovaries, adrenal gland, exogenous or ectopic production, e.g., germ-cell tumor. (medscape.com)

and embryonal carcinomas, which are rare as pure carcinomas but a common element of mixed germ cell tumors. (osmosis.org)

Ovarian germ cell tumors (GCTs) are rare in adults, but are more common in adolescents and young adults. (nih.gov)

In more severe cases, symptoms may arise from a malignant tumor metastasizing to other organs. (osmosis.org)

Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies). (medscape.com)

Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)

Contemporary management of ovarian germ cell tumors and remaining controversies. (nih.gov)

These are the commonest germ cell tumors occurring in the testes. (in4arts.com)
They two main functions of the testes are production of testosterone, the male sex hormone, and the production of sperms , the cells that are required for fertilization. (surgeonformen.com)
The testes consist of several different cells. (neolife.com.tr)
Starting from a self-renewing stem cell pool, male germ cells develop in the seminiferous tubules of the testes throughout life from puberty to old age. (biomedcentral.com)
The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells? (magtechjournal.com)
The first is that Sertoli cells express the Jagged1 ligand in mice testes. (cyberleninka.org)
Furthermore, three-dimensional culture methods could reconstruct testicular cells to the structure of the seminiferous tubule, and collagen in matrigel promoted reconstruction of testes [5]. (cyberleninka.org)
Notch2 and Notch3 are ubiquitously expressed in germ cells, and Jaggedl and Delta-like4 are expressed in elongated spermatids in adult testes [l4]. (cyberleninka.org)

In addition to driving mesenchymal proliferation,PDGFs have been shown to direct the migration, differentiation and function of a variety of specialized mesenchymal and migratory cell types, both during development and in the adult animal. (silverchair.com)
We ve been able for the first time to generate fully functional human cartilage from mesenchymal stem cells by mimicking in vitro the developmental process of mesenchymal condensation, says Gordana Vunjak-Novakovic (pictured), who led the study and is the Mikati Foundation Professor of Biomedical Engineering at Columbia Engineering and professor of medical sciences. (regenerativemedicine.net)
Sarindr Bhumiratana, postdoctoral fellow in Vunjak-Novakovic s Laboratory for Stem Cells and Tissue Engineering, came up with a new approach: inducing the mesenchymal stem cells to undergo a condensation stage as they do in the body before starting to make cartilage. (regenerativemedicine.net)

Although it's not technically an ovarian cancer, primary peritoneal carcinoma (PPC) is very closely related. (webmd.com)
Brainstem gliomas, medulloblastomas, ependymomas, and certain pineal tumors are relatively common primary malignant tumors of the CNS in children. (nih.gov)
The germinal epithelium (Fig. 2A ) consists of cells that include different developmental stages of germ cells, namely spermatogonia, primary and secondary spermatocytes and spermatids. (biomedcentral.com)
Cx45 was primary located in the cytoplasm of FS1 and TCam-2 cells and revealed similar low to medium gene expression values in both cell lines. (biomedcentral.com)
In this study, we revealed two new facts about Sertoli cells by western blotting experiments on different types of primary cells and microdissected tubules. (cyberleninka.org)

They derive from a non-invasive precursor, called germ cell neoplasia in situ, but the exact pathogenesis is still unknown. (biomedcentral.com)
A mitjans de la dècada de 1980 es crearen els primers sistemes parcialment automatitzats d'ús específic en immunohistoquímica [23] i el 1990 fou dissenyat un aparell automàtic amb capacitat d'efectuar alhora immunohistoquímica i hibridació in situ per fluorescència (FISH, de l'anglès fluorescence in situ hybridization ). (wikipedia.org)

These mixed germ cell tumors are treated as non-seminomas because they grow and spread like non-seminomas. (cancer.org)
The 2 main sub-types of these tumors areclassical (or typical) seminomas and spermatocytic seminomas. (cancer.org)
Spermatocytic tumors tend to grow more slowly and are less likely to spread to other parts of the body than classical seminomas. (cancer.org)
In contrast to the seminomas, these tumors are slow growing, masses that predominantly affect older men. (in4arts.com)

termFormat EnglishLanguage MPATH--306 "signet ring cell carcinoma") (subclass MPATH--361 MPATH--358) (subclass MPATH--42 MPATH--33) (subclass MPATH--196 MPATH--194) (subclass MPATH--163 MPATH--162) (termFormat EnglishLanguage MPATH--226 "eccrine gland adenoma") (termFormat EnglishLanguage MPATH--33 "intracellular and extracellular accumulation") (documentation Smo-Subset EnglishLanguage "Subset of OBO terms from the ontology. (ontologyportal.org)

The tumors result from either failure of a dominant mature follicle to rupture or failure of an immature follicle to undergo the normal process of atresia. (medscape.com)
They are called immature because the cancer cells are at a very early stage of development. (ovarian.org.uk)

Cell division cycle associated 2 (CDCA2) upregulation promotes the progression of hepatocellular carcinoma in a p53-dependant manner[J]. Peer J, 2022, 10:e13535. (magtechjournal.com)

Tests performed on serum are further categorized by the reason for performing the test: maternal serum, adult tumor marker, and pediatric tumor marker. (wikipedia.org)
HCG can be checked with a simple blood test and is considered a tumor marker for certain types of testicular cancer. (cancer.org)
Embryonal carcinoma can increase blood levels of a tumor marker protein called alpha- fetoprotein (AFP), as well as human chorionic gonadotropin (HCG). (cancer.org)
It normally does not increase the level of any tumor marker. (surgeonformen.com)
The detection of LC3-I to LC3-II conversion is a useful and sensitive marker for distinguishing autophagy in mammalian cells. (thermofisher.com)

Anatomy12

Diseases39

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes6

Disciplines and Occupations1

Health Care2

Choriocarcinoma3

Teratoma2

Seminoma7

Endodermal sinus10

Cancers12

Rare tumors2

Testis9

Benign15

Sarcoma5

Dermoid cyst1

Cystic1

Ovary11

Cord-stromal tumors1

Lung tumors2

Epithelial tumors4

Types of stromal1

Tumours13

Testicles14

Pleuropulmonary blastoma1

DICER17

Yolk sac1

Thyroid13

Mucinous1

Cancerous3

Secrete2

Neoplasms3

Granulosa cell t3

Subtypes of germ1

Serous4

Sperm8

Occur5

Spermatogenesis10

Ovaries6

Embryonal carcinomas1

GCTs1

Malignant tumor1

Malignancies1

Gynecologic tumors1

Ovarian germ1

Testes8

Mesenchymal3

Primary5

Situ2

Seminomas4

Adenoma1

Immature2

Hepatocellular carcinoma1

Marker5