• gene
  • Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. (wikipedia.org)
  • Although the most preclinical and clinical studies of ROS1 gene fusions have been performed in lung cancer, ROS1 fusions have been detected in multiple other tumor histologies, including ovarian carcinoma, sarcoma, cholangiocarcinomas and others. (wikipedia.org)
  • ovarian
  • It can also be used for the identification of mesenchymal tumours, such as synovial sarcoma and ovarian granulosa cell tumours. (wikipedia.org)
  • aberrant
  • Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. (wikipedia.org)
  • brentuximab
  • To expand on the clinical opportunities of brentuximab vedotin, Seattle Genetics is conducting a broad clinical development program to evaluate its therapeutic potential in earlier lines of its approved indications as well as in a range of other lymphoma and non-lymphoma settings. (wikipedia.org)
  • peripheral
  • Also, clonal T cell populations (as well as clonal B cell populations) are sometimes present in the lymph nodes or peripheral blood of patients with rheumatologic or infectious conditions. (oncologynurseadvisor.com)
  • Otherwise healthy patients over the age of 60 can also sometimes have benign clonal T cell populations in the peripheral blood. (oncologynurseadvisor.com)
  • Preparation of peripheral blood mononuclear cells. (aacrjournals.org)
  • Peripheral blood mononuclear cells (PBMCs) in RPMI 1640 containing 10% FCS (RPMI 1640/FCS) were prepared as previously described ( 6 ). (aacrjournals.org)
  • protein
  • The majority of cases are positive for the anaplastic large cell lymphoma (alk) protein. (icd10data.com)
  • The Cas family comprises other three members: NEDD9 (Neural precursor cell expressed, developmentally down-regulated 9, also called Human enhancer of filamentation 1, HEF-1 or Cas-L), EFS (Embryonal Fyn-associated substrate), and CASS4 (Cas scaffolding protein family member 4). (wikipedia.org)
  • The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. (wikipedia.org)
  • In the cell nucleus, the protein MUC1 regulates the activity of transcription factor complexes that have a documented role in tumor-induced changes of host immunity. (wikipedia.org)
  • These lymphomas show immunopositivity for ALK protein in 70% of cases. (wikipedia.org)
  • Disease
  • The presence of widespread adenopathy, the lack of empiric evidence of infection such as positive blood cultures, and a negative serologic evaluation for rheumatologic disease can often quickly exclude conditions that mimic lymphoma. (oncologynurseadvisor.com)
  • tyrosine
  • RTK-dependent p130Cas/BCAR1 tyrosine phosphorylation and the subsequent binding with specific downstream signaling molecule modulate cell processes such as actin cytoskeleton remodeling, cell adhesion, proliferation, migration, invasion and survival. (wikipedia.org)
  • The fact that both RTKs and integrin activation conveys on p130Cas/BCAR1 tyrosine phosphorylation represents a very efficient mean that cell exploit to integrate signals coming from growth factors and integrin activation and to coordinate cell responses. (wikipedia.org)
  • Noteworthy, p130Cas/BCAR1 tyrosine phosphorylation on its substrate domain can be induced by cell stretching subsequent to changes in the rigidity of the extracellular matrix, allowing cells to respond to mechanical force changes in the cell environment. (wikipedia.org)
  • nuclei
  • All morphological variants are characterized by a variable proportion of large hallmark cells with eccentric horse-shoe or kidney-shaped nuclei, often with eosinophilic region near the nucleus (Figure 1 ). (hindawi.com)
  • These so-called "hallmark" cells have lobulated and indented nuclei. (icd10data.com)
  • patients
  • For this purpose, we retrospectively selected two groups of patients from the large B-cell NHL population treated at our medical center, long-term and short-term survivors, and compared immunohistochemically the expression of several Bcl-2 family proteins in the biopsy tissue. (aacrjournals.org)
  • apoptosis
  • Inhibition of apoptosis may be involved in the pathogenesis of cancer by prolonging cell life and facilitating retention of deleterious mutations. (biomedcentral.com)
  • Due to its ability to associate with multiple signaling partners, p130Cas/BCAR1 contributes to the regulation to a variety of signaling pathways leading to cell adhesion, migration, invasion, apoptosis, hypoxia and mechanical forces. (wikipedia.org)
  • It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. (wikipedia.org)
  • Association of MUC1 with p53 in cancer results in inhibition of p53-mediated apoptosis and promotion of p53-mediated cell cycle arrest. (wikipedia.org)
  • These changes affect the normal functions of the cell, including cell proliferation, programmed cell death (apoptosis) and DNA repair. (wikipedia.org)
  • variants
  • The small and lympho-histiocytic variants display a marked variability of the neoplastic cell size that ranges from small to large. (hindawi.com)
  • All types can occur in unusual histologic variants and as mixed cell-type combinations. (wikipedia.org)