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  • NNAL
  • The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its reduction product in the body, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), are potent pulmonary carcinogens. (aacrjournals.org)
  • Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users. (semanticscholar.org)
  • smokers
  • Although differences in the production and concentrations of chemical compounds in mainstream and sidestream smoke exist, the carcinogens in mainstream smoke inhaled by active smokers are largely the same as those in SHS (a mixture of mainstream and sidestream smoke) to which both smokers and nonsmokers may be exposed. (aacrjournals.org)
  • cytochrome
  • He demonstrated that microsomal enzymes convert certain carcinogens to a form that tightly bound to DNA, and he then showed that those enzymes were of the cytochrome P-450 class. (wikipedia.org)
  • The enzyme epoxide hydrolase, then hydrates the epoxide ring to yield the vicinal diol (−)-benzo[a]pyrene-7,8-dihydrodiol, which is then oxidised by cytochrome P450 oxidase again forming the mutagen and carcinogen (+)-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide. (wikipedia.org)
  • hydrocarbons
  • Xenobiotics such as polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and trichloroethylene (TCE) accumulate in the environment due to their recalcitrant properties and have become an environmental concern due to their toxicity and accumulation. (wikipedia.org)
  • tumor
  • For example, the environmental contaminant arsenic is known to cause repression of tumor suppressor genes via methylation and to drive global DNA hypomethylation, a phenomenon frequently associated with cancer. (qiagen.com)
  • organism
  • The concept of primal prevention has been created much more recently, in relation to the new developments in molecular biology over the last fifty years, more particularly in epigenetics, which point to the paramount importance of environmental conditions - both physical and affective - on the organism during its fetal and newborn life (or so-called primal life). (wikipedia.org)
  • harmful
  • This process can be further altered to manipulate the metabolic pathways of microorganisms in order to degrade harmful xenobiotics under specific environmental conditions at a more desirable rate. (wikipedia.org)
  • shown
  • Acrylamide, used in medical laboratories was recently shown to be a carcinogen to the nervous system. (techmedexperts.com)
  • The anti stereoisomer (shown here) and its enantiomer are the ultimate carcinogens from benzo[a]pyrene, but the syn isomers are also produced. (wikipedia.org)
  • Health
  • Four years later, after an international race to find it, the gene was cloned in 1994 by scientists at University of Utah, National Institute of Environmental Health Sciences (NIEHS) and Myriad Genetics. (wikipedia.org)
  • smoke
  • His research at NCI centered on working out how the body metabolizes environmental carcinogens, such as one of the most common in our environment, benzopyrene, which occurs in tobacco smoke, auto exhaust, and other smoke-producing sources. (wikipedia.org)
  • identify
  • In Puerto Rico and throughout the Caribbean, Zimmetry Environmental provides air quality testing and industrial hygiene services to identify and mitigate respirable hazards in residential, commercial, industrial and institutional environments. (environmental-expert.com)
  • We will then study their application to identify the signature of mutational processes in the genome of mouse tumours following exposure to some carcinogens. (icas.xyz)
  • carry
  • Gelboin has left behind a number of former colleagues and trainees now working at laboratories around the world, many of whom have achieved leadership positions in the areas of drug and carcinogen metabolism and who continue to carry out his legacy of scientific inquiry. (wikipedia.org)
  • development
  • One of his publications, a paper on development of a widely used assay for a key enzyme in the metabolism of carcinogens, became an Institute for Scientific Exchange Citation Classic. (wikipedia.org)
  • As of 2015[update] Creager is researching the development of techniques for detecting environmental carcinogens and their regulation between 1960 and 1990. (wikipedia.org)