Carcinogenesis gastric acid secretion after helicobacter pylori eradication. Medical search. Frequent questions

Its helical shape (from which the genus name, helicobacter, derives) is thought to have evolved in order to penetrate the mucoid lining of the stomach and thereby establish infection. (wikipedia.org)
H. pylori infection usually has no symptoms but sometimes causes gastritis (stomach inflammation) or ulcers of the stomach or first part of the small intestine. (wikipedia.org)
In 2015, it was estimated that over 50% of the world's population had H. pylori in their upper gastrointestinal tracts with this infection (or colonization) being more common in developing countries. (wikipedia.org)
Individuals with chronic H. pylori infection have an increased risk of acquiring a cancer that is directly related to this infection. (wikipedia.org)
A digestive tract infection that can lead to ulcers ( Helicobacter pylori or H. pylori). (webmd.com)
We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 µg/mL is essential. (who.int)
Nous suggérons qu'un suivi attentif et un examen endoscopique régulier sont essentiels pour tous les patients atteints d'une infection à H. pylori persistante et présentant une concentration sérique de la E-cadhérine soluble supérieure à 5 µg/ml. (who.int)
The etiopathogenetic cascade currently available treatments, surgery to multiple endoscopic gastric mucosal of the infection leads to various errors in and radio-chemotherapy, is less than tissue biopsies. (who.int)
Dosing for H. pylori Infection (in Adults): Triple therapy: 1 gram amoxicillin, 500 mg clarithromycin, and 30 mg lansoprazole, all given twice daily (every 12 hours) for 14 days. (nih.gov)
Helicobacter pylori infection induces clinical symptoms in 15-20% of subjects, and the reason for this variation is still not clear. (archivesofmedicalscience.com)
The aim of the present study is to evaluate the expression of tryptophan hydroxylase (TpH-1) in gastric mucosa of patients with symptomatic and asymptomatic H. pylori infection in relation to the intensity of bacterial colonization and severity of dyspeptic symptoms. (archivesofmedicalscience.com)
Group I - healthy volunteers without H. pylori infection, group II - subjects with asymptomatic H. pylori infection, group III - H. pylori-infected patients with dyspeptic symptoms, mainly fasting and nocturnal epigastric pain. (archivesofmedicalscience.com)
To diagnose H. pylori infection the urea breath test (UBT-13C) and histological analysis were performed. (archivesofmedicalscience.com)
Helicobacter pylori infection is still an important worldwide medical problem. (archivesofmedicalscience.com)
Another issue is to explain why H. pylori infection induces clinical symptoms in only 15-20% of subjects. (archivesofmedicalscience.com)
It was believed to depend on the virulence of H. pylori strains, but in many studies conducted in patients with symptomatic and asymptomatic infection, there were no significant differences in the prevalence of virulent CagA and VacA strains [ 23 - 28 ], although there is still a search for them [ 29 , 30 ]. (archivesofmedicalscience.com)
Helicobacter pylori infection is the principal cause of peptic ulcer disease, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. (biomedcentral.com)
This review summarizes the results of the most relevant studies on the extra-gastroduodenal manifestations of H. pylori infection. (biomedcentral.com)
Indeed, H. pylori infection is a very good model for studying host-bacterial interactions and very attractive for those interested in the role of gut microbiota in health and diseases. (biomedcentral.com)
Here, we summarize the results of the most relevant studies on the extragastroduodenal manifestations of H. pylori infection. (biomedcentral.com)
The link between Iron deficiency anemia (IDA) and H. pylori infection was reported firstly in 1991 by Blecker et al. (biomedcentral.com)
conducted a meta-analysis of 15 case-control studies to investigate the relation between H. pylori infection and IDA [ 19 ]. (biomedcentral.com)
H. pylori infection was diagnosed by endoscopy and histological examination in five studies, in which patients with peptic ulcer disease and gastric cancer were not included. (biomedcentral.com)
The other 10 studies confirmed H. pylori infection by serology or urea breath test. (biomedcentral.com)
The data showed an increased risk of IDA in patients with H. pylori infection with an odds ratio (OR) of 2.2 (95% confidence interval [CI]:1.5-3.2) [ 19 ]. (biomedcentral.com)
In this work, the diagnosis of H. pylori infection was based on rapid urease test or histology in eight studies, in which patients with peptic ulcer disease were excluded. (biomedcentral.com)
Meanwhile, persistent Helicobacter pylori ( H. pylori ) infection causes gastric atrophic change, which itself is a major cause of gastric cancer, and it can further increase the risk of gastric cancer by strengthening corpus atrophy through interaction with PPIs. (helicojournal.org)
Prevalence of H. pylori Infection and Atrophic Gastritis Among Symptomatic and Dyspeptic Adults in Kazakhstan. (iiarjournals.org)
Objective: Use of a non-invasive blood test with four stomach-specific biomarkers [Pepsinogen-I (PG-I) and -II (PG-II), amidated gastrin-17 (G-17), and Helicobacter pylori (HP) IgG antibodies], to assess for the prevalence of stomach conditions: Helicobacter pylori (HP) infection and atrophic gastritis (AG), both known to increase GC risk of in Kazakhstan. (iiarjournals.org)
HP is the causal factor for several clinically important diseases in gastric and duodenal mucosa ( 7 - 11 ), and, in 1994, the IARC expert group classified HP infection as a group-I carcinogen for humans ( 12 ). (iiarjournals.org)
The exact mechanism by which HP-infection causes gastric cancer (GC) remains to be elucidated, but there is little doubt that HP-associated AG plays a key role in this development ( 14 , 15 ). (iiarjournals.org)
Infection by organisms other than H. pylori: Mycobacterium avium-intracellulare, enterococcal infection, Herpes simplex, and cytomegalovirus. (capsulehealth.one)
During the years after H. pylori discovery, especially following many meta-analyses and certain number of experimental evidences, it became a crucial question whether there is a link between gastric cancer and H. pylori infection (8). (docksci.com)
The third-line therapy of H. pylori is another challenging topic in treatment of this infection. (docksci.com)
Chronic inflammatory changes related to gastric Helicobacter pylori infection can also induce parietal cell changes. (medscape.com)

The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori - associated gastritis and 20 individuals as the control group. (who.int)
Gastric cancer is the fourth commonest ently reported that H. pylori eradication were subjected to routine history and malignant disorder and the second com- can lead to a regression of acute gastritis clinical examination, fol owed by an monest cause of cancer-related death and intestinal metaplasia, and that such upper gastrointestinal endoscopic ex- worldwide [1]. (who.int)
In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)
who cured IDA of a 15 year-old female presenting with anemia-related syncope and H. pylori -induced chronic active hemorrhagic gastritis by eradication therapy without iron supplements [ 14 ]. (biomedcentral.com)
First, increased iron loss can be due to hemorrhagic gastritis, peptic ulcer disease and gastric adenocarcinoma [ 22 ]. (biomedcentral.com)
Third, H. pylori -related corporal gastritis may decrease acid secretion due to gland atrophy and results in the reduction of iron absorption from diet [ 25 ]. (biomedcentral.com)
Gastritis is a condition involving inflammation of the gastric (stomach) mucosa. (capsulehealth.one)
Scheme on natural course and progression of Helicobacter pylori gastritis from a non-atrophic form to gastric malignancy (sc. (capsulehealth.one)
Moreover, since the prevalence of H. pylori and pattern of superficial gastritis can change quickly within a specific population, the incidence of gastric cancer can also shift rapidly (10). (docksci.com)
Chronic gastritis has been demonstrated to be a key cause of gastric cancer (GC), and control of gastric inflammation is regarded as an effective treatment for the clinical prevention of gastric carcinogenesis. (biomedcentral.com)

Several works also demonstrated recovery from IDA by successful eradication of H. pylori without iron supplements [ 20 ]. (biomedcentral.com)
Recent epidemiologic studies have reported an important link between long-term PPI intake and gastric cancer risk even after successful eradication of H. pylori . (helicojournal.org)

Currently, the effective control of gastric mucosal inflammation has highlighted the importance of GC inhibition [ 3 ]. (biomedcentral.com)

Other studies suggest that non-pathogenic strains of H. pylori may beneficially normalize stomach acid secretion, and regulate appetite. (wikipedia.org)
To our knowledge, certain H. pylori strains seem to differently increase the risk of cancer, depending on the existence of certain bacterial genotypes (for example: cagA) (12, 13). (docksci.com)
Taking together, in this paper, we aim to point out all important topics concerning management of H. pylori strains associated with gastric cancer. (docksci.com)

These were examined the genome of dividing gastric epithelial 20% [12]. (who.int)
The molecular mechanism of the interaction between gastric epithelial cells and H. pylori may also suggest a novel strategy for effective prevention of the development of gastric cancer (19, 20). (docksci.com)
Acid secretion by gastric epithelial cells is related to the physiologic function of oxyntic cells, which are called parietal cells. (medscape.com)

In recent decades, however, the prevalence of H. pylori colonization of the gastrointestinal tract has declined in many countries. (wikipedia.org)
The relative prevalence of H pylori in individuals of different socioeconomic backgrounds could alter this association. (medscape.com)

However, individuals infected with H. pylori have a 10% to 20% lifetime risk of developing peptic ulcers. (wikipedia.org)
Inflammation of the pyloric antrum, which connects the stomach to the duodenum, is more likely to lead to duodenal ulcers, while inflammation of the corpus (i.e. body of the stomach) is more likely to lead to gastric ulcers. (wikipedia.org)
Moreover, it leads to destructive changes in the gastric and duodenal mucosa and can be the cause of asymptomatic peptic ulcers [ 17 - 19 ]. (archivesofmedicalscience.com)

Further studies are necessary to elucidate actual role of H. pylori as causative agent to the development of gastric cancer. (docksci.com)

H. pylori has been associated with cancer of the mucosa-associated lymphoid tissue in the stomach, esophagus, colon, rectum, or tissues around the eye (termed extranodal marginal zone B-cell lymphoma of the cited organ), and of lymphoid tissue in the stomach (termed diffuse large B-cell lymphoma). (wikipedia.org)

H. pylori 감염과 별개로 PPI의 사용은 위점막의 위축성 변화(gastric atrophy)의 잠재적 위험인자가 될 수 있다[ 8 , 9 ]. (helicojournal.org)
Other mouse models have shown that a hypochloric stomach environment leads to enteric bacterial overgrowth, which may play a role in gastric atrophy, metaplasia, and cancer. (medscape.com)

Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, microaerophilic, spiral (helical) bacterium usually found in the stomach. (wikipedia.org)
Some studies suggest that H. pylori plays an important role in the natural stomach ecology, e.g. by influencing the type of bacteria that colonize the gastrointestinal tract. (wikipedia.org)
Parietal cells are mainly present in the gastric corpus and fundus, although complete mapping in the human stomach is not fully known. (medscape.com)
Genetic ablation of a Na+/H+ exchanger (NHE2), which is expressed in the stomach at high levels, leads to a decrease in gastric acid secretion, along with decreased viability of parietal cells, severe metaplasia, and hyperplasia of gastric mucosa. (medscape.com)

The loss of parietal cells results in a reduction of gastric acid secretion, which is necessary for the absorption of inorganic iron. (capsulehealth.one)
Parietal cells are responsible for secretion of hydrochloric acid and also produce intrinsic factor. (medscape.com)

Helicobacter pylori is a helix-shaped (classified as a curved rod, not spirochaete) Gram-negative bacterium about 3 μm long with a diameter of about 0.5 μm. (wikipedia.org)
The genome of the bacterium Helicobacter pylori has evolved over the millennia since its migration out of Africa along with its human host approximately 60,000 years ago. (gutnliver.org)

In group III a positive correlation was found between intensity of H. pylori colonization and TpH-1 expression as well as between TpH-1 expression and severity of dyspeptic symptoms. (archivesofmedicalscience.com)

In asymptomatic infections eradication of H. pylori is a preventive management of gastric cancer, especially in patients with a family history of this disease [ 20 - 22 ]. (archivesofmedicalscience.com)

Symptomatic response with lansoprazole does not preclude the presence of gastric malignancy. (nih.gov)
Although over the last years, incidence of gastric carcinoma is decreasing worldwide, it remains the fourth most common cancer and the second most common cause of malignancy-related death worldwide (6, 7). (docksci.com)

The relationship between H. pylori genome and gastric cancer rates is linked to the presence of the cagA gene, but the knowledge on this subject is incomplete because other genes may be involved in certain populations. (gutnliver.org)

Second, antrectomy with vagotomy is an older surgical procedure that is designed to block acid secretion regulated by gastrin release from the antrum and acetylcholine release from the vagus nerve. (medscape.com)

However, due to the methodological limitations of observational clinical studies, the causal relationship is still not clear, and a recent big data-based study reported that long-term PPI use was not related to gastric cancer incidence. (helicojournal.org)

Using metagenomic experiments can help scientists to determine properties of each microbiota member, which contributes in pathogenesis of gastric cancer. (docksci.com)

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2021;21(3):173-179. (helicojournal.org)
They include the gastrointestinal pathogen Helicobacter pylori (1), too much gastric acid (2), too much pepsin (3), and a breakdown of the protective mucus (4). (trc-p.nl)

Achlorhydria is associated with intestinal metaplasia of the gastric mucosa, which may lead to dysplasia, and is hence considered a premalignant condition. (medscape.com)

H. pylori causes IDA by several mechanisms. (biomedcentral.com)
Several potentially pathogenetic factors and mechanisms, linked with carcinogenesis, play a role and are triggered stepwise on during the course and progression of the cascade. (capsulehealth.one)

In humans, the proliferation of enterochromaffin-like (ECL) cells induced by hypergastrinemia is suspected as a potential mechanism of gastric cancer. (helicojournal.org)
Altered DNA methylation is a key mechanism of epigenetic modification in gastric cancer (GC). (gutnliver.org)

Bcl6b was gradually downregulated by its own promoter hypermethylation in parallel to an increasing inflammatory response during the progression of BaP-induced gastric carcinogenesis in mice. (biomedcentral.com)
However, whether BCL6B functions as a key tumour suppressor and inflammatory regulator during the progression of gastric oncogenesis in vivo requires further study. (biomedcentral.com)
In order to investigate the role of Bcl6b in gastric tumourigenesis, we assessed Bcl6b expression and the degree of inflammation during the progression of Benzo[a]pyrene (BaP)-induced gastric carcinogenesis in mice. (biomedcentral.com)

Many studies have pointed to impaired acid secretion in relation to increased age. (medscape.com)

L'étude portait sur 20 patients atteints d'un carcinome gastrique, 20 patients souffrant d'une gastrite à H. pylori et 20 personnes en tant que groupe témoin. (who.int)
performed a meta-analysis of 16 randomized controlled trials involving 956 patients to assess the impact of H. pylori eradication therapy on IDA [ 21 ]. (biomedcentral.com)
To minimize the possibility of gastric cancer in H. pylori -infected patients or precancerous lesions in long-term PPI users, long-term PPI administration should be limited to the minimum effective dose, and antibacterial treatment for H. pylori should be considered. (helicojournal.org)

In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology. (medscape.com)
Previously, we reported a dietary mouse NASH model with a choline-deficient, methionine-lowered, L-amino-acid-defined, high-fat diet containing shortening without trans fatty acids (CDAA-HF-T[-]), which rapidly induces fibrosis and proliferative lesions in the liver. (bvsalud.org)

H. pylori possesses five major outer membrane protein families. (wikipedia.org)
Second, CagA protein of H. pylori has been shown to participate in iron acquisition from interstitial holotransferrin [ 23 ]. (biomedcentral.com)

This study aimed to evaluate the changes in epigenetic and genetic expression of multiple Rho GTPases in Helicobacter pylori -related gastric carcinogenesis by comparing H. pylori -positive GCs and negative controls. (gutnliver.org)
Human migrations, after thousands of years of permanent settlement in those lands, resulted in seven prototypes of genetic populations of H. pylori with distinct geographical distributions. (gutnliver.org)

Concerns have been raised regarding the long-term use of proton pump inhibitors (PPIs) as an important risk factor for gastric cancer in clinical practice. (helicojournal.org)

When clinically manifested, gastric the presence or absence of any gross predominance [2]. (who.int)

May interfere with the absorption of drugs where gastric pH is important for bioavailability. (nih.gov)

Currently, the role of H. pylori in idiopathic thrombocytopenic purpura and iron deficiency anemia is well documented. (biomedcentral.com)
A contributory role for H. pylori in gastric cancer was first announced by the International Agency for Research on Cancer (IARC), when they labeled H. pylori a class I carcinogen (9). (docksci.com)
Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. (inabj.org)

Helicobacter pylori (H. pylori) is a leading cause of severe digestive disease, including gastric cancer (4, 5). (docksci.com)

Epigenetic inactivation of Bcl6b promotes gastric cancer through amplification of the gastric inflammatory response in vivo and offers a new approach for GC treatment and regenerative medicine. (biomedcentral.com)

In this condition, a defective TRPML1 (Ca2+ -permeable TRP channel) causes reduced levels and mislocalization of the gastric proton pump and alters the secretory canaliculi, causing hypochlorhydria and hypergastrinemia. (medscape.com)

Up to 90% of people infected with H. pylori never experience symptoms or complications. (wikipedia.org)
Dyspeptic symptoms are among the most common gastric complaints ( 1 ), experienced by 25-40% of the people during their lifetime ( 1 , 2 ). (iiarjournals.org)

To now, prevention is an optimal approach to deal with gastric cancer. (docksci.com)

Considering genetical background bound to high risk of gastric cancer, it is a major recommendation to eradicate H. pylori in persons with a family history of gastric cancer (21, 22). (docksci.com)
Disruption of this channel is a possible risk factor for gastric neoplasia. (medscape.com)

N-acetyl cysteine (NAC) comes from the amino acid L-cysteine. (medlineplus.gov)
Amino acids are building blocks of proteins. (medlineplus.gov)
BCL6B has a 94% identical amino acid sequence at the zinc finger motifs and a 65% identical BTB/POZ domain to BCL6, thus, they bind to similar target DNA sequences to act as transcriptional repressors. (biomedcentral.com)

H. pylori can be demonstrated in tissue by Gram stain, Giemsa stain, haematoxylin-eosin stain, Warthin-Starry silver stain, acridine orange stain, and phase-contrast microscopy. (wikipedia.org)

Taken together, despite the potential detrimental effects of PPIs, it is currently difficult to draw a definite conclusion about its association with gastric cancer. (helicojournal.org)

In all continents, present day isolates of H. pylori have molecular markers that refl ect population migrations. (gutnliver.org)

Bacterial-secreted CagA, inducing high levels of chronic inflammation, is the main factor increasing mutagenesis rate, oxidative-stress, and increased mismatch repair pathways, resulting in gastric carcinogenesis (14, 15). (docksci.com)

Therefore, the CDAA-HF-T(-) mouse model is useful for assessing NASH and NASH-associated hepatocarcinogenesis, and IL-8 signaling plays important roles in NASH-associated carcinogenesis and cirrhosis, but it may also play different roles in nontumoral liver tissue and tumorigenesis. (bvsalud.org)

Achlorhydria, in simple terms, means the absence of hydrochloric acid in gastric secretions and has been defined by multiple separate systems in reference to gastric acid secretion. (medscape.com)

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