Carcinoma heterogeneous tumors adenocarcinoma. Medical search. Frequent questions

EAC comprises a heterogeneous group of tumors of varying etiology and morphology ( 10 - 12 ). (iiarjournals.org)
Epithelial ovarian cancer comprises a heterogeneous group of tumors. (nih.gov)
Overview of Lymphoma Lymphomas are a heterogeneous group of tumors arising in the reticuloendothelial and lymphatic systems. (msdmanuals.com)

Accurate staging of tumor extent and involvement of surrounding tissue or distant metastases is critical to establishing a prognosis, and is usually guided by endoscopic ultrasound, computed tomography scans, and/or positron emission tomography scans to establish the extent of disease. (wikipedia.org)
Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
Clear cell renal carcinoma (CCRC) is a tumor with great metastatic capacity, although the presence of metastases in the thyroid gland is very uncommon. (scirp.org)
Sternal biopsy was compatible with metastases from clear cell renal carcinoma ( Figure 1 ). (scirp.org)
Lesions based on histology were classified as cortical adrenal hyperplasia ( n = 67), adenocarcinoma ( n = 17), pheochromocytoma ( n = 10), metastases ( n = 7), adrenal adenoma ( n = 4), and adrenalitis ( n = 4). (biomedcentral.com)
We report here a rare case of gastric carcinoma with multiple intramuscular metastases. (springeropen.com)
Pathological examination of an open muscle biopsy showed a poorly differentiated adenocarcinoma, supporting a diagnosis of gastric cancer metastases in multiple skeletal muscles. (springeropen.com)
Reported cases of skeletal muscle metastases from gastric carcinoma are extremely rare. (springeropen.com)
We report here a case of a patient with swelling in the thigh that was diagnosed as skeletal muscle metastases from gastric carcinoma. (springeropen.com)
An 85-year-old woman presented with epigastric discomfort and was clinically diagnosed with locally advanced unresectable carcinoma of the gallbladder associated with liver metastases. (hindawi.com)
Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment? (nature.com)
Renal metastases are usually discovered during evaluation of the primary tumor or incidentally during abdominal imaging. (msdmanuals.com)

In pediatric solid tumors and brain tumors, PLK1 inhibition leads to apoptosis in vitro and in tumor xenografts. (childrenscolorado.org)
Previous studies have shown a relationship between monocyte count and prognosis in some solid tumors. (researchsquare.com)
1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)

By contrast, oxygenated tumor cells have been thought to primarily use glucose for oxidative energy production. (jci.org)
Although lactate is generally considered a waste product, we now show that it is a prominent substrate that fuels the oxidative metabolism of oxygenated tumor cells. (jci.org)
A similar switch from lactate-fueled respiration to glycolysis by oxygenated tumor cells in both a mouse model of lung carcinoma and xenotransplanted human colorectal adenocarcinoma cells was observed after administration of CHC. (jci.org)

Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
Cancer research has been conducted using cultured cells as part of drug discovery testing, but conventional two-dimensional culture methods are unable to reflect the complex tumor microenvironment. (medsci.org)
However, the cellular environment under 2D culture is very different and often a poor reflection of the complex tumor microenvironment (TME) in vivo [ 1 ]. (medsci.org)
Pancreatic cancer spatial transcriptomics The lethality and treatment-refractory nature of pancreatic cancer are largely mediated by collaborative interactions between cancer cells and other cell types in the tumor microenvironment, including cancer-associated fibroblasts and immune cells. (harvard.edu)
Previous studies unraveled that extracellular adenosine concentration was elevated in the tumor microenvironment [ 8 ]. (biomedcentral.com)
Recently, CD73-adensine was found to be a significant pathway involved in the formation of immunosuppressive microenvironment in distinct tumors [ 3 ]. (biomedcentral.com)
It is considered that the proportional distribution of cells in peripheral blood count may reflect the severity of inflammation in the tumor microenvironment. (researchsquare.com)
The tumor microenvironment typically consists of host components including chronic inflammatory cells, stromal cells, growing vascular cells, and inflammatory infiltrate. (researchsquare.com)
Tumor-associated macrophages (TAMs) are a well-known component of the inflammatory infiltrate in the tumor microenvironment, originating from monocytes. (researchsquare.com)
However, the tumour may evade immune responses through regulatory T-cell-mediated immune suppression in the tumour microenvironment, defective antigen presentation, and production of immunosuppressive cytokines (5). (cambridgemedicine.org)

Renal Cell Carcinoma (RCC) Classification - ccRCC, pRCC, and chRCC using New miRNA Biomarker Pane Ready-to-Use fully optimized SSNA miRNA In Situ Hybridization (ISH) Kit Renal cell carcinoma (RCC) consists of an array of morphologically and genetically distinct. (biogenex.com)
Clear cell type renal cell carcinoma is a malignant tumor that can metastasize to many locations, but unusually spreads to thyroid. (scirp.org)
We expose the case of a patient with clear cell type renal cell carcinoma, with a previously known bone metastasis of renal origin and symptomatic goiter containing a nodule that was found to be a metastasic lesion. (scirp.org)
We expose the case of a patient with clear cell type renal cell carcinoma, thyroid metastasis with a previously known bone metastasis of renal origin and large goiter with compressive symptoms. (scirp.org)
Renal Cell Carcinoma Renal cell carcinoma (RCC) is the most common renal cancer. (msdmanuals.com)
The relationship between blood pressure and risk of renal cell carcinoma. (who.int)
Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)

We identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism. (jci.org)

However, the vast majority of malignant ovarian tumors (80%-85%) are classified as epithelial tumors (carcinomas). (biomedcentral.com)

These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. (biomedcentral.com)
We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). (biomedcentral.com)
According to the 2014 World Health Organization (WHO) classification and tumor morphology, primary ovarian tumors are subdivided into three categories: epithelial (60%), germ cell (30%), and sex-cord stromal tumors (8%)[ 1 ]. (biomedcentral.com)
Ovarian epithelial tumors are subclassified into several categories based on two criteria: 1) the degree of epithelial proliferation and invasion and 2) the histotype of the epithelium composing the tumor. (biomedcentral.com)
Benign epithelial tumors (adenoma and cystadenoma) are characterized by the absence of cell proliferation and invasion. (biomedcentral.com)
These tumors represent 60% of all epithelial tumors. (biomedcentral.com)
They represent 30% of all epithelial tumors and 80%-85% of all ovarian cancers. (biomedcentral.com)
Genital warts, which are a form of benign tumor of epithelial cells, are also caused by various strains of HPV. (wikipedia.org)
By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
Tumor formation and progression in these mice can be divided into four stages: hyperplasia, adenoma/mammary intra-epithelial neoplasia, early carcinoma, and late carcinoma [ 4 ] (we refer to all these four stages as tumor in this study). (biomedcentral.com)
The tumor is composed of two cellular components: Epithelial and mesenchymal. (cytojournal.com)

mucinous and Brenner malignant tumors potentially develop from the Walthard nests. (biomedcentral.com)
P =0.04) and more likely to have mucinous adenocarcinomas ( P= 0.003), and tended to survive longer ( P =0.11) than those with sporadic cases. (oncotarget.com)
The 5-year DFS per tumor origin was: 96% for perforated low grade appendiceal mucinous neoplasm (LAMN II) and 68.1% for colon origin. (unav.edu)

Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
On the other hand, the unfavorable subset (majority of patients) includes patients with adenocarcinoma metastasis to the liver or other organs, poorly differentiated carcinoma and squamous cell carcinoma of the abdominal cavity ( 1 ). (spandidos-publications.com)

Cervical carcinoma is the fourth-most frequently diagnosed carcinoma and fourth-leading cause of carcinoma-related mortality in women worldwide ( 1 - 6 ). (iiarjournals.org)
Cytology-based cervical screening has decreased the incidence and associated mortality rate of cervical carcinoma ( 7 ). (iiarjournals.org)
Despite the declining incidence of cervical carcinoma, the proportion of adenocarcinomas arising from the uterine cervix has risen steadily ( 8 , 9 ). (iiarjournals.org)
Endocervical adenocarcinoma (EAC) accounts for 20-25% of all cervical carcinomas ( 7 ). (iiarjournals.org)
During cervical carcinogenesis, T-helper (Th)-17 cells accumulate in the peripheral blood and tumor tissues of cancer patients. (bvsalud.org)
The former includes adenocarcinoma of the axillary lymph nodes, papillary serous carcinoma of the peritoneum (redefined as peritoneal cancer), squamous cell carcinoma of the cervical lymph nodes and extragonadal germ cell tumors in young men, which are derived from the middle of the body ( 4 ). (spandidos-publications.com)
Intraoperatively, a large cervical tumor was observed with greater size of the right lobe, measuring approximately 12 × 10 cm and moving the trachea to the left. (scirp.org)
About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. (wikipedia.org)
Here, we describe the case of a mid-octogenarian who presented with severe pain and nonambulatory quadriparesis attributable to MESCC at the fifth cervical vertebra, which developed 10 months after the diagnosis of undifferentiated carcinoma of the gallbladder. (hindawi.com)

Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% of all lung cancer cases. (aging-us.com)
Lung adenocarcinoma (LUAD) is the most common histological type of lung cancer and has the highest cancer mortality rate worldwide [ 1 ]. (aging-us.com)
However, the underlying functions of STARDs in lung adenocarcinoma (LUAD) have not been clarified yet. (medsci.org)
Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
TGF-β signaling activated by cancer-associated fibroblasts determines the histological signature of lung adenocarcinoma. (go.jp)
[ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)

Pathological diagnosis based on a biopsy sample of the para‑aortic lymph nodes indicated that the tumor was a high‑grade serous carcinoma of possible gynecological organ origin. (spandidos-publications.com)
A meticulous patient history taking, MMR protein immunolabeling, and germline MMR gene mutational analysis are important for the diagnosis of Lynch syndrome-related small-intestinal adenocarcinomas. (oncotarget.com)
The tumor was completely resected, the pathological diagnosis being adenocarcinoma, and small clump of cancer cells having been found in the muscularis propria (pathological stage T2N0M0 (AJCC classification), pathological effect grade 2) (Fig. 2 ). (springeropen.com)
Our differential diagnosis included myositis, tubercular muscle abscess, primary soft-tissue sarcoma, and metastatic carcinoma. (springeropen.com)
The histopathological diagnosis was undifferentiated carcinoma. (hindawi.com)

the highest expression levels were associated with moderately or poorly differentiated tumors (p=0.011). (jcancer.org)

This retarded tumor growth, as the hypoxic/glycolytic tumor cells died from glucose starvation, and rendered the remaining cells sensitive to irradiation. (jci.org)

Treatment options for adenocarcinomas involving the oesophagogastric junction are limited and the overall prognosis is extremely poor, with a five-year survival rate of approximately 30% with surgery alone. (wikipedia.org)
Significant parameters used in the determination of the prognosis and survival of esophageal cancer include tumor stage, surgical margin, and metastatic lymph node status. (researchsquare.com)
Accumulating evidence shows that in addition to the characteristics of the tumor, the immune response of the patient is also highly important for determining the prognosis. (researchsquare.com)
Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)

Cancer of unknown primary (CUP) is a heterogeneous syndrome of metastatic cancers in which the primary site cannot be determined after a standard and comprehensive search, and accounts for 1-5% of all newly diagnosed malignancies ( 1 , 2 ). (spandidos-publications.com)
Most cancers are genetically complex and heterogeneous, a serious obstacle to identifying specific genes underlying the disease. (mcw.edu)
Approximately 80-90% of newly diagnosed lung cancers are classified as NSCLC, primarily consisting of adenocarcinoma, squamous cell carcinoma, or large cell carcinoma histologies. (frontiersin.org)
Colorectal cancers are one of the most prevalent tumour types worldwide and, despite the emergence of targeted and biologic therapies, have among the highest mortality rates. (researchgate.net)
Molecular imaging with whole‐body positron emission tomography (PET)/CT or PET/MRI utilizes metabolic and receptor‐based strategies for tumor detection in staging and restaging various cancers. (radiologykey.com)

The diagnostic workup for OGJ adenocarcinoma usually involves performing an endoscopy with endoscopic biopsy of suspicious looking tissue. (wikipedia.org)
Radiation technology focuses on delivering the radiation as precisely as possible to the tumor, nonetheless both acute and long-term damage to surrounding normal tissue may develop. (biomedcentral.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Wilms Tumor Protein (WT1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Wilms Tumor Protein (WT1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
Compared to normal colon tissue, primary tumors were associated with increased expression of ALDH1B1 (p=0.008). (jcancer.org)
H-E staining showed tumor tissue-like structures specific to each cell line. (medsci.org)
In the future, it may become possible to produce tumor spheroids from tissue samples of oral cancer patients, and then apply them to drug screening and to develop individualized diagnostic and treatment methods. (medsci.org)
Therefore, it is difficult to propose that 2D culture accurately reflects the original growth state of tumor tissue. (medsci.org)
Ultrasonographic image of a heterogenous soft tissue mass (arrows) with a pocket of anechoic fluid (arrowheads) in the caudal abdomen of a doe, bordered cranially by peritoneal fluid (asterisk). (avma.org)
however, the presence of large rhabdoid cells and tissue fragments of round to oval hyperchromatic nuclei with scant cytoplasm cells excluded adenocarcinoma. (cytojournal.com)
To identify operable lung cancer patients with risk for metastatic relapse we search for new prognostic biomarkers based on analysis of genome-wide gene expression data and conventional protein marker validation based on analysis of primary tumor tissue. (lu.se)
In the past 5 years, there has been an explosion of breast cancer research on circulating tumor DNA (ctDNA), fueled by the idea that ctDNA may provide a liquid biopsy alternative to tissue biopsies. (medscape.com)
In addition, clinicians now recognize that tumors can be heterogeneous and that a single tissue biopsy may not be representative of all of the changes within a tumor. (medscape.com)

The classification system establishes guidelines for surgical approaches to tumor resection. (wikipedia.org)
In 2011 he underwent a laparoscopic rectum resection due to colorectal adenocarcinoma (pT3, N0, M0). (scirp.org)
All patients underwent curative resection of pancreatic adenocarcinoma without evidence of intraperitoneal disease. (cancernetwork.com)
Reports on laparoscopic total mesorectum excision (TME) for cancer are often retrospective and contain heterogeneous patients who had several types of resection (i.e., anterior resection, low anterior resection, all or partially laparoscopic). (sages.org)

Analysis of ultrasonographic predictive parameters showed a significant association between lesion size and malignant tumors. (biomedcentral.com)

Hepatocellular carcinoma (HCC) typically arises in fibrotic or cirrhotic livers, which are characterized by pathogenic angiogenesis. (cancerindex.org)

Gallium‐68 ( 68 Ga)‐1,4,7,10‐tetraazacyclo‐dodecane‐1,4,7,10‐tetraacetic acid DOTA‐peptides highlight neuroendocrine tumors ( NETs ) through binding the somatostatin receptors that are overexpressed on the surfaces of their cells. (radiologykey.com)
Pancreatic neuroendocrine tumors may be functional or nonfunctional. (medscape.com)
Overall, the age-adjusted incidence of neuroendocrine tumors increased sixfold from 1973 (1.09 per 100,000) to 2012 ((6.98 per 100,000), possibly because of increased early detection. (medscape.com)

The patient had received EF5 before tumor biopsy. (jci.org)
The biopsy showed nests of infiltrating tumor cells with frequent atypical mitoses, hyperchromasia, occasionally prominent nucleoli, scant eosinophilic cytoplasm and no distinct cell borders. (pathologyoutlines.com)

Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. (biomedcentral.com)
Adrenal gland lesions (nodules and masses) commonly develop in older dogs, but surgery is indicated in only a small fraction of such cases, usually in malignant and hormone-secreting tumors [ 13 ]. (biomedcentral.com)
While ultrasonography is an effective method for localizing adrenal lesions, standardized ultrasound criteria to distinguish benign from malignant lesions or functional cortisol-secreting from non-functional tumors are lacking [ 12 ]. (biomedcentral.com)
In a widely used mouse model of breast cancer, mammary gland-specific expression of the polyoma middle T (PyMT) oncoprotein under the control of the MMTV promoter/enhancer in transgenic mice (MMTV-PyMT) results in widespread transformation of the mammary epithelium and subsequent development of multifocal mammary adenocarcinomas and metastatic lesions in the lymph nodes and in the lungs [ 2 ]. (biomedcentral.com)

Oesophagogastric junctional adenocarcinoma (OGJ adenocarcinoma) is a cancer of the lower part of the oesophagus with a rising incidence in Western countries. (wikipedia.org)
The incidence of OGJ adenocarcinoma is rising rapidly in Western countries especially in recent decades, in contrast to the declining frequency of distal gastric adenocarcinoma. (wikipedia.org)
To define the incidence and characteristics of Lynch syndrome-related small-intestinal adenocarcinomas, meticulous familial and clinical histories were obtained from 195 patients with small-intestinal adenocarcinoma, and MMR protein immunohistochemistry, microsatellite instability, MLH1 methylation, and germline mutational analyses were performed. (oncotarget.com)

The pleomorphic adenoma (PA) is the most common tumor affection the salivary glands 7,8 , accounting for 33.2% to 89.9% of the cases, followed by carcinomas. (bvsalud.org)

The therapeutic decision considers clinical and functional status, the extent of primary and metastatic disease, radiological study, tumor histopathology, and biological behavior. (surgicalneurologyint.com)

Background/Aim: Gastric-type endocervical adenocarcinoma (GEA) is a rare but distinct histological type of gynecological malignancy. (iiarjournals.org)
In 1879, Harting and Hesse (1879) described autopsy findings that documented pulmonary malignancy in miners in that region and by early in the 20th century the malignancy was shown to be primary carcinoma of the lung (Arnstein 1913). (nationalacademies.org)
Breast cancer is the most common malignancy in women and a heterogeneous disease at the molecular level. (lu.se)

Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)

Approximately 75%-80% of ovarian tumors are benign, occurring in patients under 40 years of age. (biomedcentral.com)
The 5 year disease-free survival (DFS) per tumor origin was: 94% for PMP-LG, 85% for PMP-HG, 100% for benign multicyst peritoneal mesothelioma (MPM), 37.4% for colonic origin, and 54%(at 3 years) for ovarian origin. (unav.edu)

Immunohistochemistry suggested adenocarcinoma and possible breast or primary gynecologic tumor. (surgicalneurologyint.com)

Metabolic reprogramming plays an important role in tumor progression and antitumor immunity. (medsci.org)

Due to the high mortality rate of esophageal cancer, exploration of new prognostic biomarkers for this tumor is of paramount importance. (researchsquare.com)

Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
iii) to accelerate the conversion of anti-tumor type 1 macrophages into pro-tumor type 2 macrophages [ 9 ]. (biomedcentral.com)

Recent studies revealed that CD73 plays a pivotal role in tumor escape from immune surveillance. (biomedcentral.com)
TAMs are known to play an important role in tumor angiogenesis and growth. (researchsquare.com)

Ovarian tumors account for a considerable proportion of clinically relevant neoplasms in females, exhibiting a wide range of age at presentation (from infant to elderly patients). (biomedcentral.com)
These tumors are primarily found in elderly patients with a median age of 60 years. (biomedcentral.com)
Small-intestinal adenocarcinomas were the first clinical manifestation in 37% (3/8) of Lynch syndrome patients, and second malignancies developed within 5 years in 63% (5/8). (oncotarget.com)
Between November 2000 and July 2008, 104 unselected patients had laparoscopic TME for rectal adenocarcinoma. (sages.org)
Patients with locally advanced rectal carcinoma (uN+/uT4) occasionally underwent preoperative radiation or chemoradiation. (sages.org)
Methods Retrospective single center cohort study of patients who underwent pancreaticoduodenectomy over the past 10 years for carcinoma obstructing the lower common bile duct. (thieme-connect.de)
Results Sixty-two patients underwent biliary stenting alone, 5 patients underwent both biliary and pancreatic stenting, and 237 patients were not stented in the adenocarcinoma group without chronic pancreatitis. (thieme-connect.de)
Patients undergoing yttrium‐90 ( 90 Y)‐microspheres therapy for hepatic tumors must first be evaluated with liver imaging using arterially infused 99m Tc‐ macroaggregated albumin ( MAA ) as part of the planning process for a safe and effective procedure. (radiologykey.com)
Genetic counselling referral practices for patients with pancreatic adenocarcinoma: A French retrospective multicentre observational cohort study (CAPANCOGEN). (cdc.gov)
Patients with deleterious germline mutations: A heterogeneous population for pancreatic cancer screening? (cdc.gov)
Changes in levels of circulating tumor DNA very closely followed treatment responses in these patients, and tracking levels of ctDNA may provide us with an early indicator of treatment resistance," said Dawson. (medscape.com)

Head and neck cancer (HNC) is a heterogeneous group of neoplasms that share a common anatomic origin. (biomedcentral.com)
20 mm in diameter were histologically confirmed as malignant neoplasms (pheochromocytoma and adenocarcinoma). (biomedcentral.com)
Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)

Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)

Pancreatic Cancer Pancreatic cancer, primarily ductal adenocarcinoma, accounts for an estimated 64,050 cases and 50,550 deaths in the United States annually ( 1). (msdmanuals.com)
Prevalence and Risk Factors of Germline Pathogenic Variants in Pancreatic Ductal Adenocarcinoma. (cdc.gov)

See also Pancreatic Adenocarcinoma Imaging: What You Need to Know , a Critical Images slideshow, to help identify which imaging studies to use to identify and evaluate this disease. (medscape.com)

Oien] Unfortunately in 20-50% of CUP cases the primary tumor is never found. (biogenex.com)
As MCT1 was found to be expressed by an array of primary human tumors, we suggest that MCT1 inhibition has clinical antitumor potential. (jci.org)
MCT1 is expressed in a variety of different human tumor cell lines and primary human tumor biopsies. (jci.org)
Heterogeneous tumor-immune microenvironments between primary and metastatic carcinoid tumors differentially respond to anti-PD-L1 antibody therapy. (go.jp)
Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma. (go.jp)
Cancer of unknown primary (CUP) is a heterogeneous syndrome of metastatic cancer in which the primary site cannot be determined even after a standard and comprehensive search. (spandidos-publications.com)
While the standard workup did not identify the primary tumor, genomic profiling analysis was useful in therapeutic management. (spandidos-publications.com)
Although there were no primary sites in the gynecological organs, marked lymphovascular invasion was found around the left ovary, suggesting a left ovary‑derived tumor. (spandidos-publications.com)
Renal cell carcinomas (RCCs) cause for 80 to 85 percent of all primary renal neoplasm. (scirp.org)
Based on pathological report demonstrating that the primary tumor was HER2-positive, the patient was commenced on chemotherapy with trastuzumab. (springeropen.com)
Treatment is systemic therapy for the primary tumor and, rarely, surgery. (msdmanuals.com)
Evidence has shown that endoscopic ultrasonography (EUS) can be used to accurately diagnose and localize primary endocrine tumors of the pancreas, especially insulinomas and gastrinomas. (medscape.com)
By analysis of patient specific alterations in circulating tumor DNA in blood samples we aim to establish blood-based assays for early detection of lung cancer, treatment monitoring, and early detection of relapse in the primary and advanced setting. (lu.se)

There is no standardized system for the classification of OGJ adenocarcinoma. (wikipedia.org)
The Siewart classification system is a classification scheme used for OGJ adenocarcinomas that has been adopted by many clinicians. (wikipedia.org)
Since the 2014 World Health Organization (WHO) Classification of Tumors of Female Reproductive Organs ( 13 ) did not fully reflect the current understanding of diverse mechanisms underlying endocervical glandular carcinogenesis, a novel classification system was proposed to provide an updated framework for EAC classification. (iiarjournals.org)
The International Endocervical Adenocarcinoma Criteria and Classification (IECC) reliably segregated EACs into human papillomavirus (HPV)-related and HPV-unrelated tumors according to the presence or absence of HPV infection-related morphology (apical mitotic figures and basal apoptotic bodies), which is easily identifiable under scanning magnification ( 12 ). (iiarjournals.org)
With the adoption of the 2018 IECC, the updated 2020 WHO Classification of Female Genital Tumors ( 14 ) designated these tumors as HPV-associated (HPVA) and HPV-independent (HPVI) EACs. (iiarjournals.org)
Stage III lung cancer, though heterogeneous in its classification, includes non-metastatic but locally advanced disease with involvement of N1-N3 nodal stations and/or T3 and T4 primaries. (frontiersin.org)
Figure 1: Classification of the different mechanisms of tumour vascularization. (nature.com)

A and B ) MCT1 was detected by western blot ( A ) and confocal microscopy ( B ) in human tumor cell lines and control tissues. (jci.org)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)

Monocyte, an element of the immune system, is a heterogeneous cell showing different responses to different stimuli. (researchsquare.com)
In 1959, Lewis Thomas suggested that the human immune system can recognise tumour-specific antigens on the surface of newly developing tumour cells as 'foreign' and eliminate them (3). (cambridgemedicine.org)
Following this, in 1971, Sir Frank Mac Farlane Burnet hypothesised that tumour cell antigens induced immunological reaction against cancer and postulated the "immune surveillance theory" (4). (cambridgemedicine.org)
The immune system interacts closely with tumour cells via complex mechanisms and can result in either eradication of the tumour or immune evasion by the tumour (5). (cambridgemedicine.org)
Consequently, immune cells fail to recognise and kill tumour cells. (cambridgemedicine.org)

At follow-up, 2 years after surgery, concentrations of the tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) had increased. (springeropen.com)
Chimeric antigen receptor (CAR) T-cell therapy is a novel therapeutic T-cell engineering option, where T-cells obtained from a patient's blood are engineered ex vivo to express specific tumour antigen receptors. (cambridgemedicine.org)
In a recent study, researchers compared radiographic imaging of tumors with an assay of ctDNA, cancer antigen 15-3 ( CA 15-3 ), and circulating tumor cells in 30 women with MBC who were receiving systemic therapy. (medscape.com)

Siewart described three different categories of OGJ adenocarcinoma, all based upon anatomic location: A Type I tumor, located between 5 and 1cm proximal to the OGJ, is an adenocarcinoma that typically arises from an area of intestinal metaplasia of the esophagus and can infiltrate the OGJ from above. (wikipedia.org)
Low-grade tumors may recur and infiltrate adjacent structures. (medscape.com)

Additionally, genetic analysis of the tumor may yield mutations that may be clinically significant, as described below. (wikipedia.org)
Genetic testing revealed a high loss of heterozygosity score and high tumor mutational burden (TMB). (spandidos-publications.com)
Genetic analysis of susceptibility to endometrial adenocarcinoma in the BDII rat model. (mcw.edu)
Furthermore, it seems clear from the interstrain crosses not only that the onset of tumors depends on the presence of susceptibility alleles from the EAC-prone BDII strain, but also that tumor development is affected by the contribution of a genetic component derived from the nonsusceptible strains. (mcw.edu)

Conclusion: GEA can be identified cytologically based on the presence of flat, honeycomb-like sheets of tumor cells possessing vesicular nuclei, prominent nucleoli, and abundant vacuolated cytoplasm. (iiarjournals.org)
Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradient that mirrors the oxygen gradient in the tumor. (jci.org)
There is therefore a symbiosis in which glycolytic and oxidative tumor cells mutually regulate their access to energy metabolites. (jci.org)
Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer. (go.jp)
The novel PLK1 inhibitor, onvansertib, is the first available for oral administration and has shown tumor growth inhibition in hematologic tumors, osteosarcoma, ovarian carcinoma, breast cancer and colon adenocarcinoma cells. (childrenscolorado.org)
Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. (jcancer.org)
A cell line derived from cultured tumor cells. (lookformedical.com)
However, as it turned out afterwards, cancer cells in the recurrent tumor were negative for HER2. (springeropen.com)
CAR T-cells are T-cells that have been engineered to express receptors that specifically target tumour-associated antigens (8). (cambridgemedicine.org)
The second-generation CAR T-cells consist of one additional co-stimulatory component (mainly CD28, CD137 or CD134) in the intracellular domain, which amplifies anti-tumour responses in vivo (8). (cambridgemedicine.org)
Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. (nature.com)
Squamous cell carcinoma (SCC) was excluded since the spindle cells that are present in this case look different from pleomorphic cells such as "tadpole" and "fiber" cells that are seen particularly in keratinizing type of SCC. (cytojournal.com)
Histopathological examination of the tumor mass revealed an admixture of spindle cells and epithelioid cells. (cytojournal.com)
[ 4 ] CA 15-3 levels and numbers of circulating tumor cells were measured at identical time points. (medscape.com)
ctDNA was successfully detected in 97% women in whom somatic genomic alterations were identified, and CA 15-3 and circulating tumor cells were detected in 78% and 87%, respectively. (medscape.com)
ctDNA levels showed a greater dynamic range, and greater correlation with changes in tumor burden, than did CA 15-3 or circulating tumor cells. (medscape.com)

Although the tumor was considered to have been fully resected and had not spread to any nodes, the patient died of recurrent cancer within 1 year. (medscape.com)
This patient was treated with image-guided 3DCRT (IG-3DCRT) alone using a FIF technique and a unique hypofractionated dose fractionation scheme, which resulted in good tumor control and sufficient cord decompression, which in turn allowed a delayed but gradual improvement in her severe neurological dysfunction. (hindawi.com)
Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)

Serous carcinomas are thought to be derived from the fallopian tubes through foci of endosalpingiosis, which are inclusion cysts from the tubal epithelium at the ovarian and peritoneal surface. (biomedcentral.com)

1 nM IC 50 ) to inhibition of two cell cycle-regulating proteins, polo-like kinase 1 and Aurora kinase A. Finally, we show that two of these cell lines, CUTO32 and CUTO42, successfully establish xenografted tumors in nude mice. (nih.gov)

However, as explained below, recent morphologic findings and molecular analyses have demonstrated that each morphologic subtype of ovarian carcinoma might be derived from a Müllerian-type epithelium. (biomedcentral.com)
In this paper, we propose a method, CSPRV, to improve the cancer subtype prediction by incorporating multi-sources transcriptome expression data and heterogeneous biological networks. (biomedcentral.com)

They may manifest as sporadic tumors or as part of certain syndromes, including multiple endocrine neoplasia type 1 (MEN 1) and von Hippel-Lindau (VHL) disease. (medscape.com)

The distinction among these various tumors is important both clinically and epidemiologically. (medscape.com)

Borderline tumors are characterized by cell proliferation and a minor degree of nuclear atypia without stromal invasion. (biomedcentral.com)
Carcinomas are characterized by cell proliferation, nuclear atypia, and stromal invasion. (biomedcentral.com)

The clinical features of OGJ adenocarcinoma are variable depending on the extent of the tumor. (wikipedia.org)
Notably, up to one third of OGJ adenocarcinomas have been found to have human epidermal growth factor receptor 2 (HER2) overexpression or amplification, which may be targetable with trastuzumab, conferring a modest survival benefit based on initial clinical trials. (wikipedia.org)
In this pre-clinical study led by Rajeev Vibhakar, MD , investigators from multiple departments at Children's Hospital Colorado, including the Morgan Adams Foundation Pediatric Brain Tumor Research Program and the Neuro-Oncology Program for Children with Central Nervous System Tumors , sought to determine the effects of onvansertib on MYC-driven medulloblastoma as a monotherapy or in combination with radiation. (childrenscolorado.org)
Spheroids made from oral cancer cell lines appeared to have tumor-like characteristics that may reflect their clinical significance. (medsci.org)
Although nonfunctional islet cell tumors are not uncommon at autopsy, most islet cell tumors with clinical manifestations are functional. (medscape.com)
Functioning tumors produce a clinical syndrome as a result of excessive hormone production. (medscape.com)
Clinical features of the syndrome depend on tumor cell type. (medscape.com)
[ 5 ] The researchers characterized genomic architecture and inferred the clonal evolution using eight tumor biopsies and nine plasma samples collected over 1193 days of clinical follow-up using exome and targeted amplicon sequencing. (medscape.com)

Gallbladder tumors are recognized with increasing frequency, as a consequence of improvements in imaging techniques and increased utilization of these studies. (medscape.com)
It is possible to cure gallbladder cancer when tumors are treated surgically at an early stage. (medscape.com)
Here, we describe the case of a mid-octogenarian who presented with severe pain and nonambulatory tetraparesis attributable to acute MESCC from gallbladder carcinoma. (hindawi.com)

Anatomy14

Organisms6

Diseases111

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Phenomena and Processes32

Disciplines and Occupations1

Information Science4

Health Care14

Group of tumors3

Metastases12

Solid tumors3

Oxygenated tumor cells3

Microenvironment10

Renal Cell Carc9

Squamous carcinoma1

Classified as epithelial1

Epithelial11

Mucinous3

Metastasis3

Cervical9

Lung adenocarcinoma6

Diagnosis5

Poorly differentiated1

Retarded tumor growth1

Prognosis4

Cancers5

Tissue13

Resection4

Malignant tumors1

Hepatocellular carcinoma1

Neuroendocrine tumors3

Biopsy2

Lesions4

Incidence3

Salivary glands1

Metastatic disease1

Malignancy3

Comprises1

Benign2

Immunohistochemistry1

Progression1

Biomarkers1

Macrophages2

Role in tumor2

Patients11

Neoplasms3

Lymph nodes2

Ductal adenocarcinoma2

Pancreatic adenocarcinoma1

Primary13

Classification7

Tissues2

Immune5

Antigen3

Infiltrate2

Genetic4

Cells16

Patient3

Serous1

Inhibition1

Subtype2

Sporadic1

Clinically1

Cell proliferation2

Clinical8

Gallbladder3