• adenoid cystic ca
  • In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migration and invasion of salivary adenoid cystic carcinoma (SACC). (scielo.cl)
  • Salivary adenoid cystic carcinoma (SACC) is a highly malignant carcinoma that most often arises from the secretory epithelial cells of salivary glands [ 1 ] and comprises approximately 10% of all salivary tumors [ 2 ]. (scielo.cl)
  • Although mTOR is clearly an attractive therapeutic target in tumor, no clinical study on mTOR inhibition by RAD001 has been systematically conducted in adenoid cystic carcinoma. (clinicaltrials.gov)
  • In phase I study of RAD001, 2 patients with adenoid cystic carcinoma show some response to RAD001 (unpublished data). (clinicaltrials.gov)
  • So the investigators design this phase II study of RAD001 in adenoid cystic carcinoma to evaluate the efficacy of RAD001 in this orphan disease. (clinicaltrials.gov)
  • Although the histologic appearance of adenoid cystic carcinoma is low grade, management of this malignancy is a distinct therapeutic challenge because of its insidious local growth pattern, propensity for perineural involvement, tendency for distant metastasis, and pronounced ability to recur over a prolonged period. (clinicaltrials.gov)
  • In adenoid cystic carcinoma, the study focusing on PI3-K/AKT/mTOR pathway is rare. (clinicaltrials.gov)
  • According to Younes MN et al's study, adenoid cystic carcinoma cell lines have increased pAkt activity when EGF-stimulation is added. (clinicaltrials.gov)
  • When the investigators consider that the increased pAkt activity is one of possible predictor to mTOR inhibitor, the mTOR inhibitor might have an activity in adenoid cystic carcinoma. (clinicaltrials.gov)