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  • adenoid cystic ca
  • In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migration and invasion of salivary adenoid cystic carcinoma (SACC). (scielo.cl)
  • Salivary adenoid cystic carcinoma (SACC) is a highly malignant carcinoma that most often arises from the secretory epithelial cells of salivary glands [ 1 ] and comprises approximately 10% of all salivary tumors [ 2 ]. (scielo.cl)
  • Although mTOR is clearly an attractive therapeutic target in tumor, no clinical study on mTOR inhibition by RAD001 has been systematically conducted in adenoid cystic carcinoma. (clinicaltrials.gov)
  • In phase I study of RAD001, 2 patients with adenoid cystic carcinoma show some response to RAD001 (unpublished data). (clinicaltrials.gov)
  • So the investigators design this phase II study of RAD001 in adenoid cystic carcinoma to evaluate the efficacy of RAD001 in this orphan disease. (clinicaltrials.gov)
  • Although the histologic appearance of adenoid cystic carcinoma is low grade, management of this malignancy is a distinct therapeutic challenge because of its insidious local growth pattern, propensity for perineural involvement, tendency for distant metastasis, and pronounced ability to recur over a prolonged period. (clinicaltrials.gov)
  • In adenoid cystic carcinoma, the study focusing on PI3-K/AKT/mTOR pathway is rare. (clinicaltrials.gov)
  • According to Younes MN et al's study, adenoid cystic carcinoma cell lines have increased pAkt activity when EGF-stimulation is added. (clinicaltrials.gov)
  • When the investigators consider that the increased pAkt activity is one of possible predictor to mTOR inhibitor, the mTOR inhibitor might have an activity in adenoid cystic carcinoma. (clinicaltrials.gov)
  • cells
  • For example, carcinoma in situ of the skin, also called Bowen's disease , is the accumulation of dysplastic epidermal cells within the epidermis only, that has failed to penetrate into the deeper dermis. (wikipedia.org)
  • papillary
  • They are classified into the following types: basaloid (4%) warty (6%) mixed warty-basaloid (17%) verrucous (8%) papillary (7%) other SCC mixed (7%) sarcomatoid carcinomas (1%) not otherwise specified (49%) Other types of carcinomas are rare and may include small cell, Merkel cell, clear cell, sebaceous cell or basal cell tumors. (wikipedia.org)
  • cervix
  • Stage I The carcinoma has grown deeper into the cervix, but has not spread beyond it (extension to the corpus would be disregarded). (wikipedia.org)
  • stage
  • In the TNM classification, carcinoma in situ is reported as TisN0M0 ( stage 0). (wikipedia.org)
  • Anatomic Stage or Prognostic Groups of penile cancer are as follows: Stage 0-Carcinoma in situ. (wikipedia.org)
  • Treatment according to the FIGO stages of cervical carcinoma: Stage Ia1: therapeutic conization in young individuals, extrafascial hysterectomy in post reproductive age Stage Ia2, Ib1, Ib2 and IIa: warthein's radical hysterectomy Stage IIb, IIIa, IIIb and IVa: Generally chemoradiotherapy (cisplatin is used as radio sensitiser) is used. (wikipedia.org)
  • place
  • In situ , or 'in place,' describes a cancer that has not moved out of the area of the body where it originally developed. (imaginis.com)
  • form
  • Bronchioloalveolar carcinoma (BAC) of the lung is the only form of CIS that can kill directly because, in rare cases (the "pneumonic form"), it expands greatly and fills the lungs, preventing breathing and causing other dire effects on the host. (wikipedia.org)
  • adenoid cystic ca
  • In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migration and invasion of salivary adenoid cystic carcinoma (SACC). (scielo.cl)
  • Salivary adenoid cystic carcinoma (SACC) is a highly malignant carcinoma that most often arises from the secretory epithelial cells of salivary glands [ 1 ] and comprises approximately 10% of all salivary tumors [ 2 ]. (scielo.cl)
  • Although mTOR is clearly an attractive therapeutic target in tumor, no clinical study on mTOR inhibition by RAD001 has been systematically conducted in adenoid cystic carcinoma. (clinicaltrials.gov)
  • In phase I study of RAD001, 2 patients with adenoid cystic carcinoma show some response to RAD001 (unpublished data). (clinicaltrials.gov)
  • So the investigators design this phase II study of RAD001 in adenoid cystic carcinoma to evaluate the efficacy of RAD001 in this orphan disease. (clinicaltrials.gov)
  • Although the histologic appearance of adenoid cystic carcinoma is low grade, management of this malignancy is a distinct therapeutic challenge because of its insidious local growth pattern, propensity for perineural involvement, tendency for distant metastasis, and pronounced ability to recur over a prolonged period. (clinicaltrials.gov)
  • In adenoid cystic carcinoma, the study focusing on PI3-K/AKT/mTOR pathway is rare. (clinicaltrials.gov)
  • According to Younes MN et al's study, adenoid cystic carcinoma cell lines have increased pAkt activity when EGF-stimulation is added. (clinicaltrials.gov)
  • When the investigators consider that the increased pAkt activity is one of possible predictor to mTOR inhibitor, the mTOR inhibitor might have an activity in adenoid cystic carcinoma. (clinicaltrials.gov)
  • cervical cancer
  • p16 plays an important role in cell cycle regulation by decelerating cells progression from G1 phase to S phase, and therefore acts as a tumor suppressor that is implicated in the prevention of cancers, notably melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, and esophageal cancer. (wikipedia.org)