• Renal Cell Carc
  • It is now known that this classic triad of symptoms only occurs in 10-15% of cases, and is usually indicative that the renal cell carcinoma (RCC) is in an advanced stage. (wikipedia.org)
  • cortex
  • The adrenal cortex is composed of three distinct layers of endocrine cells which produce critical steroid hormones. (wikipedia.org)
  • Hyperplasia or neoplasia of the adrenal cortex produces aldosterone excess (aldosteronism), hypercortisolism (Cushing's syndrome), virilism (adreno-genital syndrome), or a mixture of these, according to whether the cells that produce mineralocorticoids, glucocorticoids, or sex hormones, respectively, are in relative excess. (springer.com)
  • lesions
  • For lymphoid neoplasms, e.g. lymphoma and leukemia, clonality is proven by the amplification of a single rearrangement of their immunoglobulin gene (for B cell lesions) or T cell receptor gene (for T cell lesions). (wikipedia.org)
  • The core hypothesis tested is that SBRT after 4 cycles of first-line chemotherapy is feasible, safe, provides durable local control of treated lesions and improves time to progression compared to historical controls. (clinicaltrials.gov)
  • Familial
  • Other genetically linked conditions also increase the risk of RCC, including hereditary papillary renal carcinoma, hereditary leiomyomatosis, Birt-Hogg-Dube syndrome, hyperparathyroidism-jaw tumor syndrome, familial papillary thyroid carcinoma, von Hippel-Lindau disease and sickle cell disease. (wikipedia.org)
  • pancreas
  • Breast cysts (as occur commonly during pregnancy and at other times) are another example, as are other encapsulated glandular swellings (thyroid, adrenal gland, pancreas). (wikipedia.org)
  • Only 1 or 2% of clinically significant pancreas neoplasms are PanNETs. (wikipedia.org)
  • commonly
  • Neoplasm is an abnormal growth of tissue which, if it forms a mass, is commonly referred to as a tumor. (wikipedia.org)
  • The various kinds of cells that can give rise to NETs are present in endocrine glands and are also diffusely distributed throughout the body, most commonly Kulchitsky cells or similar enterochromaffin-like cells, that are relatively more common in the gastrointestinal and pulmonary systems. (wikipedia.org)
  • disease
  • Egdahl RH, Melby JC: Recurrent Cushing's disease and intermittent functional adrenal cortical insufficiency following subtotal adrenalectomy. (springer.com)
  • Symptoms that suggest the presence of metastatic disease include weight loss, bone pain and neurological symptoms (headaches, fainting, convulsions, or limb weakness). (wikipedia.org)
  • Treatment
  • Fracchia AA, Farrow JH, Miller TR, et al: Hypophysectomy as compared with adrenalectomy in the treatment of advanced carcinoma of the breast. (springer.com)
  • In well differentiated PanNETs, chemotherapy is generally reserved for when there are no other treatment options. (wikipedia.org)
  • rare
  • Like nearly all lung carcinomas, however, GCCs are exceedingly rare in very young people: in the US SEER program, only 2 cases were recorded to occur in persons younger than 30 years of age between 1983 and 1987. (wikipedia.org)
  • sympathetic
  • The adrenal medulla is located anatomically at the center of each adrenal gland, and is composed of neuroendocrine (chromaffin) cells which produce and release epinephrine (adrenaline) into the bloodstream in response to activation of the sympathetic nervous system. (wikipedia.org)