• occur
  • These conditions occur largely as a consequence of aging, but may also be the result of congenital (inborn) abnormalities or specific disease or physiologic processes including rheumatic heart disease and pregnancy. (wikipedia.org)
  • Irrespective of disease process, alterations to the valve occur that produce one or a combination of these conditions. (wikipedia.org)
  • They most commonly occur in the intestine, where they are often called carcinoid tumors, but they are also found in the pancreas, lung and the rest of the body. (wikipedia.org)
  • Clinical
  • Early recognition and surgical valve replacement before advanced heart failure is established may improve the clinical outcome. (pubfacts.com)
  • Transthoracic echocardiography confirmed the clinical suspicion of carcinoid heart disease. (amjmed.org)
  • Data regarding carcinoids and other NETs, such as poorly differentiated neuroendocrine carcinomas, may be combined in some epidemiologic and clinical studies, rendering separate consideration difficult. (cancer.gov)
  • He was a clinical and research fellow in peripheral vascular disease at the Evans Memorial Foundation for Clinical Research in Boston (1977-1978) and a fellow in cardiology at Boston City Hospital (1978-1980). (wikipedia.org)
  • Clinical investigation topics include congestive heart failure, Raynaud's disease and mitral valve disease. (wikipedia.org)
  • The agonist activity of pergolide at the D1 receptor somewhat alters its clinical and side effect profile in the treatment of Parkinson's disease. (wikipedia.org)
  • To date there have been no clinical trials to determine effective treatment for this disease. (wikipedia.org)
  • Poor correlation exists between 5-HIAA level and the clinical severity of the carcinoid syndrome. (wikipedia.org)
  • lesion
  • 18F-FDG PET/CT, which evaluate for increased metabolism of glucose, may also aid in localizing the carcinoid lesion or evaluating for metastases. (wikipedia.org)
  • urinary
  • Quantitation of urinary 5-HIAA is the best test for carcinoid, but scrupulous care must be taken that specimen collection and patient preparation have been correct. (wikipedia.org)
  • congestive heart f
  • The loss of the atrial kick due to atrial fibrillation ( i.e. blood cannot flow into the left ventricle thus accumulating in the left atrium ) can cause a precipitous decrease in cardiac output and sudden congestive heart failure. (wikipedia.org)
  • elsewhere in the body
  • The cause of this was unknown at the time, but eventually it was realised that all the implicated drugs acted as agonists at 5-HT2B receptors in the heart in addition to their intended sites of action elsewhere in the body. (wikipedia.org)
  • mitral
  • In some cases vegetations form on the mitral leaflets as a result of endocarditis, an inflammation of the heart tissue. (wikipedia.org)
  • Mitral insufficiency can be caused by dilation of the left heart, often a consequence of heart failure. (wikipedia.org)
  • In these cases the left ventricle of the heart becomes enlarged and causes displacement of the attached papillary muscles, which control the mitral valve. (wikipedia.org)
  • This disease typically involves the aortic and mitral valves. (wikipedia.org)
  • severity
  • This study is being done to determine whether or not new blood test(s) can determine the severity of heart conditions. (bioportfolio.com)