AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Adrenal Gland NeoplasmsAdrenal Cortex NeoplasmsAdrenal GlandsSalivary Gland NeoplasmsSebaceous Gland NeoplasmsAnal Gland NeoplasmsCarcinomaCarcinoma, MucoepidermoidAdenoma, PleomorphicPerianal GlandsSublingual Gland NeoplasmsParotid NeoplasmsAdrenal Gland DiseasesCarcinoma, Squamous CellCarcinoma, Adenoid CysticAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, HepatocellularPalatal NeoplasmsAdrenal CortexChloropreneMyoepitheliomaAdrenal MedullaAdenolymphomaSubmandibular Gland NeoplasmsSalivary Glands, MinorImmunohistochemistryChemotherapy, AdjuvantCarcinoma in SituLiver NeoplasmsCarcinoma, PapillaryEndocrine Gland NeoplasmsSalivary GlandsAdrenal InsufficiencySweat Gland NeoplasmsLung NeoplasmsNeoplasm StagingBreast NeoplasmsCarcinoma, Ductal, BreastAntineoplastic AgentsAdrenocorticotropic HormonePrognosisCarcinoma, Basal CellAdenocarcinomaCombined Modality TherapyTumor Markers, BiologicalAdrenalectomyTreatment OutcomeCisplatinMammary Glands, AnimalCarcinoma, Transitional CellThyroid NeoplasmsNeoplasmsAdrenocortical CarcinomaOvarian NeoplasmsPancreatic NeoplasmsCell Line, TumorNeoplasm InvasivenessSubmandibular GlandExocrine GlandsNeoplasm Recurrence, LocalCarcinoma, BronchogenicAdrenocortical AdenomaSurvival AnalysisNeoplasm MetastasisSurvival RateGene Expression Regulation, NeoplasticCarcinoma, Intraductal, NoninfiltratingNasopharyngeal NeoplasmsDisease-Free SurvivalSkin NeoplasmsCarcinoma, NeuroendocrineRNA, MessengerCarcinoma, MedullaryCarcinoma, LobularCarcinoma, Small CellTumor Cells, CulturedAdrenal Hyperplasia, CongenitalNeoplasms, Multiple PrimaryCatecholaminesHead and Neck NeoplasmsCyclophosphamideStomach NeoplasmsColonic NeoplasmsTime FactorsLymphatic MetastasisDoxorubicinPheochromocytomaEsophageal NeoplasmsParotid GlandTomography, X-Ray ComputedNeoplasm ProteinsSplanchnic NervesHydrocortisoneMouth NeoplasmsDNA, NeoplasmUrinary Bladder NeoplasmsZona FasciculataColorectal NeoplasmsNeoadjuvant TherapyCushing Syndrome
TumorsTumorMetastasesMedullary carcinomaEpithelialLiverLesionsCorticalSystemicAdenocarcinomaUnresectableRadiotherapyClinicalMalignant potentialMetastasisDiagnosisMammaryMalignancyLesionLungNeuroendocrineNeuroblastomaLymphatic systemAdenomaRadiologicAdrenocorticalStagingInvadesCisplatinCortexThyroidHistologicallySurvivalAbdominalProximalPapillaryRadiation therapyLymphomaKIDNEYConsistentPatientsRareDiseaseAriseArisesDuodenumGeneticCancer
Tumors26
  • Adrenal cancer is the presence of malignant adrenal tumors, and includes neuroblastoma, adrenocortical carcinoma and some adrenal pheochromocytomas. (wikipedia.org)
  • Most adrenal pheochromocytomas and all adrenocortical adenomas are benign tumors, which do not metastasize or invade nearby tissues, but may cause significant health problems by unbalancing hormones. (wikipedia.org)
  • Both benign and malignant tumors of the adrenal cortex may produce steroid hormones, with important clinical consequences. (wikipedia.org)
  • citation needed] Adrenocortical adenomas are benign tumors of the adrenal cortex that are extremely common (present in 1-10% of persons at autopsy). (wikipedia.org)
  • However, size and weight of the adrenal cortical tumors are no longer considered to be a reliable sign of benignity or malignancy. (wikipedia.org)
  • Neuroblastoma and pheochromocytoma are the two most important tumors which arise from the adrenal medulla. (wikipedia.org)
  • Both tumors may also arise from extra-adrenal sites, specifically, in the paraganglia of the sympathetic chain. (wikipedia.org)
  • Of primary adrenal tumors, ACC is less common than cortical adenoma and pheochromocytoma. (cap.org)
  • Advanced imaging techniques often reveal adrenal tumors in asymptomatic patients. (cap.org)
  • It is important to distinguish the histological variants of conventional ACC as they share similar features to secondary tumors that not infrequently involve the adrenal gland. (cap.org)
  • Secondary lung tumors are neoplasms that spread from a primary lesion. (medscape.com)
  • Metastatic malignant neoplasms are the most common form of secondary lung tumors. (medscape.com)
  • Therefore, CT and MRI may be useful for distinguishing between renal tumors and adrenal tumors. (medscape.com)
  • It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (lookformedical.com)
  • Tumors or cancer of the THYROID GLAND. (lookformedical.com)
  • The classification of epithelial tumors of the kidney has in particular undergone substantial progress in the last two decades with major contributions from genetic typing of renal cell carcinomas (RCCs). (abdominalkey.com)
  • The role of genotyping and ancillary tools, in particular immunohistochemistry, in correctly classifying these tumors is highlighted in the section on Renal Cell Carcinoma. (abdominalkey.com)
  • Wiedemann-Beckwith syndrome is related to abnormalities on chromosome 11p15 and characterized by multiple craniofacial anomalies, abdominal wall defects, and tumors of the genitourinary tract, liver, adrenal gland, and central nervous system among other abnormalities. (abdominalkey.com)
  • Upper tract urothelial carcinomas (UTUC) are malignant tumors of the urothelium of the ureter, renal pelvis, or calyces with similar properties to bladder carcinoma concerning etiology and pathology. (urology-textbook.com)
  • One of the most important characteristics to differentiate these tumors from other renal cell neoplasms is their typical reactivity to premelanosome antigens. (biomedcentral.com)
  • These features might lead to an erroneous diagnosis of high-grade renal cell carcinoma, particularly since intra-tumoral fat can occur in these tumors [ 4 ]. (biomedcentral.com)
  • The present invention relates to compositions and methods for treating cancerous tumors, including naïve, metastatic and recurrent cancers. (justia.com)
  • Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
  • Malignant vascular tumors (MVTs), mainly composed of angiosarcoma (AS) and hemangioendothelioma (HE), are considered one of the rarest soft tissue neoplasms in contrast to their benign counterparts. (turkjpath.org)
  • She had a surgical excision for both the thyroid and the pulmonary tumors, and received adjuvant chemotherapy. (biomedcentral.com)
  • The thyroid gland is a rare target for metastatic tumors, despite its rich vascular supply [ 1 ]. (biomedcentral.com)
Tumor11
  • An adrenal tumor or adrenal mass is any benign or malignant neoplasms of the adrenal gland, several of which are notable for their tendency to overproduce endocrine hormones. (wikipedia.org)
  • Metastasis to one or both adrenal glands is the most common form of malignant adrenal lesion, and the second most common adrenal tumor after benign adenomas. (wikipedia.org)
  • Although vascular and capsular invasion cannot be assessed, cytologic features on fine needle aspiration (FNA) such as hypercellularity, necrosis, and cellular dyscohesion, in conjunction with radiologic features of tumor size (greater than 4.0 cm), heterogeneity, and enhancement, favor ACC over other adrenal neoplasms. (cap.org)
  • Secondary lung tumor is a term that is also used for the malignancies that arise in the lungs as a consequence of therapy for cancer (eg, chemotherapy, radiotherapy, or bone marrow transplant). (medscape.com)
  • Its therapeutic use is limited to the treatment of hypercalcemia and Paget's osteopathy, and as a tumor marker in medullary carcinoma. (teknon.es)
  • Nonfunctioning neuroendocrine neoplasms can still cause symptoms relating to tumor size and location such as obstruction or internal bleeding. (rarediseases.org)
  • In March 2022, Allogene Therapeutics, Inc. announced that the US Food and Drug Administration (FDA) had granted Fast Track designation (FTD) to ALLO-316, the Company's first AlloCAR T solid tumor clinical candidate for the treatment of patients with advanced or metastatic clear cell renal cell carcinoma (RCC). (northamericanreport.com)
  • Histopathological evaluation revealed seminoma of the right testis, nonseminomatous germ cell tumor of the left testis, and metastatic seminoma in the right groin postoperatively. (cancernetwork.com)
  • One patient who had 50-gene panel only also had his metastatic site (esophagus) of his tumor tested with FoundationOne. (cancerindex.org)
  • Although Kaposi's sarcoma is also classified as a malignant vascular neoplasm, there are contradictory data about the vascular origin and differentiation of this tumor. (turkjpath.org)
  • Immunohistochemistry demonstrated that these tumor cells were positive for both cytokeratin 7 (CK7) and thyroid transcription factor-1 (TTF-1) and were negative for both CK20 and thyroglobulin, which concords with metastatic disease from lung origin (Figs. 1 and 2 ). (biomedcentral.com)
Metastases5
  • Small bowel metastases from primary carcinoma of the lung are very uncommon and occur usually in patients with terminal stage disease. (ispub.com)
  • Metastases affecting the small bowel and originating from carcinoma of the lung are a rare occurrence, but recent reports suggest that they may be more frequent than previously thought as they rarely produce symptoms. (ispub.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Soft-tissue metastases from a primary carcinoma are rare lesions. (amjcaserep.com)
  • Radiologic findings were negative for both lymph node and adrenal metastases. (biomedcentral.com)
Medullary carcinoma4
Epithelial3
Liver2
Lesions3
  • Radiologic and FNA cytologic studies are also useful in staging patients with possible metastatic lesions. (cap.org)
  • Many carcinomas are solid, while several cystic or mixed lesions are benign. (teknon.es)
  • To the best of our knowledge, only a few cases of metastatic lung adenocarcinoma to the thyroid gland have been reported, describing all together four cases of thyroid lesions revealing a lung carcinoma. (biomedcentral.com)
Cortical5
  • citation needed] Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer of adrenal cortical cells, which may occur in children or adults. (wikipedia.org)
  • This case first appeared as Performance Improvement Program in Surgical Pathology (PIP) 2018, Case 23, and is an adrenal cortical carcinoma of the adrenal gland. (cap.org)
  • These findings are consistent with adrenal cortical carcinoma (ACC). (cap.org)
  • Wooten MD, King DK: Adrenal cortical carcinoma. (oncolink.org)
  • Wieneke JA, Thompson LD, Heffess CS: Adrenal cortical neoplasms in the pediatric population: a clinicopathologic and immunophenotypic analysis of 83 patients. (oncolink.org)
Systemic4
  • Also discussed is the multidisciplinary approach to determine when continued systemic chemotherapy for metastatic disease should be accompanied by radiation, surgery, or both. (medscape.com)
  • nonfunctioning neoplasms may produce hormones, but no systemic symptoms. (rarediseases.org)
  • Parathyroid carcinoma (PC) is a rare endocrine malignancy with no approved systemic therapies for unresectable locally invasive or distant metastatic disease. (cancerindex.org)
  • Systemic treatment of adrenocortical carcinoma in children: data from the German GPOH-MET 97 trial. (oncolink.org)
Adenocarcinoma4
  • Histological examination and immunohistochemical staining of the biopsy specimen strongly supported the diagnosis of metastatic lung adenocarcinoma. (ispub.com)
  • Upper tract urothelial carcinoma is urothelial carcinoma in 95%, but squamous cell carcinoma or adenocarcinoma is rarely possible. (urology-textbook.com)
  • Salivary Gland Polymorphous Adenocarcinoma: Clinicopathological Features and Gene Alterations in 36 Japanese Patients. (nagoya-u.ac.jp)
  • We report the case of a 74-year-old woman who presented with late-onset (recurrent disease), solitary, subcutaneous metastasis in the posterior aspect of the left thigh, deriving from a pancreatic head adenocarcinoma, 2 years after initial treatment with R0 resection (pancreaticoduodenectomy) and adjuvant chemotherapy. (amjcaserep.com)
Unresectable2
  • In February 2022, Eisai and Merck & Co., Inc., announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) had approved the combination of LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, plus KEYTRUDA, the anti-PD-1 therapy from Merck & Co., for radically unresectable or metastatic renal cell carcinoma (RCC). (northamericanreport.com)
  • Re-irradiation with concomitant chemotherapy of unresectable recurrent head and neck cancer: a potentially curable disease. (uchicago.edu)
Radiotherapy2
  • Hodgkin Lymphoma treatment is multimodal and includes chemotherapy, radiotherapy and stem cell transplantation. (jcimcr.org)
  • Perspectives on combination chemotherapy with concomitant radiotherapy for poor-prognosis head and neck cancer. (uchicago.edu)
Clinical3
  • citation needed] The clinical significance of these neoplasms is twofold. (wikipedia.org)
  • In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Metastatic Renal Cell Carcinoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details. (northamericanreport.com)
  • Genetic profiling as a clinical tool in advanced parathyroid carcinoma. (cancerindex.org)
Malignant potential1
Metastasis1
Diagnosis2
  • During admission for the second round of chemotherapy and one month after diagnosis, the patient complained of diffuse abdominal pain and abdominal tenderness. (ispub.com)
  • Cystoscopy is done at the initial diagnosis of UTUC and during follow-up to rule out urothelial carcinoma of the lower urinary tract. (urology-textbook.com)
Mammary1
  • Advances in the understanding of may be more susceptible at a par- sembled for IARC Group 1 carcino- host susceptibility in tandem with the ticular site (i.e. the mammary gland gens contains information on mecha- evolution of the knowledge on the in females). (who.int)
Malignancy1
  • Neutrophilic eccrine hidradenitis (NEH) is a neutrophilic dermatosis primarily affecting the eccrine glands and occurs most commonly in patients undergoing chemotherapy for a malignancy. (annals.edu.sg)
Lesion2
  • Cancer spread through direct extension is not frequently encountered and most commonly includes direct invasion by a primary neoplasm, involving a contiguous organ or structure (eg, thyroid, esophagus, thymus, or chest wall), or spread from a neoplasm metastatic to another intrathoracic structure (eg, rib or mediastinal lymph node, commonly causing an obstructive lesion of the trachea or bronchus). (medscape.com)
  • Our case is rare as it describes a case where the thyroid lesion was the revealing sign of an unknown lung carcinoma. (biomedcentral.com)
Lung3
  • CT scanning is the most sensitive imaging modality for detecting metastatic lung nodules. (medscape.com)
  • The results of cytological examination of bronchial excretions however, proved positive for non-small cell carcinoma of the lung. (ispub.com)
  • As to primary lung cancer metastasizing to the thyroid gland, only a few cases have been described in the literature. (biomedcentral.com)
Neuroendocrine3
  • citation needed] The adrenal medulla is located anatomically at the center of each adrenal gland, and is composed of neuroendocrine (chromaffin) cells which produce and release epinephrine (adrenaline) into the bloodstream in response to activation of the sympathetic nervous system. (wikipedia.org)
  • Pancreatic neuroendocrine neoplasms (pNENs) are an increasingly common group of malignancies that arise within the endocrine tissue of the pancreas. (rarediseases.org)
  • G3 neuroendocrine carcinomas have a similar poor prognosis as pancreatic adenocarinomas. (rarediseases.org)
Neuroblastoma1
  • Adrenal neuroblastoma typically presents with a rapidly enlarging abdominal mass. (wikipedia.org)
Lymphatic system2
  • The mechanisms through which cancer spreads to the lungs are direct extension and true metastatic spread through the bloodstream, airway, or lymphatic system. (medscape.com)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
Adenoma1
  • The current World Health Organization (WHO) endocrine edition distinguishes adult ACC from adrenal adenoma based on the Weiss criteria. (cap.org)
Radiologic1
  • Incidentally found adrenal masses can be further classified as benign or malignant and primary adrenal versus metastatic using radiologic-cytologic or pathologic correlation. (cap.org)
Adrenocortical4
  • They should not be confused with adrenocortical "nodules", which are not true neoplasms. (wikipedia.org)
  • This can result in expensive additional testing and invasive procedures to rule out the slight possibility of an early adrenocortical carcinoma. (wikipedia.org)
  • Due to their location deep in the retroperitoneum, most adrenocortical carcinomas are not diagnosed until they have grown quite large. (wikipedia.org)
  • Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). (oncolink.org)
Staging1
Invades1
  • The mass grossly invades the adjacent adrenal gland. (cap.org)
Cisplatin2
Cortex1
Thyroid2
  • The thyroid gland weighs, on average, 15 g, and is composed of two lateral lobes that extend to the sides of the larynx to very close to the midline of the thyroid cartilage, and that are joined by an isthmus that pass in front of the trachea. (teknon.es)
  • The most common sites that have been reported to metastasize to the thyroid gland are breast and kidney. (biomedcentral.com)
Histologically1
Survival2
  • The incidence of UTUC is rising due to the effective treatment of bladder carcinoma with better survival rates (length time bias). (urology-textbook.com)
  • Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer: improved disease control and survival. (uchicago.edu)
Abdominal1
  • Abdominal contrast-enhancing CT: proximal ureteral carcinoma with indwelling ureteral stent on the right side in frontal and transverse planes. (urology-textbook.com)
Proximal1
  • Upper gastrointestinal endoscopy performed with a colonoscope revealed active bleeding from a metastatic tumour involving the duodenum and the proximal jejunum. (ispub.com)
Papillary3
Radiation therapy2
  • Chemotherapy, radiation therapy, and hormonal therapy may also be employed in the treatment of this disease. (wikipedia.org)
  • Late rectal sequelae following definitive radiation therapy for carcinoma of the uterine cervix: a dosimetric analysis. (uchicago.edu)
Lymphoma1
  • Primary Mediastinal Large B-Cell Lymphoma (PMBL) is a rare neoplasm that arises in the mediastinum, and then forms a mass. (jcimcr.org)
KIDNEY2
Consistent1
Patients6
  • The FDA granted FTD based on the potential of ALLO-316 to address the unmet need for patients with difficult-to-treat renal cell carcinomas (RCC) who have failed standard RCC therapies. (northamericanreport.com)
  • Patients with renal cell cancer (RCC) develop metastatic spread in approximately 33% of cases. (northamericanreport.com)
  • Synchronous bilateral testicular neoplasm is a rare situation, involving about 2% of patients. (cancernetwork.com)
  • 2-4% of patients with bladder carcinoma experience a recurrence in the upper urinary tract. (urology-textbook.com)
  • Rare, aggressive malignant neoplasm found almost exclusively in patients with sickle cell trait , or, less frequently, sickle cell disease. (capsulehealth.one)
  • Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer. (uchicago.edu)
Rare1
Disease1
  • In the right inguinal region, an enlarged lymph node, suspicious for metastatic disease, was palpable. (cancernetwork.com)
Arise1
  • Neoplasms that arise from endocrine tissue may also secrete hormones, resulting in excessive levels of these hormones in the body and potentially a wide variety of symptoms. (rarediseases.org)
Arises1
  • The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
Duodenum2
  • Metastatic involvement of the duodenum presenting with melaena has been described extremely rarely in the literature. (ispub.com)
  • The pancreas is a gland located between the stomach, spleen, duodenum and colon transversum. (rarediseases.org)
Genetic1
  • The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
Cancer3
  • In July 2021, City of Hope and Osel Inc. announced that the City of Hope had granted an exclusive worldwide license to Osel for intellectual property on the novel use of an LBP CBM588 to enhance the efficacy of checkpoint inhibitors to treat cancer, including metastatic renal cell carcinoma. (northamericanreport.com)
  • However, metastatic bilateral testicular cancer of different histology is a challenging situation for the urologist, which warrants further discussion. (cancernetwork.com)
  • Interest in targeting polyamine metabolism as a potential strategy for cancer chemotherapy was stimulated in the early 1970s. (justia.com)