• hodgkin's
  • Gustmann C, Altmannsberger M, Osborn M, Griesser H, Feller AC: Cytokeratin expression and vimentin content in large cell anaplastic lymphomas and other non-Hodgkin's lymphomas. (springer.com)
  • Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. (hindawi.com)
  • Hodgkin's lymphoma (HL) is a lymphoid tumor representing less than 1% of all de novo neoplasms occurring every year world wide [ 1 ]. (hindawi.com)
  • The tumoral population also includes a variable number of mononuclear elements-Hodgkin's cells (HCs)-showing similar cytological features to RS cells and neoplastic cell variants, each corresponding to a specific subtype of HL. (hindawi.com)
  • Molecular studies have only recently shown that in most if not all cases RS cells, Hodgkin's cells, and cell variants belong to the same clonal population, which is derived from peripheral B cell [ 1 - 9 ]. (hindawi.com)
  • Long-term cure is now possible for ∼50% of all patients with aggressive non-Hodgkin's lymphoma (NHL). (aacrjournals.org)
  • Tumors
  • This phase I trial studies the side effects and best dose of dasatinib in treating patients with solid tumors or lymphomas that are metastatic or cannot be removed by surgery. (clinicaltrials.gov)
  • Tumors that are intrinsically resistant to chemotherapy are unable to activate the apoptotic machinery and may therefore be fundamentally resistant to chemotherapeutic cell death. (aacrjournals.org)
  • However, increasing evidence that CD4 + T-helper (Th) cells play a significant role in the regulation and maintenance of the CTL response to tumors ( 8 - 10 ) means it is important to identify CD4 + Th cell peptide-binding epitope(s) within the ALK protein to maximize the efficacy of future ALK-based immunotherapeutic strategies. (aacrjournals.org)
  • p130Cas/BCAR1 plays a role in cell transformation and cancer progression and alterations of p130Cas/BCAR1 expression and the resulting activation of selective signalling are determinants for the occurrence of different types of human tumors. (wikipedia.org)
  • It is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. (wikipedia.org)
  • Giant cell tumors include giant cell tumor of bone and giant cell tumor of the tendon sheath. (wikipedia.org)
  • In these cases, the tumors should be classified as combined small cell lung carcinoma (c-SCLC), and are (usually) treated like "pure" SCLC. (wikipedia.org)
  • For example, larger tumors in the frontal lobe can cause changes in the ability to think. (wikipedia.org)
  • These tumors are referred to as anaplastic or undifferentiated carcinomas. (wikipedia.org)
  • Very rarely, tumors may contain individuals components resembling both carcinoma and true sarcoma, including carcinosarcoma and pulmonary blastoma. (wikipedia.org)
  • Gene rearrangements involving the ROS1 gene were first detected in glioblastoma tumors and cell lines. (wikipedia.org)
  • ovarian
  • It can also be used for the identification of mesenchymal tumours, such as synovial sarcoma and ovarian granulosa cell tumours. (wikipedia.org)
  • Although the most preclinical and clinical studies of ROS1 gene fusions have been performed in lung cancer, ROS1 fusions have been detected in multiple other tumor histologies, including ovarian carcinoma, sarcoma, cholangiocarcinomas and others. (wikipedia.org)
  • brentuximab
  • To expand on the clinical opportunities of brentuximab vedotin, Seattle Genetics is conducting a broad clinical development program to evaluate its therapeutic potential in earlier lines of its approved indications as well as in a range of other lymphoma and non-lymphoma settings. (wikipedia.org)
  • peripheral
  • Also, clonal T cell populations (as well as clonal B cell populations) are sometimes present in the lymph nodes or peripheral blood of patients with rheumatologic or infectious conditions. (oncologynurseadvisor.com)
  • Otherwise healthy patients over the age of 60 can also sometimes have benign clonal T cell populations in the peripheral blood. (oncologynurseadvisor.com)
  • Preparation of peripheral blood mononuclear cells. (aacrjournals.org)
  • Peripheral blood mononuclear cells (PBMCs) in RPMI 1640 containing 10% FCS (RPMI 1640/FCS) were prepared as previously described ( 6 ). (aacrjournals.org)
  • variants
  • All morphological variants are characterized by a variable proportion of large hallmark cells with eccentric horse-shoe or kidney-shaped nuclei, often with eosinophilic region near the nucleus (Figure 1 ). (hindawi.com)
  • The small and lympho-histiocytic variants display a marked variability of the neoplastic cell size that ranges from small to large. (hindawi.com)
  • All types can occur in unusual histologic variants and as mixed cell-type combinations. (wikipedia.org)
  • Disease
  • The presence of widespread adenopathy, the lack of empiric evidence of infection such as positive blood cultures, and a negative serologic evaluation for rheumatologic disease can often quickly exclude conditions that mimic lymphoma. (oncologynurseadvisor.com)
  • protein
  • There is a variant of diffuse large B cell lymphoma (DLBCL) that is CD20 negative and expresses EMA as well as the ALK protein. (oncologynurseadvisor.com)
  • The majority of cases are positive for the anaplastic large cell lymphoma (alk) protein. (icd10data.com)
  • The Cas family comprises other three members: NEDD9 (Neural precursor cell expressed, developmentally down-regulated 9, also called Human enhancer of filamentation 1, HEF-1 or Cas-L), EFS (Embryonal Fyn-associated substrate), and CASS4 (Cas scaffolding protein family member 4). (wikipedia.org)
  • These lymphomas show immunopositivity for ALK protein in 70% of cases. (wikipedia.org)
  • The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. (wikipedia.org)
  • In the cell nucleus, the protein MUC1 regulates the activity of transcription factor complexes that have a documented role in tumor-induced changes of host immunity. (wikipedia.org)
  • nuclei
  • These so-called "hallmark" cells have lobulated and indented nuclei. (icd10data.com)
  • they measure 20-60 μ m in diameter and display a large rim of cytoplasm and at least two nuclei with acidophilic or amphophilic nucleoli, covering more than 50% of the nuclear area (Figure 1 ). (hindawi.com)
  • patients
  • There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. (hindawi.com)
  • Grippingly, CD27 + /ALDH ++ B-cells, clonally related to lymph node HRS cells, were also detected in the blood of HL patients. (hindawi.com)
  • For this purpose, we retrospectively selected two groups of patients from the large B-cell NHL population treated at our medical center, long-term and short-term survivors, and compared immunohistochemically the expression of several Bcl-2 family proteins in the biopsy tissue. (aacrjournals.org)
  • apoptosis
  • Inhibition of apoptosis may be involved in the pathogenesis of cancer by prolonging cell life and facilitating retention of deleterious mutations. (biomedcentral.com)
  • Due to its ability to associate with multiple signaling partners, p130Cas/BCAR1 contributes to the regulation to a variety of signaling pathways leading to cell adhesion, migration, invasion, apoptosis, hypoxia and mechanical forces. (wikipedia.org)
  • It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. (wikipedia.org)
  • Association of MUC1 with p53 in cancer results in inhibition of p53-mediated apoptosis and promotion of p53-mediated cell cycle arrest. (wikipedia.org)
  • These changes affect the normal functions of the cell, including cell proliferation, programmed cell death (apoptosis) and DNA repair. (wikipedia.org)
  • Tissue
  • Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal and ectodermal germ layer during embryogenesis. (wikipedia.org)
  • proteins
  • Thus, the ratio of the antiapoptotic to the proapoptotic proteins determines whether a given cell will respond to or ignore an apoptotic stimulus. (aacrjournals.org)
  • glycosylation
  • The ability of chemotherapeutic drugs to access the cancer cells is inhibited by the heavy glycosylation in the extracellular domain of MUC1. (wikipedia.org)